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  1. Article ; Online: MR imaging after patellar MACI and MPFL reconstruction: a comparison of isolated versus combined procedures.

    Baumann-Jungmann, Pia M / Giesler, Paula / Schneider, Julia / Jung, Matthias / Karampinos, Dimitrios C / Weidlich, Dominik / Gersing, Alexandra S / Baumann, Frederic A / Imhoff, Andreas B / Woertler, Klaus / Bamberg, Fabian / Holwein, Christian

    Skeletal radiology

    2024  Volume 53, Issue 7, Page(s) 1319–1332

    Abstract: Objective: To qualitatively and quantitatively evaluate the 2.5-year MRI outcome after Matrix-associated autologous chondrocyte implantation (MACI) at the patella, reconstruction of the medial patellofemoral ligament (MPFL), and combined procedures.: ... ...

    Abstract Objective: To qualitatively and quantitatively evaluate the 2.5-year MRI outcome after Matrix-associated autologous chondrocyte implantation (MACI) at the patella, reconstruction of the medial patellofemoral ligament (MPFL), and combined procedures.
    Methods: In 66 consecutive patients (age 22.8 ± 6.4years) with MACI at the patella (n = 16), MPFL reconstruction (MPFL; n = 31), or combined procedures (n = 19) 3T MRI was performed 2.5 years after surgery. For morphological MRI evaluation WORMS and MOCART scores were obtained. In addition quantitative cartilage T2 and T1rho relaxation times were acquired. Several clinical scores were obtained. Statistical analyses included descriptive statistics, Mann-Whitney-U-tests and Pearson correlations.
    Results: WORMS scores at follow-up (FU) were significantly worse after combined procedures (8.7 ± 4.9) than after isolated MACI (4.3 ± 3.6, P = 0.005) and after isolated MPFL reconstruction (5.3 ± 5.7, P = 0.004). Bone marrow edema at the patella in the combined group was the only (non-significantly) worsening WORMS parameter from pre- to postoperatively. MOCART scores were significantly worse in the combined group than in the isolated MACI group (57 ± 3 vs 88 ± 9, P < 0.001). Perfect defect filling was achieved in 26% and 69% of cases in the combined and MACI group, respectively (P = 0.031). Global and patellar T2 values were higher in the combined group (Global T2: 34.0 ± 2.8ms) and MACI group (35.5 ± 3.1ms) as compared to the MPFL group (31.1 ± 3.2ms, P < 0.05). T2 values correlated significantly with clinical scores (P < 0.005). Clinical Cincinnati scores were significantly worse in the combined group (P < 0.05).
    Conclusion: After combined surgery with patellar MACI and MPFL reconstruction inferior MRI outcomes were observed than after isolated procedures. Therefore, patients with need for combined surgery may be at particular risk for osteoarthritis.
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Male ; Female ; Treatment Outcome ; Patella/diagnostic imaging ; Patella/surgery ; Adult ; Chondrocytes/transplantation ; Transplantation, Autologous ; Young Adult ; Patellofemoral Joint/diagnostic imaging ; Patellofemoral Joint/surgery ; Plastic Surgery Procedures/methods ; Ligaments, Articular/diagnostic imaging ; Ligaments, Articular/surgery ; Adolescent
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Journal Article ; Comparative Study
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-024-04582-x
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    Zs.A 1304: Show issues Location:
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  2. Book ; Online ; Thesis: Diffusion-Weighted Magnetic Resonance Techniques for Probing the Microstructure of Fat-Containing Tissues

    Weidlich, Dominik Johannes [Verfasser] / Karampinos, Dimitrios [Akademischer Betreuer] / Menze, Björn [Gutachter] / Karampinos, Dimitrios [Gutachter] / Laun, Frederik B. [Gutachter]

    2022  

    Author's details Dominik Johannes Weidlich ; Gutachter: Björn Menze, Dimitrios Karampinos, Frederik B. Laun ; Betreuer: Dimitrios Karampinos
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  3. Article ; Online: Headache frequency and neck pain are associated with trapezius muscle T2 in tension-type headache among young adults.

