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  1. Article ; Online: Correction to 'Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus'.

    Krause, Marina / Wei Yang, Feng / Te Lindert, Mariska / Isermann, Philipp / Schepens, Jan / Maas, Ralph J A / Venkataraman, Chandrasekhar / Lammerding, Jan / Madzvamuse, Anotida / Hendriks, Wiljan / Te Riet, Joost / Wolf, Katarina

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2019  Volume 374, Issue 1786, Page(s) 20190657

    Language English
    Publishing date 2019-10-07
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2019.0657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cytotoxicity and genome-wide microarray analysis of intestinal smooth muscle cells in response to hexavalent chromium induction.

    Jin, Li-Fang / Wang, Yuan-Yuan / Zhang, Zi-Dong / Yuan, Yi-Meng / Hu, Yi-Rui / Wei, Yang-Feng / Ni, Jian

    Dong wu xue yan jiu = Zoological research

    2013  Volume 34, Issue E3, Page(s) E93–100

    Abstract: Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice; however, information on its toxicity on intestinal smooth muscle cells is limited. The present study aimed to assess the in ... ...

    Abstract Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice; however, information on its toxicity on intestinal smooth muscle cells is limited. The present study aimed to assess the in vitro and in vivo toxicological effects of Cr(VI) on intestinal smooth muscle cells. Human intestinal smooth muscle cells (HISM cells) were cultured with different concentrations of Cr(VI) to evaluate effects on cell proliferation ability, oxidative stress levels, and antioxidant system. Furthermore, tissue sections in Cr(VI) exposed rabbits were analyzed to evaluate toxicity on intestinal muscle cells in vivo. Gene chips were utilized to assess differential gene expression profiles at the genome-wide level in 1 μmol/L Cr(VI) treated cells. Intestinal tissue biopsy results showed that Cr(VI) increased the incidences of diffuse epithelial hyperplasia in intestinal jejunum but caused no obvious damage to the structure of the muscularis. Cell proliferation analysis revealed that high concentrations (≥64 μmol/L) but not low concentrations of Cr(VI) (≤16 μmol/L) significantly inhibited the growth of HISM cells. For oxidative stress levels, the expression of reactive oxygen species (ROS) and nitric oxide (NO) was elevated at high concentrations (≥64 μmol/L) but not at low concentrations of Cr(VI) (≤16 μmol/L). In addition, dose-dependent increases in the activity of oxidized glutathione (GSSH)/total-glutathione (T-GSH) were also observed. Gene chip screened 491 differentially expressed genes including genes associated with cell apoptosis, oxidations, and cytoskeletons. Some of these differentially expressed genes may be unique to smooth muscle cells in response to Cr(VI) induction.
    MeSH term(s) Animals ; Cell Proliferation/drug effects ; Chromium/toxicity ; Female ; Gene Expression/drug effects ; Genome/drug effects ; Humans ; Intestines/cytology ; Intestines/drug effects ; Male ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Oligonucleotide Array Sequence Analysis ; Rabbits
    Chemical Substances Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9)
    Language English
    Publishing date 2013-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2196960-7
    ISSN 0254-5853
    ISSN 0254-5853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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