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  1. Article: Sphenopalatine Ganglion Block and Radiofrequency Ablation: Technical Notes and Efficacy.

    Tolba, Reda / Weiss, Austin L / Denis, Daniel J

    The Ochsner journal

    2019  Volume 19, Issue 1, Page(s) 32–37

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.18.0163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Atypical Facial Pain: a Comprehensive, Evidence-Based Review.

    Weiss, Austin L / Ehrhardt, Ken P / Tolba, Reda

    Current pain and headache reports

    2017  Volume 21, Issue 2, Page(s) 8

    Abstract: Purpose of review: The purpose of this article is to focus on an excruciating disorder of the face, named atypical facial pain or persistent idiopathic facial pain (PIFP). It is considered an underdiagnosed condition with limited treatment options. ... ...

    Abstract Purpose of review: The purpose of this article is to focus on an excruciating disorder of the face, named atypical facial pain or persistent idiopathic facial pain (PIFP). It is considered an underdiagnosed condition with limited treatment options. Facial pain can be a debilitating disorder that affects patients' quality of life. Up to 26% of the general population has suffered from facial pain at some point in their lives. It is important to highlight the different types of facial pain to be able to properly manage this condition accordingly.
    Recent findings: Newer interventional modalities such as pulsed radiofrequency ablation (PFR) of the sphenopalatine ganglion, peripheral nerve field stimulators (PNFS), and botulinum toxin injections have promising results. In summary, more prospective studies such as randomized controlled trials are necessary to explore the possibility of their more widespread use as viable procedures for the treatment of PIFP. In this review article, we describe the workup and diagnosis of PIFP and highlight recent literature regarding the pathophysiology and treatment of PIFP. PIFP is an excruciating disorder of the face often misdiagnosed as trigeminal neuralgia (TN) However, unlike TN symptoms, the pain is persistent rather than intermittent, usually unilateral, and without autonomic signs or symptoms. When a clinician encounters a patient with neuropathic facial pain whose symptoms are incongruent with the more common etiologies, the diagnosis of atypical facial pain must be entertained. Treatment of PIFP is multidisciplinary. Unfortunately, few randomized controlled trials for the treatment of PIFP exist. However, there are a select number of pharmacological, non-pharmacological, and interventional treatment options that have proven to be moderately effective.
    MeSH term(s) Evidence-Based Medicine ; Facial Pain/diagnosis ; Facial Pain/therapy ; Humans
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055062-5
    ISSN 1534-3081 ; 1531-3433
    ISSN (online) 1534-3081
    ISSN 1531-3433
    DOI 10.1007/s11916-017-0609-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5477: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: Validating Spray Coverage Rate Using Liquid Mass on a Spray Card

    Sama, Michael P. / Weiss, Austin M. / Benedict, Emma K.

    Transactions of the ASABE. , v. 61, no. 3

    2018  

    Abstract: Validation of agricultural sprayers is important for quantifying as-applied coverage rates under field conditions. The complexity of modern sprayer control systems presents a challenge for precise field validation due to the use of nozzle control ... ...

    Abstract Validation of agricultural sprayers is important for quantifying as-applied coverage rates under field conditions. The complexity of modern sprayer control systems presents a challenge for precise field validation due to the use of nozzle control technologies, such as pulse width modulation, to meter chemical flow rates at individual nozzles. Non-uniform flow over time may result in local variations at high spatial resolutions that are ignored when estimating as-applied coverage rates across a field. The purpose of this study was to test several methods for estimating the mass of water applied to a water-sensitive paper spray card target using steady-state and instantaneous measurement techniques. The steady-state method consisted of a spray patternator table used to quantify the mass flow rate distribution across the nozzle width at varying nozzle pressures. The mass flow rate was then projected onto a two-dimensional area traveling across the spray width to calculate the mass of water that was deposited in the area. Two instantaneous sampling methods were used. The first method directly measured the mass of the spray card and water for 5 min after exposure to model the evaporation rate and solve for the initial mass at the time of exposure. The second method indirectly used the percent coverage of the exposed spray card by droplets. Results showed that the error between the calculated mass of water from the mass flow rate and the estimated initial mass of water from the evaporation rate varied between 2% and 8%. The relationships between the calculated and estimated initial mass of water methods and the spray card percent coverage were highly linear (R2 > 0.98). Both instantaneous methods produced results with higher variability between replications than the steady-state method, but the number of replications resulted in acceptably small differences between average mass measurements. These results show the potential for using evaporation rates for laboratory validation and percent coverage for laboratory or field validation of as-applied coverage rates. Keywords: Evaporation rate, Flow measurement, Precision agriculture, Sprayers, Water-sensitive paper.
    Keywords evaporation rate ; liquids ; mass flow ; precision agriculture ; spray coverage ; sprayers
    Language English
    Size p. 887-895.
    Publishing place American Society of Agricultural and Biological Engineers (ASABE)
    Document type Article
    ZDB-ID 2232767-8
    ISSN 2151-0032
    ISSN 2151-0032
    DOI 10.13031/trans.12565
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2084: Show issues

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  4. Article ; Online: Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility.

