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Article ; Online: Effect of Reactive Oxygen Scavenger N,N′-Dimethylthiourea (DMTU) on Seed Germination and Radicle Elongation of Maize

Wei-Qing Li / Jia-Yu Li / Yi-Fei Zhang / Wen-Qi Luo / Yi Dou / Song Yu

International Journal of Molecular Sciences, Vol 24, Iss 21, p

2023 Volume 15557

Abstract: Reactive oxygen species (ROS) are an important part of adaptation to biotic and abiotic stresses and regulate seed germination through positive or negative signaling. Seed adaptation to abiotic stress may be mediated by hydrogen peroxide (H 2 O 2 ). The ... ...

Abstract	Reactive oxygen species (ROS) are an important part of adaptation to biotic and abiotic stresses and regulate seed germination through positive or negative signaling. Seed adaptation to abiotic stress may be mediated by hydrogen peroxide (H 2 O 2 ). The effects of the ROS scavenger N,N′-dimethylthiourea (DMTU) on maize seed germination through endogenous H 2 O 2 regulation is unclear. In this study, we investigated the effects of different doses of DMTU on seed endogenous H 2 O 2 and radicle development parameters using two maize varieties (ZD958 and DMY1). The inhibitory effect of DMTU on the germination rate and radicle growth was dose-dependent. The inhibitory effect of DMTU on radicle growth ceased after transferring maize seeds from DMTU to a water medium. Histochemical analyses showed that DMTU eliminated stable H 2 O 2 accumulation in the radicle sheaths and radicles. The activity of antioxidant enzyme and the expression of antioxidant enzyme-related genes ( ZmAPX2 and ZmCAT2 ) were reduced in maize seeds cultured with DMTU compared with normal culture conditions (0 mmol·dm −3 DMTU). We suggest the use of 200 mmol·dm −3 DMTU as an H 2 O 2 scavenger to study the ROS equilibrium mechanisms during the germination of maize seeds, assisting in the future with the efficient development of plant growth regulators to enhance the seed germination performance of test maize varieties under abiotic stress.
Keywords	seed germination ; DMTU ; H 2 O 2 ; maize ; gene expression ; radicle elongation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nucleic acid quantification using nicking-displacement, rolling circle amplification and bio-bar-code mediated triple-amplification.

Li, Xue-Mei / Luo, Jie / Zhang, Ning-Bo / Wei, Qing-Li

Analytica chimica acta

2015 Volume 881, Page(s) 117–123

Abstract: In the present study, an inductively-coupled plasma-mass spectrometry (ICP-MS)-based triple-amplification system, by combination of nicking-displacement, rolling circle amplification (RCA) and bio-bar-code probes, was fabricated for the detection of DNA ... ...

Abstract	In the present study, an inductively-coupled plasma-mass spectrometry (ICP-MS)-based triple-amplification system, by combination of nicking-displacement, rolling circle amplification (RCA) and bio-bar-code probes, was fabricated for the detection of DNA target. By using this system, hepatitis B virus (HBV) DNA target down to 3.2×10(-17)M was detected by DNA probes labeled with Au nanoparticles (AuNPs). Single nucleotide polymorphisms in genes can also be effectively discriminated. In addition, we proved that this strategy is capable of detecting the target in complicated biological samples and holds great potential application in biomedical research.
MeSH term(s)	DNA Probes/chemistry ; DNA, Viral/blood ; DNA, Viral/genetics ; Gold/chemistry ; Hepatitis B virus/genetics ; Hepatitis B virus/isolation & purification ; Humans ; Metal Nanoparticles/chemistry ; Nucleic Acid Amplification Techniques/methods ; Sensitivity and Specificity ; Spectrophotometry, Atomic/methods
Chemical Substances	DNA Probes ; DNA, Viral ; Gold (7440-57-5)
Language	English
Publishing date	2015-06-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2015.05.011
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Article ; Online: A dual-amplified electrochemical detection of mRNA based on duplex-specific nuclease and bio-bar-code conjugates.