    Sollmann, Nico / Schandelmaier, Paul / Weidlich, Dominik / Stelter, Jonathan / Joseph, Gabby B / Börner, Corinna / Schramm, Severin / Beer, Meinrad / Zimmer, Claus / Landgraf, Mirjam N / Heinen, Florian / Karampinos, Dimitrios C / Baum, Thomas / Bonfert, Michaela V

    The journal of headache and pain

    2023  Volume 24, Issue 1, Page(s) 84

    Abstract: Background: Tension-type headache (TTH) is the most prevalent primary headache disorder. Neck pain is commonly associated with primary headaches and the trigemino-cervical complex (TCC) refers to the convergence of trigeminal and cervical afferents onto ...

    Abstract Background: Tension-type headache (TTH) is the most prevalent primary headache disorder. Neck pain is commonly associated with primary headaches and the trigemino-cervical complex (TCC) refers to the convergence of trigeminal and cervical afferents onto neurons of the brainstem, thus conceptualizes the emergence of headache in relation to neck pain. However, no objective biomarkers exist for the myofascial involvement in primary headaches. This study aimed to investigate the involvement of the trapezius muscles in primary headache disorders by quantitative magnetic resonance imaging (MRI), and to explore associations between muscle T2 values and headache frequency and neck pain.
    Methods: This cohort study prospectively enrolled fifty participants (41 females, age range 20-31 years): 16 subjects with TTH only (TTH-), 12 with mixed-type TTH plus migraine (TTH+), and 22 healthy controls (HC). The participants completed fat-suppressed T2-prepared three-dimensional turbo spin-echo MRI, a headache diary (over 30 days prior to MRI), manual palpation (two weeks before MRI), and evaluation of neck pain (on the day of MRI). The bilateral trapezius muscles were manually segmented, followed by muscle T2 extraction. Associations between muscle T2 and the presence of neck pain as well as the number of days with headache (considering the 30 days prior to imaging using the headache calendar) were analyzed using regression models (adjusting for age, sex, and body mass index).
    Results: The TTH+ group demonstrated the highest muscle T2 values (right side: 31.4 ± 1.2 ms, left side: 31.4 ± 0.8 ms) as compared to the TTH- group or HC group (p < 0.001). Muscle T2 was significantly associated with the number of headache days (β-coefficient: 2.04, p = 0.04) and the presence of neck pain (odds ratio: 2.26, p = 0.04). With muscle T2 as the predictor, the area under the curve for differentiating between HC and the TTH+ group was 0.82.
    Conclusions: Increased T2 of trapezius muscles may represent an objective imaging biomarker for myofascial involvement in primary headache disorders, which could help to improve patient phenotyping and therapy evaluation. Pathophysiologically, the increased muscle T2 values could be interpreted as a surrogate of neurogenic inflammation and peripheral sensitization within myofascial tissues.
    MeSH term(s) Female ; Young Adult ; Humans ; Adult ; Tension-Type Headache/diagnostic imaging ; Neck Pain/diagnostic imaging ; Cohort Studies ; Superficial Back Muscles/diagnostic imaging ; Headache
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036768-5
    ISSN 1129-2377 ; 1129-2369
    ISSN (online) 1129-2377
    ISSN 1129-2369
    DOI 10.1186/s10194-023-01626-w
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    Zs.A 5464: Show issues Location:
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  4. Article ; Online: Magnetic resonance imaging as a diagnostic tool for periodontal disease: A prospective study with correlation to standard clinical findings-Is there added value?