    Barrera, Maria Claudia / Rojas, Laura Jimena / Weiss, Austin / Fernandez, Olga / McMahon-Pratt, Diane / Saravia, Nancy G / Gomez, Maria Adelaida

    Acta tropica

    2017  Volume 176, Page(s) 355–363

    Abstract: The mechanisms of Leishmania resistance to antimonials have been primarily determined in experimentally derived Leishmania strains. However, their participation in the susceptibility phenotype in field isolates has not been conclusively established. ... ...

    Abstract The mechanisms of Leishmania resistance to antimonials have been primarily determined in experimentally derived Leishmania strains. However, their participation in the susceptibility phenotype in field isolates has not been conclusively established. Being an intracellular parasite, the activity of antileishmanials is dependent on internalization of drugs into host cells and effective delivery to the intracellular compartments inhabited by the parasite. In this study we quantified and comparatively analyzed the gene expression of nine molecules involved in mechanisms of xenobiotic detoxification and Leishmania resistance to antimonial drugs in resistant and susceptible laboratory derived and clinical L.(Viannia) panamensis strains(n=19). In addition, we explored the impact of Leishmania susceptibility to antimonials on the expression of macrophage gene products having putative functions in transport, accumulation and metabolism of antimonials. As previously shown for other Leishmania species, a trend of increased abcc3 and lower aqp-1 expression was observed in the laboratory derived Sb-resistant L.(V.) panamensis line. However, this was not found in clinical strains, in which the expression of abca2 was significantly higher in resistant strains as both, promastigotes and intracellular amastigotes. The effect of drug susceptibility on host cell gene expression was evaluated on primary human macrophages from patients with cutaneous leishmaniasis (n=17) infected ex-vivo with the matched L.(V.) panamensis strains isolated at diagnosis, and in THP-1 cells infected with clinical strains (n=6) and laboratory adapted L.(V.) panamensis lines. Four molecules, abcb1 (p-gp), abcb6, aqp-9 and mt2a were differentially modulated by drug resistant and susceptible parasites, and among these, a consistent and significantly increased expression of the xenobiotic scavenging molecule mt2a was observed in macrophages infected with Sb-susceptible L. (V.) panamensis. Our results substantiate that different mechanisms of drug resistance operate in laboratory adapted and clinical Leishmania strains, and provide evidence that parasite-mediated modulation of host cell gene expression of molecules involved in drug transport and metabolism could contribute to the mechanisms of drug resistance and susceptibility in Leishmania.
    Language English
    Publishing date 2017-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2017.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.136: Show issues Location:
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  5. Article: Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility

    Barrera, Maria Claudia / Rojas, Laura Jimena / Weiss, Austin / Fernandez, Olga / McMahon-Pratt, Diane / Saravia, Nancy G / Gomez, Maria Adelaida

    Acta tropica. 2017 Dec., v. 176

    2017  

    Abstract: The mechanisms of Leishmania resistance to antimonials have been primarily determined in experimentally derived Leishmania strains. However, their participation in the susceptibility phenotype in field isolates has not been conclusively established. ... ...

