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Book ; Online: Estimating Angle of Arrival (AoA) of multiple Echoes in a Steering Vector Space

Wei, Yu-Lin / Choudhury, Romit Roy

2021

Abstract: Consider a microphone array, such as those present in Amazon Echos, conference phones, or self-driving cars. One of the goals of these arrays is to decode the angles in which acoustic signals arrive at them. This paper considers the problem of estimating ...

Abstract	Consider a microphone array, such as those present in Amazon Echos, conference phones, or self-driving cars. One of the goals of these arrays is to decode the angles in which acoustic signals arrive at them. This paper considers the problem of estimating K angle of arrivals (AoA), i.e., the direct path's AoA and the AoA of subsequent echoes. Significant progress has been made on this problem, however, solutions remain elusive when the source signal is unknown (such as human voice) and the channel is strongly correlated (such as in multipath settings). Today's algorithms reliably estimate the direct-path-AoA, but the subsequent AoAs diverge in noisy real-world conditions. We design SubAoA, an algorithm that improves on the current body of work. Our core idea models signal in a new AoA sub-space, and employs a cancellation approach that successively cancels each AoA to decode the next. We explain the behavior and complexity of the algorithm from the first principles, simulate the performance across a range of parameters, and present results from real-world experiments. Comparison against multiple existing algorithms like GCC-PHAT, MUSIC, and VoLoc shows increasing gains for the latter AoAs, while our computation complexity allows real-time operation. We believe progress in multi-AoA estimation is a fundamental building block to various acoustic and RF applications, including human or vehicle localization, multi-user separation, and even (blind) channel estimation. Comment: 14 pages, 20 figures
Keywords	Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing
Publishing date	2021-09-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluating the comparative efficiency of medical centers in Taiwan

Cheng-Ming Chiu / Ming-Shu Chen / Chung-Shun Lin / Wei-Yu Lin / Hui-Chu Lang

BMC Health Services Research, Vol 22, Iss 1, Pp 1-

a dynamic data envelopment analysis application

2022 Volume 11

Abstract: Abstract Background People in Taiwan enjoy comprehensive National Health Insurance coverage. However, under the global budget constraint, hospitals encounter enormous challenges. This study was designed to examine Taiwan medical centers' efficiency and ... ...

Abstract	Abstract Background People in Taiwan enjoy comprehensive National Health Insurance coverage. However, under the global budget constraint, hospitals encounter enormous challenges. This study was designed to examine Taiwan medical centers' efficiency and factors that influence it. Methods We obtained data from open sources of government routine publications and hospitals disclosed by law to the National Health Insurance Administration, Ministry of Health and Welfare, Taiwan. The dynamic data envelopment analysis (DDEA) model was adopted to estimate all medical centers' efficiencies during 2015–2018. Beta regression models were used to model the efficiency level obtained from the DDEA model. We applied an input-oriented approach under both the constant returns-to-scale (CRS) and variable returns-to-scale (VRS) assumptions to estimate efficiency. Results The findings indicated that 68.4% (13 of 19) of medical centers were inefficient according to scale efficiency. The mean efficiency scores of all medical centers during 2015–2018 under the CRS, VRS, and Scale were 0.85, 0.930, and 0.95,respectively. Regression results showed that an increase in the population less than 14 years of age, assets, nurse-patient ratio and bed occupancy rate could increase medical centers' efficiency. The rate of emergency return within 3-day and patient self-pay revenues were associated significantly with reduced hospital efficiency (p < 0.05). The result also showed that the foundation owns medical center has the highest efficiency than other ownership hospitals. Conclusions The study results provide information for hospital managers to consider ways they could adjust available resources to achieve high efficiency.
Keywords	Data envelopment analysis ; Dynamic efficiency ; Projections ; Beta regression ; Hospital performance ; Public aspects of medicine ; RA1-1270
Subject code	338
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Urothelial Calcium-Sensing Receptor Modulates Micturition Function via Mediating Detrusor Activity and Ameliorates Bladder Hyperactivity in Rats

Wei-Yi Wu / Shih-Pin Lee / Bing-Juin Chiang / Wei-Yu Lin / Chiang-Ting Chien

Pharmaceuticals, Vol 14, Iss 960, p

2021 Volume 960

Abstract: The urothelium displays mechano- and chemosensory functions via numerous receptors and channels. The calcium-sensing receptor (CaSR) detects extracellular calcium and modulates several physiological functions. Nonetheless, information about the ... ...

