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Article ; Online: Changes in smoking use and subsequent lung cancer risk in the ATBC study.

Gutiérrez-Torres, Daniela S / Kim, Sungduk / Albanes, Demetrius / Weinstein, Stephanie J / Inoue-Choi, Maki / Albert, Paul S / Freedman, Neal D

Journal of the National Cancer Institute

2024

Abstract: Background: Reducing cigarettes/day may lower the risk of lung cancer compared with continuing to smoke at the same intensity. Other changes in smoking behaviors, such as increasing cigarette consumption or quitting for a period and relapsing, may also ... ...

Abstract	Background: Reducing cigarettes/day may lower the risk of lung cancer compared with continuing to smoke at the same intensity. Other changes in smoking behaviors, such as increasing cigarette consumption or quitting for a period and relapsing, may also affect lung cancer risk. Methods: We examined changes in smoking status and cigarettes/day among 24,613 Finnish male smokers aged 50-69 years who participated in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Longitudinal data on smoking were collected during study follow-up visits three times a year (approximately every 4 months) between 1985 and 1993. Incident lung cancer cases through 2012 were identified by the Finnish Cancer Registry. Risk ratios (RRs) and 95% confidence intervals (95%CI) were estimated using Cox proportional hazards regression. Results: Compared with smoking 20 cigarettes/day continuously across the intervention period, reducing an average of 5 cigarettes/day per year while smoking was associated with a 20% lower risk of lung cancer (95%CI : 0.71 to 0.90). A substantially lower risk of lung cancer was also observed when participants smoked at 50% (RR = 0.72; 95%CI : 0.57-0.90) and 10% (RR = 0.55; 95%CI : 0.36-0.83) of study visits, relative to smoked at 100% of study visits. Conclusions: Smokers may lower their risk of lung cancer by reducing smoking intensity (cigarettes per day while smoking) and the time they smoke. However, quitting smoking completely is the most effective way for smokers to reduce their risk of lung cancer.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djae012
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Article ; Online: Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies.

Gan, Lu / Zhao, Bin / Inoue-Choi, Maki / Liao, Linda M / Graubard, Barry I / Weinstein, Stephanie J / Albanes, Demetrius / Huang, Jiaqi

BMC medicine

2024 Volume 22, Issue 1, Page(s) 132

Abstract: Background: The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose-response associations, and sex ... ...

Abstract	Background: The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose-response associations, and sex differences in the relationship between sodium and potassium intakes and overall and cause-specific mortality remain to be elucidated and a comprehensive examination is lacking. Our study objective was to determine whether intake of sodium and potassium and the sodium-potassium ratio are associated with overall and cause-specific mortality in men and women. Methods: We conducted a prospective analysis of 237,036 men and 179,068 women in the National Institutes of Health-AARP Diet and Health Study. Multivariable-adjusted Cox proportional hazard regression models were utilized to calculate hazard ratios. A systematic review and meta-analysis of cohort studies was also conducted. Results: During 6,009,748 person-years of follow-up, there were 77,614 deaths, 49,297 among men and 28,317 among women. Adjusting for other risk factors, we found a significant positive association between higher sodium intake (≥ 2,000 mg/d) and increased overall and CVD mortality (overall mortality, fifth versus lowest quintile, men and women HRs = 1.06 and 1.10, P Conclusions: Our study demonstrates significant positive associations between daily sodium intake (within the range of sodium intake between 2,000 and 7,500 mg/d), the sodium-potassium ratio, and risk of CVD and overall mortality, with women having stronger sodium-potassium ratio-mortality associations than men, and with the meta-analysis providing compelling support for the CVD associations. These data may suggest decreasing sodium intake and increasing potassium intake as means to improve health and longevity, and our data pointing to a sex difference in the potassium-mortality and sodium-potassium ratio-mortality relationships provide additional evidence relevant to current dietary guidelines for the general adult population. Systematic review registration: PROSPERO Identifier: CRD42022331618.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Cohort Studies ; Sodium ; Cause of Death ; Prospective Studies ; Diet ; Cardiovascular Diseases ; Risk Factors ; Sodium, Dietary/adverse effects ; Potassium
Chemical Substances	Sodium (9NEZ333N27) ; Sodium, Dietary ; Potassium (RWP5GA015D)
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-024-03350-x
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Article ; Online: Serum metabolomic profile of hair dye use.

