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  1. Article: Low factor VIII levels are a risk factor for bleeding in patients with factor XI deficiency.

    Weiss, H J

    Journal of thrombosis and haemostasis : JTH

    2005  Volume 3, Issue 1, Page(s) 181–182

    MeSH term(s) Blood Coagulation Disorders/blood ; Factor VIII/biosynthesis ; Factor XI Deficiency/blood ; Hemophilia A/blood ; Humans ; ROC Curve ; Risk ; Risk Factors ; Thrombin/chemistry ; Time Factors ; von Willebrand Diseases/blood
    Chemical Substances Factor VIII (9001-27-8) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2005-02-19
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/j.1538-7836.2004.01079.x
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  2. Article: The bleeding tendency in patients with low von Willebrand factor and type 1 phenotype is greater in the presence of impaired collagen-induced platelet aggregation.

    Weiss, H J

    Journal of thrombosis and haemostasis : JTH

    2003  Volume 2, Issue 1, Page(s) 198–199

    MeSH term(s) Collagen/pharmacology ; Hemorrhage/etiology ; In Vitro Techniques ; Phenotype ; Platelet Aggregation/drug effects ; Risk Factors ; von Willebrand Diseases/blood ; von Willebrand Diseases/classification ; von Willebrand Diseases/complications ; von Willebrand Diseases/genetics ; von Willebrand Factor/genetics ; von Willebrand Factor/metabolism
    Chemical Substances von Willebrand Factor ; Collagen (9007-34-5)
    Language English
    Publishing date 2003-07-14
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/j.1538-7836.2004.0562e.x
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  3. Article: The discovery of the antiplatelet effect of aspirin: a personal reminiscence.

    Weiss, H J

    Journal of thrombosis and haemostasis : JTH

    2003  Volume 1, Issue 9, Page(s) 1869–1875

    MeSH term(s) Aspirin/history ; Aspirin/pharmacology ; Bleeding Time ; History, 20th Century ; Humans ; Platelet Aggregation Inhibitors/history ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Factor 3/physiology ; Thrombosis/prevention & control
    Chemical Substances Platelet Aggregation Inhibitors ; Platelet Factor 3 (37270-93-2) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2003-07-14
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1046/j.1538-7836.2003.00433.x
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  4. Article: Type 2B von Willebrand disease and related disorders of patients with increased ristocetin-induced platelet aggregation: what they tell us about the role of von Willebrand factor in hemostasis.

    Weiss, H J

    Journal of thrombosis and haemostasis : JTH

    2003  Volume 2, Issue 11, Page(s) 2055–2056

    MeSH term(s) Blood Platelet Disorders ; Dimerization ; Hemostasis ; History, 20th Century ; History, 21st Century ; Humans ; Platelet Aggregation/drug effects ; Ristocetin ; von Willebrand Diseases/blood ; von Willebrand Diseases/classification ; von Willebrand Diseases/history ; von Willebrand Factor/analysis ; von Willebrand Factor/physiology
    Chemical Substances von Willebrand Factor ; Ristocetin (1404-55-3)
    Language English
    Publishing date 2003-07-14
    Publishing country England
    Document type Historical Article ; Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/j.1538-7836.2004.00976.x
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  5. Article: Flow-related platelet deposition on subendothelium.

    Weiss, H J

    Thrombosis and haemostasis

    1995  Volume 74, Issue 1, Page(s) 117–122

    Abstract: The deposition of platelets on subendothelium is controlled both by flow factors that determine their transport to the surface through convective diffusion, and by the kinetics of their interactions with the surface. Red cells influence platelet ... ...

    Abstract The deposition of platelets on subendothelium is controlled both by flow factors that determine their transport to the surface through convective diffusion, and by the kinetics of their interactions with the surface. Red cells influence platelet transport by several mechanisms, and may also influence platelet reactivity. Platelets initially contact the surface through the binding of membrane GPIb to von Willebrand factor (vWf) that is present in the subendothelium or deposited there from plasma. Platelet spreading on the surface is promoted by the binding of the arg1744 gly1745 asp1746 (RGD) region of vWf (at high shear rates) to platelet GPIIb-IIIa. At high (arterial) shear rates, vWf binding to GPIIb-IIIa also promotes thrombus formation. At these shear rates, thrombin that is generated at the subendothelial surface is not involved in platelet adhesion or thrombus formation that occurs early in thrombogenesis, but is a major mediator of subsequent thrombus growth and/or stabilization.
    MeSH term(s) Animals ; Aorta ; Diffusion ; Endothelium, Vascular/injuries ; Erythrocytes/physiology ; Hemorheology/instrumentation ; Hemostasis/physiology ; Models, Biological ; Oligopeptides/physiology ; Platelet Adhesiveness/physiology ; Platelet Membrane Glycoproteins/physiology ; Rabbits ; Surface Properties ; Thrombin/physiology ; Thrombosis/physiopathology ; von Willebrand Factor/physiology
    Chemical Substances Oligopeptides ; Platelet Membrane Glycoproteins ; von Willebrand Factor ; arginyl-glycyl-aspartic acid (78VO7F77PN) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 1995-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
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  6. Article: Scott syndrome: a disorder of platelet coagulant activity.

