Article ; Online: Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
2020 Volume 54, Issue 1, Page(s) 27–36
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2- ... ...
Abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2-associated viral pneumonia pandemic was first reported in December 2019 in China. Based on known pharmacological mechanisms, many therapeutic drugs have been repurposed to target SARS-CoV-2. Among these drugs, remdesivir appears to be the currently most promising according to several clinical trials and reports of compassionate use. In this mini-review, we summarize the current evidence on the efficacy and challenges of remdesivir for the treatment of coronavirus disease 2019 (COVID-19). |
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MeSH term(s) | Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/analogs & derivatives ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; Antiviral Agents/administration & dosage ; COVID-19/drug therapy ; COVID-19/epidemiology ; China/epidemiology ; Clinical Trials as Topic ; Humans ; Pandemics ; Randomized Controlled Trials as Topic ; SARS-CoV-2/drug effects |
Chemical Substances | Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX) |
Keywords | covid19 |
Language | English |
Publishing date | 2020-10-05 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 1497590-7 |
ISSN | 1995-9133 ; 1684-1182 ; 0253-2662 |
ISSN (online) | 1995-9133 |
ISSN | 1684-1182 ; 0253-2662 |
DOI | 10.1016/j.jmii.2020.09.002 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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