Abstract	The urothelium displays mechano- and chemosensory functions via numerous receptors and channels. The calcium-sensing receptor (CaSR) detects extracellular calcium and modulates several physiological functions. Nonetheless, information about the expression and the role of CaSR in lower urinary tract has been absent. We aimed to determine the existence of urothelial CaSR in urinary bladder and its effect on micturition function. We utilized Western blot to confirm the expression of CaSR in bladder and used immunofluorescence to verify the location of the CaSR in the bladder urothelium via colocalization with uroplakin III A. The activation of urothelial CaSR via the CaSR agonist, AC-265347 (AC), decreased urinary bladder smooth muscle (detrusor) activity, whereas its inhibition via the CaSR antagonist, NPS-2143 hydrochloride (NPS), increased detrusor activity in in vitro myography experiments. Cystometry, bladder nerve activities recording, and bladder surface microcirculation detection were conducted to evaluate the effects of the urothelial CaSR via intravesical administrations. Intravesical AC inhibited micturition reflex, bladder afferent and efferent nerve activities, and reversed cystitis-induced bladder hyperactivity. The urothelial CaSR demonstrated a chemosensory function, and modulated micturition reflex via regulating detrusor activity. This study provided further evidence of how the urothelial CaSR mediated micturition and implicated the urothelial CaSR as a potential pharmacotherapeutic target in the intervention of bladder disorders.
Keywords	calcium-sensing receptor ; chemosensory ; detrusor activity ; micturition ; urothelium ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	616
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Association of ABO Blood Type with Bleeding Severity in Patients with Acute Gastroesophageal Variceal Bleeding

Wei-Yu Lin / Ming-Yuan Hong / Chih-Hao Lin / Peng-Peng Chang / Shao-Chung Chu / Chia-Lung Kao

Medicina, Vol 57, Iss 1323, p

2021 Volume 1323

Abstract: Background and Objectives : ABO blood types have been implicated as potential risk factors for various hemorrhagic diseases. No study has investigated the association between gastroesophageal variceal bleeding and ABO blood types. We aimed to evaluate ... ...

Abstract	Background and Objectives : ABO blood types have been implicated as potential risk factors for various hemorrhagic diseases. No study has investigated the association between gastroesophageal variceal bleeding and ABO blood types. We aimed to evaluate the impact of ABO blood types on mortality and bleeding risk in acute gastroesophageal variceal bleeding. Materials and Methods : This is a retrospective observational study. Patients presenting with acute gastroesophageal varices bleeding diagnosed by endoscopy were enrolled, and were divided by blood type into a type O group and non-type O group. The outcomes were death within 30 days and the proportion of further bleeding. We used generalized linear mixed-effects models to analyze the outcomes. Results : A total of 327 patients and 648 records of emergency room visits were included. The 30-day mortality was 14.8% (21 of 142 patients) in the type O group, and 16.2% (30 of 185 patients) in the non-type O group ( p = 0.532). Further bleeding within 30 days occurred in 34 cases (12.6%) in the type O group, and in 26 cases (6.9%) in the non-type O group ( p = 0.539). Conclusions : There was no significant difference in blood transfusion volume in 24 h, recurrent bleeding rates, or mortality between patients with blood type O and those with non-type O.
Keywords	ABO blood group system ; gastroesophageal variceal bleeding ; mortality ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differentially Expressed Genes Correlated with Fibrosis in a Rat Model of Chronic Partial Bladder Outlet Obstruction

Yuan-Shuo Hsueh / Hui Hua Chang / Shun-Yao Ko / Yi-Pai Lin / Wei-Yu Lin

Processes, Vol 9, Iss 2219, p

2021 Volume 2219

Abstract: Chronic partial bladder outlet obstruction (PBOO) is a prevalent clinical problem that may result from multiple etiologies. PBOO may be a secondary condition to various anatomical and functional abnormalities. Bladder fibrosis is the worst outcome of ... ...