    Abstract The mechanisms of Leishmania resistance to antimonials have been primarily determined in experimentally derived Leishmania strains. However, their participation in the susceptibility phenotype in field isolates has not been conclusively established. Being an intracellular parasite, the activity of antileishmanials is dependent on internalization of drugs into host cells and effective delivery to the intracellular compartments inhabited by the parasite. In this study we quantified and comparatively analyzed the gene expression of nine molecules involved in mechanisms of xenobiotic detoxification and Leishmania resistance to antimonial drugs in resistant and susceptible laboratory derived and clinical L.(Viannia) panamensis strains(n=19). In addition, we explored the impact of Leishmania susceptibility to antimonials on the expression of macrophage gene products having putative functions in transport, accumulation and metabolism of antimonials. As previously shown for other Leishmania species, a trend of increased abcc3 and lower aqp-1 expression was observed in the laboratory derived Sb-resistant L.(V.) panamensis line. However, this was not found in clinical strains, in which the expression of abca2 was significantly higher in resistant strains as both, promastigotes and intracellular amastigotes. The effect of drug susceptibility on host cell gene expression was evaluated on primary human macrophages from patients with cutaneous leishmaniasis (n=17) infected ex-vivo with the matched L.(V.) panamensis strains isolated at diagnosis, and in THP-1 cells infected with clinical strains (n=6) and laboratory adapted L.(V.) panamensis lines. Four molecules, abcb1 (p-gp), abcb6, aqp-9 and mt2a were differentially modulated by drug resistant and susceptible parasites, and among these, a consistent and significantly increased expression of the xenobiotic scavenging molecule mt2a was observed in macrophages infected with Sb-susceptible L. (V.) panamensis. Our results substantiate that different mechanisms of drug resistance operate in laboratory adapted and clinical Leishmania strains, and provide evidence that parasite-mediated modulation of host cell gene expression of molecules involved in drug transport and metabolism could contribute to the mechanisms of drug resistance and susceptibility in Leishmania.
    Keywords Leishmania ; P-glycoproteins ; amastigotes ; antileishmanials ; antimony ; cutaneous leishmaniasis ; drug resistance ; drugs ; gene expression ; genes ; humans ; macrophages ; metabolism ; parasites ; patients ; phenotype ; promastigotes ; xenobiotics
    Language English
    Dates of publication 2017-12
    Size p. 355-363.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2017.08.017
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    In stock of ZB MED Bonn / Germany

    Z 52/75: Show issues

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  6. Article: Diagnostic PCR can be used to illuminate meiofaunal diets and trophic relationships.

    Maghsoud, Hanna / Weiss, Austin / Smith, Julian P S / Litvaitis, Marian K / Fegley, Stephen R

    Invertebrate biology : a quarterly journal of the American Microscopical Society and the Division of Invertebrate Zoology/ASZ

    2014  Volume 133, Issue 2, Page(s) 121–127

    Abstract: Analysis of the meiofaunal food web is hampered because few prey have features that persist long enough in a predator's digestive tract to allow identification to species. Hence, at least for platyhelminth predators, direct observations of prey ... ...

    Abstract Analysis of the meiofaunal food web is hampered because few prey have features that persist long enough in a predator's digestive tract to allow identification to species. Hence, at least for platyhelminth predators, direct observations of prey preference are almost nonexistent, and where they occur, prey identification is often limited to phylum. Studies using an
    Language English
    Publishing date 2014-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227821-x
    ISSN 1077-8306
    ISSN 1077-8306
    DOI 10.1111/ivb.12048
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 811: Show issues Location:
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  7. Article: Diagnostic PCR can be used to illuminate meiofaunal diets and trophic relationships

    Maghsoud, Hanna / Weiss, Austin / Smith, Julian P.S., III / Litvaitis, Marian K. / Fegley, Stephen R.

    Invertebrate biology

    Volume v. 133,, Issue no. 2

    Abstract: Analysis of the meiofaunal food web is hampered because few prey have features that persist long enough in a predator's digestive tract to allow identification to species. Hence, at least for platyhelminth predators, direct observations of prey ... ...

    Abstract Analysis of the meiofaunal food web is hampered because few prey have features that persist long enough in a predator's digestive tract to allow identification to species. Hence, at least for platyhelminth predators, direct observations of prey preference are almost nonexistent, and where they occur, prey identification is often limited to the phylum level. Studies using an in vitro approach are rare because they are extremely time‐consuming and are subject to the criticism that predators removed from their natural environment may exhibit altered behaviors. Although PCR‐based approaches have achieved wide application in food‐web analysis, their application to meiofaunal flatworms suffers from a number of limitations. Most importantly, the microscopic size of both the predator and prey does not allow for removal of prey material from the digestive tract of the predator, and thus the challenge is to amplify prey sequences in the presence of large quantities of predator sequence. Here, we report on the successful use of prey‐taxon‐specific primers in diagnostic PCR to identify, to species level, specific prey items of 13 species of meiofaunal flatworms. Extension of this method will allow, for the first time, the development of a species‐level understanding of trophic interactions among the meiofauna.
    Keywords diet ; digestive tract ; food webs ; Platyhelminthes ; species identification ; polymerase chain reaction ; predators
    Language English
    Document type Article
    ISSN 1077-8306
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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