Lim, Jung-Eun / Huang, Jiaqi / Weinstein, Stephanie J / Parisi, Dominick / Mӓnnistö, Satu / Albanes, Demetrius

Scientific reports

2023 Volume 13, Issue 1, Page(s) 3776

Abstract: The International Agency for Research on Cancer reported that some chemicals in hair dyes are probably carcinogenic to those exposed to them occupationally. Biological mechanisms through which hair dye use may be related to human metabolism and cancer ... ...

Abstract	The International Agency for Research on Cancer reported that some chemicals in hair dyes are probably carcinogenic to those exposed to them occupationally. Biological mechanisms through which hair dye use may be related to human metabolism and cancer risk are not well-established. We conducted the first serum metabolomic examination comparing hair dye users and nonusers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Metabolite assays were conducted using ultrahigh performance liquid chromatography-tandem mass spectrometry. The association between metabolite levels and hair dye use was estimated using linear regression, adjusting for age, body mass index, smoking, and multiple comparisons. Among the 1,401 detected metabolites, 11 compounds differed significantly between the two groups, including four amino acids and three xenobiotics. Redox-related glutathione metabolism was heavily represented, with L-cysteinylglycine disulfide showing the strongest association with hair dye (effect size (β) = - 0.263; FDR adjusted p-value = 0.0311), along with cysteineglutathione disulfide (β = - 0.685; FDR adjusted p-value = 0.0312). 5alpha-Androstan-3alpha,17beta-diol disulfate was reduced in hair dye users (β = - 0.492; FDR adjusted p-value = 0.077). Several compounds related to antioxidation/ROS and other pathways differed significantly between hair dye users and nonusers, including metabolites previously associated with prostate cancer. Our findings suggest possible biological mechanisms through which the use of hair dye could be associated with human metabolism and cancer risk.
MeSH term(s)	Humans ; Male ; Hair Dyes ; Metabolomics ; Amino Acids ; Carcinogenesis ; Disulfides
Chemical Substances	Hair Dyes ; Amino Acids ; Disulfides
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30590-3
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Article ; Online: Metabolomic profile of prostate cancer-specific survival among 1812 Finnish men.

Huang, Jiaqi / Zhao, Bin / Weinstein, Stephanie J / Albanes, Demetrius / Mondul, Alison M

BMC medicine

2022 Volume 20, Issue 1, Page(s) 362

Abstract: Background: Abnormal metabolism and perturbations in metabolic pathways play significant roles in the development and progression of prostate cancer; however, comprehensive metabolomic analyses of human data are lacking and needed to elucidate the ... ...