Li, Xue-Mei / Wang, Lin-Lin / Luo, Jie / Wei, Qing-Li

Biosensors & bioelectronics

2015 Volume 65, Page(s) 245–250

Abstract: On the basis of strong preference for cleaving double-stranded DNA or DNA in DNA:RNA heteroduplexes of duplex-specific nuclease (DSN), a dual-amplified electrochemical detection of mRNA was developed in this article, by coupling the enhancement of DSN ... ...

Abstract	On the basis of strong preference for cleaving double-stranded DNA or DNA in DNA:RNA heteroduplexes of duplex-specific nuclease (DSN), a dual-amplified electrochemical detection of mRNA was developed in this article, by coupling the enhancement of DSN and bio-bar-code conjugates. Capture probe was linked with magnetic nanoparticles (MNPs) at its 5' end and bio-bar-code at its 3' end. In the presence of target surviving mRNA, all hybridized S1 strands were cleaved off the biosensor by the DSN, and the bio-bar-code probe with CdS nanoparticles (CdS NPs) was released into the solution. The metal sulfide nanoparticles were measured by anodic stripping voltammetry (ASV) subsequently. This assay exhibited high sensitivity and selectivity with a detection limit of 0.48fM. In addition, we proved that this simple and cost-effective strategy is capable of detecting the target in complicated biological samples and holds great potential application in biomedical research and clinical diagnostics.
MeSH term(s)	Animals ; Anomura/enzymology ; Automatic Data Processing ; Biosensing Techniques/methods ; Cadmium Compounds/chemistry ; Deoxyribonucleases/metabolism ; Electrochemical Techniques/methods ; Gold/chemistry ; HeLa Cells ; Humans ; Magnetite Nanoparticles/chemistry ; Nanoparticles/chemistry ; Nucleic Acid Amplification Techniques/methods ; Nucleic Acid Hybridization/methods ; RNA, Messenger/analysis ; RNA, Messenger/metabolism ; Ribonucleases/metabolism ; Sulfides/chemistry
Chemical Substances	Cadmium Compounds ; Magnetite Nanoparticles ; RNA, Messenger ; Sulfides ; cadmium sulfide (057EZR4Z7Q) ; Gold (7440-57-5) ; Deoxyribonucleases (EC 3.1.-) ; Ribonucleases (EC 3.1.-)
Language	English
Publishing date	2015-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2014.10.051
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Article: Systematic Pharmacological Strategies to Explore the Regulatory Mechanism of Ma Xing Shi Gan Decoction on COVID-19

Shi-Ying, Zhang / Ling, Li / Ning, Zhang / Hong-Tao, Xia / Fang-Guo, Lu / Wei-Qing, Li

Digital Chinese Medicine

Abstract: OBJECTIVE: To use systematic pharmacological strategies to explore the regulatory mechanisms of Ma Xing Shi Gan Decoction (MXSGD) against the coronavirus disease 2019 (COVID-19) METHODS: Data on the compounds and targets of MXSGD were collected from the ... ...

Abstract	OBJECTIVE: To use systematic pharmacological strategies to explore the regulatory mechanisms of Ma Xing Shi Gan Decoction (MXSGD) against the coronavirus disease 2019 (COVID-19) METHODS: Data on the compounds and targets of MXSGD were collected from the Traditional Chinese Medicene Systems Parmacology Database and Analysis Platform (TCMSP) and TCM Databases@Taiwan Data on ACE2-related targets and the protein-protein interaction (PPI) were collected from the String database The Cytoscape 3 7 2 was used to construct and analyze the networks The DAVID platform was used for Gene Ontology (GO) and pathway enrichment analyses RESULTS: Data on 272 MXSGD targets and 21 SARS-CoV-2 potential targets were collected Four networks were constructed and analyzed based on the data: (1) compound-target network of MXSGD;(2) MXSGD-SARS-CoV-2-PPI network;(3) cluster of MXSGD-SARS-CoV-2-PPI network;(4) Herb-Pathway-Target network The core targets included AKT1, MAPK3, IL-6, TP53, VEGFA, TNF, CASP3, EGFR, EGF and MAPK1 The antiviral biological processes were inflammatory responses (inflammatory cells, inflammatory cytokines and their signaling pathways), immune responses (T cells, monocytes, B cells and other immune cells), immune factors (IFN-γ, TNF-α and so on), virus defense, humoral immunity and mucosal innate immune response The antivirus-related signaling pathways included TNF, NOD-like receptor, FoxO, PI3K-AKT and Toll-like receptor signaling pathways CONCLUSIONS: MXSGD can control disease progression by regulating multiple compounds and targets;it can reduce inflammation and balance immunity by regulating several proteins that interact with ACE2 and signaling pathways closely related to disease development
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #657612
Database	COVID19

