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Article: 10 Experten - 10 Thesen Konsensuspapier - Grapefruitflavonoide beim metabolischen Syndrom

Weickert, Martin O.

2021 Volume 38, Issue 3, Page(s) 11

Language	German
Document type	Article
ZDB-ID	2120551-6
ISSN	1612-7307
Database	Current Contents Medicine

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Article ; Online: Metabolic-Associated Fatty Liver Disease and the Gut Microbiota.

Barber, Thomas M / Hanson, Petra / Weickert, Martin O

Endocrinology and metabolism clinics of North America

2023 Volume 52, Issue 3, Page(s) 485–496

Abstract: As an important sequela of the burgeoning global obesity problem, metabolic-associated fatty liver disease (MAFLD) has gained increasing prominence recently. The gut-liver axis (GLA) provides a direct conduit to the liver for the gut microbiota and their ...

Abstract	As an important sequela of the burgeoning global obesity problem, metabolic-associated fatty liver disease (MAFLD) has gained increasing prominence recently. The gut-liver axis (GLA) provides a direct conduit to the liver for the gut microbiota and their metabolic by-products (including secondary bile acids, ethanol, and trimethylamine). These GLA-related factors, including the host inflammatory response and integrity of the gut mucosal wall, likely contribute to the pathogenesis of MAFLD. Accordingly, these GLA-related factors are targets for possible preventive and treatment strategies for MAFLD, and include probiotics, prebiotics, bile acids, short-chain fatty acids, fecal microbiota transplantation, carbon nanoparticles, and bacteriophages.
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Non-alcoholic Fatty Liver Disease ; Liver/metabolism ; Obesity
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	92116-6
ISSN	1558-4410 ; 0889-8529
ISSN (online)	1558-4410
ISSN	0889-8529
DOI	10.1016/j.ecl.2023.01.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High fiber intake, dietary protein, and prevention of type 2 diabetes.

Weickert, Martin O

Expert review of endocrinology & metabolism

2018 Volume 13, Issue 5, Page(s) 223–224

MeSH term(s)	Diabetes Mellitus, Type 2/prevention & control ; Dietary Fiber ; Dietary Proteins ; Humans
Chemical Substances	Dietary Fiber ; Dietary Proteins
Language	English
Publishing date	2018-08-24
Publishing country	England
Document type	Editorial
ISSN	1744-8417
ISSN (online)	1744-8417
DOI	10.1080/17446651.2018.1513320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How might remote management of diabetes mellitus during the COVID-19 pandemic impact patient care?

Barber, Thomas M / Weickert, Martin O

Expert review of endocrinology & metabolism

2021 Volume 16, Issue 4, Page(s) 155–158

MeSH term(s)	COVID-19 ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Humans ; Pandemics ; Patient Care ; SARS-CoV-2
Language	English
Publishing date	2021-06-30
Publishing country	England
Document type	Journal Article ; Comment
ISSN	1744-8417
ISSN (online)	1744-8417
DOI	10.1080/17446651.2021.1947795
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effects of the Mediterranean Diet on Health and Gut Microbiota.

Barber, Thomas M / Kabisch, Stefan / Pfeiffer, Andreas F H / Weickert, Martin O

Nutrients

2023 Volume 15, Issue 9

Abstract: The Mediterranean Diet (MD) is plant-based and consists of multiple daily portions of vegetables, fruit, cereals, and olive oil. Although there are challenges with isolating the MD from the typical Mediterranean lifestyle and culture (including prolonged ...

Abstract	The Mediterranean Diet (MD) is plant-based and consists of multiple daily portions of vegetables, fruit, cereals, and olive oil. Although there are challenges with isolating the MD from the typical Mediterranean lifestyle and culture (including prolonged 'social' meals and siestas), much evidence supports the health benefits of the MD that include improved longevity, reduced metabolic risk of Diabetes Mellitus, obesity, and Metabolic Syndrome, reduced risk of malignancy and cardiovascular disease, and improved cognitive function. The MD is also associated with characteristic modifications to gut microbiota, mediated through its constituent parts (primarily dietary fibres, extra virgin olive oil, and polyunsaturated fatty acids [including ω-3]). These include enhanced growth of species that produce short-chain fatty acids (butyrate), such as
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Diet, Mediterranean ; Bacteroides ; Bifidobacterium ; Butyrates
Chemical Substances	Butyrates
Language	English
Publishing date	2023-04-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15092150
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metabolic-Associated Fatty Liver Disease and Insulin Resistance: A Review of Complex Interlinks.

Barber, Thomas M / Kabisch, Stefan / Pfeiffer, Andreas F H / Weickert, Martin O

Metabolites

2023 Volume 13, Issue 6

Abstract: Metabolic-associated fatty liver disease (MAFLD) has now surpassed alcohol excess as the most common cause of chronic liver disease globally, affecting one in four people. Given its prevalence, MAFLD is an important cause of cirrhosis, even though only a ...