    Probst, Monika / Burian, Egon / Robl, Teresa / Weidlich, Dominik / Karampinos, Dimitrios / Brunner, Teresa / Zimmer, Claus / Probst, Florian Andreas / Folwaczny, Matthias

    Journal of clinical periodontology

    2021  Volume 48, Issue 7, Page(s) 929–948

    Abstract: Aim: To evaluate the correlation between standard clinical findings, radiographic (OPT) and magnetic resonance imaging (MRI) as well as to assess whether MRI is capable of providing additional information related to the severity and extent of ... ...

    Abstract Aim: To evaluate the correlation between standard clinical findings, radiographic (OPT) and magnetic resonance imaging (MRI) as well as to assess whether MRI is capable of providing additional information related to the severity and extent of periodontal disease.
    Methods: 42 patients with generalized periodontitis received pre-interventional MRI scans. These were compared to MR images of a periodontal healthy control group (n = 34). The extent of the osseous oedema, detected by MRI, was set in correlation with clinical periodontitis-associated findings.
    Results: A highly significant correlation between bone oedema and clinical testings such as probing depth (p < 0.0001) and bleeding on probing (p < 0.0001) was revealed. The oedema exceeded the extent of demineralized bone. Patients with a positive BOP test showed a 2.51-fold increase in risk of already having a bone oedema around the respective tooth even if probing depth was ≤3 mm (logistic binary regression analysis, OR 2.51; 95% CI: 1.54-4.11; p < 0.0001).
    Conclusion: MRI findings correlated with standard clinical findings, and MRI was able to depict intraosseous changes before any osseous defect had occurred.
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Periodontal Diseases ; Periodontitis/diagnostic imaging ; Prospective Studies
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188647-2
    ISSN 1600-051X ; 0303-6979
    ISSN (online) 1600-051X
    ISSN 0303-6979
    DOI 10.1111/jcpe.13458
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    Zs.A 1003: Show issues Location:
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  5. Article ; Online: A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function.

    Honecker, Julius / Weidlich, Dominik / Heisz, Simone / Lindgren, Cecilia M / Karampinos, Dimitrios C / Claussnitzer, Melina / Hauner, Hans

    International journal of obesity (2005)

    2021  Volume 45, Issue 9, Page(s) 2108–2117

    Abstract: Objective: Cell diameter, area, and volume are established quantitative measures of adipocyte size. However, these different adipocyte sizing parameters have not yet been directly compared regarding their distributions. Therefore, the study aimed to ... ...

    Abstract Objective: Cell diameter, area, and volume are established quantitative measures of adipocyte size. However, these different adipocyte sizing parameters have not yet been directly compared regarding their distributions. Therefore, the study aimed to investigate how these adipocyte size measures differ in their distribution and assessed their correlation with anthropometry and laboratory chemistry. In addition, we were interested to investigate the relationship between fat cell size and adipocyte mitochondrial respiratory chain capacity.
    Methods: Subcutaneous and visceral histology-based adipocyte size estimates from 188 individuals were analyzed by applying a panel of parameters to describe the underlying cell population. Histology-based adipocyte diameter distributions were compared with adipocyte diameter distributions from collagenase digestion. Associations of mean adipocyte size with body mass index (BMI), glucose, HbA
    Results: All adipocyte area estimates derived from adipose tissue histology were not normally distributed, but rather characterized by positive skewness. The shape of the size distribution depends on the adipocyte sizing parameter and on the method used to determine adipocyte size. Despite different distribution shapes histology-derived adipocyte area, diameter, volume, and surface area consistently showed positive correlations with BMI. Furthermore, associations between adipocyte sizing parameters and glucose, HbA
    Conclusions: Despite different underlying size distributions, the correlation with obesity-related traits was consistent across adipocyte sizing parameters. Decreased mitochondrial respiratory capacity with increasing subcutaneous adipocyte diameter could display a novel link between adipocyte hypertrophy and adipose tissue function.
    MeSH term(s) Adipocytes/classification ; Adipocytes/physiology ; Adipose Tissue/metabolism ; Adult ; Body Mass Index ; Female ; Humans ; Male ; Middle Aged ; Mitochondria/physiology ; Obesity/physiopathology ; Weights and Measures/instrumentation ; Weights and Measures/standards
    Language English
    Publishing date 2021-06-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-021-00883-6
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    Zs.A 1325: Show issues Location:
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  6. Article ; Online: Reduction of vibration-induced signal loss by matching mechanical vibrational states: Application in high b-value diffusion-weighted MRS.

