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Article: Influence of Rifamycin on Survival in Patients with Concomitant Lung Cancer and Pulmonary Tuberculosis.

Lee, Ho-Sheng / Wei, Yu-Feng / Shu, Chin-Chung

2023 Volume 11, Issue 12

Abstract: Background: The coexistence of lung cancer and tuberculosis is not rare. Rifamycin plays a pivotal role in anti-tuberculosis therapy. However, its potential impact on the liver metabolism of oncology drugs raises concerns. We performed this study to ... ...

Abstract	Background: The coexistence of lung cancer and tuberculosis is not rare. Rifamycin plays a pivotal role in anti-tuberculosis therapy. However, its potential impact on the liver metabolism of oncology drugs raises concerns. We performed this study to explore whether Rifamycin affects the survival of patients with tuberculosis and lung cancer. Methods: Drawing from the Taiwan National Health Insurance Research Database, we identified patients diagnosed with concurrent lung cancer and tuberculosis between 2000 and 2014. Patients were categorized based on whether they underwent rifamycin-inclusive or rifamycin-exempt anti-tuberculosis therapy. Subsequently, we paired them at a 1:1 ratio and evaluated the mortality risk over a two-year span. Results: Out of the study participants, 1558 (81.4%) received rifamycin-based anti-tuberculosis therapy, while 356 (18.6%) underwent a rifamycin-free regimen. Analysis revealed no marked variance in the biennial mortality rate between the groups (adjusted hazard ratio: 1.33, 95% confidence interval 0.93-1.90, Conclusions: For individuals with concomitant lung cancer and tuberculosis, rifamycin's administration did not adversely influence two-year survival. Thus, rifamycin-containing anti-TB regimens should be prescribed for the indicated patients.
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11123130
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genomic insights into the genetic basis of eagle-beak jaw, large head, and long tail in the big-headed turtle.

Gong, Shiping / Ge, Yan / Wei, Yufeng / Gao, Yangchun

Ecology and evolution

2023 Volume 13, Issue 7, Page(s) e10361

Abstract: The big-headed turtle ( ...

Abstract	The big-headed turtle (
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10361
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between waist-hip ratio and Female Infertility in the United States: Data from National Health and Nutrition Examination Survey 2017-2020.

Lai, Jun / Li, Xinqing / Liu, Zongyan / Liao, Yuanyue / Xiao, Zuomiao / Wei, Yufeng / Cao, Yongxiao

Obesity facts

2024

Abstract: Introduction: Obesity has previously been correlated with an elevated risk of reproductive system diseases in women. The waist-hip ratio (WHR) has been shown to be correlated with visceral fat, making it one of the most commonly used indicators of ... ...

Abstract	Introduction: Obesity has previously been correlated with an elevated risk of reproductive system diseases in women. The waist-hip ratio (WHR) has been shown to be correlated with visceral fat, making it one of the most commonly used indicators of abdominal obesity. However, little is known about the relationship between WHR and infertility. Therefore, the aim of this study was to evaluate the effect of the WHR on infertility in women of childbearing age. Methods: The study used cross-sectional data from women aged 20 to 45 who participated in the National Health and Nutrition Examination Survey (NHANES), which was conducted between 2017 and 2020. We collected details of their Waist Circumference, hip Circumference, fertility status and several other essential variables. We used multivariate logistic regression analysis and subgroup analyses to assess the association between WHR and infertility. Results: There were 976 participants, with 12.0% (117/976) who experienced infertility. After adjusting for potential confounding factors, our multivariate logistic regression analysis revealed that every 0.1 unit increase in WHR resulted in a more than 35% higher risk of infertility (OR (95% CI): 1.35 (1.01~1.81), P = 0.043). Compared to the group with WHR <0.85, the risk of infertility increased in the group with WHR ≥0.85, with an adjusted odds ratio (OR) of 1.74 (95% CI 1.06~2.85). When WHR was treated as a continuous variable, it was observed that each 0.1 unit increase in WHR was associated with a relatively high risk in the secondary infertility population after adjusting all covariates, with an OR of 1.66 (95% CI 1.14~2.40, P = 0.01). When WHR was analyzed as a categorical variable, the group with WHR≥0.85 exhibited a significantly higher risk of secondary infertility than the group with WHR<0.85, with the OR of 2.75 (95% CI: 1.35-5.59, P = 0.01) after adjusting for all covariates. Furthermore, the interaction analysis indicated that there was a significant interaction between age status on WHR and the risk of infertility. Conclusion: WHR showed a positive correlation with the risk of infertility. This study highlights the importance of effectively managing abdominal fat and promoting the maintenance of optimal WHR levels to mitigate the progression of infertility, particularly for younger women.
Language	English
Publishing date	2024-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2417831-7
ISSN	1662-4033 ; 1662-4025
ISSN (online)	1662-4033
ISSN	1662-4025
DOI	10.1159/000538974
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Article ; Online: PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.