Abstract	Background: Abnormal metabolism and perturbations in metabolic pathways play significant roles in the development and progression of prostate cancer; however, comprehensive metabolomic analyses of human data are lacking and needed to elucidate the interrelationships. Methods: We examined the serum metabolome in relation to prostate cancer survival in a cohort of 1812 cases in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Using an ultrahigh-performance LC-MS/MS platform, we identified 961 known metabolites in prospectively collected serum. Median survival time from diagnosis to prostate cancer-specific death (N=472) was 6.6 years (interquartile range=2.9-11.1 years). Cox proportional hazards regression models estimated hazard ratios and 95% confidence intervals of the associations between the serum metabolites (in quartiles) and prostate cancer death, adjusted for age at baseline and diagnosis, disease stage, and Gleason sum. In order to calculate risk scores, we first randomly divided the metabolomic data into a discovery set (70%) and validated in a replication set (30%). Results: Overall, 49 metabolites were associated with prostate cancer survival after Bonferroni correction. Notably, higher levels of the phospholipid choline, amino acid glutamate, long-chain polyunsaturated fatty acid (n6) arachidonate (20:4n6), and glutamyl amino acids gamma-glutamylglutamate, gamma-glutamylglycine, and gamma-glutamylleucine were associated with increased risk of prostate cancer-specific mortality (fourth versus first quartile HRs=2.07-2.14; P-values <5.2×10 Conclusions: The metabolic traits identified in this study, including for choline, glutamate, arachidonate, gamma-glutamyl amino acids, fibrinopeptides, and endocannabinoid and redox pathways and their composite risk score, corroborate our previous analysis of fatal prostate cancer and provide novel insights and potential leads regarding the molecular basis of prostate cancer progression and mortality.
MeSH term(s)	Male ; Humans ; Chromatography, Liquid ; beta Carotene ; alpha-Tocopherol ; Endocannabinoids ; Finland/epidemiology ; Cysteine ; Fibrinopeptide B ; Tandem Mass Spectrometry ; Prostatic Neoplasms ; Fatty Acids ; Amino Acids ; Choline ; Glutamates ; Phospholipids ; Oxalates ; Fatty Acids, Unsaturated ; Lipoproteins, HDL ; Cholesterol
Chemical Substances	beta Carotene (01YAE03M7J) ; alpha-Tocopherol (H4N855PNZ1) ; Endocannabinoids ; Cysteine (K848JZ4886) ; Fibrinopeptide B (36204-23-6) ; Fatty Acids ; Amino Acids ; Choline (N91BDP6H0X) ; Glutamates ; Phospholipids ; Oxalates ; Fatty Acids, Unsaturated ; Lipoproteins, HDL ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-10-25
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-022-02561-4
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Article ; Online: Metabolomic analysis of serum alpha-tocopherol among men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.

Lawrence, Wayne R / Lim, Jung-Eun / Huang, Jiaqi / Sampson, Joshua N / Weinstein, Stephanie J / Albanes, Demetrius

European journal of clinical nutrition

2022 Volume 76, Issue 9, Page(s) 1254–1265

Abstract: Background/objectives: The role of vitamin E in chronic disease risk remains incompletely understood, particularly in an un-supplemented state, and evidence is sparse regarding the biological actions and pathways involved in its influence on health ... ...

Abstract	Background/objectives: The role of vitamin E in chronic disease risk remains incompletely understood, particularly in an un-supplemented state, and evidence is sparse regarding the biological actions and pathways involved in its influence on health outcomes. Identifying vitamin-E-associated metabolites through agnostic metabolomics analyses can contribute to elucidating the specific associations and disease etiology. This study aims to investigate the association between circulating metabolites and serum α-tocopherol concentration in an un-supplemented state. Subjects/methods: Metabolomic analysis of 4,294 male participants was conducted based on pre-supplementation fasting serum in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. The associations between 1,791 known metabolites measured by ultra-high-performance LC-MS/GC-MS and HPLC-determined α-tocopherol concentration were estimated using multivariable linear regression. Differences in metabolite levels per unit difference in α-tocopherol concentration were calculated as standardized β-coefficients and standard errors. Results: A total of 252 metabolites were associated with serum α-tocopherol at the Bonferroni-corrected p value (p < 2.79 × 10 Conclusions: The large number of metabolites, particularly lipid and amino acid compounds associated with serum α-tocopherol provide leads regarding potential mechanisms through which vitamin E influences human health, including its role in cardiovascular disease and cancer.
MeSH term(s)	Amino Acids ; Humans ; Lipids ; Male ; Neoplasms/prevention & control ; Vitamin E ; alpha-Tocopherol ; beta Carotene
Chemical Substances	Amino Acids ; Lipids ; beta Carotene (01YAE03M7J) ; Vitamin E (1406-18-4) ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-022-01112-7
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Zs.A 1045: Show issues

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Article ; Online: A 28-year prospective analysis of serum vitamin E, vitamin E-related genetic variation and risk of prostate cancer.

Lawrence, Wayne R / Lim, Jung-Eun / Huang, Jiaqi / Weinstein, Stephanie J / Mӓnnistӧ, Satu / Albanes, Demetrius

Prostate cancer and prostatic diseases

2022 Volume 25, Issue 3, Page(s) 553–560

Abstract: Objective: Investigate the relationship between serum α-tocopherol concentration and long-term risk of prostate cancer, and evaluate the interaction with vitamin E-related genetic variants and their polygenic risk score (PRS).: Methods: We conducted ... ...

