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  1. Article: Human muscle in gene edited pigs for treatment of volumetric muscle loss.

    Greising, Sarah M / Weiner, Joshua I / Garry, Daniel J / Sachs, David H / Garry, Mary G

    Frontiers in genetics

    2022  Volume 13, Page(s) 948496

    Abstract: Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment ... ...

    Abstract Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.
    Language English
    Publishing date 2022-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.948496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mechanisms and strategies to promote cardiac xenotransplantation.

    Garry, Daniel J / Weiner, Joshua I / Greising, Sarah M / Garry, Mary G / Sachs, David H

    Journal of molecular and cellular cardiology

    2022  Volume 172, Page(s) 109–119

    Abstract: End stage heart failure is a terminal disease, and the only curative therapy is orthotopic heart transplantation. Due to limited organ availability, alternative strategies have received intense interest for treatment of patients with advanced heart ... ...

    Abstract End stage heart failure is a terminal disease, and the only curative therapy is orthotopic heart transplantation. Due to limited organ availability, alternative strategies have received intense interest for treatment of patients with advanced heart failure. Recent studies using gene-edited porcine organs suggest that cardiac xenotransplantation may provide a future source of organs. In this review, we highlight the historical milestones for cardiac xenotransplantation and the gene editing strategies designed to overcome immunological barriers, which have culminated in a recent cardiac pig-to-human xenotransplant. We also discuss recent results of studies on the engineering of human-porcine chimeric organs that may provide an alternative and complementary strategy to overcome some of the major immunological barriers to producing a new source of transplantable organs.
    MeSH term(s) Humans ; Swine ; Animals ; Transplantation, Heterologous/adverse effects ; Transplantation, Heterologous/methods ; Heart Transplantation/methods ; Transplants ; Heart Failure/genetics ; Heart Failure/therapy ; Gene Editing
    Language English
    Publishing date 2022-08-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2022.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 426: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Cardiac Xenotransplantation: Clinical Impact of Science and Discovery.

    Garry, Daniel J / Weiner, Joshua I / Greising, Sarah M / Garry, Mary G / Sachs, David H

    Circulation

    2022  Volume 146, Issue 13, Page(s) 961–963

    MeSH term(s) Heart ; Heart Transplantation ; Humans ; Transplantation, Heterologous
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.059191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs.

    Garry, Daniel J / Weiner, Joshua I / Greising, Sarah M / Sachs, David H / Garry, Mary G

    Xenotransplantation

    2022  Volume 30, Issue 1, Page(s) e12786

    Abstract: Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and ... ...

    Abstract Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.
    MeSH term(s) Animals ; Swine ; Humans ; Transplantation, Heterologous ; Organ Transplantation ; Heart Transplantation ; Tissue Donors ; Transplants
    Language English
    Publishing date 2022-11-11
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1236298-0
    ISSN 1399-3089 ; 0908-665X
    ISSN (online) 1399-3089
    ISSN 0908-665X
    DOI 10.1111/xen.12786
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    Zs.A 4514: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Distinctive Leukocyte Subpopulations According to Organ Type in Cynomolgus Macaques.

    Zitsman, Jonah S / Alonso-Guallart, Paula / Ovanez, Christopher / Kato, Yojiro / Rosen, Joanna F / Weiner, Joshua I / Duran-Struuck, Raimon

    Comparative medicine

    2016  Volume 66, Issue 4, Page(s) 308–323

    Abstract: Cynomolgus macaques (CYNO; Macaca fascicularis) are a well-established NHP model used for studies in immunology. To provide reference values on the baseline cell distributions in the hematopoietic and lymphoid organs (HLO) of these animals, we used flow ... ...

