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Article ; Online: Advances in Immunotherapy and Vaccine for Prostate Cancer

Wei Zhou / Yikai Zhang

Annals of Urologic Oncology, Vol

2023 Volume 6

Abstract: Prostate cancer is one of the most common malignant tumors of the urinary system. The incidence of prostate cancer is high in the elderly male patients, which seriously threatens the life and health. In recent years, immunotherapy to activate anti-cancer ...

Abstract	Prostate cancer is one of the most common malignant tumors of the urinary system. The incidence of prostate cancer is high in the elderly male patients, which seriously threatens the life and health. In recent years, immunotherapy to activate anti-cancer host immune cells to kill tumors has become a new area of research for the treatment of prostate cancer. As an important component of immunotherapy, cancer vaccines have a unique position in the precise treatment of malignant tumors. There are many types of prostate cancer vaccines, including monocyte vaccines, dendritic cell vaccines, viral vaccines, peptide vaccines, and DNA/mRNA vaccines, etc. As the most important cancer vaccine based on monocytes, it is the only prostate cancer therapeutic vaccine approved by the US Food and Drug Administration at present, which plays an extremely important role in the immunotherapy of prostate cancer. However, due to its own limitations, SipuleucelT has not been widely adopted. Currently, the complexity of immunotherapy and the specificity of prostate cancer mean that other prostate cancer vaccines have not shown expected clinical benefits in large randomized phase II and III trials, and further in-depth studies are still needed.
Keywords	prostate cancer ; cancer vaccine ; sipuleucel-t ; immunotherapy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Asian Medical Press Ltd.(H.K.)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Will customer change affect enterprise innovation efficiency? A study from the perspective of social networks.

Xuqian, Wen / Hui, Wang / Wei, Zhou

Heliyon

2024 Volume 10, Issue 3, Page(s) e24848

Abstract: An enterprise innovation strategy is the driving force for the healthy and sustainable development of enterprises, and high-quality, efficient innovation is important for improving enterprises' market value and promoting their high-quality development. ... ...

Abstract	An enterprise innovation strategy is the driving force for the healthy and sustainable development of enterprises, and high-quality, efficient innovation is important for improving enterprises' market value and promoting their high-quality development. Customer relationships are an important factor affecting enterprise product technology and enterprise innovation; however, few studies have evaluated the impact of customer change on innovation efficiency. Therefore, from the perspective of social capital, we use China's listed manufacturing companies' data from 2013 to 2020 to systematically examine how customer changes affect enterprise innovation performance, and test the impact of social networks on the relationship between customer change and enterprise innovation efficiency. The empirical research shows that customer change reduces enterprises' innovation efficiency, and that social network relationships have an intermediary effect on the relationship between customer change and innovation efficiency; that is, the social network relationships reduce the negative impact of customer change on enterprise innovation efficiency. Further analysis shows that this mediating effect is not obvious for enterprises experiencing large customer changes but is prominent for nonstate-owned or nontechnology-intensive enterprises. Our study enriches and expands the research on how customer relationships influence enterprise innovation efficiency, clarifies different mechanisms due to various "networks", and provides new empirical evidence to enable enterprises to improve their competitiveness.
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24848
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Clinical observation of Xiaoluowan (II) in treating epididymitis].

Zhou, Yu-Chun / Huang, Wei-Zhou / Shang, Xue-Jun

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 5, Page(s) 441–444

Abstract: Objective: To observe the clinical efficacy of Xiaoluowan (II) on epididymitis.: Methods: 61 patients with epididymitis were divided into two groups, acute group (23 cases) and non-acute group (38 cases) . Both groups of patients were treated with ... ...

