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  1. Article ; Online: From Diversity to Coordination

    PACCES, Alessio M. / WEIMER, Maria

    European Journal of Risk Regulation

    A European Approach to COVID-19

    2020  Volume 11, Issue 2, Page(s) 283–296

    Abstract: The COVID-19 pandemic is changing the face of Europe. Member States’ divergent responses to this crisis reveal a lack of unity in the face of a humanitarian catastrophe. At best, this undermines the effectiveness of health protection within the European ... ...

    Abstract The COVID-19 pandemic is changing the face of Europe. Member States’ divergent responses to this crisis reveal a lack of unity in the face of a humanitarian catastrophe. At best, this undermines the effectiveness of health protection within the European Union (EU). At worst, it risks breaking up the Union altogether. Divergent national responses to COVID-19 reflect different national preferences and political legitimacy, and thus cannot be completely avoided. In this article, we argue that these responses should be better coordinated. Without coordination, the price for diversity is high. Firstly, there are damaging spill-overs between Member States, which undermine key pillars of European integration such as the free movement of persons and of goods. Secondly, national policy-making is easily captured by local interest groups. Our proposal is that the EU indicates – not mandates – a European exit strategy from asymmetric containment policies of COVID-19. In particular, the EU should help Member States procure and validate tests for infection and immunity. The EU should also indicate ways in which testing could be used to create safe spaces to work, thereby restoring the free movement of persons and of goods. We see a great advantage in such EU guidance: it could improve mutual learning between Member States, which have faced different timings of the epidemic and learned different lessons. Although the local political economy has so far delayed learning and undermined cooperation, the EU can mitigate both effects and indicate the way for Europe to resurrect united from the ashes of COVID-19.
    Keywords Safety Research ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2600871-3
    ISSN 2190-8249 ; 1867-299X
    ISSN (online) 2190-8249
    ISSN 1867-299X
    DOI 10.1017/err.2020.36
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: From diversity to coordination: A European approach to covid-19

    Pacces, Alessio M. / Weimer, Maria

    Eur. J. Risk Regul.

    Abstract: The COVID-19 pandemic is changing the face of Europe. Member States' divergent responses to this crisis reveal a lack of unity in the face of a humanitarian catastrophe. At best, this undermines the effectiveness of health protection within the European ... ...

    Abstract The COVID-19 pandemic is changing the face of Europe. Member States' divergent responses to this crisis reveal a lack of unity in the face of a humanitarian catastrophe. At best, this undermines the effectiveness of health protection within the European Union (EU). At worst, it risks breaking up the Union altogether. Divergent national responses to COVID-19 reflect different national preferences and political legitimacy, and thus cannot be completely avoided. In this article, we argue that these responses should be better coordinated. Without coordination, the price for diversity is high. Firstly, there are damaging spill-overs between Member States, which undermine key pillars of European integration such as the free movement of persons and of goods. Secondly, national policy-making is easily captured by local interest groups. Our proposal is that the EU indicates - not mandates - a European exit strategy from asymmetric containment policies of COVID-19. In particular, the EU should help Member States procure and validate tests for infection and immunity. The EU should also indicate ways in which testing could be used to create safe spaces to work, thereby restoring the free movement of persons and of goods. We see a great advantage in such EU guidance_ it could improve mutual learning between Member States, which have faced different timings of the epidemic and learned different lessons. Although the local political economy has so far delayed learning and undermined cooperation, the EU can mitigate both effects and indicate the way for Europe to resurrect united from the ashes of COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #65392
    Database COVID19

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  3. Book ; Online: We need a European exit strategy for Covid-19 before it's too late

    Pacces, Alessio / Weimer, Maria

    2020  

    Abstract: In the Covid-19 crisis, Europe is paying a high price for diversity, write Alessio Pacces and Maria Weimer. The failure to coordinate national public health responses in the initial stage of the outbreak has undermined both the fight to save lives and ... ...

    Abstract In the Covid-19 crisis, Europe is paying a high price for diversity, write Alessio Pacces and Maria Weimer. The failure to coordinate national public health responses in the initial stage of the outbreak has undermined both the fight to save lives and core European values and principles. But the fight against Covid-19 is a marathon, not a sprint. Going forward, Europe’s survival will depend on how it handles the exit from this crisis. The Commission has published a European Roadmap for lifting Covid-19 measures – member states must follow its recommendations before it is too late.
    Keywords HJ Public Finance ; HV Social pathology. Social and public welfare. Criminology ; RA0421 Public health. Hygiene. Preventive Medicine ; JN Political institutions (Europe) ; covid19
    Language Undetermined
    Publishing date 2020-04-22
    Publisher London School of Economics and Political Science
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: From Diversity to Coordination

    Pacces, Alessio Maria / Weimer, Maria

    SSRN Electronic Journal ; ISSN 1556-5068

    A European Approach to COVID19

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3576392
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Neurosarcoidosis in Pediatric Patients: A Case Report and Review of Isolated and Systemic Neurosarcoidosis.

