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  1. Article ; Online: Corrigendum

    Jiayuan Bai / Wei Lu

    Frontiers in Public Health, Vol

    A comparative study for accessing primary healthcare between planning assessment and actual utilization for older adults: a case from Dalian City, China

    2024  Volume 11

    Keywords healthy aging ; community-oriented ; primary health care ; accessibility ; planning assessment ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Mechanism of Gualou Xiebai Banxia Decoction against Myocardial Infarction.

    Wang, Wei-Lu / Chen, Yan

    Genes

    2024  Volume 15, Issue 4

    Abstract: The aim of this study was to investigate targets through which Gualou Xiebai Banxia decoction aids in treating myocardial infarction (MI) using network pharmacology in combination with molecular docking. The principal active ingredients of Gualou Xiebai ... ...

    Abstract The aim of this study was to investigate targets through which Gualou Xiebai Banxia decoction aids in treating myocardial infarction (MI) using network pharmacology in combination with molecular docking. The principal active ingredients of Gualou Xiebai Banxia decoction were identified from the TCMSP database using the criteria of drug-likeness ≥30% and oral bioavailability ≥0.18. Interactions and pathway enrichment were investigated using protein-protein interaction (PPI) networks and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, respectively. Active component structures were docked with those of potential protein targets using AutoDock molecular docking relative softwares. HIF1A was of particular interest as it was identified by the PPI network, GO and KEGG pathway enrichment analyses. In conclusion, the use of network pharmacology prediction and molecular docking assessments provides further information on the active components and mechanisms of action Gualou Xiebai Banxia decoction.
    MeSH term(s) Molecular Docking Simulation ; Myocardial Infarction/drug therapy ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Protein Interaction Maps/drug effects ; Network Pharmacology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/chemistry
    Chemical Substances Drugs, Chinese Herbal ; Hypoxia-Inducible Factor 1, alpha Subunit
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15040392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Minimal Linear Codes Constructed from Sunflowers

    Xia Wu / Wei Lu

    Entropy, Vol 25, Iss 12, p

    2023  Volume 1669

    Abstract: Sunflower in coding theory is a class of important subspace codes and can be used to construct linear codes. In this paper, we study the minimality of linear codes over ... F q ... constructed from sunflowers of size s in all cases. For ... ...

    Abstract Sunflower in coding theory is a class of important subspace codes and can be used to construct linear codes. In this paper, we study the minimality of linear codes over <semantics> F q </semantics> constructed from sunflowers of size s in all cases. For any sunflower, the corresponding linear code is minimal if <semantics> s ≥ q + 1 </semantics> , and not minimal if <semantics> 2 ≤ s ≤ 3 ≤ q </semantics> . In the case where <semantics> 3 < s ≤ q </semantics> , for some sunflowers, the corresponding linear codes are minimal, whereas for some other sunflowers, the corresponding linear codes are not minimal.
    Keywords linear code ; minimal code ; sunflower ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
    Subject code 511
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A comparative study for accessing primary healthcare between planning assessment and actual utilization for older adults

    Jiayuan Bai / Wei Lu

    Frontiers in Public Health, Vol

    a case from Dalian City, China

    2023  Volume 11

    Abstract: IntroductionAs China has rapidly evolved into an aging society, the Chinese government has developed a community-oriented primary healthcare system to vigorously expedite the transfer of primary health care (PHC) from higher-level hospitals to community ... ...

    Abstract IntroductionAs China has rapidly evolved into an aging society, the Chinese government has developed a community-oriented primary healthcare system to vigorously expedite the transfer of primary health care (PHC) from higher-level hospitals to community health centers (CHCs). However, current planning standards for CHCs have not considered the heterogeneity of older adults in supply-demand services, such that the areas with severe aging may comprise of underestimated levels of accessibility.MethodsThis study focuses on the gap in PHC access between planning assessment and actual utilization for older adults. We conducted an empirical study in the city area of Dalian based on the check-in and survey data from CHCs during the COVID-19 pandemic. A comparison model was built to calculate matching probability using a modified Gaussian Two-Step Floating Catchment Area (G2SFCA) method.ResultsAs indicated by the results, the communities in the primary healthcare shortage area (PHCSA) increased 6.8% by considering the heterogeneity of older adults; these communities with underserved PHC were ignored by the current planning assessment. Based on the comparison of actual and theoretical accessibility for older adults, we found that the average matching probability was about 76.6%, which means approximately a quarter of older adults have been misestimated the accessibility of PHC.DiscussionFurther analysis for the older adults with mismatched accessibility showed two causes of the gap, one is the lack of connection between the spatial distribution of facilities and the allocation of service supply, and the other is the subjective cross-catchment visit to CHCs for older adults.
    Keywords healthy aging ; community-oriented ; primary health care ; accessibility ; planning assessment ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Average capacity of quantum entanglement

    Wei, Lu

    2022  

    Abstract: As an alternative to entanglement entropies, the capacity of entanglement becomes a promising candidate to probe and estimate the degree of entanglement of quantum bipartite systems. In this work, we study the typical behavior of entanglement capacity ... ...

