Article ; Online: Multifrequency Investigation of Single- and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors.
2022 Volume 12, Issue 7
Abstract: Due to the occurrence of THz-excited vibrational modes in biomacromolecules, the THz frequency range has been identified as particularly suitable for developing and applying new bioanalytical methods. We present a scalable THz metamaterial-based ... ...
| Abstract | Due to the occurrence of THz-excited vibrational modes in biomacromolecules, the THz frequency range has been identified as particularly suitable for developing and applying new bioanalytical methods. We present a scalable THz metamaterial-based biosensor being utilized for the multifrequency investigation of single- and double-stranded DNA (ssDNA and dsDNA) samples. It is demonstrated that the metamaterial resonance frequency shift by the DNA's presence depends on frequency. Our experiments with the scalable THz biosensors demonstrate a major change in the degree of the power function for dsDNA by 1.53 ± 0.06 and, in comparison, 0.34 ± 0.11 for ssDNA as a function of metamaterial resonance frequency. Thus, there is a significant advantage for dsDNA detection that can be used for increased sensitivity of biomolecular detection at higher frequencies. This work represents a first step for application-specific biosensors with potential advantages in sensitivity, specificity, and robustness. |
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| MeSH term(s) | Biosensing Techniques ; DNA ; DNA, Single-Stranded |
| Chemical Substances | DNA, Single-Stranded ; DNA (9007-49-2) |
| Language | English |
| Publishing date | 2022-07-01 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2662125-3 |
| ISSN | 2079-6374 ; 2079-6374 |
| ISSN (online) | 2079-6374 |
| ISSN | 2079-6374 |
| DOI | 10.3390/bios12070483 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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