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Article: Study on the movement mechanism of rice stem under the action of canopy-opening device based on explicit dynamics simulation.

Jing, Lin-Long / Wei, Xin-Hua / Song, Qi / Wang, Fei

2023 Volume 14, Page(s) 1252247

Abstract: The dense canopy of rice causes attenuation of droplet dispersion during pesticide application. The canopy-opening device can increase droplet deposition in the middle and lower canopy of rice by causing disturbance to the rice canopy. However, the ... ...

Abstract	The dense canopy of rice causes attenuation of droplet dispersion during pesticide application. The canopy-opening device can increase droplet deposition in the middle and lower canopy of rice by causing disturbance to the rice canopy. However, the conditions for use of the canopy-opening device are difficult to determine. Rice morphological structure parameters and material parameters were measured to study the movement mechanism of the rice stems under the action of the canopy-opening device, and the canopy-opening process was then simulated using the explicit dynamic method. The simulation scene of the rice canopy-opening process considered the combination of three different heights and three different driving velocities of the canopy-opening device. The movement mechanism of the rice stems under the operation of the canopy-opening device was investigated, and the entire movement process was separated into two stages: contact and oscillation. The simulation results and high-speed photography experimental results show a strong correlation, with a correlation coefficient of 0.733. The simulation results indicate that when the canopy-opening device is closer to the ground and the driving velocity is higher, the disturbance to the rice stem during the contact stage is stronger. However, for the oscillation stage, there exists a critical value for both the height and driving velocity of the canopy-opening device. During the oscillation stage, there is a critical value for both the height and driving velocity of the canopy-opening device. The numerical-based explicit dynamics approach was employed in this work to investigate the rice canopy motion mechanism, and this study has a definite reference value for the investigation of complicated motion mechanisms in the field crop production process.
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1252247
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Article ; Online: Noninvasive Characterization of Metabolic Changes in Ischemic Stroke Using Z-spectrum-fitted Multiparametric Chemical Exchange Saturation Transfer-weighted Magnetic Resonance Imaging.

Wang, Zhen-Xiong / Wei, Xin-Hua / Cai, Ke-Jia / Zhu, Wen-Zhen / Su, Chang-Liang

Current medical science

2023 Volume 43, Issue 5, Page(s) 970–978

Abstract: Objective: This study aimed to noninvasively characterize the metabolic alterations in ischemic brain tissues using Z-spectrum-fitted multiparametric chemical exchange saturation transfer-weighted magnetic resonance imaging (CEST-MRI).: Methods: ... ...

Abstract	Objective: This study aimed to noninvasively characterize the metabolic alterations in ischemic brain tissues using Z-spectrum-fitted multiparametric chemical exchange saturation transfer-weighted magnetic resonance imaging (CEST-MRI). Methods: Three sets of Z-spectrum data with saturation power (B Results: Ischemic lesions showed increased APT Conclusion: The Z-spectrum-fitted multiparametric CEST-MRI can comprehensively detect metabolic alterations in ischemic brain tissues.
Language	English
Publishing date	2023-09-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-023-2785-7
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Article ; Online: Abbreviated Versus Full-Protocol MRI for Breast Cancer Neoadjuvant Chemotherapy Response Assessment: Diagnostic Performance by General and Breast Radiologists.

Tang, Wen-Jie / Chen, Si-Yi / Hu, Wen-Ke / Li, Xue-Li / Zheng, Bing-Jie / Wang, Zhen-Sui / Ding, Han-Jun / Chen, Lei-Xin / Zhang, Qiong-Qiong / Yu, Xiao-Meng / Sui, Yi / Wei, Xin-Hua / Guo, Yuan

AJR. American journal of roentgenology

2023 Volume 220, Issue 6, Page(s) 817–825

Abstract: BACKGROUND. ...

Abstract	BACKGROUND.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Retrospective Studies ; Neoadjuvant Therapy ; Neoplasm, Residual ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.22.28686
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Article: [Pharmacokinetic study on five components in phthalide target areas of Chaxiong and its β-CD inclusion compounds based on UPLC-MS/MS].

Zhong, Ying-Huai / Feng, Jian-Fang / Xia, Ming-Yan / Wei, Xin-Hua / Wu, Qiu-Yan / Li, Dong-Xun / Liu, Xue-Mei / Zhang, Guo-Song

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 46, Issue 4, Page(s) 972–980

Abstract: This study aims to establish a method for the determination of the concentration of five main components of phthalide target areas of Chaxiong(CPTA) and its inclusion of β-CD in the plasma of rats, and determine the pharmacokinetic parameters, absolute ... ...