    Weidlich, Dominik / Zamskiy, Mark / Maeder, Marcus / Ruschke, Stefan / Marburg, Steffen / Karampinos, Dimitrios C

    Magnetic resonance in medicine

    2019  Volume 84, Issue 1, Page(s) 39–51

    Abstract: Purpose: Diffusion encoding gradients are known to yield vibrations of the typical clinical MR scanner hardware with a frequency of 20 to 30 Hz, which may lead to signal loss in diffusion-weighted MR measurements. This work proposes to mitigate ... ...

    Abstract Purpose: Diffusion encoding gradients are known to yield vibrations of the typical clinical MR scanner hardware with a frequency of 20 to 30 Hz, which may lead to signal loss in diffusion-weighted MR measurements. This work proposes to mitigate vibration-induced signal loss by introducing a vibration-matching gradient (VMG) to match vibrational states during the 2 diffusion gradient pulses.
    Theory and methods: A theoretical description of displacements induced by gradient switching was introduced and modeled by a 2-mass-spring-damper system. An additional preceding VMG mimicking timing and properties of the diffusion encoding gradients was added to a high b-value diffusion-weighted MR spectroscopy sequence. Laser interferometry was employed to measure 3D displacements of a phantom surface. Lipid ADC was assessed in water-fat phantoms and in vivo in the tibial bone marrow of 3 volunteers.
    Results: The modeling and the laser interferometer measurements revealed that the displacement curves are more similar during the 2 diffusion gradients with the VMG compared to the standard sequence, resulting in less signal loss of the diffusion-weighted signal. Phantom results showed lipid ADC overestimation up to 119% with the standard sequence and an error of 5.5% with the VMG. An 18% to 35% lower coefficient of variation was obtained for in vivo lipid ADC measurement when employing the VMG.
    Conclusion: The application of the VMG reduces the signal loss introduced by hardware vibrations in a high b-value diffusion-weighted MRS sequence in phantoms and in vivo. Reference measurements based on laser interferometry and mechanical modelling confirmed the findings.
    MeSH term(s) Diffusion ; Diffusion Magnetic Resonance Imaging ; Humans ; Magnetic Resonance Spectroscopy ; Phantoms, Imaging ; Vibration
    Language English
    Publishing date 2019-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.28128
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    Zs.A 1959: Show issues Location:
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  7. Article ; Online: Beyond mean value analysis - a voxel-based analysis of the quantitative MR biomarker water T<sub>2</sub> in the presence of fatty infiltration in skeletal muscle tissue of patients with neuromuscular diseases.

    Schlaeger, Sarah / Weidlich, Dominik / Zoffl, Agnes / Becherucci, Edoardo Aitala / Kottmaier, Elisabeth / Montagnese, Federica / Deschauer, Marcus / Schoser, Benedikt / Zimmer, Claus / Baum, Thomas / Karampinos, Dimitrios C / Kirschke, Jan S

    NMR in biomedicine

    2022  Volume 35, Issue 12, Page(s) e4805

    Abstract: The main pathologies in the muscles of patients with neuromuscular diseases (NMD) are fatty infiltration and edema. Recently, quantitative magnetic resonance (MR) imaging for determination of the MR biomarkers proton density fat fraction (PDFF) and water ...