    Abstract As an alternative to entanglement entropies, the capacity of entanglement becomes a promising candidate to probe and estimate the degree of entanglement of quantum bipartite systems. In this work, we study the typical behavior of entanglement capacity over major models of random states. In particular, the exact and asymptotic formulas of average capacity have been derived under the Hilbert-Schmidt and Bures-Hall ensembles. The obtained formulas generalize some partial results of average capacity computed recently in the literature. As a key ingredient in deriving the results, we make use of recent advances in random matrix theory pertaining to the underlying orthogonal polynomials and special functions. Numerical study has been performed to illustrate the usefulness of average capacity as an entanglement indicator.

    Comment: 21 pages, 1 figure
    Keywords Mathematical Physics ; Computer Science - Information Theory ; High Energy Physics - Theory ; Quantum Physics
    Subject code 190
    Publishing date 2022-05-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Institutions as Constraints and Enablers

    WEI LU

    The Copenhagen Journal of Asian Studies, Vol 36, Iss

    Changes in Human Resource Management Practices of Foreign Companies during Economic Reform in China

    2019  Volume 2

    Abstract: This article demonstrates how the development of labour market institutions alongside economic reform has impacted the human resource management (HRM) practices of foreign companies in China. A historical approach is applied to examine the transformation ...

    Abstract This article demonstrates how the development of labour market institutions alongside economic reform has impacted the human resource management (HRM) practices of foreign companies in China. A historical approach is applied to examine the transformation of China from a centrally planned labour administration system to a market-based labour institution. The HRM practices of foreign companies are seen being embedded in China's macro-institutional environment, which constrains and/or enables foreign companies to exercise people management. Drawing on previous research, the study shows that HRM practices in the early reform period were primarily constrained both by formal and by informal institutions. The evidence from Finnish companies operating in China shows that HRM practices in the late reform period are largely enabled by formal institutions; however, foreign companies face the need for adaptation to the demands of informal institutions. Furthermore, the scarcity of human resources and rapid yet heterogeneous socio-economic development pose additional challenges for people management in China today.
    Keywords economic reform ; institutional transition ; labour market institution ; human resource management (HRM) practice ; foreign companies ; China ; Political institutions and public administration - Asia (Asian studies only) ; JQ1-6651 ; Social sciences and state - Asia (Asian studies only) ; H53
    Subject code 950
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher CBS Open Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: On the Exact Variance of Tsallis Entanglement Entropy in a Random Pure State.

    Wei, Lu

    Entropy (Basel, Switzerland)

    2019  Volume 21, Issue 5

    Abstract: The Tsallis entropy is a useful one-parameter generalization to the standard von Neumann entropy in quantum information theory. In this work, we study the variance of the Tsallis entropy of bipartite quantum systems in a random pure state. The main ... ...

    Abstract The Tsallis entropy is a useful one-parameter generalization to the standard von Neumann entropy in quantum information theory. In this work, we study the variance of the Tsallis entropy of bipartite quantum systems in a random pure state. The main result is an exact variance formula of the Tsallis entropy that involves finite sums of some terminating hypergeometric functions. In the special cases of quadratic entropy and small subsystem dimensions, the main result is further simplified to explicit variance expressions. As a byproduct, we find an independent proof of the recently proven variance formula of the von Neumann entropy based on the derived moment relation to the Tsallis entropy.
    Language English
    Publishing date 2019-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e21050539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Association of systemic inflammation response index with all-cause mortality as well as cardiovascular mortality in patients with chronic kidney disease.

    Wei, Lu / Mao, Shiqing / Liu, Xianhong / Zhu, Chuanqi

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1363949

    Abstract: Background: Chronic Kidney Disease (CKD) stands as a formidable health challenge, recognized not only for its growing prevalence but also for its association with elevated mortality rates. Emerging evidence suggests that CKD is inherently linked to ... ...

