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  1. Book: Aging and vulnerability to environmental chemicals

    Weiss, Bernard

    age related disorders and their origins in environmental exposures

    (Issues in toxicology ; 16)

    2013  

    Title variant age-related
    Author's details ed. by Bernard Weiss
    Series title Issues in toxicology ; 16
    Collection
    Keywords Aging--Physiological aspects ; Toxicology ; Hazardous substances--Health aspects ; Older people--Health and hygiene
    Subject code 612.67
    Language English
    Size XX, 484 S. : Ill., 25 cm
    Publisher RSC Publ
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018523841
    ISBN 978-1-84973-418-9 ; 1-84973-418-6 ; 9781849734660 ; 1849734666
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Developmental neurotoxicity of methanol exposure by inhalation in rats

    Weiss, Bernard

    includes the commentary of the Institute's Health Review Committee

    (Research report / Health Effects Institute ; 73)

    1996  

    Institution Health Effects Institute
    Author's details Bernard Weiss
    Series title Research report / Health Effects Institute ; 73
    Collection
    Keywords Methanol / toxicity ; Methanol / blood ; Administration, Inhalation ; Brain / drug effects ; Brain / cytology ; Behavior, Animal / drug effects ; Prenatal Exposure Delayed Effects ; Rats
    Language English
    Size III, 70 S. : Ill., graph. Darst.
    Publisher Health Effects Inst
    Publishing place Cambridge, Mass
    Publishing country United States
    Document type Book
    HBZ-ID HT007603270
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Conference proceedings: Risk assessment for neurobehavioral toxicity

    Weiss, Bernard

    June 12 - 17, 1994, Rochester, NY

    (Environmental health perspectives ; 104, Suppl. 2 ; NIH publication ; 96-218)

    1996  

    Title variant Neurobehavioral toxicity
    Institution Workshop on Risk Assessment Methodology for Neurobehavioral Toxicity
    Scientific Group on Methodologies for the Safety Evaluation of Chemicals
    Author's details The 11th Workshop of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals and the 19th Rochester International Conference on Environmental Toxicity ; [Workshop on Risk Assessment Methodology for Nerobehavioral Toxicity]
    Series title Environmental health perspectives ; 104, Suppl. 2
    NIH publication ; 96-218
    Collection
    Keywords Neurotoxins / toxicity / congresses ; Behavior / drug effects / congresses ; Behavior, Animal / drug effects / congresses ; Risk Assessment / congresses ; Nervensystem ; Krankheit ; Umweltgift
    Subject Alltagsgift ; Umweltschadstoff ; Umweltnoxe ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS
    Language English
    Size S. 171 - 418 : graph. Darst.
    Publisher National Inst. of Environmental Health Sciences
    Publishing place Research Triangle Park, NC
    Publishing country United States
    Document type Book ; Conference proceedings
    Note Auf der HTS falscher Kongreß angegeben
    HBZ-ID HT007207249
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Conference proceedings: Neurobehavioral toxicity

    Weiss, Bernard

    analysis and interpretation ; [proceedings of the workshop]

    1994  

    Author's details ed. Bernard Weiss
    Keywords Behavior / drug effects / congresses ; Nervous System / drug effects / congresses ; Risk Factors / congresses ; Neuroethologie ; Toxikose
    Subject Verhalten
    Language English
    Size XIX, 391 S. : graph. Darst.
    Publisher Raven Press
    Publishing place New York
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT006382072
    ISBN 0-7817-0172-4 ; 978-0-7817-0172-3
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Stormy weather.

    Weiss, Bernard

    Neurotoxicology

    2016  Volume 56, Page(s) 233

    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2016.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Aging and vulnerability to environmental chemicals

    Weiss, Bernard

    age-related disorders and their origins in environmental exposures

    (Issues in toxicology, ; no. 16)

    2013  

    Institution Royal Society of Chemistry (Great Britain),
    Author's details edited by Bernard Weiss
    Series title Issues in toxicology, ; no. 16
    MeSH term(s) Aging/drug effects ; Environmental Exposure/adverse effects ; Hazardous Substances/poisoning ; Aging/pathology ; Age Factors ; Risk Factors
    Language English
    Size xx, 484 pages :, illustrations.
    Document type Book
    ISBN 9781849734189 ; 1849734186
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book ; Online: Aging and vulnerability to environmental chemicals

    Weiss, Bernard

    age-related disorders and their origins in environmental exposures

    (Issues in toxicology ; 16)

    2013  

    Abstract: The world's aging populations, with age-related disorders affecting every organ system, are generating medical care costs rising at an unsustainable rate. Although such disorders are expected, we are now beginning to ask whether exposures to toxic ... ...

    Author's details ed. by Bernard Weiss
    Series title Issues in toxicology ; 16
    Abstract The world's aging populations, with age-related disorders affecting every organ system, are generating medical care costs rising at an unsustainable rate. Although such disorders are expected, we are now beginning to ask whether exposures to toxic environmental chemicals hasten or account for their onset. This book provides a detailed review of current knowledge about the possible associations between a variety of chemical contaminants and adverse effects later in life. It will serve as a guide to policy decisions about protecting us from chemical exposures that distort the aging process. It p
    Keywords Environmental health ; Older people/Effect of environment on
    Language English
    Size Online-Ressource
    Publisher Royal Society of Chemistry
    Publishing place Cambridge
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9781849734189 ; 1849734666 ; 9781849734660 ; 1849734186
    DOI 10.1039/9781849734660
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book: Aging and vulnerability to environmental chemicals

    Weiss, Bernard

    age-related disorders and their origins in environmental exposures

    (Issues in toxicology ; 16)

    2013  

    Abstract: This book focuses on how chemical agents may affect the health of aging populations."-- ...