Abstract	Objective: Investigate the relationship between serum α-tocopherol concentration and long-term risk of prostate cancer, and evaluate the interaction with vitamin E-related genetic variants and their polygenic risk score (PRS). Methods: We conducted a biochemical analysis of 29,102 male Finnish smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Serum α-tocopherol was measured at baseline using high-performance liquid chromatography, and 2724 prostate cancer cases were identified during 28 years of follow-up. Cox proportional hazards models examined whether serum α-tocopherol concentrations were associated with prostate cancer risk. Among 8383 participants, three SNPs related to vitamin E status (rs964184, rs2108622, and rs11057830) were examined to determine whether they modified the relationship between serum α-tocopherol concentrations and prostate cancer risk, both individually and as a PRS using logistic regression models. Results: No association was observed between serum α-tocopherol and prostate cancer risk (fifth quintile (Q5) vs. Q1 hazard ratio (HR) = 0.87, 95% confidence interval (95% CI) 0.75, 1.02; P-trend = 0.57). Though no interactions were seen by population characteristics, high α-tocopherol concentration was associated with reduced prostate cancer risk among the trial α-tocopherol supplementation group (Q5 quintile vs. Q1 HR = 0.79, 95% CI 0.64, 0.99). Finally, no associated interaction between the three SNPs or their PRS and prostate cancer risk was observed. Conclusion: Although there was a weak inverse association between α-tocopherol concentration and prostate cancer risk over nearly three decades, our findings suggest that men receiving the trial α-tocopherol supplementation who had higher baseline serum α-tocopherol concentration experienced reduced prostate cancer risk. Vitamin E-related genotypes did not modify the serum α-tocopherol-prostate cancer risk association.
MeSH term(s)	Humans ; Male ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/etiology ; Prostatic Neoplasms/genetics ; Risk Factors ; Vitamin E ; alpha-Tocopherol ; beta Carotene
Chemical Substances	beta Carotene (01YAE03M7J) ; Vitamin E (1406-18-4) ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-022-00511-y
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Zs.A 5277: Show issues

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Article ; Online: Dietary Quality and Circulating Lipidomic Profiles in 2 Cohorts of Middle-Aged and Older Male Finnish Smokers and American Populations.

Zhang, Ting / Naudin, Sabine / Hong, Hyokyoung G / Albanes, Demetrius / Männistö, Satu / Weinstein, Stephanie J / Moore, Steven C / Stolzenberg-Solomon, Rachael Z

The Journal of nutrition

2023 Volume 153, Issue 8, Page(s) 2389–2400

Abstract: Background: Higher dietary quality is associated with lower disease risks and has not been examined extensively with lipidomic profiles.: Objectives: Our goal was to examine associations of the Healthy Eating Index (HEI)-2015, Alternate HEI-2010 ( ... ...