    Rao, Rashmi / Dimitriades, Victoria R / Weimer, Maria / Sandlin, Chelsey

    Pediatric neurology

    2016  Volume 63, Page(s) 45–52

    Abstract: Background: Neurosarcoidosis occurs in fewer than 5% of adults with systemic sarcoid. However, only 53 examples of neurosarcoidosis have been reported in the pediatric population, with nine of those cases being isolated neurosarcoidosis. We present the ... ...

    Abstract Background: Neurosarcoidosis occurs in fewer than 5% of adults with systemic sarcoid. However, only 53 examples of neurosarcoidosis have been reported in the pediatric population, with nine of those cases being isolated neurosarcoidosis. We present the tenth case of a child with an initial presentation of isolated neurosarcoidosis and a review of the literature.
    Methods: We searched the Ovid Medline database from 1946 to May 28, 2015. The Mesh terms "neurosarcoidosis," "pediatric," and "child" were exploded, and the Boolean "AND" was used to combine "neurosarcoidosis" with "pediatric" or "child." Articles that were not available in the English language were not included.
    Results: A literature search revealed 53 children with neurosarcoidosis. The most common manifestations included cranial neuropathy (21%), papilledema or optic neuritis (15%), seizures (24.5%), and hypothalamic dysfunction (17%), with the latter two being more likely in younger children. Diagnosis is made by biopsy, but imaging and laboratory tests can aid in diagnosis. Treatment includes corticosteroids or other immunosuppressants.
    Conclusions: Neurosarcoidosis in children is rare, and our patient is only the tenth child with isolated neurosarcoidosis. These patients highlight the importance of considering a noninfectious diagnosis in the setting of clinical and radiographic findings suggestive of neurosarcoidosis.
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2016.05.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Lambert-eaton myasthenic syndrome.

    Weimer, Maria B / Wong, Joaquin

    Current treatment options in neurology

    2009  Volume 11, Issue 2, Page(s) 77–84

    Abstract: Lambert Eaton myasthenic syndrome (LEMS) is a rare neuromuscular junction disease. Often, the signs and symptoms of LEMS are mistaken for myasthenia gravis and therefore the workup is misdirected. A physician must look for an occult malignancy when the ... ...

    Abstract Lambert Eaton myasthenic syndrome (LEMS) is a rare neuromuscular junction disease. Often, the signs and symptoms of LEMS are mistaken for myasthenia gravis and therefore the workup is misdirected. A physician must look for an occult malignancy when the diagnosis is made and then continue to search for a malignancy for at least 5 years after diagnosis. The diagnosis of LEMS can be confirmed with electrophysiologic studies or with serum calcium channel antibodies. In most patients with LEMS, 3,4-diaminopyridine will improve strength. In patients without malignancy, immunosuppressants do have a role in the treatment of LEMS. Patients and physicians must be aware that certain situations and drugs may exacerbate weakness.
    Language English
    Publishing date 2009-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057342-X
    ISSN 1534-3138 ; 1092-8480
    ISSN (online) 1534-3138
    ISSN 1092-8480
    DOI 10.1007/s11940-009-0010-z
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    Zs.A 5535: Show issues Location:
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  7. Article ; Online: Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.

    Jackson, Kasey L / Dayton, Robert D / Fisher-Perkins, Jeanne M / Didier, Peter J / Baker, Kate C / Weimer, Maria / Gutierrez, Amparo / Cain, Cooper D / Mathis, J Michael / Gitcho, Michael A / Bunnell, Bruce A / Klein, Ronald L

    Journal of medical primatology

    2015  Volume 44, Issue 2, Page(s) 66–75

    Abstract: Background: Most amyotrophic lateral sclerosis (ALS) research has focused on mice, but there are distinct differences in the functional neuroanatomy of the corticospinal pathway in primates vs. rodents. A non-human primate model may be more sensitive ... ...