    Abstract Background: Chronic Kidney Disease (CKD) stands as a formidable health challenge, recognized not only for its growing prevalence but also for its association with elevated mortality rates. Emerging evidence suggests that CKD is inherently linked to inflammatory processes, marking it as an inflammatory disorder. In this landscape, the systemic inflammatory response index (SIRI) emerges as a novel inflammation marker, yet to be applied for assessing the risk of mortality in CKD patients.
    Objective: This study aims to investigate the prognostic significance of the SIRI in all-cause and cardiovascular disease (CVD) mortality among patients with CKD.
    Method: This study conducted a retrospective observational study using the National Health and Nutrition Examination Survey (NHANES) database, encompassing data from 1999 to 2018. This analysis included 9,115 CKD patients, categorized based on SIRI quartiles. Key outcomes were all-cause and CVD mortality, analyzed using Kaplan-Meier survival curves, restricted cube splines (RCS) and cox proportional hazards models.
    Result: In this study of 9,115 CKD patients, the Kaplan-Meier survival analysis revealed a greater incidence of all-cause death among groups with higher SIRI (P-log rank <0.001). In the fully adjusted model (Model 3), each unit increase in SIRI led to a 20% increase in the risk of all-cause mortality. Additionally, higher SIRI quartiles (Q3 and Q4) were associated with increased risk compared to the lowest quartile (Q1) (Q3: HR: 1.16, 95% CI: 1.01-1.34; Q4: HR: 1.63, 95% CI: 1.40-1.90;
    Conclusion: SIRI was positively associated with all-cause and CVD mortality in patients with CKD.
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1363949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Self-Adaptive Telemedicine Specialist Recommendation Considering Specialist Activity and Patient Feedback

    Wei Lu / Yunkai Zhai

    International Journal of Environmental Research and Public Health, Vol 19, Iss 5594, p

    2022  Volume 5594

    Abstract: Purpose: With the rapid development of medical informatization, information overload and asymmetry have become major obstacles that limit patients’ ability to find appropriate telemedicine specialists. Although doctor recommendation methods have been ... ...

    Abstract Purpose: With the rapid development of medical informatization, information overload and asymmetry have become major obstacles that limit patients’ ability to find appropriate telemedicine specialists. Although doctor recommendation methods have been proposed, they fail to address data sparsity and cold-start issues, and electronic medical records (EMRs), patient preferences, potential interest of service providers and the changes over time are largely under-explored. Therefore, this study develops a self-adaptive telemedicine specialist recommendation method that incorporates specialist activity and patient utility feedback from the perspective of privacy protection to fill the research gaps. Methods: First, text vectorization, view similarity and probabilistic topic model are used to construct the patient and specialist feature models based on patients’ EMRs and specialists’ long- and short-term knowledge backgrounds, respectively. Second, the recommended specialist candidate set and recommendation index are obtained based on the similarity between patient features. Then, the specialist long-term knowledge feature model is used to update the newly registered specialist recommendation index and the recommended specialist candidate set to overcome the data sparsity and cold-start issues, and the specialist short-term knowledge feature model is adopted to extend the recommended specialist candidate set at the semantic level. Finally, we introduce the specialists’ activity and patients’ perceived utility feedback mechanism to construct a closed-loop adjusted and optimized specialist recommendation method. Results: An empirical study was conducted integrating EMRs of telemedicine patients from the National Telemedicine Center of China and specialists’ profiles and ratings from an online healthcare platform. The proposed method successfully recommended relevant and active telemedicine specialists to the target patient, and increased the recommended opportunities for newly registered specialists to some extent. ...
    Keywords specialist recommendation ; telemedicine ; activity ; feedback adjustment ; cold start ; Medicine ; R
    Subject code 330
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Women and children’s real-world economic and drug indicators from 2015 to 2019

    Jun Zou / Che Zhang / Guohua Jia / Wei Lu

    Journal of Market Access & Health Policy, Vol 11, Iss

    2023  Volume 1

    Abstract: ABSTRACTObjectives: To obtain real-world data on rational drug use, pharmacoeconomic regarding women’s and children’s health and the benefits of Hainan free trade port (HFTP) health policies, we retrospectively investigated drug indicators, prescribing ... ...

    Abstract ABSTRACTObjectives: To obtain real-world data on rational drug use, pharmacoeconomic regarding women’s and children’s health and the benefits of Hainan free trade port (HFTP) health policies, we retrospectively investigated drug indicators, prescribing trend, and economic data.Method: We retrospectively gathered the data from the database of the hospital information system and the quality indicators of pharmacy; we compared the monthly indicators from 2015 to 2019.Results: In 2017, the HFTP maternal mortality ratio (MMR) was 24.46. In 2019, the HFTP infant mortality rate (‰) was 4.15, and the under-five mortality rate (‰) was 6.19. A total of 1,922,798 prescriptions included in the analysis, the defined daily dose of 2015–2019 ranged from 46.59 to 32.34. In 2019, the proportions of antibiotics prescribed in outpatient, emergency, and inpatient care were 14.19%, 16.68%, and 46.26%, respectively. The injection prescription percentage ranged from 13.08% to 8.08%. The proportion of medicine income to total hospital income of 2015–2019 ranged from 26.66% to 25.31%.Conclusion: According to the analysis of women’s and children’s real-world drug data, economic investment and strict quality control of antimicrobial stewardship programs can lead to the rational use of drugs.
    Keywords Real-world study ; pharmacoepidemiology ; pharmacoeconomic analysis ; rational drug use ; antimicrobial stewardship program ; antibiotic percent ; Public aspects of medicine ; RA1-1270 ; Business ; HF5001-6182
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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