Ikedife, Joyce / He, Jianlin / Wei, Yufeng

Scientific reports

2022 Volume 12, Issue 1, Page(s) 116

Abstract: Phosphoprotein enriched in astrocytes, 15 kDa (PEA-15) is a death-effector domain (DED) containing protein involved in regulating mitogen-activated protein kinase and apoptosis pathways. In this molecular dynamics study, we examined how phosphorylation ... ...

Abstract	Phosphoprotein enriched in astrocytes, 15 kDa (PEA-15) is a death-effector domain (DED) containing protein involved in regulating mitogen-activated protein kinase and apoptosis pathways. In this molecular dynamics study, we examined how phosphorylation of the PEA-15 C-terminal tail residues, Ser-104 and Ser-116, allosterically mediates conformational changes of the DED and alters the binding specificity from extracellular-regulated kinase (ERK) to Fas-associated death domain (FADD) protein. We delineated that the binding interfaces between the unphosphorylated PEA-15 and ERK2 and between the doubly phosphorylated PEA-15 and FADD are similarly composed of a scaffold that includes both the DED and the C-terminal tail residues of PEA-15. While the unphosphorylated serine residues do not directly interact with ERK2, the phosphorylated Ser-116 engages in strong electrostatic interactions with arginine residues on FADD DED. Upon PEA-15 binding, FADD repositions its death domain (DD) relative to the DED, an essential conformational change to allow the death-inducing signaling complex (DISC) assembly.
MeSH term(s)	Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/metabolism ; Fas-Associated Death Domain Protein/chemistry ; Fas-Associated Death Domain Protein/metabolism ; Humans ; Mitogen-Activated Protein Kinase 1/chemistry ; Mitogen-Activated Protein Kinase 1/metabolism ; Molecular Dynamics Simulation ; Multiprotein Complexes ; Phosphorylation ; Protein Binding ; Protein Conformation ; Serine ; Static Electricity ; Structure-Activity Relationship
Chemical Substances	Apoptosis Regulatory Proteins ; FADD protein, human ; Fas-Associated Death Domain Protein ; Multiprotein Complexes ; PEA15 protein, human ; Serine (452VLY9402) ; MAPK1 protein, human (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24)
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-04099-6
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Article: On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities.

Wei, Yufeng

Pharmaceuticals (Basel, Switzerland)

2015 Volume 8, Issue 3, Page(s) 455–473

Abstract: Phosphoprotein enriched in astrocytes, 15 KDa (PEA-15), a ubiquitously expressed small protein in all mammals, is known for decades for its potent interactions with various protein partners along distinct biological pathways. Most notable interacting ... ...

Abstract	Phosphoprotein enriched in astrocytes, 15 KDa (PEA-15), a ubiquitously expressed small protein in all mammals, is known for decades for its potent interactions with various protein partners along distinct biological pathways. Most notable interacting partners of PEA-15 include extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the mitogen activated protein kinase (MAPK) pathway, the Fas-associated death domain (FADD) protein involving in the formation of the death-inducing signaling complex (DISC), and the phospholipase D1 (PLD1) affecting the insulin sensitivity. However, the actual cellular functions of PEA-15 are still mysterious, and the question why this protein is expressed in almost all cell and tissue types remains unanswered. Here we synthesize the most recent structural, biological, and clinical studies on PEA-15 with emphases on its anti-apoptotic, anti-proliferative, and anti-inflammative properties, and propose a converged protective role of PEA-15 that maintains the balance of death and survival in different cell types. Under conditions that this delicate balance is unsustainable, PEA-15 may become pathological and lead to various diseases, including cancers and diabetes. Targeting PEA-15 interactions, or the use of PEA-15 protein as therapeutics, may provide a wider window of opportunities to treat these diseases.
Language	English
Publishing date	2015-07-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph8030455
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Article: Substance Use Disorder in the COVID-19 Pandemic: A Systematic Review of Vulnerabilities and Complications.

Wei, Yufeng / Shah, Rameen

Pharmaceuticals (Basel, Switzerland)

2020 Volume 13, Issue 7

Abstract: As the world endures the coronavirus disease 2019 (COVID-19) pandemic, the conditions of 35 million vulnerable individuals struggling with substance use disorders (SUDs) worldwide have not received sufficient attention for their special health and ... ...