Abstract	This study aims to establish a method for the determination of the concentration of five main components of phthalide target areas of Chaxiong(CPTA) and its inclusion of β-CD in the plasma of rats, and determine the pharmacokinetic parameters, absolute bioavailability and relative bioavailability of CPTA/β-CD inclusion compound in vivo. The plasma concentrations of senkyunolide A, N-butylphthalide, new osthol lactone, Z-ligustilide and butenyl phthalide were determined with UPLC-MS/MS. The content determination was conducted at the chromatographic conditions as follows: Shim-pack GIST C_(18)-AQ HP column(2.1 mm×100 mm, 3 μm), mobile phase of 0.1% formic acid solution(A)-acetonitrile(B), gradient elution, flow rate of 0.3 mL·min~(-1), column temperature of 35 ℃ and injection volume of 2 μL. The mass spectra were obtained with electrospray ion source(ESI), positive ion mode and multi reaction monitoring. CPTA/β-CD inclusion compound was prepared by grinding method, DAS 2.0 software was used to model the data, and the absolute bioavailability of CPTA and relative bioavailability of inclusion compound were calculated. Finally, the methods for the determination of five components of senkyunolide A, N-butylphthalide, new osthol lactone, Z-ligustilide and butenyl phthalide in CPTA, were successfully established. The linear relationship among the five components was good within their respective ranges, r>0.99. The absolute bioavailability of the five components in rats was 22.30%, 16.32%, 21.90%, 10.16% and 12.43%, respectively. After CPTA/β-CD inclusion was prepared, the relative bioavailability of the five components was 138.69%, 198.39%, 218.01%, 224.54% and 363.55%, respectively, significantly improved. This method is rapid, accurate and sensitive, so it is suitable for the pharmacokinetic study of extracts in traditional Chinese medicine and their preparations.
MeSH term(s)	Animals ; Benzofurans ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Tandem Mass Spectrometry
Chemical Substances	Benzofurans ; phthalide (8VV922U86J)
Language	Chinese
Publishing date	2021-03-01
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20201012.201
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Zs.A 3056: Show issues

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Article ; Online: Evaluation of the Effects of Anti-PD-1 Therapy on Triple-Negative Breast Cancer in Mice by Diffusion Kurtosis Imaging and Dynamic Contrast-Enhanced Imaging.

Tang, Wen-Jie / Yao, Wang / Jin, Zhe / Kong, Qing-Cong / Hu, Wen-Ke / Liang, Yun-Shi / Chen, Lei-Xin / Chen, Si-Yi / Zhang, Qiong-Qiong / Wei, Xin-Hua / Xu, Xiang-Dong / Guo, Yuan / Jiang, Xin-Qing

Journal of magnetic resonance imaging : JMRI

2022 Volume 56, Issue 6, Page(s) 1912–1923

Abstract: Background: The monitoring of immunotherapies is still based on changes in the tumor size in imaging, with a long evaluation period and low sensitivity.: Purpose: To investigate the effectiveness of diffusion kurtosis imaging (DKI) and dynamic ... ...

Abstract	Background: The monitoring of immunotherapies is still based on changes in the tumor size in imaging, with a long evaluation period and low sensitivity. Purpose: To investigate the effectiveness of diffusion kurtosis imaging (DKI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in assessing the therapeutic efficacy of anti-programmed death-1 (PD-1) therapy in a mouse triple negative breast cancer (TNBC) model. Study type: Prospective. Animal model: A total of 54 BALB/c mouse subcutaneous 4 T1 transplantation models of TNBC. Field strength/sequence: A 3.0-T; turbo spin echo (TSE) T2-weighted imaging, DKI with seven b values (0, 500, 1000, 1500, 2000, 2500, and 3000 sec/mm Assessment: DKI and DCE-MRI parameters were evaluated by two radiologists independently. Regions of interest (ROIs) were drawn manually on the maximum cross-sectional area of the lesion; care was taken to avoid necrotic areas. The tumor cell density, the CD45 and CD31 levels were analyzed by two pathologists. Statistical tests: The two-tailed unpaired t-test, Mann-Whitney U test, Fisher's exact test and Pearson correlation coefficient were performed. A P < 0.05 was considered statistically significant. Results: The apparent diffusion coefficient (ADC), mean diffusivity (MD), K Data conclusion: DKI and DCE-MRI could reflect the changes in tumor microstructure and tumor tissue vasculature after anti-PD-1 therapy, respectively. Level of evidence: 1 TECHNICAL EFFICACY: Stage 4.
MeSH term(s)	Humans ; Mice ; Animals ; Triple Negative Breast Neoplasms/diagnostic imaging ; Triple Negative Breast Neoplasms/drug therapy ; Contrast Media/chemistry ; Prospective Studies ; Diffusion Magnetic Resonance Imaging/methods ; Diffusion Tensor Imaging
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28215
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Whole-Lesion Histogram Analysis of the Apparent Diffusion Coefficient as a Quantitative Imaging Biomarker for Assessing the Level of Tumor-Infiltrating Lymphocytes: Value in Molecular Subtypes of Breast Cancer.