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Article ; Online: Systematic Pharmacological Strategies to Explore the Regulatory Mechanism of Ma Xing Shi Gan Decoction on COVID-19

Shi-Ying, Zhang / Ling, Li / Ning, Zhang / Hong-Tao, Xia / Fang-Guo, Lu / Wei-Qing, Li

Digital Chinese Medicine

2020 Volume 3, Issue 2, Page(s) 96–115

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	2589-3777
DOI	10.1016/j.dcmed.2020.06.004
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A simple, accurate, time-saving and green method for the determination of 15 sulfonamides and metabolites in serum samples by ultra-high performance supercritical fluid chromatography

Zhang, Yuan / Feng Zhang / Shao-Hui Li / Wei-E Zhou / Wei-Qing Li / Wen-Jie Wu / Xue-Song Feng / Yu Zhou / Zhi-Qin Ren

Journal of chromatography. 2016 Feb. 05, v. 1432

2016

Abstract: An analytical method based on ultra-high performance supercritical fluid chromatography (UHPSFC) with photo-diode array detection (PDA) has been developed to quantify 15 sulfonamides and their N4-acetylation metabolites in serum. Under the optimized ... ...

Abstract	An analytical method based on ultra-high performance supercritical fluid chromatography (UHPSFC) with photo-diode array detection (PDA) has been developed to quantify 15 sulfonamides and their N4-acetylation metabolites in serum. Under the optimized gradient elution conditions, it took only 7min to separate all 15 sulfonamides and the critical pairs of each parent drug and metabolite were completely separated. Variables affecting the UHPSFC were optimized to get a better separation. The performance of the developed method was evaluated. The UHPSFC method allowed the baseline separation and determination of 15 sulfonamides and metabolites with limit of detection ranging from 0.15 to 0.35Î¼g/mL. Recoveries between 90.1 and 102.2% were obtained with satisfactory precision since relative standard deviations were always below 3%. The proposed method is simple, accurate, time-saving and green, it is applicable to a variety of sulfonamides detection in serum samples.
Keywords	blood serum ; detection limit ; drugs ; metabolites ; statistical analysis ; sulfonamides ; supercritical fluid chromatography
Language	English
Dates of publication	2016-0205
Size	p. 132-139.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	218139-3
ISSN	0021-9673 ; 0378-4355 ; 0376-737X
ISSN	0021-9673 ; 0378-4355 ; 0376-737X
DOI	10.1016/j.chroma.2015.12.075
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of clazosentan in patients with aneurysmal subarachnoid hemorrhage

Xiang Wang / Yi-Ming Li / Wei-Qing Li / Cheng-Guang Huang / Yi-Cheng Lu / Li-Jun Hou

PLoS ONE, Vol 7, Iss 10, p e

a meta-analysis of randomized controlled trials.

2012 Volume 47778

Abstract: BACKGROUND: Cerebral vasospasm is the most important potentially treatable cause of mortality and morbidity following aneurysmal subarachnoid hemorrhage (aSAH). Clazosentan, a selective endothelinreceptor antagonist, has been suggested to help reduce the ...