Abstract	Objective: To observe the clinical efficacy of Xiaoluowan (II) on epididymitis. Methods: 61 patients with epididymitis were divided into two groups, acute group (23 cases) and non-acute group (38 cases) . Both groups of patients were treated with Xiaoluowan (II) 6g twice a day orally, while acute group patients were given antibiotics intravenously. The treatment period is 4 weeks. The acute group evaluates the therapeutic efficacy comprehensively based on changes in clinical symptoms and signs, while recording changes in visual pain score (VAS). Chronic epididymitis symptom index (CESI) was used to evaluate the clinical symptoms before and after treatment in the non-acute group, and the curative efficacy was evaluated. Results: After treatment, the VAS scores in the acute group decreased from 7.08 ± 1.09 to 2.10 ± 1.37 (P<0.05). Total efficiency is 82.60% . In the non-acute group, the scores of pain before and after treatment were 7.08 ± 1.09 and 2.10 ± 1.37, the scores of quality of life were 7.28 ± 1.14 and 1.87 ± 1.56, the total scores were 14.37 ± 1.78 and 3.97±2.73, respectively. The difference was significant(P<0.05). Total efficiency is 84.21% . Conclusion: Xiaoluowan (II) is an effective method to treat epididymitis and an effective supplement to modern medicine.
MeSH term(s)	Male ; Humans ; Epididymitis/drug therapy ; Quality of Life ; Drugs, Chinese Herbal/therapeutic use ; Pain
Chemical Substances	xiaoluowan ; Drugs, Chinese Herbal
Language	Chinese
Publishing date	2024-04-11
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article ; Online: Early Starvation Contributes to the Adaptive Capacity of Corythucha marmorata (Uhler), an Emerging Pest in China

Wei Zhou / Wenlong Chen

Biology, Vol 11, Iss 80, p

2022 Volume 80

Abstract: Food shortages severely reduce the prospects of insect survival in natural settings, including in the case of herbivorous insects. However, the early starvation experience of some insects has positive effects throughout their entire lifespan. It is ... ...

Abstract	Food shortages severely reduce the prospects of insect survival in natural settings, including in the case of herbivorous insects. However, the early starvation experience of some insects has positive effects throughout their entire lifespan. It is important to discuss the effects of refeeding and host plants on the capacity of herbivorous insects to adapt to starvation and low temperatures, considering that starvation resistance is expected to show some degree of adaptive phenotypic plasticity. We tested the relationship between host plant, starvation, and the supercooling capacity of the invasive pest Corythucha marmorata . In particular, we highlighted how early starvation affects the refeeding and recovery phases. Among the various range of hosts, the chrysanthemum lace bug has the fastest growth rate on Helianthus annuus , and the strongest supercooling capacity on Symphyotrichum novi-belgii . Especially, starvation for 2 days increases the rates of survival, development, and number of eggs upon refeeding, in comparison to no starvation. A 3-day starvation period in the nymphal stage significantly increased the supercooling capacity of 5th instar nymphs and adults, as observed in our study.
Keywords	food shortage ; development ; survival ; supercooling capacity ; Corythucha marmorata ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Dynamic morphological plasticity in response to emergence timing in Abutilon theophrasti (Malvaceae)

Shu Wang / Dao‐Wei Zhou

Plant-Environment Interactions, Vol 3, Iss 3, Pp 118-

2022 Volume 129

Abstract: Abstract Selections on emergence time might be conflicting, suggesting the existence of the optimal emergence time for plants. However, we know little about this and how morphological plasticity contributes to the strategies of plants in response to ... ...

Abstract	Abstract Selections on emergence time might be conflicting, suggesting the existence of the optimal emergence time for plants. However, we know little about this and how morphological plasticity contributes to the strategies of plants in response to emergence timing. To better understand this issue from a dynamic perspective, we conducted a field experiment by subjecting plants of Abutilon theophrasti to four emergence treatments (ET1 ~ ET4) and measuring a number of mass and morphological traits on them at different growth stages (I ~ IV). On day 50, 70, and/or final harvest, among all ET treatments, plants germinated in late spring (ET2) performed the best in total mass, spring germinants (ET1) and ET2 performed better in stem allocation, stem, and root diameters than later germinants (ET3 and ET4); summer germinants (ET3) had the highest reproductive mass and allocation, while late‐summer germinants (ET4) had the greatest leaf mass allocation, with greater or canalized leaf number, and root length traits than others. Plants that emerged in late spring can maximize their growth potential, while those with either advanced or delayed emergence are still capable of adaptation via allocation and morphological plasticity. Early germinants (ET1 and ET2) preferred stem growth to leaf and reproductive growth, due to sufficient time for reproduction in the growth season. With limited time for growth, plants that emerged late may prefer to quicken leaf growth (indicated by increased leaf mass allocation and leaf number) at the cost of stem or root growth for the complete life cycle, reflecting both positive and negative effects of delayed emergence.
Keywords	biomass allocation ; germination time ; growth period ; leaf growth ; life cycle ; morphological plasticity ; Environmental sciences ; GE1-350 ; Botany ; QK1-989
Subject code	580
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Precise Supervision of Enterprise Environmental Protection Behavior Based on Boolean Matrix Factorization under Low Carbon Background

Wei Zhou / Feipeng Guo

International Journal of Environmental Research and Public Health, Vol 19, Iss 7739, p

2022 Volume 7739

Abstract: Supervising the environmental protection behavior of enterprises is a key strategy to achieve “carbon peaking and carbon neutrality”. This research innovatively proposes the concept of precise supervision, aiming to implement differentiated supervision ... ...

