Article ; Online: Extra centrosomes delay DNA damage-driven tumorigenesis.
2024 Volume 10, Issue 13, Page(s) eadk0564
Abstract: Deregulated centrosome numbers are frequently found in human cancer and can promote malignancies in model organisms. Current research aims to clarify if extra centrosomes are cause or consequence of malignant transformation, and if their biogenesis can ... ...
Abstract | Deregulated centrosome numbers are frequently found in human cancer and can promote malignancies in model organisms. Current research aims to clarify if extra centrosomes are cause or consequence of malignant transformation, and if their biogenesis can be targeted for therapy. Here, we show that oncogene-driven blood cancer is inert to genetic manipulation of centrosome numbers, whereas the formation of DNA damage-induced malignancies is delayed. We provide first evidence that this unexpected phenomenon is connected to extra centrosomes eliciting a pro-death signal engaging the apoptotic machinery. Apoptosis induction requires the PIDDosome multi-protein complex, as it can be abrogated by loss of any of its three components, |
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MeSH term(s) | Humans ; Centrosome ; Apoptosis/genetics ; Neoplasms/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; DNA Damage |
Language | English |
Publishing date | 2024-03-29 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2810933-8 |
ISSN | 2375-2548 ; 2375-2548 |
ISSN (online) | 2375-2548 |
ISSN | 2375-2548 |
DOI | 10.1126/sciadv.adk0564 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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