Abstract	As the world endures the coronavirus disease 2019 (COVID-19) pandemic, the conditions of 35 million vulnerable individuals struggling with substance use disorders (SUDs) worldwide have not received sufficient attention for their special health and medical needs. Many of these individuals are complicated by underlying health conditions, such as cardiovascular and lung diseases and undermined immune systems. During the pandemic, access to the healthcare systems and support groups is greatly diminished. Current research on COVID-19 has not addressed the unique challenges facing individuals with SUDs, including the heightened vulnerability and susceptibility to the disease. In this systematic review, we will discuss the pathogenesis and pathology of COVID-19, and highlight potential risk factors and complications to these individuals. We will also provide insights and considerations for COVID-19 treatment and prevention in patients with SUDs.
Keywords	covid19
Language	English
Publishing date	2020-07-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph13070155
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Book ; Online: Adaptive wave-particle decomposition in UGKWP method for high-speed flow simulations

Wei, Yufeng / Cao, Junzhe / Ji, Xing / Xu, Kun

2023

Abstract: With wave-particle decomposition, a unified gas-kinetic wave-particle (UGKWP) method has been developed for the multiscale flow simulations. The UGKWP method captures the transport process in all flow regimes without kinetic solver's constraint on the ... ...

Abstract	With wave-particle decomposition, a unified gas-kinetic wave-particle (UGKWP) method has been developed for the multiscale flow simulations. The UGKWP method captures the transport process in all flow regimes without kinetic solver's constraint on the numerical mesh size and time step being less than the particle mean free path and collision time. In the current UGKWP method, the cell's Knudsen number, defined as the ratio of collision time to numerical time step, is used to distribute the components in the wave-particle decomposition. However, the adaptation of particle in UGKWP is mainly for the capturing of the non-equilibrium transport, and the cell's Knudsen number alone is not enough to identify the non-equilibrium state. For example, in the equilibrium flow regime with a Maxwellian distribution function, even at a large cell's Knudsen number, the flow evolution can be still modelled by the Navier-Stokes solver. Therefore, to further improve the efficiency, an adaptive UGKWP (AUGKWP) method will be developed with the introduction of an additional local flow variable gradient-dependent Knudsen number. As a result, the wave-particle decomposition in UGKWP will be determined by both cell's and gradient's Knudsen numbers, and the particle in UGKWP is solely used to capture the non-equilibrium flow transport. The AUGKWP becomes much more efficient than the previous one with the cell's Knudsen number only in the determination of wave-particle composition. Many numerical tests, including Sod tube, shock structure, flow around a cylinder, flow around a reentry capsule, and an unsteady nozzle plume flow, have been conducted to validate the accuracy and efficiency of AUGKWP. Compared with the original UGKWP, the AUGKWP achieves the same accuracy but has advantages in memory reduction and computational efficiency in the simulation for the flow with the co-existing of multiple regimes. Comment: arXiv admin note: substantial text overlap with arXiv:2211.12922
Keywords	Physics - Fluid Dynamics ; Physics - Computational Physics
Subject code	621
Publishing date	2023-03-23
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Nonequilibrium flow simulations using unified gas-kinetic wave-particle method

Long, Wenpei / Wei, Yufeng / Xu, Kun

2023

Abstract: Nonequilibrium flows are common in aerospace engineering, and numerical simulations are vital in understanding non-equilibrium flow dynamics in spacecraft flight. The unified gas-kinetic wave-particle (UGKWP) method has been developed for multi-scale ... ...

Abstract	Nonequilibrium flows are common in aerospace engineering, and numerical simulations are vital in understanding non-equilibrium flow dynamics in spacecraft flight. The unified gas-kinetic wave-particle (UGKWP) method has been developed for multi-scale flow simulation, which models the coupled particle transport and collision within a numerical time in the flux evaluation across a cell interface. The UGKWP balances precision and efficiency in multiscale flow simulations, particularly in high-speed flow. In this study, the UGKWP method is used to simulate supersonic flow around a sphere, hypersonic flow around a space vehicle, nozzle plume into a vacuum, and side-jet impingement on hypersonic flow. The UGKWP accurately renders the Navier-Stokes solution within the nozzle, extending to free molecular flow in the external environment, all within a singular computation. Complicated structures in flow interaction have been captured by the UGKWP method. All simulation results have been verified through experimental measurements or Direct Simulation Monte Carlo (DSMC) methods. The UGKWP method requires only 60 GiB of memory to simulate a three-dimensional space vehicle with 560593 cells under different flow conditions, making it efficient and accurate for aerospace engineering applications. Comment: 39 pages with 31 figures and 13 tables
Keywords	Physics - Fluid Dynamics ; Physics - Computational Physics
Subject code	621 ; 532
Publishing date	2023-10-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Adaptive unified gas-kinetic scheme for diatomic gases with rotational and vibrational nonequilibrium

Wei, Yufeng / Long, Wenpei / Xu, Kun

2023

Abstract: Multiscale non-equilibrium physics at large variations of local Knudsen number are encountered in applications of aerospace engineering and micro-electro-mechanical systems, such as high-speed flying vehicles and low pressure of the encapsulation. An ... ...