Abstract	Supervising the environmental protection behavior of enterprises is a key strategy to achieve “carbon peaking and carbon neutrality”. This research innovatively proposes the concept of precise supervision, aiming to implement differentiated supervision measures for different types of enterprises, and realize the precise supervision method of enterprise environmental protection, which is different from the traditional supervision mode. Firstly, this paper proposes a novel MEBF+ method based on the benchmark algorithm MEBF, and obtains MEBF++ after incorporating the model bias. Secondly, based on the dataset of environmental supervision and certification of listed Chinese companies, the accuracy and robustness of the proposed method are verified by using multiple evaluation indicators. Finally, based on the analysis of the experimental results, two precise supervision concepts, narrow and broad, are proposed under the low-carbon background. The results show that compared with the benchmark method, the accuracy of the proposed method has been improved to a large extent. In addition, the precise supervision proposed in this paper can help reduce the consumption of manpower and resources as well as unite the public to monitor the environmental protection behavior of enterprises.
Keywords	low carbon ; enterprise environmental protection behavior ; Boolean matrix factorization ; precise supervision ; preventive measures ; Medicine ; R
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fish fauna of the Red River, Southeast Asia

Wei Zhou / Xu Li

Ecological Indicators, Vol 141, Iss , Pp 109063- (2022)

Indictors and implications for planning fish species preserves

2022

Abstract: The composition of fish fauna in the Red River basin was analyzed based on 288 fish species belonging to 138 genera, 53 families (subfamilies), and 14 orders, using the Traditional Fish Fauna Analysis (TFFA) and the Value of Fish Fauna Presence (VFFP) ... ...

Abstract	The composition of fish fauna in the Red River basin was analyzed based on 288 fish species belonging to 138 genera, 53 families (subfamilies), and 14 orders, using the Traditional Fish Fauna Analysis (TFFA) and the Value of Fish Fauna Presence (VFFP) methods. The TFFA and VFFP methods allow for a ranking of the taxa according to commonality and uniqueness of the taxa to the river basin; however, both methods provide different, complimentary results. Based on the results from the TFFA method, 15 families (subfamilies), including 85 genera and 219 species, were identified as the main fish taxa in the Red River basin. Based on the results of the VFFP method, 17 families (subfamilies), including 89 species and 52 genera, were highlighted as representative families (subfamilies) and genera in the Red River basin. Overall, Cypriniformes was the most abundant order, followed by Siluriformes and Gobiiformes. Although the Red River basin is geographically situated in Southeast Asia, it had obvious characteristics of East Asian fish fauna rather than Southeast Asian fish fauna. Therefore, the Red River fish fauna can be considered the boundary between the fish fauna of Southeast Asia and East Asia. This paper further detailed the indexes and calculations of the TFFA and VFFP methods. The authors proposed using the results of the TFFA and VFFP methods as indicators for planning fish preserves as well as discussed the specific methods related to using these indicators to plan and establish fish preserves.
Keywords	Fish fauna ; Traditional fish fauna analysis ; Value of fish fauna presence ; Fish preserves ; Red River basin ; Southeast Asia ; Ecology ; QH540-549.5
Subject code	590
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Associations between leaf developmental stability, variability, canalization, and phenotypic plasticity in Abutilon theophrasti

Shu Wang / Dao‐Wei Zhou

Ecology and Evolution, Vol 12, Iss 4, Pp n/a-n/a (2022)

2022

Abstract: Abstract Developmental stability, canalization, and phenotypic plasticity are the most common sources of phenotypic variation, yet comparative studies investigating the relationships between these sources, specifically in plants, are lacking. To ... ...

