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Article ; Online: Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria

Wei Xu / Xiaodong Li

Molecules, Vol 28, Iss 4432, p

2023 Volume 4432

Abstract: The circadian clock regulates daily changes in behavioral, endocrine, and metabolic activities in mammals. Circadian rhythms in cellular physiology are significantly affected by aging. In particular, we previously found that aging has a profound impact ... ...

Abstract	The circadian clock regulates daily changes in behavioral, endocrine, and metabolic activities in mammals. Circadian rhythms in cellular physiology are significantly affected by aging. In particular, we previously found that aging has a profound impact on daily rhythms in mitochondrial functions in mouse liver, leading to increased oxidative stress. This is not due to molecular clock malfunctions in peripheral tissues in old mice, however, as robust clock oscillations are observed therein. Nonetheless, aging induces changes in gene expression levels and rhythms in peripheral and probably central tissues. In this article, we review recent findings on the roles of the circadian clock and the aging process in regulating mitochondrial rhythms and redox homeostasis. Chronic sterile inflammation is implicated in mitochondrial dysfunction and increased oxidative stress during aging. In particular, upregulation of the NADase CD38 by inflammation during aging contributes to mitochondrial dysregulation.
Keywords	circadian rhythms ; peripheral clock ; inflammatory response ; aging ; senescence ; Organic chemistry ; QD241-441
Subject code	571
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantitative Evaluation of Carbon Reduction Policy Based on the Background of Global Climate Change

Junyan Meng / Wei Xu

Sustainability, Vol 15, Iss 14581, p

2023 Volume 14581

Abstract: High-quality carbon reduction policies play a crucial role in tackling global climate change and reducing carbon dioxide emissions. China, as the world’s largest emitter of carbon dioxide, has committed to peaking its carbon emission by 2030. This study ... ...

Abstract	High-quality carbon reduction policies play a crucial role in tackling global climate change and reducing carbon dioxide emissions. China, as the world’s largest emitter of carbon dioxide, has committed to peaking its carbon emission by 2030. This study focuses on the evaluation of 12 carbon reduction policies implemented by the Chinese government. A quantitative evaluation index system for carbon reduction policies was designed. Next, the policy modeling consistency (PMC) index method was utilized to assess the quality of these policies. The findings are as follows: Firstly, the average PMC index value of the 12 carbon reduction policies is 6.75, indicating a good performance overall. Secondly, the carbon reduction policies established by the Chinese government are generally effective; among the twelve policies analyzed, one policy received a perfect evaluation grade, four policies were graded as excellent, six policies were graded as good, and one policy received a bad evaluation grade. Thirdly, the indicators Z 3 , Z 4 , Z 5 , and Z 9 in the evaluation index system for carbon reduction policies scored relatively low, suggesting that there are some deficiencies in terms of policy timeliness, issuing institutions, policy tools, and policy evaluation within the 12 policies. Fourthly, this study presents a PMC curved surface diagram to visually illustrate the strengths and weaknesses of the carbon reduction policies. Finally, based on the research findings, recommendations are provided to enhance the quality of carbon reduction policies.
Keywords	climate change ; carbon reduction policy ; policy evaluation ; China ; policy modeling consistency index model ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	300
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Continuity and changes in grandchild care and the risk of depression for Chinese grandparents

Yue Hong / Wei Xu

Frontiers in Public Health, Vol

new evidence from CHARLS

2023 Volume 11

Abstract: ObjectivesAlthough studies have researched the mental effects of intergenerational care, little is known about the impact of transformations in caregiving intensity on depression. This study explores grand-parents’ depressive symptom outcomes in terms of ...