    Weiss, H J

    Seminars in hematology

    1994  Volume 31, Issue 4, Page(s) 312–319

    MeSH term(s) Blood Coagulation Disorders/blood ; Blood Coagulation Factors/metabolism ; Blood Platelet Disorders/blood ; Cell Membrane/physiology ; Child, Preschool ; Female ; Humans ; Syndrome
    Chemical Substances Blood Coagulation Factors
    Language English
    Publishing date 1994-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
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  7. Article: Aspirin: how does it prevent thrombosis?

    Weiss, H J

    The Journal of laboratory and clinical medicine

    1992  Volume 119, Issue 6, Page(s) 594–595

    MeSH term(s) Aspirin/therapeutic use ; Blood Platelets/drug effects ; Blood Platelets/physiology ; Humans ; Thrombosis/blood ; Thrombosis/prevention & control
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 1992-06
    Publishing country United States
    Document type Comment ; Editorial ; Review
    ZDB-ID 80208-6
    ISSN 1532-6543 ; 0022-2143
    ISSN (online) 1532-6543
    ISSN 0022-2143
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  8. Article: von Willebrand factor and platelet function.

    Weiss, H J

    Annals of the New York Academy of Sciences

    1991  Volume 614, Page(s) 125–137

    MeSH term(s) Blood Platelets/physiology ; Endothelium, Vascular/physiology ; Humans ; Platelet Adhesiveness ; Platelet Membrane Glycoproteins/physiology ; von Willebrand Factor/physiology
    Chemical Substances Platelet Membrane Glycoproteins ; von Willebrand Factor
    Language English
    Publishing date 1991
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.1991.tb43698.x
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  9. Article: Greater inhibition of platelet procoagulant activity by antibody-derived glycoprotein IIb--IIIa inhibitors than by peptide and peptidomimetic inhibitors.

    Lages, B / Weiss, H J

    British journal of haematology

    1999  Volume 113, Issue 1, Page(s) 65–71

    Abstract: Antibody-derived GPIIb-IIIa antagonists, such as the c7E3 Fab fragment abciximab, have been shown to inhibit platelet procoagulant activity as well as platelet aggregation. Whether low-molecular-weight peptide-derived and peptidomimetic antagonists also ... ...

    Abstract Antibody-derived GPIIb-IIIa antagonists, such as the c7E3 Fab fragment abciximab, have been shown to inhibit platelet procoagulant activity as well as platelet aggregation. Whether low-molecular-weight peptide-derived and peptidomimetic antagonists also inhibit platelet procoagulant activity in a similar manner has not been fully investigated. We compared the effects of the antibody-derived antagonists c7E3 Fab and m10E5 IgG, the peptide-derived antagonists eptifibatide, MK-852 and RGDS, and the peptidomimetic RO44--9883 on platelet procoagulant activity and on the stimulated cytosolic calcium increases that promote procoagulant activity. Procoagulant activity was measured as prothrombinase activity in gel-filtered platelets, activated by collagen plus thrombin or collagen alone, with and without stirring. The stimulated increases in cytosolic calcium were measured in parallel samples of platelets loaded with fura-2AM. Both c7E3 and m10E5 inhibited prothrombinase activity by 40--50% under all conditions of activation tested and inhibited cytosolic calcium increases to a similar extent in stirred, but not unstirred, platelets. The low-molecular-weight antagonists caused significantly less inhibition of prothrombinase activity in collagen plus thrombin-stimulated platelets, and produced no inhibition but rather a slight enhancement of activity in platelets stimulated by collagen alone. These antagonists also had little or no effect on the cytosolic calcium increases in stirred platelets. These differential effects of antibody-derived versus non-antibody GPIIb-IIIa antagonists on procoagulant activity may be a factor contributing to the differing anti-thrombotic effects of these antagonists seen in clinical trials.
    MeSH term(s) Abciximab ; Antibodies, Monoclonal/pharmacology ; Blood Platelets/metabolism ; Blood Platelets/physiology ; Calcium/metabolism ; Cytosol/metabolism ; Enzyme Inhibitors/pharmacology ; Eptifibatide ; Fura-2 ; Humans ; Immunoglobulin Fab Fragments/pharmacology ; Immunoglobulin Fragments/pharmacology ; Oligopeptides/pharmacology ; Peptides/pharmacology ; Peptides, Cyclic/pharmacology ; Platelet Activation ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors ; Thiazolidines ; Thromboplastin/metabolism
    Chemical Substances Antibodies, Monoclonal ; Enzyme Inhibitors ; Immunoglobulin Fab Fragments ; Immunoglobulin Fragments ; Oligopeptides ; Peptides ; Peptides, Cyclic ; Platelet Aggregation Inhibitors ; Platelet Glycoprotein GPIIb-IIIa Complex ; Thiazolidines ; MK 0852 (138199-64-1) ; Thromboplastin (9035-58-9) ; arginyl-glycyl-aspartyl-serine (AC6UDA2MFC) ; Eptifibatide (NA8320J834) ; Calcium (SY7Q814VUP) ; Fura-2 (TSN3DL106G) ; Abciximab (X85G7936GV)
    Language English
    Publishing date 1999-08-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1046/j.1365-2141.2001.02721.x
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  10. Article: Secreted dense granule adenine nucleotides promote calcium influx and the maintenance of elevated cytosolic calcium levels in stimulated human platelets.