    Abstract Cynomolgus macaques (CYNO; Macaca fascicularis) are a well-established NHP model used for studies in immunology. To provide reference values on the baseline cell distributions in the hematopoietic and lymphoid organs (HLO) of these animals, we used flow cytometry to analyze the peripheral blood, bone marrow, mesenteric lymph nodes, spleen, and thymus of a cohort of male, adult, research-naïve, Mauritian CYNO. Our findings demonstrate that several cell distribution patterns differ between CYNO and humans. First, the CD4(+):CD8(+) T-cell ratio is lower in CYNO compared with humans. Second, the peripheral blood of CYNO contains a population of CD4(+)CD8(+) T cells. Third, the CD31 level was elevated in all organs studied, suggesting that CD31 may not be an accurate marker of recent thymic emigrants within the CD4(+) T cells of CYNO. Finally the B-cell population is lower in CYNO compared with humans. In summary, although the majority of immune cell populations are similar between cynomolgus macaques and humans, several important differences should be considered when using CYNO in immunologic studies. Our current findings provide valuable information to not only researchers but also veterinarians working with CYNO at research centers, in zoos, or in the wild.
    MeSH term(s) Animals ; Antigens, CD34/metabolism ; B-Lymphocytes/cytology ; CD4-CD8 Ratio ; CD56 Antigen/metabolism ; Forkhead Transcription Factors/metabolism ; Hematopoietic System/cytology ; Hematopoietic System/immunology ; Humans ; Interleukin-2 Receptor alpha Subunit/metabolism ; Leukocyte Common Antigens/metabolism ; Leukocytes/classification ; Leukocytes/cytology ; Leukocytes/immunology ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Macaca fascicularis/anatomy & histology ; Macaca fascicularis/blood ; Macaca fascicularis/immunology ; Male ; Monocytes/cytology ; Organ Specificity ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Species Specificity ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology
    Chemical Substances Antigens, CD34 ; CD56 Antigen ; Forkhead Transcription Factors ; Interleukin-2 Receptor alpha Subunit ; Platelet Endothelial Cell Adhesion Molecule-1 ; Leukocyte Common Antigens (EC 3.1.3.48)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2006425-1
    ISSN 1532-0820 ; 0023-6764
    ISSN 1532-0820 ; 0023-6764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 601: Show issues Location:
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  6. Article ; Online: Ex vivo pancreaticoduodenectomy and liver autotransplantation for pancreatic head tumor with extensive involvement of the hepatoduodenal ligament.

    Matsuoka, Nobuhide / Weiner, Joshua I / Griesemer, Adam D / Samstein, Benjamin B / Zhao, Yejun / Emond, Jean C / Kato, Tomoaki

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2015  Volume 21, Issue 12, Page(s) 1553–1556

    MeSH term(s) Adult ; Female ; Humans ; Liver Transplantation/methods ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/methods ; Transplantation, Autologous
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.24229
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    Zs.A 4702: Show issues Location:
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  7. Article: Novel H-shunt Venovenous Bypass for Liver Transplantation in Cynomolgus Macaques.

    Kato, Yojiro / Griesemer, Adam D / Wu, Anette / Sondermeijer, Hugo P / Weiner, Joshua I / Duran-Struuck, Raimon / Martinez, Mercedes / Slate, Andrea R / Romanov, Alexander / Lefkowitch, Jay H / Sykes, Megan / Kato, Tomoaki

    Comparative medicine

    2017  Volume 67, Issue 5, Page(s) 436–441

    Abstract: Cynomolgus monkeys are often used in preclinical transplantation research. Performing liver transplantation in cynomolgus monkeys is challenging because they poorly tolerate portal vein clamping during the anhepatic phase. Finding an alternative to ... ...

    Abstract Cynomolgus monkeys are often used in preclinical transplantation research. Performing liver transplantation in cynomolgus monkeys is challenging because they poorly tolerate portal vein clamping during the anhepatic phase. Finding an alternative to portal vein clamping is necessary before preclinical liver transplant models can be performed with reliable outcomes. We used 3 different techniques to perform 5 liver transplants in male cynomolgus macaques (weight, 7.4-10.8 kg; mismatched for MHC I and II; matched for ABO). In procedure A, we clamped the portal vein briefly, as in human transplants, as well as the superior mesentery artery to minimize congestion at the expense of temporary ischemia (n = 2). In procedure B, we performed a temporary portocaval shunt with extracorporeal venovenous bypass (n = 1). For procedure C, we developed an H-shunt system (modified portocaval shunt) with extracorporeal bypass (n = 2). Postoperative immunosuppression comprised cyclosporine A, mycophenolate mofetil, and steroids. Recipients in procedure A developed hemodynamic instability and were euthanized within 2 d. The recipient that underwent procedure B was euthanized within 11 d due to inferior vena caval thrombosis. The H-shunt in procedure C led to minimal PV congestion during the anhepatic phase, and both recipients reached the 21-d survival endpoint with good graft function. Our novel H-shunt bypass system resulted in successful liver transplantation in cynomolgus macaques, with long-term posttransplant survival possible. This technical innovation makes possible the use of cynomolgus monkeys for preclinical liver transplant tolerance models.
    Language English
    Publishing date 2017-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006425-1
    ISSN 1532-0820 ; 0023-6764
    ISSN 1532-0820 ; 0023-6764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 601: Show issues Location:
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