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  1. Book: Artemisinins in malaria therapy

    Li, Qigui / Milhous, Wilbur K. / Weina, Peter J.

    (Nova biomedical)

    2007  

    Author's details Qigui Li ; Wilbur K. Milhous and Peter J. Weina
    Series title Nova biomedical
    Keywords Antimalarials / therapeutic use ; Artemisinins / pharmacokinetics ; Artemisinins / toxicity ; Artemisinins / therapeutic use ; Malaria / drug therapy
    Language English
    Size VIII, 133 S. : Ill., graph. Darst.
    Publisher Nova Biomed. Books
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; Efficacy potency of artemisinins in vitro and in vivo -- Neurotoxicity concerning drug pharmacokinetics -- Drug pharmacokinetic role in reproductive toxicity -- Relationship between drug efficacy and pharmacokinetics -- How to maintain rapid efficacy and avoid lethal toxicities
    HBZ-ID HT016167571
    ISBN 1-600-21781-8 ; 978-1-600-21781-4
    Database Catalogue ZB MED Medicine, Health

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    2009 A 6534 order for loan Magazin

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  2. Article ; Online: Military Medicine Regulatory "Delays" … Not as Bad as Advertised.

    Weina, Peter J

    The American journal of bioethics : AJOB

    2016  Volume 16, Issue 8, Page(s) 38–39

    MeSH term(s) Humans ; Military Medicine ; Military Personnel
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2016.1187229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pre-clinical drug-drug interactions (DDIs) of gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, and venlafaxine.

    Luong, Thu-Lan T / Powers, Chelsea N / Reinhardt, Brian J / Weina, Peter J

    Current research in pharmacology and drug discovery

    2022  Volume 3, Page(s) 100112

    Abstract: Objective: To evaluate drug-drug interactions (DDIs) between gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs).: Methods: In vitro: Results: The isoenzymes that showed drug degradation are listed in parentheses ... ...

    Abstract Objective: To evaluate drug-drug interactions (DDIs) between gefitinib with/without losartan and selective serotonin reuptake inhibitors (SSRIs).
    Methods: In vitro
    Results: The isoenzymes that showed drug degradation are listed in parentheses beside the respective drug: gefitinib (CYP2D6, 3A4, 1A2, 2C9, and 2C19), losartan (CYP2C9 and 3A4), citalopram (CYP2D6, 2C19, 3A4, and 2C9), fluoxetine (CYP2D6, 2C9, and 2C19), fluvoxamine (CYP2D6, 2C9, and 2C19), paroxetine (CYP2D6, 3A4, and 2C9), sertraline (CYP2D6, 2C9, 2C19, 1A2, and 3A4), and venlafaxine (CYP2D6 and 2C19).DDIs from human hepatocytes assays revealed that gefitinib had significant metabolic changes in (1:1) combination with paroxetine or sertraline (p-value ​= ​0.042 and 0.025 respectively) and (1:1:1) combination with losartan and fluoxetine, fluvoxamine, paroxetine, or sertraline (p-value ​= ​0.009, 0.027, 0.048, and 0.037 respectively). Losartan showed significant changes in (1:1:1) combination with gefitinib and fluoxetine or sertraline (p-value ​= ​0.026 and 0.008 respectively). Fluoxetine, fluvoxamine, and paroxetine underwent significant changes in (1:1:1) combination with gefitinib and losartan (p-value ​= ​0.003, 0.022, and 0.046 respectively). Sertraline had significant changes within all combinations: DDIs with gefitinib alone and in combination with gefitinib and losartan (p-value ​= ​0.009 and 0.008 respectively). Citalopram and venlafaxine appeared to be unaffected by any combination.
    Conclusion: The study provides a clear proof-of concept for
    Language English
    Publishing date 2022-06-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2571
    ISSN (online) 2590-2571
    DOI 10.1016/j.crphar.2022.100112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Retrospective Evaluation of Drug-Drug Interactions With Erlotinib and Gefitinib Use in the Military Health System.

    Luong, Thu-Lan T / Powers, Chelsea N / Reinhardt, Brian J / McAnulty, Michael J / Weina, Peter J / Shou, Karen J / Ambar, Caban B

    Federal practitioner : for the health care professionals of the VA, DoD, and PHS

    2023  Volume 40, Issue Suppl 3, Page(s) S24–S34

    Abstract: Background: Erlotinib and gefitinib are epidermal growth factor receptor-tyrosine kinase inhibitors approved for non-small cell lung cancer treatment by the US Food and Drug Administration. Drug-drug interactions (DDIs) with these agents are vague and ... ...