Abstract	Background: Higher dietary quality is associated with lower disease risks and has not been examined extensively with lipidomic profiles. Objectives: Our goal was to examine associations of the Healthy Eating Index (HEI)-2015, Alternate HEI-2010 (AHEI-2010), and alternate Mediterranean Diet Index (aMED) diet quality indices with serum lipidomic profiles. Methods: We conducted a cross-sectional analysis of HEI-2015, AHEI-2010, and aMED with lipidomic profiles from 2 nested case-control studies within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (n = 627) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 711). We used multivariable linear regression to determine associations of the indices, derived from baseline food-frequency questionnaires (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial: 1993-2001, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: 1985-1988) with serum concentrations of 904 lipid species and 252 fatty acids (FAs) across 15 lipid classes and 28 total FAs, within each cohort and meta-analyzed results using fixed-effect models for lipids significant at Bonferroni-corrected threshold in common in both cohorts. Results: Adherence to HEI-2015, AHEI-2010, or aMED was associated positively with 31, 41, and 54 lipid species and 8, 6, and 10 class-specific FAs and inversely with 2, 8, and 34 lipid species and 1, 3, and 5 class-specific FAs, respectively. Twenty-five lipid species and 5 class-specific FAs were common to all indices, predominantly triacylglycerols, FA22:6 [docosahexaenoic acid (DHA)]-containing species, and DHA. All indices were positively associated with total FA22:6. AHEI-2010 and aMED were inversely associated with total FA18:1 (oleic acid) and total FA17:0 (margaric acid), respectively. The identified lipids were most associated with components of seafood and plant proteins and unsaturated:saturated fat ratio in HEI-2015; eicosapentaenoic acid plus DHA in AHEI-2010; and fish and monounsaturated:saturated fat ratio in aMED. Conclusions: Adherence to HEI-2015, AHEI-2010, and aMED is associated with serum lipidomic profiles, mostly triacylglycerols or FA22:6-containing species, which are related to seafood and plant proteins, eicosapentaenoic acid-DHA, fish, or fat ratio index components.
MeSH term(s)	Male ; Animals ; United States ; Humans ; Female ; Lipidomics ; Smokers ; Finland ; Cross-Sectional Studies ; alpha-Tocopherol ; beta Carotene ; Eicosapentaenoic Acid ; Diet ; Diet, Mediterranean ; Triglycerides ; Colorectal Neoplasms ; Ovarian Neoplasms
Chemical Substances	alpha-Tocopherol (H4N855PNZ1) ; beta Carotene (01YAE03M7J) ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Triglycerides
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.06.010
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Article ; Online: Lipidomics and pancreatic cancer risk in two prospective studies.

Naudin, Sabine / Sampson, Joshua N / Moore, Steven C / Albanes, Demetrius / Freedman, Neal D / Weinstein, Stephanie J / Stolzenberg-Solomon, Rachael

European journal of epidemiology

2023 Volume 38, Issue 7, Page(s) 783–793

Abstract: Pancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 ... ...

Abstract	Pancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 lipid species and 252 fatty acids across 15 lipid classes in pre-diagnostic serum (up to 24 years) in a PDAC nested-case control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, NCT00002540) with 332 matched case-control sets including 272 having serial blood samples and Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC, NCT00342992) with 374 matched case-control sets. Controls were matched to cases by cohort, age, sex, race, and date at blood draw. We used conditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) per one-standard deviation increase in log-lipid concentrations within each cohort, and combined ORs using fixed-effects meta-analyses. Forty-three lipid species were associated with PDAC (false discovery rate, FDR ≤ 0.10), including lysophosphatidylcholines (LPC, n = 2), phosphatidylethanolamines (PE, n = 17), triacylglycerols (n = 13), phosphatidylcholines (PC, n = 3), diacylglycerols (n = 4), monoacylglycerols (MAG, n = 2), cholesteryl esters (CE, n = 1), and sphingomyelins (n = 1). LPC(18:2) and PE(O-16:0/18:2) showed significant inverse associations with PDAC at the Bonferroni threshold (P value < 5.5 × 10
MeSH term(s)	Male ; Humans ; Prospective Studies ; Lipidomics ; Risk Factors ; Case-Control Studies ; Pancreatic Neoplasms/epidemiology ; Fatty Acids ; Pancreatic Neoplasms
Chemical Substances	Fatty Acids
Language	English
Publishing date	2023-05-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-023-01014-3
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Article ; Online: Fiber and whole grain intakes in relation to liver cancer risk: An analysis in 2 prospective cohorts and systematic review and meta-analysis of prospective studies.

Watling, Cody Z / Wojt, Aika / Florio, Andrea A / Butera, Gisela / Albanes, Demetrius / Weinstein, Stephanie J / Huang, Wen-Yi / Parisi, Dominick / Zhang, Xuehong / Graubard, Barry I / Petrick, Jessica L / McGlynn, Katherine A

Hepatology (Baltimore, Md.)

2024

Abstract: Background and aims: The association between fiber or whole grain intakes and the risk of liver cancer remains unclear. We assessed the associations between fiber or whole grain intakes and liver cancer risk among 2 prospective studies, and ... ...