    Abstract The main pathologies in the muscles of patients with neuromuscular diseases (NMD) are fatty infiltration and edema. Recently, quantitative magnetic resonance (MR) imaging for determination of the MR biomarkers proton density fat fraction (PDFF) and water T<sub>2</sub> (T<sub>2w</sub> ) has been advanced. Biophysical effects or pathology can have different effects on MR biomarkers. Thus, for heterogeneously affected muscles, the routinely performed mean or median value analyses of MR biomarkers are questionable. Our work presents a voxel-based histogram analysis of PDFF and T<sub>2w</sub> images to point out potential quantification errors. In 12 patients with NMD, chemical-shift encoding-based water-fat imaging for PDFF and T<sub>2</sub> mapping with spectral adiabatic inversion recovery (SPAIR) for T<sub>2w</sub> determination was performed. Segmentation of nine thigh muscles was performed bilaterally (n = 216). PDFF and T<sub>2</sub> maps were coregistered. A voxel-based comparison of PDFF and T<sub>2w</sub> showed a decreased T<sub>2w</sub> with increasing PDFF. Mean T<sub>2w</sub> and mean T<sub>2w</sub> <sup>without fatty voxels</sup> (PDFF < 10%) show good agreement, whereas standard deviation (σ) T<sub>2w</sub> and σ T<sub>2w</sub> <sup>without fatty voxels</sup> show increasing difference with increasing values of σ. Thereby two subgroups can be observed, referring to muscles in which the exclusion of fatty voxels has a negligible influence versus muscles in which a strong dependency of the T<sub>2w</sub> value distribution on the exclusion of fatty voxels is present. Because of the two opposite effects that influence T<sub>2w</sub> in a voxel, namely, (i) a pathophysiologically increased water mobility leading to T<sub>2w</sub> elevation, and (ii) a dependency of T<sub>2w</sub> on the PDFF leading to decreased T<sub>2w</sub> , the T<sub>2w</sub> distribution within a muscle might be heterogenous and the routine mean or median analysis can lead to a misinterpretation of the muscle health. It was concluded that muscle T<sub>2w</sub> mean values can wrongly suggest healthy muscle tissue. A deeper analysis of the underlying value distribution is necessary. Therefore, a quantitative analysis of T<sub>2w</sub> histograms is a potential alternative.
    MeSH term(s) Humans ; Water ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; Magnetic Resonance Imaging/methods ; Neuromuscular Diseases/diagnostic imaging ; Neuromuscular Diseases/pathology ; Adipose Tissue/diagnostic imaging ; Adipose Tissue/pathology ; Protons ; Biomarkers
    Chemical Substances Water (059QF0KO0R) ; Protons ; Biomarkers
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4805
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    Zs.A 2869: Show issues Location:
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  8. Article ; Online: Investigation of the Relationship between MR-Based Supraclavicular Fat Fraction and Thyroid Hormones.

    Junker, Daniela / Syväri, Jan / Weidlich, Dominik / Holzapfel, Christina / Drabsch, Theresa / Waschulzik, Birgit / Rummeny, Ernst J / Hauner, Hans / Karampinos, Dimitrios C

    Obesity facts

    2020  Volume 13, Issue 3, Page(s) 331–343

    Abstract: Purpose: Brown adipose tissue (BAT) plays a potential role in energy and glucose metabolism in humans. Thyroid hormones (TH) are main regulators of BAT development and function. However, it remains unknown how the magnetic resonance (MR)-based proton ... ...