    Abstract Background: Erlotinib and gefitinib are epidermal growth factor receptor-tyrosine kinase inhibitors approved for non-small cell lung cancer treatment by the US Food and Drug Administration. Drug-drug interactions (DDIs) with these agents are vague and poorly understood. Because DDIs can have an effect on clinical outcomes, we aimed to identify drugs that interact with erlotinib or gefitinib and describe their clinical manifestations.
    Methods: A retrospective analysis was performed on the health records of patients in the US Department of Defense Cancer Registry (retrieved September 2021), Comprehensive Ambulatory/Professional Encounter Records, and Pharmacy Data Transaction Service database (both retrieved May 2022). Patients' medical history, diagnoses, and demographics were extracted and analyzed for differences in adverse effects when these agents were used alone vs concomitantly with other prescription drugs. Patients' diagnoses and prescription drug use were extracted to compare completed vs discontinued treatment groups, identify medications commonly co-administered with erlotinib or gefitinib, and evaluate DDIs with antidepressants.
    Results: Of 387 patients using erlotinib, 264 completed treatments; 28 of 33 patients using gefitinib completed treatment. The
    Conclusions: This review cannot conclude that concomitant use with prescription drug(s) resulted in erlotinib or gefitinib discontinuation. There were no significant DDIs determined between erlotinib or gefitinib and antidepressants.
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ISSN 1078-4497
    ISSN 1078-4497
    DOI 10.12788/fp.0401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Letter to the editor regarding the article "The use of Psychiatric Electroencephalography Evaluations Registry (PEER) to personalize pharmacotherapy".

    Weina, Peter J / Brooks, Sanjur

    Neuropsychiatric disease and treatment

    2017  Volume 13, Page(s) 2527–2530

    Language English
    Publishing date 2017-10-04
    Publishing country New Zealand
    Document type Journal Article ; Comment
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S148087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan.

    Luong, Thu-Lan T / McAnulty, Michael J / Evers, David L / Reinhardt, Brian J / Weina, Peter J

    Current research in toxicology

    2021  Volume 2, Page(s) 217–224

    Abstract: Objective: To evaluate drug-drug interactions (DDIs) between gefitinib or erlotinib with fluoxetine, and/or losartan.: Methods: Human pooled microsomes, supersomes, and cryopreserved human hepatocytes were used to monitor DDIs : Results: Gefitinib ...

    Abstract Objective: To evaluate drug-drug interactions (DDIs) between gefitinib or erlotinib with fluoxetine, and/or losartan.
    Methods: Human pooled microsomes, supersomes, and cryopreserved human hepatocytes were used to monitor DDIs
    Results: Gefitinib is significantly metabolized by Cytochrome P450 (CYP) 2D6 and CYP3A4, with less than 80% of the drug remaining. Erlotinib is significantly metabolized by CYP3A4, CYP2D6, and CYP1A2. Although gefitinib and erlotinib were metabolized by the same CYP isoenzymes, the metabolites formed from degradation of the two drugs were different.Fluoxetine inhibited CYP2D6 and CYP3A4 metabolism of gefitinib with an IC
    Conclusion: As could be predicted by previous studies involving the inhibitory effect of fluoxetine on CYP3A4 and CYP2D6, and studies involving CYP metabolism of gefitinib and erlotinib, the tests performed here confirmed that fluoxetine has an inhibitory effect on metabolism of gefitinib or erlotinib by the main CYP isoenzymes involved. This study suggests a variable inhibitory effect of fluoxetine particularly on CYP2D6 activity towards gefitinib or erlotinib; erlotinib metabolism is less affected. Likewise, the combination of fluoxetine and losartan does not significantly affect hepatocyte metabolism of erlotinib, but does for that of gefitinib. The results presented in this study thus indicate a need for DDI assays to involve multiple drugs to properly study multidrug regimens.
    Language English
    Publishing date 2021-06-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-027X
    ISSN (online) 2666-027X
    DOI 10.1016/j.crtox.2021.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Real World Impact of Remdesivir and Dexamethasone on Clinical Outcomes of Severe Coronavirus Disease 2019 in a Community Hospital.

    Larson, Derek T / Ewers, Evan C / Gallagher, Kia M / Mahoney, Alexandra M / Paul, Madison L / Weina, Peter J

    Military medicine

    2022  

    Abstract: Background: Evidence has emerged showing potential benefit of Remdesivir and dexamethasone in severe coronavirus disease 2019 (COVID-19) but results from large randomized control trials are conflicting. While initial data for dexamethasone indicated a ... ...