Tang, Wen-Jie / Jin, Zhe / Zhang, Yan-Ling / Liang, Yun-Shi / Cheng, Zi-Xuan / Chen, Lei-Xin / Liang, Ying-Ying / Wei, Xin-Hua / Kong, Qing-Cong / Guo, Yuan / Jiang, Xin-Qing

Frontiers in oncology

2021 Volume 10, Page(s) 611571

Abstract: Purpose: To assess whether apparent diffusion coefficient (ADC) metrics can be used to assess tumor-infiltrating lymphocyte (TIL) levels in breast cancer, particularly in the molecular subtypes of breast cancer.: Methods: In total, 114 patients with ... ...

Abstract	Purpose: To assess whether apparent diffusion coefficient (ADC) metrics can be used to assess tumor-infiltrating lymphocyte (TIL) levels in breast cancer, particularly in the molecular subtypes of breast cancer. Methods: In total, 114 patients with breast cancer met the inclusion criteria (mean age: 52 years; range: 29-85 years) and underwent multi-parametric breast magnetic resonance imaging (MRI). The patients were imaged by diffusion-weighted (DW)-MRI (1.5 T) using a single-shot spin-echo echo-planar imaging sequence. Two readers independently drew a region of interest (ROI) on the ADC maps of the whole tumor. The mean ADC and histogram parameters (10 Results: A statistically significant difference existed in the 10 Conclusions: Our findings suggest that whole-lesion ADC histogram parameters can be used as surrogate biomarkers to evaluate TIL levels in molecular subtypes of breast cancer.
Language	English
Publishing date	2021-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.611571
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Article ; Online: Performance of radiomics models for tumour-infiltrating lymphocyte (TIL) prediction in breast cancer: the role of the dynamic contrast-enhanced (DCE) MRI phase.

Tang, Wen-Jie / Kong, Qing-Cong / Cheng, Zi-Xuan / Liang, Yun-Shi / Jin, Zhe / Chen, Lei-Xin / Hu, Wen-Ke / Liang, Ying-Ying / Wei, Xin-Hua / Guo, Yuan / Jiang, Xin-Qing

European radiology

2021 Volume 32, Issue 2, Page(s) 864–875

Abstract: Objective: To systematically investigate the effect of imaging features at different DCE-MRI phases to optimise a radiomics model based on DCE-MRI for the prediction of tumour-infiltrating lymphocyte (TIL) levels in breast cancer.: Materials and ... ...

Abstract	Objective: To systematically investigate the effect of imaging features at different DCE-MRI phases to optimise a radiomics model based on DCE-MRI for the prediction of tumour-infiltrating lymphocyte (TIL) levels in breast cancer. Materials and methods: This study retrospectively collected 133 patients with pathologically proven breast cancer, including 73 patients with low TIL levels and 60 patients with high TIL levels. The volumes of breast cancer lesions were manually delineated on T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and each phase of DCE-MRI, followed by 6250 quantitative feature extractions. The least absolute shrinkage and selection operator (LASSO) method was used to select predictive feature sets for the classifiers. Four models were developed for predicting TILs: (1) single enhanced phase radiomics models; (2) fusion enhanced multi-phase radiomics models; (3) fusion multi-sequence radiomics models; and (4) a combined radiomics-based clinical model. Results: Image features extracted from the delayed phase MRI, especially DCE_Phase 6 (DCE_P6), demonstrated dominant predictive performances over features from other phases. The fusion multi-sequence radiomics model and combined radiomics-based clinical model achieved the highest predictive performances with areas under the curve (AUCs) of 0.934 and 0.950, respectively; however, the differences were not statistically significant. Conclusion: The DCE-MRI radiomics model, especially image features extracted from the delayed phases, can help improve the performance in predicting TILs. The radiomics nomogram is effective in predicting TILs in breast cancer. Key points: • Radiomics features extracted from DCE-MRI, especially delayed phase images, help predict TIL levels in breast cancer. • We developed a nomogram based on MRI to predict TILs in breast cancer that achieved the highest AUC of 0.950.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating ; Magnetic Resonance Imaging ; Nomograms ; Retrospective Studies
Language	English
Publishing date	2021-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-021-08173-5
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Zs.A 3300: Show issues

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Article: Magnetic Resonance Imaging (MRI) Phenotypes May Provide Additional Information for Risk Stratification for Encapsulated Papillary Carcinoma of the Breast.