Abstract	Multiscale non-equilibrium physics at large variations of local Knudsen number are encountered in applications of aerospace engineering and micro-electro-mechanical systems, such as high-speed flying vehicles and low pressure of the encapsulation. An accurate description of flow physics in all flow regimes within a single computation requires a genuinely multiscale method. The adaptive unified gas-kinetic scheme (AUGKS) is developed for such multiscale flow simulation. The AUGKS applies discretized velocity space to accurately capture the non-equilibrium physics in the multiscale UGKS, and adaptively employs continuous distribution functions following Chapman-Enskog expansion to efficiently recover near-equilibrium flow region in GKS. The UGKS and GKS are dynamically connected at the cell interface through the fluxes from the discretized and continuous gas distribution functions, which avoids any buffer zone between them. In this study, the AUGKS method with rotation and vibration non-equilibrium is developed. The real gas effect in different flow regimes has been captured. To capture aerodynamic heating accurately, the heat flux modifications are also included. Unstructured discrete particle velocity space is adopted to further improve the computational performance. Numerical tests, including Sod tube, normal shock structure, high-speed flow around the two-dimensional cylinder and three-dimensional sphere and space vehicles, and an unsteady nozzle plume flow from the continuum flow to the background vacuum, have been conducted to validate the current scheme. In comparison with the original UGKS, the current scheme speeds up the computation, reduces the memory requirement, and maintains the equivalent accuracy for multiscale flow simulation, which provides an effective tool for non-equilibrium flow simulations, especially for the flows at low and medium speed. Comment: arXiv admin note: text overlap with arXiv:2211.12922
Keywords	Physics - Fluid Dynamics ; Physics - Computational Physics
Subject code	621
Publishing date	2023-12-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Incorporating physiological data into species distribution models to predict the potential distribution range of the red-eared slider in China

Gong, Shiping / Gao, Yangchun / Duan, Haoran / Ge, Yan / Wei, Yufeng

Ecological Indicators. 2023 Oct., v. 154 p.110749-

2023

Abstract: Species distribution models (SDMs) have been widely used to predict potentially suitable habitats for invasive alien species (IAS) and evaluate invasion risk. However, SDMs have been discredited because they ignore the physiological processes by which ... ...

Abstract	Species distribution models (SDMs) have been widely used to predict potentially suitable habitats for invasive alien species (IAS) and evaluate invasion risk. However, SDMs have been discredited because they ignore the physiological processes by which species respond to their environment. Integrating physiological tolerance into the model is essential to improve the prediction accuracy of SDMs. Currently, this approach has not been applied in the study of the worldwide invasive species, the red-eared slider (Trachemys scripta elegans), which is one of the world’s 100 worst invasive species and is widespread in China. In this study, based on hatching experiments, we found that the embryo temperature tolerance range of the red-eared slider was between 21.8 °C and 33.1 °C. Further, we studied the effect of embryo temperature tolerance on the prediction of potential invasion areas for this alien reptile species. The high suitability area (530,214.71 km²) predicted by the SDM incorporating embryo temperature tolerance data were 20.9% smaller than that (641,107.60 km²) predicted by the SDM without considering embryo temperature tolerance. The difference between the two SDMs is primarily concentrated at the edges of the high suitability areas. The incorporation of embryo temperature tolerance data influenced the model's predictions by effectively reducing the extent of edges of the high suitability areas. High suitability areas for red-eared sliders are mainly concentrated in South China, Central China, and East China, with a few in North and Southwest China. There is almost no invasion risk in most of the northeast and northwest provinces of China. This study not only has theoretical significance for optimizing model predictions, but also provides an important scientific basis for prevention and risk assessment of invasion by red-eared sliders in China.
Keywords	Trachemys scripta elegans ; geographical distribution ; invasive species ; models ; prediction ; reptiles ; risk ; risk assessment ; temperature ; China ; Invasive alien species ; Red-eared slider ; Embryo temperature tolerance ; Potential invasion area ; Prediction accuracy
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2023.110749
Database	NAL-Catalogue (AGRICOLA)

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