Article ; Online: HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor.
2024 Volume 626, Issue 8000, Page(s) 843–851
Abstract: HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that this entry proceeds through nuclear pore complexes (NPCs), with the 120 × 60 nm capsid squeezing through an approximately 60-nm-wide central ... ...
| Abstract | HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that this entry proceeds through nuclear pore complexes (NPCs), with the 120 × 60 nm capsid squeezing through an approximately 60-nm-wide central channel |
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| MeSH term(s) | Humans ; Active Transport, Cell Nucleus ; Capsid/chemistry ; Capsid/metabolism ; Glycine/metabolism ; HIV-1/chemistry ; HIV-1/genetics ; HIV-1/metabolism ; Nuclear Pore/chemistry ; Nuclear Pore/metabolism ; Nuclear Pore/virology ; Nuclear Pore Complex Proteins/chemistry ; Nuclear Pore Complex Proteins/metabolism ; Permeability ; Phenylalanine/metabolism ; Solubility ; Virus Internalization ; Capsid Proteins/chemistry ; Capsid Proteins/metabolism | |||||||||||||||
| Chemical Substances | Glycine (TE7660XO1C) ; Nuclear Pore Complex Proteins ; Phenylalanine (47E5O17Y3R) ; Capsid Proteins | |||||||||||||||
| Language | English | |||||||||||||||
| Publishing date | 2024-01-24 | |||||||||||||||
| Publishing country | England | |||||||||||||||
| Document type | Journal Article | |||||||||||||||
| ZDB-ID | 120714-3 | |||||||||||||||
| ISSN | 1476-4687 ; 0028-0836 | |||||||||||||||
| ISSN (online) | 1476-4687 | |||||||||||||||
| ISSN | 0028-0836 | |||||||||||||||
| DOI | 10.1038/s41586-023-06966-w | |||||||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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