    Abstract Purpose: Brown adipose tissue (BAT) plays a potential role in energy and glucose metabolism in humans. Thyroid hormones (TH) are main regulators of BAT development and function. However, it remains unknown how the magnetic resonance (MR)-based proton density fat fraction (PDFF) of supraclavicular adipose tissue used as a surrogate marker for BAT presence relates to TH. Therefore, the purpose of this analysis was to investigate the relationship between supraclavicular PDFF and serum levels of TH.
    Methods: In total, 96 adult volunteers from a large cross-sectional study who underwent additional MR examination of the neck and pelvis were included in this analysis. Segmented PDFF maps of the supraclavicular and gluteal subcutaneous adipose tissue were generated. Delta PDFF was calculated as the difference between gluteal and supraclavicular PDFF and grouped as high (≥12%) or low (<12%) based on the median and the clinical rationale of a high versus low probability of BAT being present. Thyroid-stimulating hormone (mIU/L), free triiodothyronine (FT3, pg/mL) and free thyroxine (FT4, ng/dL) levels were determined in blood samples. Body mass index (BMI) was calculated as weight (kg)/height (m)2. Statistical analyses included the use of paired samples ttest, simple linear regression analysis and a multivariable linear regression analysis.
    Results: The median age of the subjects (77% female) was 33 years, BMI ranged from 17.2 to 43.1 kg/m2. Supraclavicular and gluteal PDFF differed significantly (76.5 ± 4.8 vs. 89.4 ± 3.5 %, p < 0.01). Supraclavicular PDFF was associated with FT3 in subjects with high delta PDFF (R2 = 0.17, p < 0.01), with higher FT3 being associated with lower supraclavicular PDFF (y = 85.2 + -3.6 x). In a multivariable linear regression analysis considering further potential prognostic factors, the interaction between the delta PDFF group and FT3 remained a predictor for supraclavicular PDFF (B = -4.65, p < 0.01).
    Discussion/conclusions: Supraclavicular PDFF corresponds to the presence of BAT. In the present analysis, supraclavicular PDFF is correlated with FT3 in subjects with high delta PDFF. Therefore, the present findings suggest that biologically active T3 may be involved in the development of supraclavicular BAT.
    MeSH term(s) Adipose Tissue, Brown/metabolism ; Adult ; Body Mass Index ; Cross-Sectional Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Thyroid Hormones/metabolism ; Thyrotropin/metabolism
    Chemical Substances Thyroid Hormones ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2020-06-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2417831-7
    ISSN 1662-4033 ; 1662-4025
    ISSN (online) 1662-4033
    ISSN 1662-4025
    DOI 10.1159/000507294
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  9. Article ; Online: Magnetic resonance neurography of the lumbosacral plexus at 3 Tesla - CSF-suppressed imaging with submillimeter resolution by a three-dimensional turbo spin echo sequence.

    Sollmann, Nico / Cervantes, Barbara / Klupp, Elisabeth / Weidlich, Dominik / Makowski, Marcus R / Kirschke, Jan S / Hu, Houchun H / Karampinos, Dimitrios C

    Magnetic resonance imaging

    2020  Volume 71, Page(s) 132–139

    Abstract: Purpose: To investigate magnetic resonance neurography (MRN) of the lumbosacral plexus (LSP) with cerebrospinal fluid (CSF) suppression by using submillimeter resolution for three-dimensional (3D) turbo spin echo (TSE) imaging.: Materials and methods!# ...

    Abstract Purpose: To investigate magnetic resonance neurography (MRN) of the lumbosacral plexus (LSP) with cerebrospinal fluid (CSF) suppression by using submillimeter resolution for three-dimensional (3D) turbo spin echo (TSE) imaging.
    Materials and methods: Using extended phase graph (EPG) analysis, the signal response of CSF was simulated considering dephasing from coherent motion for frequency-encoding voxel sizes ranging from 0.3 to 1.3 mm and for CSF velocities ranging from 0 to 4 cm/s. In-vivo MRN included 3D TSE data with frequency encoding parallel to the feet/head axis from 15 healthy adults (mean age: 28.5 ± 3.8 years, 5 females; acquisition voxel size: 2 × 2 × 2 mm
    Results: According to simulations, the CSF signal is reduced along the echo train for moving spins. Specifically, it can be reduced by over 90% compared to the maximum simulated signal for flow velocities above 2 cm/s, and could be most effectively suppressed by considering a frequency-encoding voxel size of 0.8 mm or less. For in-vivo measurements, mean CSFNR was 1.52 ± 0.22 for adults and 0.10 ± 0.03 for pediatric patients (p < .0001). Differences in CSFNR were significant between measurements using a voxel size of 2 × 2 × 2 mm
    Conclusions: Applying frequency-encoding voxel sizes in submillimeter range for 3D TSE imaging with frequency encoding parallel to the feet/head axis may considerably improve MRN of LSP pathology in adults in the future because of favorable CSF suppression.
    MeSH term(s) Adult ; Child ; Child, Preschool ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Lumbosacral Plexus/diagnostic imaging ; Lumbosacral Plexus/physiopathology ; Magnetic Resonance Imaging ; Male ; Movement ; Young Adult
    Language English
    Publishing date 2020-06-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2020.06.009
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  10. Article ; Online: Magnetic Resonance Imaging of Adipose Tissue in Metabolic Dysfunction.