    Abstract Background: Evidence has emerged showing potential benefit of Remdesivir and dexamethasone in severe coronavirus disease 2019 (COVID-19) but results from large randomized control trials are conflicting. While initial data for dexamethasone indicated a mortality benefit, the impact of Remdesivir was best demonstrated in decreased time to recovery. Despite extensive disease burden throughout the world efficacy data of individual interventions is lacking in part due to extensive concurrent use of confounding investigational therapeutics.
    Materials and methods: We performed a retrospective analysis of the impact of Remdesivir and dexamethasone on real-world outcomes in severe COVID-19. All patients admitted to our community hospital between March 2020 and December 31, 2020 were included, and all patients admitted before national guidelines endorsed Remdesivir and dexamethasone outside of clinical trials were treated with only supportive care and used as historical controls. No other investigational therapeutics were utilized. This study was reviewed and approved by the Fort Belvoir Community Hospital IRB.
    Results: 58 hospitalized patients met criteria for severe COVID-19 as confirmed by RT-PCR, and 14 (25%) were used as historical controls. Baseline demographics and overall mortality rate (7.1%) did not significantly differ between the groups. The median length of stay was 7 days and 6 days in the historical control group and interventional group, respectively (P = 0.55).
    Conclusions: We did not observe an appreciable impact on the duration of hospitalization when Remdesivir and dexamethasone were added to supportive care in a community hospital. This study was not sufficiently powered to detect the previously described mortality benefit of dexamethasone.
    Language English
    Publishing date 2022-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usac052
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  8. Article ; Online: A simple empirical algorithm to distinguish among Leishmania braziliensis, major, and tropica species by MALDI-TOF mass spectrometry.

    Evers, David L / Frye, Franz A / Weina, Peter J

    Journal of microbiological methods

    2017  Volume 148, Page(s) 46–48

    Abstract: This work developed a simple empirical algorithm to distinguish three Leishmania species using MALDI-TOF mass spectrometry. It suggests that complicated computer algorithms may not always be necessary for clinically useful microbiology applications. ...

    Abstract This work developed a simple empirical algorithm to distinguish three Leishmania species using MALDI-TOF mass spectrometry. It suggests that complicated computer algorithms may not always be necessary for clinically useful microbiology applications.
    MeSH term(s) Algorithms ; Humans ; Leishmania braziliensis/chemistry ; Leishmania braziliensis/classification ; Leishmaniasis, Cutaneous/parasitology ; Microbiological Techniques/methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
    Language English
    Publishing date 2017-12-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2017.12.009
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  9. Article: Texting away malaria: a new alternative to directly observed therapy.

    Scott, William / Weina, Peter J

    Military medicine

    2013  Volume 178, Issue 2, Page(s) e255–9

    Abstract: Objective: Operation Onward Liberty is the current U.S. military mentorship program working with the Armed Forces of Liberia, training their national army. Throughout West Africa, and Liberia in particular, malaria remains a serious health concern. This ...

    Abstract Objective: Operation Onward Liberty is the current U.S. military mentorship program working with the Armed Forces of Liberia, training their national army. Throughout West Africa, and Liberia in particular, malaria remains a serious health concern. This is a critical concern to all U.S. Forces deployed in areas endemic with malaria. In January 2011, a new protocol was instituted among Operation Onward Liberty members using short message service (SMS) technology to ensure 100% daily accountability.
    Methods: Beginning in January 2011, SMS was used to report completion of daily ingestion of malaria chemoprophylaxis by U.S. Forces in Liberia.
    Results: Since then, there were no cases of malaria identified by both Binax rapid diagnostic test and thin smear. The previous year (2010) saw 12 cases of malaria among U.S. Forces in Liberia (9 during the same 6-month period), with 3 evacuations for malaria, costing an estimated 1.5 million dollars.
    Conclusions: Although directly observed therapy is still the gold standard of malaria chemoprophylaxis, use of cellular telephone texting technology, or SMS, for communicating ingestion may be the best alternative for reasonable accountability in the deployed setting, especially considering the highly decentralized nature of this and other deployment locations.
    MeSH term(s) Antimalarials/therapeutic use ; Chemoprevention/methods ; Directly Observed Therapy/methods ; Humans ; Incidence ; Malaria/epidemiology ; Malaria/prevention & control ; Military Personnel ; Retrospective Studies ; Travel ; United States/epidemiology
    Chemical Substances Antimalarials
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.7205/MILMED-D-12-00257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care.

    Larson, Derek T / Sherner, John H / Gallagher, Kia M / Judy, Cynthia L / Paul, Madison B / Mahoney, Alexandra M / Weina, Peter J

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 74, Issue 1, Page(s) 133–135

    Abstract: Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This retrospective study of an institutional cohort including 135 patients with confirmed COVID-19 ... ...

    Abstract Calls for adherence to evidence-based medicine have emerged during the initial wave of the COVID-19 pandemic but reports of outcomes are lacking. This retrospective study of an institutional cohort including 135 patients with confirmed COVID-19 demonstrates positive outcomes when organizational standards of care consist of evidence-based supportive therapies.
    MeSH term(s) COVID-19 ; Cohort Studies ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa678
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