Tang, Wen-Jie / Liang, Yun-Shi / Yan, Jing / Hu, Yue / Sun, Mei-Li / Liu, Guo-Shun / Pan, Xiao-Huan / Wei, Xin-Hua / Jiang, Xin-Qing / Guo, Yuan

Cancer management and research

2020 Volume 12, Page(s) 11751–11760

Abstract: Background: Encapsulated papillary carcinoma (EPC) of the breast is a rare entity. EPC can be underappreciated on percutaneous biopsy, which may require additional procedures if invasion is not recognized preoperatively. We aimed to investigate the ... ...

Abstract	Background: Encapsulated papillary carcinoma (EPC) of the breast is a rare entity. EPC can be underappreciated on percutaneous biopsy, which may require additional procedures if invasion is not recognized preoperatively. We aimed to investigate the magnetic resonance imaging (MRI) phenotypes correlated with preoperative pathological risk stratification for clinical guidance. Materials and methods: The preoperative MRI scans of 30 patients diagnosed with 36 EPCs in multiple centers between August 2015 and February 2020 were reviewed by two breast radiologists. According to the WHO classification published in 2019, EPCs were classified into two pathological subtypes: encapsulated papillary carcinoma and encapsulated papillary carcinoma with invasion. Clinicopathological analysis of the two subtypes and MR feature analysis were performed. Results: Evaluation of the MRI phenotypes and pathological subtype information revealed that not circumscribed (P=0.04) was more common in EPCs with invasion than in EPCs. There was a significant difference in the age of patients (P=0.05), and the risk increased with age. The maximum diameter of the tumor increased with tumor risk, but there was no significant difference (P=0.36). Nearly half of the EPC with invasion patients showed hyperintensity on T1WI (P=0.19). A total of 63.6% of the EPC with invasion group showed non-mass enhancement surrounding (P=0.85). In addition, 29 patients (96.7%) had no axillary lymph node metastasis, and only one patient with EPC with invasion had axillary lymph node metastasis. Further pathological information analysis of EPCs showed that higher Ki-67 levels were more common in patients with EPCs with invasion (P=0.04). A total of 29 patients (96.7%) had the luminal phenotype, and one patient with EPC with invasion had the Her-2-positive phenotype. Conclusion: The margin, age and Ki-67 level were the key features for EPC risk stratification. In addition, these MRI signs, including a larger tumor, non-mass enhancement surrounding and axillary lymph node metastasis, may be suggestive of a high-risk stratification. Therefore, MRI phenotypes may provide additional information for the risk stratification of EPCs.
Language	English
Publishing date	2020-11-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S277980
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Article ; Online: Can whole-tumor apparent diffusion coefficient histogram analysis be helpful to evaluate breast phyllode tumor grades?

Guo, Yuan / Tang, Wen-Jie / Kong, Qing-Cong / Liang, Ying-Ying / Han, Xiao-Rui / Zheng, Bing-Jie / Sun, Lei / Wei, Xin-Hua / Jin, Zhe / Liu, Chun-Ling

European journal of radiology

2019 Volume 114, Page(s) 25–31

Abstract: Purpose: To investigate whether whole-tumor apparent diffusion coefficient (ADC) histogram analysis could be helpful to evaluate breast phyllode tumor (PT) grades.: Materials and methods: This institutional review board-approved retrospective study ... ...