    Author's details ed. by Bernard Weiss
    Series title Issues in toxicology ; 16
    Abstract "This book focuses on how chemical agents may affect the health of aging populations."--
    Keywords Environmental health ; Older people/Effect of environment on
    Language English
    Size XX, 484 S., Ill., graph. Darst., Kt., 24 cm
    Publisher RSC Publ., Royal Soc. of Chemistry
    Publishing place Cambridge
    Document type Book
    Note Editor: Bernard Weiss (Department of Environmental Medicine, University of Rochester, NY, USA) ; Includes bibliographical references and index
    ISBN 9781849734189 ; 9781849734660 ; 1849734186 ; 1849734666
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: The intersection of neurotoxicology and endocrine disruption.

    Weiss, Bernard

    Neurotoxicology

    2012  Volume 33, Issue 6, Page(s) 1410–1419

    Abstract: Endocrine disruption, the guiding theme of the 27th International Neurotoxicology Conference, merged into the neurotoxicology agenda largely because hormones help steer the process of brain development. Although the disruption motif first attracted ... ...

    Abstract Endocrine disruption, the guiding theme of the 27th International Neurotoxicology Conference, merged into the neurotoxicology agenda largely because hormones help steer the process of brain development. Although the disruption motif first attracted public health attention because of reproductive anomalies in both wildlife and humans, the neurobehavioral implications had been planted decades earlier. They stemmed from the principle that sex differences in behavior are primarily the outcomes of differences in how the brain is sexually differentiated during early development by gonadal hormones (the Organizational Hypothesis). We also now understand that environmental chemicals are capable of altering these underlying events and processes. Among those chemicals, the group labeled as endocrine disrupting chemicals (EDCs) offers the clearest evidence of such selectivity, a consequence of their actions on the endogenous sex steroids, androgens and estrogens. Two EDCs in particular offer useful and intriguing examples. One is phthalate esters. The other is bisphenol A. Both agents are used extensively in plastics manufacture, and are pervasive in the environment. Both are produced in immense quantities. Both are found in almost all humans. Phthalates are considered to function in essence as anti-androgens, while bisphenol A is labeled as an estrogen. Their associations with brain sexual differentiation are reviewed and further questions noted. Both EDCs produce a wider spectrum of health effects, however, than would be extrapolated simply from their properties as anti-androgens and estrogens. Obesity is one example. Further complicating their assessment as health risks are questions about nonmonotonic dose-response functions and about transgenerational effects incurred via epigenetic mechanisms. All these facets of endocrine disruption are pieces of a puzzle that challenge neurotoxicologists for solutions.
    MeSH term(s) Age Factors ; Animals ; Behavior, Animal/drug effects ; Benzhydryl Compounds/toxicity ; Brain/drug effects ; Brain/growth & development ; Brain/pathology ; Brain/physiopathology ; Dose-Response Relationship, Drug ; Endocrine Disruptors/toxicity ; Environmental Exposure ; Environmental Pollutants/toxicity ; Female ; Humans ; Male ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/pathology ; Neurotoxicity Syndromes/physiopathology ; Phenols/toxicity ; Phthalic Acids/toxicity ; Reproduction/drug effects ; Risk Assessment ; Sex Characteristics ; Sex Differentiation ; Sex Factors
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Environmental Pollutants ; Phenols ; Phthalic Acids ; phthalic acid (6O7F7IX66E) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2012-05-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2012.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endocrine disruptors as a threat to neurological function.

    Weiss, Bernard

    Journal of the neurological sciences

    2011  Volume 305, Issue 1-2, Page(s) 11–21

    Abstract: Endocrine disruption is a concept and principle whose origins can be traced to the beginnings of the environmental movement in the 1960s. It began with puzzlement about and the flaring of research on the decline of wildlife, particularly avian species. ... ...

    Abstract Endocrine disruption is a concept and principle whose origins can be traced to the beginnings of the environmental movement in the 1960s. It began with puzzlement about and the flaring of research on the decline of wildlife, particularly avian species. The proposed causes accented pesticides, especially persistent organochlorines such as DDT. Its scope gradually widened beyond pesticides, and, as endocrine disruption offered an explanation for the wildlife phenomena, it seemed to explain, as well, changes in fertility and disorders of male reproduction such as testicular cancer. Once disturbed gonadal hormone function became the most likely explanation, it provoked other questions. The most challenging arose because of how critical gonadal hormones are to brain function, especially as determinants of brain sexual differentiation. Pursuit of such connections has generated a robust literature embracing a broad swath of chemical classes. How endocrine disrupting chemicals influence the adult and aging brain is a question, so far mostly ignored because of the emphasis on early development, that warrants vigorous investigation. Gonadal hormones are crucial to optimal brain function during maturity and even senescence. They are pivotal to the processes of neurogenesis. They exert protective actions against neurodegenerative disorders such as dementia and support smoothly functioning cognitive activities. The limited research conducted so far on endocrine disruptors, aging, and neurogenesis argues that they should be overlooked no longer.
    MeSH term(s) Animals ; Disorders of Sex Development/chemically induced ; Disorders of Sex Development/physiopathology ; Endocrine Disruptors/adverse effects ; Gonadal Steroid Hormones/agonists ; Gonadal Steroid Hormones/antagonists & inhibitors ; Gonadal Steroid Hormones/physiology ; Hazardous Substances/adverse effects ; Humans ; Nervous System Malformations/chemically induced ; Nervous System Malformations/physiopathology
    Chemical Substances Endocrine Disruptors ; Gonadal Steroid Hormones ; Hazardous Substances
    Language English
    Publishing date 2011-04-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2011.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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