Abstract	Background and aims: The association between fiber or whole grain intakes and the risk of liver cancer remains unclear. We assessed the associations between fiber or whole grain intakes and liver cancer risk among 2 prospective studies, and systematically reviewed and meta-analyzed these results with published prospective studies. Approach and results: A total of 111,396 participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) and 26,085 men from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study were included. Intakes of total fiber and whole grains were estimated from validated food frequency questionnaires. Study-specific HRs and 95% CI with liver cancer risk were estimated using multivariable-adjusted Cox regression. We systematically reviewed existing literature, and studies were combined in a dose-response meta-analysis. A total of 277 (median follow-up = 15.6 y) and 165 (median follow-up = 16.0 y) cases of liver cancer were observed in Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, respectively. Dietary fiber was inversely associated with liver cancer risk in Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (HR 10g/day : 0.69; 95% CI: 0.55-0.86). No significant associations were observed between whole grain intakes and liver cancer risk in either study. Our meta-analysis included 2383 incident liver cancer cases (7 prospective cohorts) for fiber intake and 1523 cases (5 prospective cohorts) for whole grain intake; combined HRs for liver cancer risk were 0.83 (0.76-0.91) per 10 g/day of fiber and 0.92 (0.85-0.99) per 16 g/day (1 serving) of whole grains. Conclusions: Dietary fiber and whole grains were inversely associated with liver cancer risk. Further research exploring potential mechanisms and different fiber types is needed.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000819
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Article ; Online: Helicobacter hepaticus and Helicobacter bilis in liver and biliary cancers from ATBC and PLCO.

Murphy, Gwen / Freedman, Neal D / Abnet, Christian C / Albanes, Demetrius / Cross, Amanda J / Huang, Wen-Yi / Koshiol, Jill / McGlynn, Katherine / Parisi, Dominick / Männistö, Satu / Weinstein, Stephanie J / Waterboer, Tim / Butt, Julia

Helicobacter

2024 Volume 29, Issue 1, Page(s) e13053

Abstract: Background: Helicobacter species (spp.) have been detected in human bile and hepatobiliary tissue Helicobacter spp. promote gallstone formation and hepatobiliary tumors in laboratory studies, though it remains unclear whether Helicobacter spp. ... ...

Abstract	Background: Helicobacter species (spp.) have been detected in human bile and hepatobiliary tissue Helicobacter spp. promote gallstone formation and hepatobiliary tumors in laboratory studies, though it remains unclear whether Helicobacter spp. contribute to these cancers in humans. We used a multiplex panel to assess whether seropositivity to Helicobacter (H.) hepaticus or H. bilis proteins was associated with the development of hepatobiliary cancers in the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, and US-based Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Methods: We included 62 biliary and 121 liver cancers, and 190 age-matched controls from ATBC and 74 biliary and 105 liver cancers, and 364 age- and sex-matched controls from PLCO. Seropositivity to 14 H. hepaticus and H. bilis antigens was measured using a multiplex assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for major hepatobiliary cancer risk factors and Helicobacter pylori serostatus. Results: Seropositivity to the H. bilis antigen, P167D, was associated with more than a twofold higher risk of liver cancer (OR: 2.38; 95% CI: 1.06, 5.36) and seropositivity to the H. hepaticus antigens HH0407 or HH1201, or H. bilis antigen, HRAG 01470 were associated with higher risk of biliary cancer (OR: 5.01; 95% CI: 1.53, 16.40; OR: 2.40; 95% CI: 1.00, 5.76; OR: 3.27; 95% CI: 1.14, 9.34, respectively) within PLCO. No associations for any of the H. hepaticus or H. bilis antigens were noted for liver or biliary cancers within ATBC. Conclusions: Further investigations in cohort studies should examine the role of Helicobacter spp. in the etiology of liver and biliary cancers.
MeSH term(s)	Humans ; Male ; Biliary Tract Neoplasms/epidemiology ; Helicobacter ; Helicobacter hepaticus ; Helicobacter Infections/complications ; Helicobacter pylori ; Liver Neoplasms ; Female ; Clinical Trials as Topic
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1330665-0
ISSN	1523-5378 ; 1083-4389
ISSN (online)	1523-5378
ISSN	1083-4389
DOI	10.1111/hel.13053
Database	MEDical Literature Analysis and Retrieval System OnLINE

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