    Lages, B / Weiss, H J

    Thrombosis and haemostasis

    1999  Volume 81, Issue 2, Page(s) 286–292

    Abstract: Evidence that secreted dense granule adenine nucleotides mediate part of the agonist-induced cytosolic calcium ([Ca2+]i) responses in human platelets was obtained from comparisons of fura-2-loaded platelets from normal subjects and from patients with a ... ...

    Abstract Evidence that secreted dense granule adenine nucleotides mediate part of the agonist-induced cytosolic calcium ([Ca2+]i) responses in human platelets was obtained from comparisons of fura-2-loaded platelets from normal subjects and from patients with a form of platelet storage pool deficiency (SPD) in which the secretory dense granules and their contents are virtually absent. SPD platelets had normal initial [Ca2+]i increases induced by thrombin and the endoperoxide analog U46619, but a significantly enhanced decay of elevated [Ca2+]i levels following the initial increases. With thrombin, this enhanced [Ca2+]i decay was associated with decreased Ca2+ influx, as measured by Mn2+ quench of fura-2 fluorescence. Addition of micromolar concentrations of ADP, alone or together with ATP, after stimulation reversed the enhanced [Ca2+]i decay and increased Mn2+ quench in SPD platelets, but had no effect on these responses in normal platelets, while addition of 100-fold higher concentrations of ATP or apyrase before stimulation increased [Ca2+]i decay and decreased Mn2+ quench in normal platelets, but had little effect in SPD platelets. ATP and alpha,beta-methylene ATP, a specific agonist for P2X1 receptors, at micromolar concentrations also increased Mn2+ quench, but to lesser extents than did ADP, in SPD platelets isolated and loaded with fura-2 in the presence of apyrase. Similar effects of ADP and excess ATP were seen in U46619-stimulated platelets, but decreased Ca2+ influx could not be measured directly in SPD platelets, presumably due to the very transient influx response seen with U46619. These results suggest that secreted dense granule ADP and ATP contribute to the maintenance of elevated [Ca2+]i levels, but not to the initial [Ca2+]i increases, in stimulated human platelets, most likely via a nucleotide-specific component of Ca2+ influx which may be mediated by interactions with both P2X1 and P2Y1 purinoceptors.
    MeSH term(s) 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Adenine Nucleotides/physiology ; Adenine Nucleotides/secretion ; Adenosine Diphosphate/pharmacology ; Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/pharmacology ; Apyrase/pharmacology ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Blood Platelets/secretion ; Calcium/metabolism ; Cytoplasmic Granules/secretion ; Cytosol/chemistry ; Drug Interactions ; Fura-2 ; Humans ; Ion Transport ; Platelet Activation/physiology ; Platelet Storage Pool Deficiency/blood ; Platelet Storage Pool Deficiency/pathology ; Purinergic P2 Receptor Agonists ; Receptors, Purinergic P2X ; Thrombin/pharmacology
    Chemical Substances Adenine Nucleotides ; Purinergic P2 Receptor Agonists ; Receptors, Purinergic P2X ; Adenosine Diphosphate (61D2G4IYVH) ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid (76898-47-0) ; Adenosine Triphosphate (8L70Q75FXE) ; Thrombin (EC 3.4.21.5) ; Apyrase (EC 3.6.1.5) ; alpha,beta-methyleneadenosine 5'-triphosphate (NYX13NT29D) ; Calcium (SY7Q814VUP) ; Fura-2 (TSN3DL106G)
    Language English
    Publishing date 1999-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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