Abstract	ObjectivesAlthough studies have researched the mental effects of intergenerational care, little is known about the impact of transformations in caregiving intensity on depression. This study explores grand-parents’ depressive symptom outcomes in terms of changes over time in grandparental childcare, with considerations for subgroup differences.MethodUsing data from the 2015–2018 China Health and Retirement Longitudinal Study on grandparents aged 45 and older, we adopted generalized estimating equations to estimate the effects of seven category changes [(1) continued to provide high-intensity or (2) low-intensity care at both waves; (3) never provided care; (4) started caregiving; (5) ended caregiving; (6) provided less intensive care; and (7) provided more intensive care] over time in grandparental childcare on depressive symptoms among 17,701 grandparents with at least one grandchild, as well as how the impact varies by gender and urban/rural areas.ResultsGrandparents who decreased the intensity of care, stopped childcare, or offered continuous low-intensity care were associated with a lower level of depression compared with those providing no childcare. In addition, the benefit of continuous caregiving on mental health was especially noticeable in urban grandmothers.ConclusionProviding continuous low-intensity, decreased-intensity grandparenting and the cessation of caregiving were associated with a decreased level of depression for Chinese grandparents; however, there were complex interactions at play. Policies aimed at supporting grandparenting should consider caregiving intensity transitions relevant to gender and urban/rural residence.
Keywords	grandchild care ; depression ; changes in caregiving intensity ; rural–urban context ; gender norms ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ghana’s Free Zones Strategy and the “Role of China” in It

Paola Pasquali / Wei Xu

Revue Internationale des Études du Développement, Vol 252, Pp 57-

2023 Volume 81

Abstract: This paper explores the history of free zones in Ghana and Ghanaian policy makers’ related strategy. It looks at the “role of China” in these zones: both in terms of Chinese companies’ presence there, and in terms of reference to a “Chinese model” to ... ...

Abstract	This paper explores the history of free zones in Ghana and Ghanaian policy makers’ related strategy. It looks at the “role of China” in these zones: both in terms of Chinese companies’ presence there, and in terms of reference to a “Chinese model” to develop free zones. On the one hand, the domestic success of special economic zones in China has validated this model and justified the creation of “Chinese SEZs” in a few African countries. On the other hand, despite a significant presence of Chinese investors and companies in Ghana - including one newly established Chinese industrial park - we find that China’s role in Ghanaian free zones is negligible. We attribute this finding, together with the absence of “Chinese SEZs” in Ghana, to a host of variables, including: Ghanaian leaders’ and policy-makers’ strategies, the country’s framework and trajectory with regard to free zones, the business environment, and some missed political opportunities.
Keywords	free trade zones ; export processing zones ; special economic zones ; Ghana ; China ; Africa ; Social Sciences ; H
Subject code	950
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Éditions de la Sorbonne
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Strategic significance of constructing a Chinese medicine prevention and control system for the implementation of the bone health program].

Zhu, Li-Guo / Wei, Xu / Zhang, Yi-Li

Zhongguo gu shang = China journal of orthopaedics and traumatology

2024 Volume 37, Issue 1, Page(s) 1–2

MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Bone Density ; Drugs, Chinese Herbal ; China
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2024-01-29
Publishing country	China
Document type	Journal Article
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.20240068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Low-Energy-Density Microwave Treatment on Graphene/Polyvinyl Alcohol-Modified Poplar Veneer

Shuangshuang Wu / Wei Xu

Forests, Vol 13, Iss 210, p

2022 Volume 210

Abstract: The combination of natural wood and graphene can provide a new type of material with excellent mechanical properties and thermal conductivity. However, it is difficult for graphene to uniformly penetrate the wood due to the anisotropy of natural wood and ...

Abstract	The combination of natural wood and graphene can provide a new type of material with excellent mechanical properties and thermal conductivity. However, it is difficult for graphene to uniformly penetrate the wood due to the anisotropy of natural wood and the agglomeration of graphene. In this work, poplar veneer was treated with low-energy-density microwave to expand the entry pathways for the graphene steering liquid. The porosity, weight percent gain, and chromatic aberration were used to examine the impact of the microwave time and power. We tested the mechanical properties, thermal conductivity of the graphene/polyvinyl alcohol-modified poplar veneer to evaluate its properties. At the same time, SEM, XRD, and FT-IR were used to characterize its physical and chemical structure. The results showed that low-energy-density microwave treatment increased the weight percentage gain (WPG) and porosity without affecting the mechanical properties of the poplar veneer. The graphene-modified poplar veneer with the optimal overall performance was obtained by microwave treatment at 100% microwave power for 50 s. Indeed, the micro-characterization also revealed that the microwave treatment mostly attacked the wood rays but had little effect on the materialized structure. Therefore, low-energy-density microwave treatment could be an energy-saving and efficient way to improve graphene-impregnated veneers.
Keywords	microwave treatment ; poplar veneer ; multilayer graphene ; impregnation effect ; Plant ecology ; QK900-989
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Moving event detection from LiDAR point streams