Abstract	Metabolic-associated fatty liver disease (MAFLD) has now surpassed alcohol excess as the most common cause of chronic liver disease globally, affecting one in four people. Given its prevalence, MAFLD is an important cause of cirrhosis, even though only a small proportion of patients with MAFLD ultimately progress to cirrhosis. MAFLD suffers as a clinical entity due to its insidious and often asymptomatic onset, lack of an accurate and reliable non-invasive diagnostic test, and lack of a bespoke therapy that has been designed and approved for use specifically in MAFLD. MAFLD sits at a crossroads between the gut and the periphery. The development of MAFLD (including activation of the inflammatory cascade) is influenced by gut-related factors that include the gut microbiota and intactness of the gut mucosal wall. The gut microbiota may interact directly with the liver parenchyma (through translocation via the portal vein), or indirectly through the release of metabolic metabolites that include secondary bile acids, trimethylamine, and short-chain fatty acids (such as propionate and acetate). In turn, the liver mediates the metabolic status of peripheral tissues (including insulin sensitivity) through a complex interplay of hepatokines, liver-secreted metabolites, and liver-derived micro RNAs. As such, the liver plays a key central role in influencing overall metabolic status. In this concise review, we provide an overview of the complex mechanisms whereby MAFLD influences the development of insulin resistance within the periphery, and gut-related factors impact on the development of MAFLD. We also discuss lifestyle strategies for optimising metabolic liver health.
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13060757
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of cereal soluble fiber in the beneficial modulation of glycometabolic gastrointestinal hormones.

Kabisch, Stefan / Weickert, Martin O / Pfeiffer, Andreas F H

Critical reviews in food science and nutrition

2022 Volume 64, Issue 13, Page(s) 4331–4347

Abstract: According to cohort studies, cereal fiber, and whole-grain products might decrease risk for type 2 diabetes (T2DM), inflammatory processes, cancer, and cardiovascular diseases. These associations, mainly affect insoluble, but not soluble cereal fiber. In ...

Abstract	According to cohort studies, cereal fiber, and whole-grain products might decrease risk for type 2 diabetes (T2DM), inflammatory processes, cancer, and cardiovascular diseases. These associations, mainly affect insoluble, but not soluble cereal fiber. In intervention studies, soluble fiber elicit anti-hyperglycemic and anti-inflammatory short-term effects, partially explained by fermentation to short-chain fatty acids, which acutely counteract insulin resistance and inflammation. ß-glucans lower cholesterol levels and possibly reduce liver fat. Long-term benefits are not yet shown, maybe caused by T2DM heterogeneity, as insulin resistance and fatty liver disease - the glycometabolic points of action of soluble cereal fiber - are not present in every patient. Thus, only some patients might be susceptive to fiber. Also, incretin action in response to fiber could be a relevant factor for variable effects. Thus, this review aims to summarize the current knowledge from human studies on the impact of soluble cereal fiber on glycometabolic gastrointestinal hormones. Effects on GLP-1 appear to be highly contradictory, while these fibers might lower GIP and ghrelin, and increase PYY and CCK. Even though previous results of specific trials support a glycometabolic benefit of soluble fiber, larger acute, and long-term mechanistic studies are needed in order to corroborate the results.
MeSH term(s)	Dietary Fiber ; Humans ; Edible Grain/chemistry ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/prevention & control ; Gastrointestinal Hormones/metabolism ; Insulin Resistance ; Glucagon-Like Peptide 1/metabolism ; beta-Glucans/pharmacology ; Fermentation ; Whole Grains/chemistry
Chemical Substances	Dietary Fiber ; Gastrointestinal Hormones ; Glucagon-Like Peptide 1 (89750-14-1) ; beta-Glucans
Language	English
Publishing date	2022-11-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2141190
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Changes in 24-h energy expenditure, substrate oxidation, and body composition following resistance exercise and a high protein diet via whey protein supplementation in healthy older men.

Griffen, Corbin / Renshaw, Derek / Duncan, Michael / Weickert, Martin O / Hattersley, John

Physiological reports

2023 Volume 10, Issue 11, Page(s) e15268

Abstract: Purpose: To investigate changes in 24-h energy expenditure (EE), substrate oxidation, and body composition following resistance exercise (RE) and a high protein diet via whey protein supplementation (alone and combined) in healthy older men.: Methods!# ...

Abstract	Purpose: To investigate changes in 24-h energy expenditure (EE), substrate oxidation, and body composition following resistance exercise (RE) and a high protein diet via whey protein supplementation (alone and combined) in healthy older men. Methods: In a pooled groups analysis, 33 healthy older men [(mean ± SE) age: 67 ± 1 years; BMI: 25.4 ± 0.4 kg/m Results: Resistance exercise resulted in greater increases in fat-free mass (1.0 ± 0.3 kg), resting metabolic rate [(RMR) 36 ± 14 kcal/d], sedentary EE (60 ± 33 kcal/d), and sleeping metabolic rate [(SMR) 45 ± 7 kcal/d] compared to non-exercise (p < 0.05); however, RE decreased activity energy expenditure in free-living (-90 ± 25 kcal/d; p = 0.049) and non-exercise activity inside the respiration chamber (-1.9 ± 1.1%; p = 0.049). PRO decreased fat mass [(FM) -0.5 ± 0.3 kg], increased overnight protein oxidation (30 ± 6 g/d), and decreased 24-h protein balance (-20 ± 4 g/d) greater than CON (p < 0.05). RE+PRO decreased FM (-1.0 ± 0.5 kg) greater than RE+CON (p = 0.04). Conclusion: Resistance exercise significantly increased RMR, SMR, and sedentary EE in healthy older men, but not total EE. PRO alone and combined with RE decreased FM and aided body weight maintenance. This study was registered at clinicaltrials.gov as NCT03299972.
MeSH term(s)	Male ; Humans ; Aged ; Whey Proteins ; Resistance Training ; Energy Metabolism ; Body Composition ; Diet, High-Protein ; Dietary Supplements
Chemical Substances	Whey Proteins
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15268
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Obesity: novel and unusual predisposing factors.