Abstract	Chronic partial bladder outlet obstruction (PBOO) is a prevalent clinical problem that may result from multiple etiologies. PBOO may be a secondary condition to various anatomical and functional abnormalities. Bladder fibrosis is the worst outcome of PBOO. However, gene alterations and the mechanism of fibrosis development after PBOO onset are not clear. Therefore, we aimed to investigate gene expression alterations during chronic PBOO. A rat model of PBOO was established and validated by a significant increase in rat bladder weight. The bladder samples were further analyzed by microarray, and differentially expressed genes (DEGs) that are more related to PBOO compared with the control genes were selected. The data showed that 16 significantly upregulated mRNAs and 3 significantly downregulated mRNAs are involved in fibrosis. Moreover, 13 significantly upregulated mRNAs and 12 significantly downregulated mRNAs are related to TGFB signaling. Twenty-two significantly upregulated mRNAs and nine significantly downregulated mRNAs are related to the extracellular matrix. The genes with differential expressions greater than four-fold included Grem1 , Thbs1 , Col8a1 , Itga5 , Tnc , Lox , Timp1 , Col4a1 , Col4a2 , Bhlhe40 , Itga1 , Tgfb3 , and Gadd45b . The gene with a differential expression less than a quarter-fold was Thbs2 . These findings show the potential roles of these genes in the physiology of PBOO.
Keywords	chronic partial bladder outlet obstruction ; fibrosis ; Tgfb ; microarray ; Thbs1 ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Study on the Mechanism of Yiqi Chutan Recipe in the Treatment of Lung Cancer with Splenasthenic Syndrome].

Wei, Yu-lin / Wang, Shu-mei / Liu, Qi-ou / Luo, Yang

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2018 Volume 39, Issue 9, Page(s) 2097–2101

Abstract: Objective: To investigate the mechanism of Yiqi Chutan recipe( YCR) in the treatment of lung cancer with splenasthenic syndrome from the perspective of the endoplasmic reticulum stress( ERS).: Methods: 60 mice were successfully modeled as Lewis lung ... ...

Abstract	Objective: To investigate the mechanism of Yiqi Chutan recipe( YCR) in the treatment of lung cancer with splenasthenic syndrome from the perspective of the endoplasmic reticulum stress( ERS). Methods: 60 mice were successfully modeled as Lewis lung cancer mice with spleen deficiency, which were randomly divided into model group( normal saline),cisplatin group( 1 mg / kg),low dose( 2 g/kg) YCR group, middle dose( 4 g/kg) YCR group,high dose( 8 g/kg) YCR group and the combined medication group( YCR 4 g/kg + cisplatin 1 mg / kg),with 10 mice in each group. The mice were killed after 14 days,the size and weight of tumor in mice were measured,morphological changes of tumor were observed by HE staining method, the expression of CHOP and DR5 protein in tumor tissue was detected by immunohistochemical method and Western blot method. Results: Compared with model group, the volume and weight of tumor in cisplatin group, middle dose YCR group, high dose YCR group and combined medication group were significantly decreased( P < 0. 01),and the tumor cells in transplanted tumor were large necrosis and the protein expression of CHOP and DR5 were increased significantly( P < 0. 01). The effect in treatment of lung cancer with splenasthenic syndrone in combined medication group was higher( P < 0. 05 or P < 0. 01). Conclusion: Yiqi Chutan recipe has different degrees of inhibition on lung cancer, the combined use of cisplatin can obviously improve the curative effect. The mechanism may be related to up-regulating the expression of CHOP and DR5 in endoplasmic reticulum stress-related proteins.
MeSH term(s)	Animals ; Cisplatin ; Drugs, Chinese Herbal ; Lung Neoplasms ; Mice ; Neoplasm Transplantation ; Proteomics
Chemical Substances	Drugs, Chinese Herbal ; Cisplatin (Q20Q21Q62J)
Language	Chinese
Publishing date	2018-09-12
Publishing country	China
Document type	Journal Article
ISSN	1001-4454
ISSN	1001-4454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [The key point of studying sub-health is to solve the technical problem].

Wei, Yu-lin

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2007 Volume 27, Issue 10, Page(s) 872–873

MeSH term(s)	Health ; Health Promotion/methods ; Health Status ; Humans ; Medicine, Chinese Traditional/methods
Language	Chinese
Publishing date	2007-10
Publishing country	China
Document type	Journal Article
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
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Article ; Online: Antitumor Activity of the Cardiac Glycoside α-L-Diginoside by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells

Jing-Ru Weng / Wei-Yu Lin / Li-Yuan Bai / Jing-Lan Hu / Chia-Hsien Feng

International Journal of Molecular Sciences, Vol 21, Iss 7947, p

2020 Volume 7947

Abstract: We recently isolated a cardiac glycoside (CG), α-L-diginoside, from an indigenous plant in Taiwan, which exhibits potent tumor-suppressive efficacy in oral squamous cell carcinoma (OSCC) cell lines (SCC2095 and SCC4, IC 50 < 0.2 µM; 3-(4,5- ... ...