Huajie Wu / Yihang Li / Wei Xu / Fanze Kong / Fu Zhang

Nature Communications, Vol 15, Iss 1, Pp 1-

2024 Volume 14

Abstract: Abstract In dynamic environments, robots require instantaneous detection of moving events with microseconds of latency. This task, known as moving event detection, is typically achieved using event cameras. While light detection and ranging (LiDAR) ... ...

Abstract	Abstract In dynamic environments, robots require instantaneous detection of moving events with microseconds of latency. This task, known as moving event detection, is typically achieved using event cameras. While light detection and ranging (LiDAR) sensors are essential for robots due to their dense and accurate depth measurements, their use in event detection has not been thoroughly explored. Current approaches involve accumulating LiDAR points into frames and detecting object-level motions, resulting in a latency of tens to hundreds of milliseconds. We present a different approach called M-detector, which determines if a point is moving immediately after its arrival, resulting in a point-by-point detection with a latency of just several microseconds. M-detector is designed based on occlusion principles and can be used in different environments with various types of LiDAR sensors. Our experiments demonstrate the effectiveness of M-detector on various datasets and applications, showcasing its superior accuracy, computational efficiency, detection latency, and generalization ability.
Keywords	Science ; Q
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of sodium fluoride on myocardial damage by regulating apoptosis through JNK signaling pathway

Liting CAO / Wei XU / Baohui MA

环境与职业医学, Vol 40, Iss 2, Pp 224-

2023 Volume 229

Abstract: BackgroundIt has been found that fluoride may cause cardiomyocyte damage. c-Jun N-terminal kinases (JNK) signaling pathway plays an important role in apoptosis, but its role in fluorosis-induced cardiomyocyte damage is still unknown yet. ObjectiveTo ... ...

Abstract	BackgroundIt has been found that fluoride may cause cardiomyocyte damage. c-Jun N-terminal kinases (JNK) signaling pathway plays an important role in apoptosis, but its role in fluorosis-induced cardiomyocyte damage is still unknown yet. ObjectiveTo explore the toxic effect of sodium fluoride (NaF) on H9c2 cardiomyocytes of rats and whether NaF affects cardiomyocyte apoptosis through the JNK signaling pathway. MethodsAccording to the concentrations of sodium fluoride and whether sp600125 (JNK inhibitor) was added, cardiomyocytes of rats were divided into six groups, including control group, SP600125 group (SP group), 0.24, 0.48, and 0.96 mmol·L−1 NaF groups, and 0.96 mmol·L−1 NaF+SP600125 group (NaF+SP group). Cardiomyocytes exposed to NaF for 24 h were observed using a fluorescence inverted microscope. The changes of cell viability at 24, 48, and 72 h after the treatment were detected by CCK-8 method. The levels of reactive oxygen species (ROS) at 24 h after the treatment in H9c2 cardiomyocytes were determined by fluorescent probe method. The expression levels of Bcl-2, Bax, Caspase-3, and JNK mRNA at 24 h after the treatment were detected by real-time PCR. The protein expression levels of Bcl-2, Bax, Caspase-3, and p-JNK at 24 h after the treatment were detected by Western blotting. ResultsCompared with the control group, after being exposed to 0.48 and 0.96 mmol·L−1 NaF for 24 h, the cell growth density decreased. With the increase of NaF concentration, rounded cells and some suspended dead cells appeared. At 24h after exposure to NaF, the cell viability of the 0.48 and 0.96 mmol·L−1 NaF groups decreased compared with the control group (P<0.05). At 48h and 72h after exposure to NaF, the cell viability levels of the NaF treated groups were significantly lower than that of the control group (P<0.05). After NaF exposure for 24 h, compared with the control group, the intracellular ROS levels were increased (P<0.05); the mRNA expression levels of Bcl-2 were decreased to varying degrees, especially in the ...
Keywords	sodium fluoride ; h9c2 cardiomyocyte ; jnk signaling pathway ; apoptosis ; oxidative stress ; reactive oxygen species ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Editorial Committee of Journal of Environmental and Occupational Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Financing Efficiency and Influencing Factors of High-Tech Small and Medium-Sized Enterprises of Information Technology Industry in the China Yangtze River Delta

Wei Xu / Mengting Zhang / Feng Wang

SAGE Open, Vol

2023 Volume 13

Abstract: High-tech small and medium-sized enterprises (high-tech SMEs) play a driving role in the economic transformation of the China Yangtze River Delta. However, comparatively little research and attention has been paid to evaluating the financing efficiency ... ...