    Abstract Background: Most amyotrophic lateral sclerosis (ALS) research has focused on mice, but there are distinct differences in the functional neuroanatomy of the corticospinal pathway in primates vs. rodents. A non-human primate model may be more sensitive and more predictive for therapeutic efficacy.
    Methods: Rhesus macaques received recombinant adeno-associated virus (AAV9) encoding either the ALS-related pathological protein TDP-43 or a green fluorescent protein (GFP) control by intravenous administration. Motor function and electromyography were assessed over a nine-month expression interval followed by post-mortem analyses.
    Results: Recombinant TDP-43 or GFP was stably expressed long term. Although the TDP-43 subjects did not manifest severe paralysis and atrophy, there were trends of a partial disease state in the TDP-43 subjects relative to the control.
    Conclusions: These data indicate that a higher gene vector dose will likely be necessary for more robust effects, yet augur that a relevant primate model is feasible.
    MeSH term(s) Administration, Intravenous ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Amyotrophic Lateral Sclerosis/physiopathology ; Amyotrophic Lateral Sclerosis/therapy ; Animals ; DNA-Binding Proteins/administration & dosage ; DNA-Binding Proteins/genetics ; Dependovirus/genetics ; Disease Models, Animal ; Electromyography ; Genetic Therapy/methods ; Genetic Vectors/genetics ; Green Fluorescent Proteins/administration & dosage ; Humans ; Macaca mulatta ; Motor Activity ; Recombinant Proteins/genetics
    Chemical Substances DNA-Binding Proteins ; Recombinant Proteins ; green fluorescent protein, Aequorea victoria ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2015-01-29
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121206-0
    ISSN 1600-0684 ; 0047-2565
    ISSN (online) 1600-0684
    ISSN 0047-2565
    DOI 10.1111/jmp.12162
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    Zs.A 819: Show issues Location:
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  8. Book ; Thesis: Untersuchungen zum Problem des einfachen und doppelten Blindversuches im kurzdauernden pharmakologischen Experiment am Menschen

    Weimer, Maria

    1965  

    Author's details Maria Weimer
    Language German
    Size 72 S, 8
    Publishing place Bonn
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Med. F., Diss. v. 27. Sept. 1965--Bonn, 27
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article: Serial electrophysiologic studies in rhesus monkeys with Krabbe disease.

    Weimer, Maria B / Gutierrez, Amparo / Baskin, Gary B / Borda, Juan T / Veazey, Ronald S / Myers, Leann / Phillippi-Falkenstein, Kathrine M / Bunnell, Bruce A / Ratterree, Marion S / England, John D

    Muscle & nerve

    2005  Volume 32, Issue 2, Page(s) 185–190

    Abstract: Krabbe disease is a progressive leukodystrophy that results in demyelination in the central and peripheral nervous systems in humans. It has been described in a number of mammalian species including the rhesus monkey. We performed serial nerve conduction ...

    Abstract Krabbe disease is a progressive leukodystrophy that results in demyelination in the central and peripheral nervous systems in humans. It has been described in a number of mammalian species including the rhesus monkey. We performed serial nerve conduction studies beginning within the first 2 months of life in four homozygous, two heterozygous, and two normal rhesus monkeys (Macaca mulatta) to characterize the peripheral neuropathy. Mean conduction velocities of the median, ulnar, and tibial nerves were significantly slower in the affected than unaffected monkeys at all ages (P < 0.0001). The conduction velocity differences became more apparent between the affected and unaffected as the monkeys aged. When compared to the unaffected monkeys, the serial conduction velocities suggested occurrence of dysmyelination followed by demyelination in the affected monkeys. These observations provide further insight into the disease process and suggest an early window of opportunity for treating Krabbe disease.
    MeSH term(s) Action Potentials/physiology ; Age Factors ; Aging/physiology ; Animals ; Demyelinating Diseases/diagnosis ; Demyelinating Diseases/etiology ; Demyelinating Diseases/physiopathology ; Electrodiagnosis ; Leukodystrophy, Globoid Cell/complications ; Leukodystrophy, Globoid Cell/physiopathology ; Macaca mulatta ; Median Nerve/physiopathology ; Nerve Fibers, Myelinated/pathology ; Neural Conduction/physiology ; Peripheral Nerves/physiopathology ; Peripheral Nervous System Diseases/diagnosis ; Peripheral Nervous System Diseases/etiology ; Peripheral Nervous System Diseases/physiopathology ; Tibial Nerve/physiopathology ; Ulnar Nerve/physiopathology
    Language English
    Publishing date 2005-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.20350
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