Article: Klotho and lean mass as novel cardiovascular risk factors in hemodialysis patients.
2023 Volume 16, Issue 12, Page(s) 2587–2596
Abstract: Background: Patients with chronic kidney disease (CKD) present a higher risk of cardiovascular (CV) morbidity and mortality compared with the general population. While there are several well-established traditional CV risk factors, few studies have ... ...
| Abstract | Background: Patients with chronic kidney disease (CKD) present a higher risk of cardiovascular (CV) morbidity and mortality compared with the general population. While there are several well-established traditional CV risk factors, few studies have addressed novel potential risk factors such as α-Klotho, asymmetric dimethylarginine (ADMA) and lean mass. Methods: This was an observational, prospective, single-center, cohort study that included prevalent hemodialysis (online hemodiafiltration) adult patients. By univariate logistic regression models, univariate and multivariate Cox proportional hazards models, and Kaplan-Meier analysis, we evaluated the association between the levels of α-Klotho, ADMA and lean mass, with the risk of peripheral vascular disease (PVD), CV events and all-cause mortality in these patients. Results: A total of 200 HD patients was included. We found that increased levels of log-α-Klotho were significantly associated with decreased odds of both PVD [odds ratio (OR) 0.521, 95% confidence interval (CI) 0.270-0.954, Conclusions: Novel long-term clinical associations were generated that support α-Klotho and lean mass as novel CV risk factors in hemodialysis patients. |
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| Language | English |
| Publishing date | 2023-09-27 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2655800-2 |
| ISSN | 2048-8513 ; 2048-8505 |
| ISSN (online) | 2048-8513 |
| ISSN | 2048-8505 |
| DOI | 10.1093/ckj/sfad166 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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