Abstract	Purpose: To investigate whether whole-tumor apparent diffusion coefficient (ADC) histogram analysis could be helpful to evaluate breast phyllode tumor (PT) grades. Materials and methods: This institutional review board-approved retrospective study included 56 PTs (23 benign lesions, 22 borderline lesions, and 11 malignant lesions) from August 2011 to November 2017. MRI was performed using a 1.5 T MR system equipped with a 4-channel SENSE breast coil. All cases were divided into two groups, benign PT (BPT) and borderline or malignant PT (BMPT). The conventional MR parameters included age, longest diameter, shape, margin, internal enhancement characteristics, cystic component of the tumor, wall of the cystic component, peritumoral edema on T2-weighted imaging (T2WI), T1-weighted imaging (T1WI) and T2WI signal intensity, time-signal intensity curve (TIC) patterns and early-stage enhancement ratio (EER). The ADC values were determined in three different types of regions of interest (ROIs), including a circular ROI (ROI-c), single-slice ROI (ROI-s), and whole-tumor ROI (ROI-w). All ADC values were measured twice by Observer A and B (with a 2-week interval). The Ki-67 index was determined, and cases were classified into a "negative group" (Ki-67<14%) and a "positive group" (Ki-67≥14%). SPSS Statistics V21.0 was used for the statistical analyses. Results: Our study included 23 cases of BPT and 33 cases of BMPT (including 22 borderline PTs and 11 malignant PTs). Only 23 patients in BMPT group had Ki-67 results, and 17 of these were positive. Regarding conventional MR features, significant differences were observed in the margin (P = 0.011), cystic component (P<0.001), peritumoral edema on T2WI (P<0.001), and cystic wall (P = 0.011) of the PT between the BPT and BMPT groups. Regarding the ADC value, good intraobserver agreement for ROI-c, ROI-s and ROI-w measurements was obtained. For the three different ROIs, the intraclass correlation coefficient (ICC) values were 0.905 for ROI-c (P > 0.05), 0.965 (P > 0.05) for ROI-s and 0.994 (P > 0.05) for ROI-w. ADC parameter indicated that the figure of ROI-s tended to be higher than the ROI-c and ROI-w, while the ROI-c and ROI-w values were similar. However, no significant difference was found in ADC values between the BPT and BMPT groups for ROI-c, ROI-s and mean ROI-w values and the 10th, 25th, 50th and 75th ROI-w. The areas under the ROC curves for the mean ROI-w and the 10th, 25th, 50th and 75th ROI-w were 0.568, 0.613, 0.567, 0.544, and 0.540, respectively. Conclusion: Based on the results obtained in our study, the whole-tumor ADC histogram could not improve differentiation of the breast PT grade, while conventional MR images could provide more meaningful information, so morphological characteristics may be valuable than ADC value, and ADC could be used as a supplemental method to differentiate PT grades.
MeSH term(s)	Adult ; Breast/pathology ; Breast Neoplasms/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Margins of Excision ; Neoplasm Grading ; Phyllodes Tumor/pathology ; ROC Curve ; Retrospective Studies
Language	English
Publishing date	2019-02-27
Publishing country	Ireland
Document type	Evaluation Studies ; Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2019.02.035
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Article: Surface functionalization of superparamagnetic nanoparticles by an acid-liable polysaccharide-based prodrug for combinatorial monitoring and chemotherapy of hepatocellular carcinoma

Fu, Chaoping / Yang, Rui-Meng / Wang, Li / Li, Nan-nan / Qi, Meng / Xu, Xiang-dong / Wei, Xin-hua / Jiang, Xin-Qing / Zhang, Li-Ming

RSC advances. 2017 Aug. 30, v. 7, no. 66

2017

Abstract: For combinatorial monitoring and chemotherapy of hepatocellular carcinoma, the macromolecular prodrug based on hyaluronic acid and doxorubicin hydrochloride was prepared by an acid-labile hydrazone linkage, and then conjugated with amine-modified iron ... ...

Abstract	For combinatorial monitoring and chemotherapy of hepatocellular carcinoma, the macromolecular prodrug based on hyaluronic acid and doxorubicin hydrochloride was prepared by an acid-labile hydrazone linkage, and then conjugated with amine-modified iron oxide nanoparticles by a carbodiimide mediated coupling reaction. The resultant hybrid nanoparticles have the characteristics of good water dispersibility, superparamagnetic property and high magnetic relaxivity for magnetic resonance imaging. In particular, they demonstrated significant cellular uptake and specific accumulation in human hepatocellular liver carcinoma HepG2 cells due to specific biological recognition of hyaluronic acid. In addition, in vitro cumulative release of doxorubicin hydrochloride from the resultant hybrid nanoparticles was significantly accelerated at a mildly acidic pH of 5.0–6.0 when compared to its release at the physiological pH of 7.4, suggesting the pH-responsive feature of this conjugated prodrug for effective chemotherapy of hepatocellular carcinoma. In vivo antitumor efficacy of the mice further confirmed the effect.
Keywords	carcinoma ; dispersibility ; doxorubicin ; drug therapy ; hepatoma ; human cell lines ; humans ; hyaluronic acid ; hydrazones ; liver ; magnetic resonance imaging ; magnetism ; mice ; monitoring ; nanoparticles ; pH
Language	English
Dates of publication	2017-0830
Size	p. 41919-41928.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c7ra05042a
Database	NAL-Catalogue (AGRICOLA)

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