Abstract	High-tech small and medium-sized enterprises (high-tech SMEs) play a driving role in the economic transformation of the China Yangtze River Delta. However, comparatively little research and attention has been paid to evaluating the financing efficiency and investigating both external and internal influencing factors on financing efficiency based on the information of these enterprises. This study evaluates the financing efficiencies in a homogeneous environment of high-tech SMEs of information technology industry in the China Yangtze River Delta for the period 2014 to 2020 employing the panel three-stage Data Envelopment Analysis model. We have concluded that the financing technical efficiency presents a U-shaped trend from 2014 to 2020, at a moderate level due to the low pure technical efficiency; financing efficiency shows different spatial distribution patterns; most decision-making units are in the quasi-relatively inefficient range, while only a minority are at the efficiency frontier. Furthermore, the external and internal environmental factors are investigated based on Panel Stochastic Frontier Analysis and Tobit model. According to the empirical results, the optimization of the financial and technical environment contributes to financing efficiency; by contrast, a good economic and policy environment appears to restrict it; internal environmental factors such as growth ability, debt solvency, and the average age of managers have significant impacts on financing efficiency.
Keywords	History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
Subject code	338
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chondroitin sulfate functionalized palmitic acid and cysteine cografted-quaternized chitosan for CD44 and gut microbiota dual-targeted delivery of curcumin

Yinzhuo Xie / Wei Xu / Zheng Jin / Kai Zhao

Materials Today Bio, Vol 20, Iss , Pp 100617- (2023)

2023

Abstract: Curcumin (CUR) has a regulatory effect on the gut microbiota (GM), and its significant anti-inflammatory properties make it a research hotspot for inflammatory bowel disease (IBD) treatment. However, the low bioavailability and poor pharmacokinetic ... ...

Abstract	Curcumin (CUR) has a regulatory effect on the gut microbiota (GM), and its significant anti-inflammatory properties make it a research hotspot for inflammatory bowel disease (IBD) treatment. However, the low bioavailability and poor pharmacokinetic properties of CUR limit its practical application. Herein, CD44 and GM dual-targeted nanoparticles (NPs) loaded with CUR (CUR@Chs-PNC NPs) were derived from a quaternized chitosan and surface functionalization with chondroitin sulfate (Chs). The generated CUR@Chs-PNC NPs had an ideal average particle size (238.9 nm), a uniform size distribution, and a positive surface charge (+41.93 mV). Strikingly, the CUR@Chs-PNC NPs had a good sustained-release effect in a simulated gastrointestinal environment and exhibited the full drug release when in a simulated colon environment. Moreover, Chs functionalization endowed the NPs with a notable CD44-targeted drug delivery ability and thereby enhanced the CUR content in the plasma of SD rats. The biodistribution of the CUR@Chs-PNC NPs in vivo indicated that the NPs could prolong the intestinal residence time, thereby promoting the interaction between CUR and GM. Most importantly, in a DSS-induced colitis mouse model, the CUR@Chs-PNC NPs decreased the disease activity index, improved the oxidative stress and inflammation condition, promoted the production of short-chain fatty acids (SCFAs), regulated immune cells, and maintained intestinal microbiome homeostasis. This study demonstrates that CUR@Chs-PNC NPs, which exhibit excellent biocompatibility and biodegradability, on-demand drug release property, and CD44 and GM dual-targeted capacities, have the potential for further application in the treatment of colitis.
Keywords	Curcumin ; Inflammatory bowel disease ; Mucoadhesive nanoparticles ; CD44 glycoprotein ; Targeted delivery ; Gut microbiota ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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