Hanson, Petra / Weickert, Martin O / Barber, Thomas M

Therapeutic advances in endocrinology and metabolism

2020 Volume 11, Page(s) 2042018820922018

Abstract: To tackle the complexity of the global obesity epidemic, it is important to consider the many predisposing factors that underlie progressive and sustained weight gain. Some of the biological drivers for weight gain following initial weight loss include ... ...

Abstract	To tackle the complexity of the global obesity epidemic, it is important to consider the many predisposing factors that underlie progressive and sustained weight gain. Some of the biological drivers for weight gain following initial weight loss include persistent changes in appetite hormones [including ghrelin and postprandial plasma peptide YY (PYY)], and 'persistent metabolic adaptation'. However, many factors within our busy, stressful modern-day environment seem to conspire towards promotion of weight gain. These include the effects of sleep deprivation on appetite regulation, and the effects of modern-day technology on 'attention competition'. These factors, combined with cultural and societal factors can result in a 'mindless' attitude regarding eating-related behaviour that is likely to predispose to weight gain. In addition to the external environment, our internal environment within the gut has also changed radically within the last few decades, resulting from changes in fibre intake, and increased ingestion of highly refined, sterilised and processed foods. Although contentious, these dietary changes have implications for our gut microbiota, and possible downstream effects on control of appetite and metabolism. In this brief review, we consider some of the novel predisposing factors for weight gain within our modern-day 21st century environments (both external and internal), and explore how legal terminology can help to conceptualise the numerous factors that contribute towards weight gain, and, ultimately the global obesity epidemic.
Language	English
Publishing date	2020-05-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2554822-0
ISSN	2042-0196 ; 2042-0188
ISSN (online)	2042-0196
ISSN	2042-0188
DOI	10.1177/2042018820922018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction.

Barber, Thomas M / Kyrou, Ioannis / Randeva, Harpal S / Weickert, Martin O

International journal of molecular sciences

2021 Volume 22, Issue 2

Abstract: Obesity mediates most of its direct medical sequelae through the development of insulin resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways that are the phosphatidylinositol 3-kinase (PI3-K) and the mitogen- ... ...

Abstract	Obesity mediates most of its direct medical sequelae through the development of insulin resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways that are the phosphatidylinositol 3-kinase (PI3-K) and the mitogen-activated protein kinase (MAP-K) pathways. Obesity-related IR implicates the PI3-K pathway that confers the metabolic effects of insulin. Numerous and complex pathogenic pathways link obesity with the development of IR, including chronic inflammation, mitochondrial dysfunction (with the associated production of reactive oxygen species and endoplasmic reticulum stress), gut microbiota dysbiosis and adipose extracellular matrix remodelling. IR itself plays a key role in the development of metabolic dysfunction, including hypertension, dyslipidaemia and dysglycaemia. Furthermore, IR promotes weight gain related to secondary hyperinsulinaemia, with a resulting vicious cycle of worsening IR and its metabolic sequelae. Ultimately, IR underlies obesity-related conditions such as type 2 diabetes mellitus (T2D) and polycystic ovary syndrome (PCOS). IR also underlies many obesity-related malignancies, through the effects of compensatory hyperinsulinaemia on the relatively intact MAP-K insulin pathway, which controls cellular growth processes and mitoses. Furthermore, the emergent data over recent decades support an important role of obesity- and T2D-related central IR in the development of cognitive dysfunction, including effects on hippocampal synaptic plasticity. Importantly, IR is largely reversible through the optimisation of lifestyle factors that include regular engagement in physical activity with the avoidance of sedentariness, improved diet including increased fibre intake and sleep sufficiency. IR lies at the key crossroad between obesity and both metabolic and cognitive dysfunction. Given the importance of IR in the pathogenesis of many 21st century chronic diseases and its eminent reversibility, it is important that we all embrace and facilitate optimised lifestyles to improve the future health and wellbeing of the populace.
MeSH term(s)	Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Humans ; Insulin/metabolism ; Insulin Resistance/genetics ; MAP Kinase Signaling System/genetics ; Mitogen-Activated Protein Kinases/genetics ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Phosphatidylinositol 3-Kinase/genetics
Chemical Substances	Insulin ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2021-01-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22020546
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