Abstract	We recently isolated a cardiac glycoside (CG), α-L-diginoside, from an indigenous plant in Taiwan, which exhibits potent tumor-suppressive efficacy in oral squamous cell carcinoma (OSCC) cell lines (SCC2095 and SCC4, IC 50 < 0.2 µM; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays). Here, we report that α-L-diginoside caused Sphase arrest and apoptosis, through the inhibition of a series of signaling pathways, including those mediated by cyclin E, phospho-CDC25C (p-CDC25C), and janus kinase/signal transducer and activator of transcription (JAK/STAT)3. α-L-diginoside induced apoptosis, as indicated by caspase activation and poly (ADP-ribose) polymerase (PARP) cleavage. Equally important, α-L-diginoside reduced Mcl-1 expression through protein degradation, and overexpression of Mcl-1 partially protected SCC2095 cells from α-L-diginoside’s cytotoxicity. Taken together, these data suggest the translational potential of α-L-diginoside to foster new therapeutic strategies for OSCC treatment.
Keywords	cardiac glycoside ; α-L-diginoside ; oral squamous cell carcinoma ; apoptosis ; cell-cycle arrest ; Mcl-1 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Inferring Facing Direction from Voice Signals

Wei, Yu-Lin / Li, Rui / Mehrotra, Abhinav / Choudhury, Romit Roy / Lane, Nic

2021

Abstract: Consider a home or office where multiple devices are running voice assistants (e.g., TVs, lights, ovens, refrigerators, etc.). A human user turns to a particular device and gives a voice command, such as ``Alexa, can you .''. This paper focuses on the ... ...

Abstract	Consider a home or office where multiple devices are running voice assistants (e.g., TVs, lights, ovens, refrigerators, etc.). A human user turns to a particular device and gives a voice command, such as ``Alexa, can you .''. This paper focuses on the problem of detecting which device the user was facing, and therefore, enabling only that device to respond to the command. Our core intuition emerges from the fact that human voice exhibits a directional radiation pattern, and the orientation of this pattern should influence the signal received at each device. Unfortunately, indoor multipath, unknown user location, and unknown voice signals pose as critical hurdles. Through a new algorithm that estimates the line-of-sight (LoS) power from a given signal, and combined with beamforming and triangulation, we design a functional solution called CoDIR. Results from $500+$ configurations, across $5$ rooms and $9$ different users, are encouraging. While improvements are necessary, we believe this is an important step forward in a challenging but urgent problem space. Comment: 12 pages, 16 figures
Keywords	Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing
Publishing date	2021-09-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk of end-stage renal disease after cancer nephrectomy in Taiwan

Wei-Yu Lin / Fu-Wen Liang / Tsung-Hsueh Lu

PLoS ONE, Vol 10, Iss 5, p e

a nationwide population-based study.

2015 Volume 0126965

Abstract: The conclusions of population-based studies examining the risk of developing end-stage renal disease (ESRD) after nephrectomy among patients with renal cell carcinoma (RCC) remain inconclusive. In this study, we sought to examine whether patients with ... ...

Abstract	The conclusions of population-based studies examining the risk of developing end-stage renal disease (ESRD) after nephrectomy among patients with renal cell carcinoma (RCC) remain inconclusive. In this study, we sought to examine whether patients with RCC undergoing radical nephrectomy (RN) have higher risk of ESRD compared to those undergoing partial nephrectomy (PN).Nationwide population-based retrospective cohort of 7670 patients with RCC who underwent RN or PN between 2000 and 2011 as recorded in the Taiwan National Health Insurance in-patient claims data were analyzed. The primary outcome of interest was the occurrence of ESRD requiring regular renal hemodialysis. Multivariable Cox proportional hazard regression model was performed to assess the risk.The median follow-up for the post-propensity matched cohort (1212 PN and 2424 RN) was 48 months. Seventy patients (2.9%) developed ESRD among those who underwent RN, for an incidence rate of 6.9 cases per 1000 person-years. In contrast, only 23 patients (1.9%) developed ESRD among patients who underwent PN, for an incidence rate of 5.5 cases per 1000 person-years. Despite the higher incidence rate of ESRD among RN, the aIRR (RN/PN) was 1.26 (95% CI 0.78-2.01), which was not statistically significant.This Taiwan nationwide population-based study suggests that patients with RCC undergoing RN do not have significantly higher risk of developing ESRD compared to those undergoing PN.
Keywords	Medicine ; R ; Science ; Q
Subject code	616 ; 610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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