    Franz, Daniela / Syväri, Jan / Weidlich, Dominik / Baum, Thomas / Rummeny, Ernst J / Karampinos, Dimitrios C

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2018  Volume 190, Issue 12, Page(s) 1121–1130

    Abstract: Background:  Adipose tissue has become an increasingly important tissue target in medicine. It plays a central role in the storage and release of energy throughout the human body and has recently gained interest for its endocrinologic function. Magnetic ...

    Title translation MR-Bildgebung von Fettgewebe bei Stoffwechselstörungen.
    Abstract Background:  Adipose tissue has become an increasingly important tissue target in medicine. It plays a central role in the storage and release of energy throughout the human body and has recently gained interest for its endocrinologic function. Magnetic resonance imaging (MRI) is an established method for quantitative direct evaluation of adipose tissue distribution, and is used increasingly as the modality of choice for metabolic phenotyping. The purpose of this review was the identification and presentation of the currently available literature on MRI of adipose tissue in metabolic dysfunction.
    Method:  A PubMed (http://www.ncbi.nlm.nih.gov/pubmed) keyword search up to August 2017 without starting date limitation was performed and reference lists of relevant articles were searched.
    Results and conclusion:  MRI provides excellent tools for the evaluation of adipose tissue distribution and further characterization of the tissue. Standard as well as newly developed MRI techniques allow a risk stratification for the development of metabolic dysfunction and enable monitoring without the use of ionizing radiation or contrast material.
    Key points:   · Different types of adipose tissue play a crucial role in various types of metabolic dysfunction.. · Magnetic resonance imaging (MRI) is an excellent tool for noninvasive adipose tissue evaluation with respect to distribution, composition and metabolic activity.. · Both standard and newly developed MRI techniques can be used for risk stratification for the development of metabolic dysfunction and allow monitoring without the use of ionizing radiation or contrast material..
    Citation format: · Franz D, Syväri J, Weidlich D et al. Magnetic Resonance Imaging of Adipose Tissue in Metabolic Dysfunction. Fortschr Röntgenstr 2018; 190: 1121 - 1130.
    MeSH term(s) Adipose Tissue, Brown/diagnostic imaging ; Adipose Tissue, Brown/physiopathology ; Adipose Tissue, White/diagnostic imaging ; Adipose Tissue, White/physiopathology ; Anorexia Nervosa/diagnostic imaging ; Anorexia Nervosa/physiopathology ; Body Composition/physiology ; Body Fat Distribution/methods ; Cachexia/diagnostic imaging ; Cachexia/physiopathology ; Diabetes Mellitus/diagnostic imaging ; Diabetes Mellitus/physiopathology ; Energy Metabolism/physiology ; Humans ; Magnetic Resonance Imaging/methods ; Metabolic Diseases/diagnostic imaging ; Metabolic Diseases/physiopathology ; Metabolic Syndrome/diagnostic imaging ; Metabolic Syndrome/physiopathology ; Obesity/diagnostic imaging ; Obesity/physiopathology ; Risk Factors
    Language English
    Publishing date 2018-06-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/a-0612-8006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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