Abstract	Abstract Developmental stability, canalization, and phenotypic plasticity are the most common sources of phenotypic variation, yet comparative studies investigating the relationships between these sources, specifically in plants, are lacking. To investigate the relationships among developmental stability or instability, developmental variability, canalization, and plasticity in plants, we conducted a field experiment with Abutilon theophrasti, by subjecting plants to three densities under infertile vs. fertile soil conditions. We measured the leaf width (leaf size) and calculated fluctuating asymmetry (FA), coefficient of variation within and among individuals (CVintra and CVinter), and plasticity (PIrel) in leaf size at days 30, 50, and 70 of plant growth, to analyze the correlations among these variables in response to density and soil conditions, at each of or across all growth stages. Results showed increased density led to lower leaf FA, CVintra, and PIrel and higher CVinter in fertile soil. A positive correlation between FA and PIrel occurred in infertile soil, while correlations between CVinter and PIrel and between CVinter and CVintra were negative at high density and/or in fertile soil, with nonsignificant correlations among them in other cases. Results suggested the complexity of responses of developmental instability, variability, and canalization in leaf size, as well as their relationships, which depend on the strength of stresses. Intense aboveground competition that accelerates the decrease in leaf size (leading to lower plasticity) will be more likely to reduce developmental instability, variability, and canalization in leaf size. Increased developmental instability and intra‐ and interindividual variability should be advantageous and facilitate adaptive plasticity in less stressful conditions; thus, they are more likely to positively correlate with plasticity, whereas developmental stability and canalization with lower developmental variability should be beneficial for stabilizing plant ...
Keywords	aboveground competition ; canalization ; developmental instability ; fluctuating asymmetry ; increased density ; intraindividual variability ; Ecology ; QH540-549.5
Subject code	580
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Raw Bayer Pattern Image Synthesis with Conditional GAN

Wei, Zhou

2021

Abstract: In this paper, we propose a method to generate Bayer pattern images by Generative adversarial network (GANs). It is shown theoretically that using the transformed data in GANs training is able to improve the generator learning of the original data ... ...

Abstract	In this paper, we propose a method to generate Bayer pattern images by Generative adversarial network (GANs). It is shown theoretically that using the transformed data in GANs training is able to improve the generator learning of the original data distribution, owing to the invariant of Jensen Shannon(JS) divergence between two distributions under invertible and differentiable transformation. The Bayer pattern images can be generated by configuring the transformation as demosaicing, by converting the existing standard color datasets to Bayer domain, the proposed method is promising in the applications such as to find the optimal ISP configuration for computer vision tasks, in the in sensor or near sensor computing, even in photography. Experiments show that the images generated by our proposed method outperform the original Pix2PixHD model in FID score, PSNR, and SSIM, and the training process is more stable. For the situation similar to in sensor or near sensor computing for object detection, by using our proposed method, the model performance can be improved without the modification to the image sensor. Comment: 9 pages
Keywords	Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2021-10-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chinese digestive surgery interns’ learning quality and English reading proficiency during COVID-19 pandemic

Wei Zhou / Zehua Wang / Feifei Han / Liu Hong

Heliyon, Vol 9, Iss 2, Pp e13434- (2023)

Comparison between face-to-face versus WeChat teaching and learning

2023

Abstract: Gastrointestinal clinical teaching is of vital important for gastrointestinal surgery interns. However, during COVID-19 pandemic, due to frequent lockdowns and essential social distancing policy implemented in China, face-to-face teaching was interrupted ...

Abstract	Gastrointestinal clinical teaching is of vital important for gastrointestinal surgery interns. However, during COVID-19 pandemic, due to frequent lockdowns and essential social distancing policy implemented in China, face-to-face teaching was interrupted significantly. To find a cost-effective way to deliver medical education to ensure that teaching and learning would be continued and uninterrupted, many social media tools and mobile applications have been used in medical teaching and learning. WeChat has been frequently employed in teaching and learning in many disciplines in Chinese universities due to its powerful functions and free cost. This study compared Chinese digestive surgery interns' learning quality, English reading proficiency, and learning satisfaction in two teaching conditions: the traditional face-to-face teaching versus WeChat teaching via an experiment. The study recruited 60 final year clinical medical students, who were randomly and equally assigned into two groups: traditional face-to-face teaching versus WeChat teaching. Interns' learning quality and learning satisfaction were measured by Likert-scale questionnaires; and their English reading proficiency was measured by the reading section in a standardized English test. The results showed that interns in WeChat group had significantly higher learning quality on understanding mechanisms and current knowledge by both self-assessment and peer-assessment. WeChat group also outperformed face-to-face group on inferencing, details, and main ideas in English reading. With regard to learning satisfaction, WeChat group were higher on learning interests, learning objectives, learning format, and English reading proficiency than face-to-face group. However, interns did not differ in terms of their learning satisfaction on medical skills, which might indicate that WeChat had limitations on training interns’ medical practical ability.
Keywords	WeChat ; Digestive surgery interns ; Learning quality ; English reading proficiency ; Learning satisfaction ; COVID-19 pandemic ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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