Abstract	BACKGROUND: Cerebral vasospasm is the most important potentially treatable cause of mortality and morbidity following aneurysmal subarachnoid hemorrhage (aSAH). Clazosentan, a selective endothelinreceptor antagonist, has been suggested to help reduce the incidence of vasospasm in patients with aSAH. However, the results were controversial in previous trials. This meta-analysis attempts to assess the effect of clazosentan in patients with aSAH. METHODOLOGY/PRINCIPAL FINDINGS: We systematically searched Pubmed, Embase, and the Cochrane Library from their inception until June, 2012. All randomized controlled trials (RCTs) related to the effect of clazosentan in aSAH were included. The primary outcomes included the incidence of angiographic vasospasm, new cerebral infarction (NCI), delayed ischemic neurological deficits (DIND), and vasospasm-related morbidity/mortality (M/M); the second outcomes included the occurrence of rescue therapy, all-cause-mortality, and poor outcome. 4 RCTs were included with a total of 2156 patients. The risk of angiographic vasospasm (relative risk [RR] =0.58; 95% CI, 0.48 to 0.71), DIND (RR=0.76; 95% CI, 0.62 to 0.92), and vasospasm-related M/M (RR=0.80; 95% CI, 0.67 to 0.96) were statistically significantly reduced in the clazosentan group. Patients treated with clazosentan had a reduced occurrence of rescue therapy (RR=0.62; 95% CI, 0.49 to 0.79). However, no statistically significant effects were observed in NCI (RR=0.74; 95% CI, 0.52 to 1.04), mortality (RR=1.03; 95% CI, 0.71 to 1.49), and poor outcome (RR=1.12; 95% CI, 0.96 to 1.30). CONCLUSIONS/SIGNIFICANCE: Our pooling data supports that clazosentan is probably effective in preventing the occurrence of angiographic vasospasm, vasospasm-related DIND, vasospasm related M/M, and rescue therapy. However, no evidence lends significant supports to the benefits of clazosentan in decreasing the occurrence of NCI, mortality or improving the functional outcome.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article: 3,3-Dimethyl-1-[5-(1H-1,2,4-triazol-1-yl-meth-yl)-1,3,4-thia-diazol-2-ylsulfan-yl]butan-2-one.

Wei, Qing-Li / He, Fu-Jin / Li, Fang / Bi, Sai

Acta crystallographica. Section E, Structure reports online

2008 Volume 64, Issue Pt 2, Page(s) o412

Abstract: In the mol-ecule of the title compound, C(11)H(15)N(5)OS(2), the thia-diazole and triazole rings are not coplanar, the dihedral angle formed by their mean planes being 59.9 (2)°. The exocyclic S atom, and the methyl-ene, carbonyl, tert-butyl and one ... ...

Abstract	In the mol-ecule of the title compound, C(11)H(15)N(5)OS(2), the thia-diazole and triazole rings are not coplanar, the dihedral angle formed by their mean planes being 59.9 (2)°. The exocyclic S atom, and the methyl-ene, carbonyl, tert-butyl and one methyl carbon form an approximately planar zigzag chain, which makes a dihedral angle of 74.6 (1)° with the thia-diazole ring.
Language	English
Publishing date	2008-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	1600-5368
ISSN	1600-5368
DOI	10.1107/S1600536807068286
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Article ; Online: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation

Adam Kosti / Patricia Rosa de Araujo / Wei-Qing Li / Gabriela D. A. Guardia / Jennifer Chiou / Caihong Yi / Debashish Ray / Fabiana Meliso / Yi-Ming Li / Talia Delambre / Mei Qiao / Suzanne S. Burns / Franziska K. Lorbeer / Fanny Georgi / Markus Flosbach / Sarah Klinnert / Anne Jenseit / Xiufen Lei / Carolina Romero Sandoval /

Kevin Ha / Hong Zheng / Renu Pandey / Aleksandra Gruslova / Yogesh K. Gupta / Andrew Brenner / Erzsebet Kokovay / Timothy R. Hughes / Quaid D. Morris / Pedro A. F. Galante / Stefano Tiziani / Luiz O. F. Penalva

Genome Biology, Vol 21, Iss 1, Pp 1-

2020 Volume 32

Abstract: Abstract Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. ... ...

Abstract	Abstract Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory networks provide new opportunities for targeted therapy. Results We identify the RNA-binding protein SERBP1 as a novel regulator of glioblastoma (GBM) development. High SERBP1 expression is prevalent in GBMs and correlates with poor patient survival and poor response to chemo- and radiotherapy. SERBP1 knockdown causes delay in tumor growth and impacts cancer-relevant phenotypes in GBM and glioma stem cell lines. RNAcompete identifies a GC-rich region as SERBP1-binding motif; subsequent genomic and functional analyses establish SERBP1 regulation role in metabolic routes preferentially used by cancer cells. An important consequence of these functions is SERBP1 impact on methionine production. SERBP1 knockdown decreases methionine levels causing a subsequent reduction in histone methylation as shown for H3K27me3 and upregulation of genes associated with neurogenesis, neuronal differentiation, and function. Further analysis demonstrates that several of these genes are downregulated in GBM, potentially through epigenetic silencing as indicated by the presence of H3K27me3 sites. Conclusions SERBP1 is the first example of an RNA-binding protein functioning as a central regulator of cancer metabolism and indirect modulator of epigenetic regulation in GBM. By bridging these two processes, SERBP1 enhances glioma stem cell phenotypes and contributes to GBM poorly differentiated state.
Keywords	GBM ; SERBP1 ; RNA-binding protein ; Cancer metabolism ; One carbon cycle ; Epigenetic regulation ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
Subject code	570
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Simultaneous determination of 12 β-agonists in feeds by ultra-high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry.

Xiu-Juan, Wang / Feng, Zhang / Fei, Ding / Wei-Qing, Li / Qing-Yu, Chen / Xiao-Gang, Chu / Cheng-Bao, Xu

Journal of chromatography. A

2013 Volume 1278, Page(s) 82–88

Abstract: A new analysis method using ultra-performance liquid chromatography (UPLC)-quadrupole-time-of-flight mass spectrometry (Q/TOF MS) was developed for screening and confirmation of 12 β-agonists in feeds. Under the optimized gradient elution conditions, it ... ...

Abstract	A new analysis method using ultra-performance liquid chromatography (UPLC)-quadrupole-time-of-flight mass spectrometry (Q/TOF MS) was developed for screening and confirmation of 12 β-agonists in feeds. Under the optimized gradient elution conditions, it takes only 6 min to separate all 12 β-agonists, and the critical pair of Ractopamine and Isoxsuprine isomers was almost completely separated. Based on the over 10,000 full-width at half maximum (FWHM) mass resolution and high mass accuracy features of TOF MS with 20 mDa mass window, accurate mass chromatograms were reconstructed for individual compounds. The fragmentation pathways of 12 β-agonists were also studied using Q-TOF MS. The potential of UPLC-Q/TOF MS for confirmatory analysis was shown by determining the accurate mass of all compounds and fragment ions upon collision-induced-dissociation (CID) at different energies. The extra mass measurement errors for all β-agonists were found to be within 5 ppm. The limits of detection (LODs) and limits of quantitation (LOQs) were determined for all β-agonists in feeds and found to be 1-5 ng/mL and 5-50 μg/kg, respectively. The method of UPLC-Q/TOF MS developed in this study was initially applied to the research of feeds for analysis of 12 β-agonists and proved to be accurate, sensitive, convenient and practical.
MeSH term(s)	Adrenergic beta-Agonists/analysis ; Animal Feed/analysis ; Chromatography, High Pressure Liquid/methods ; Mass Spectrometry/methods
Chemical Substances	Adrenergic beta-Agonists
Language	English
Publishing date	2013-02-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2012.12.060
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