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  1. Book ; Online ; E-Book: Cannabis use disorders

    Montoya, Ivan D. / Weiss, Susan R. B.

    2019  

    Author's details Ivan D. Montoya, Susan R. B. Weiss editors
    Keywords Psychiatry ; Family medicine ; Toxicology ; Rehabilitation
    Subject code 616.89
    Language English
    Size 1 Online-Ressource (XII, 271 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019931145
    ISBN 978-3-319-90365-1 ; 9783319903644 ; 3-319-90365-9 ; 3319903640
    DOI 10.1007/978-3-319-90365-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Forty years with coronaviruses.

    Weiss, Susan R

    The Journal of experimental medicine

    2020  Volume 217, Issue 5

    Abstract: I have been researching coronaviruses for more than forty years. This viewpoint summarizes some of the major findings in coronavirus research made before the SARS epidemic and how they inform current research on the newly emerged SARS-CoV-2. ...

    Abstract I have been researching coronaviruses for more than forty years. This viewpoint summarizes some of the major findings in coronavirus research made before the SARS epidemic and how they inform current research on the newly emerged SARS-CoV-2.
    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus/genetics ; Coronavirus/pathogenicity ; Coronavirus/physiology ; Coronavirus Infections/epidemiology ; Genome ; Humans ; Immune Evasion ; Interprofessional Relations ; Middle East Respiratory Syndrome Coronavirus/genetics ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; Pandemics ; Phylogeny ; Pneumonia, Viral/epidemiology ; RNA, Viral/genetics ; Research/trends ; Severe acute respiratory syndrome-related coronavirus/genetics ; Severe acute respiratory syndrome-related coronavirus/pathogenicity ; SARS-CoV-2 ; Viral Proteins/physiology ; Virion ; Virology/trends
    Chemical Substances RNA, Viral ; Viral Proteins
    Keywords covid19
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20200537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: Improved Culture Methods for Human Coronaviruses HCoV-OC43, HCoV-229E, and HCoV-NL63.

    Fausto, Alejandra / Otter, Clayton J / Bracci, Nicole / Weiss, Susan R

    Current protocols

    2024  Volume 4, Issue 3, Page(s) e1031

    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Published Erratum
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.1031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Forty years with coronaviruses

    Weiss, Susan R

    J. exp. med

    Abstract: I have been researching coronaviruses for more than forty years. This viewpoint summarizes some of the major findings in coronavirus research made before the SARS epidemic and how they inform current research on the newly emerged SARS-CoV-2. ...

    Abstract I have been researching coronaviruses for more than forty years. This viewpoint summarizes some of the major findings in coronavirus research made before the SARS epidemic and how they inform current research on the newly emerged SARS-CoV-2.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32232339
    Database COVID19

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  5. Article ; Online: Forty years with coronaviruses

    Weiss, Susan R.

    Journal of Experimental Medicine

    2020  Volume 217, Issue 5

    Abstract: I have been researching coronaviruses for more than forty years. This viewpoint summarizes some of the major findings in coronavirus research made before the SARS epidemic and how they inform current research on the newly emerged SARS-CoV-2. ...

    Abstract I have been researching coronaviruses for more than forty years. This viewpoint summarizes some of the major findings in coronavirus research made before the SARS epidemic and how they inform current research on the newly emerged SARS-CoV-2.
    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Rockefeller University Press
    Publishing country us
    Document type Article ; Online
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20200537
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Improved Culture Methods for Human Coronaviruses HCoV-OC43, HCoV-229E, and HCoV-NL63.

    Fausto, Alejandra / Otter, Clayton J / Bracci, Nicole / Weiss, Susan R

    Current protocols

    2023  Volume 3, Issue 10, Page(s) e914

    Abstract: HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1 are four of the seven known human coronaviruses (HCoVs) and, unlike the highly pathogenic SARS-CoV, MERS-CoV, and SARS-CoV-2, these four so-called seasonal HCoVs generally cause mild upper-respiratory-tract ... ...

    Abstract HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1 are four of the seven known human coronaviruses (HCoVs) and, unlike the highly pathogenic SARS-CoV, MERS-CoV, and SARS-CoV-2, these four so-called seasonal HCoVs generally cause mild upper-respiratory-tract illness. As Biosafety Level 2 (BSL-2) pathogens, the seasonal HCoVs are more accessible and can be used as surrogates for studying the highly pathogenic HCoVs. However, scientists have for many years found these difficult to study because of the lack of a universal culture system and the inability of typical culture methods to yield high-titer infectious stocks. We have developed assays to grow and quantify infectious virus and viral RNA for HCoV-OC43, -229E, and -NL63. We identified which immortalized cell lines should be used to optimize the replication of HCoV-OC43, -229E, and -NL63 in order to generate high titers (Vero E6, Huh-7, and LLC-MK2 cells, respectively). Here we present protocols for improved propagation and quantification of each seasonal HCoV. © 2023 Wiley Periodicals LLC. Basic Protocol 1: Growth of HCoVs Basic Protocol 2: Quantification of HCoV by plaque assay Basic Protocol 3: Quantification of HCoV RNA products of replication Basic Protocol 4: Concentrating HCoVs via ultracentrifugation.
    MeSH term(s) Humans ; Coronavirus OC43, Human ; Coronavirus 229E, Human ; Coronavirus NL63, Human ; Culture Techniques ; RNA, Viral/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Can Science Help Resolve the Controversy on the Origins of the SARS-CoV-2 Pandemic?

    Casadevall, Arturo / Weiss, Susan R / Imperiale, Michael J

    mBio

    2021  Volume 12, Issue 4, Page(s) e0194821

    Abstract: The origins of the calamitous SARS-CoV-2 pandemic are now the subject of vigorous discussion and debate between two competing hypotheses for how it entered the human population: (i) direct infection from a feral source, likely a bat and possibly with an ... ...

    Abstract The origins of the calamitous SARS-CoV-2 pandemic are now the subject of vigorous discussion and debate between two competing hypotheses for how it entered the human population: (i) direct infection from a feral source, likely a bat and possibly with an intermediate mammalian host, and (ii) a lab accident whereby bat isolates infected a researcher, who then passed it to others. Here, we ask whether the tools of science can help resolve the origins question and conclude that while such studies can provide important information, these are unlikely to provide a definitive answer. Currently available data combined with historical precedent from other outbreaks and viewed through the prism of Occam's razor favor the feral source hypothesis, but science can provide only probabilities, not certainty.
    MeSH term(s) Accidents, Occupational ; Animals ; COVID-19/transmission ; Chiroptera/virology ; Humans ; Public Health Surveillance/methods ; SARS-CoV-2 ; Zoonoses/transmission ; Zoonoses/virology
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01948-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Coordinating cannabis data collection globally: Policy implications.

    Weiss, Susan R B / Volkow, Nora D

    Addiction (Abingdon, England)

    2021  Volume 117, Issue 6, Page(s) 1520–1521

    MeSH term(s) Cannabinoids ; Cannabis ; Data Collection ; Hallucinogens ; Humans ; Medical Marijuana ; Policy
    Chemical Substances Cannabinoids ; Hallucinogens ; Medical Marijuana
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.15751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 551: Show issues Location:
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  9. Article ; Online: Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions.

    Otter, Clayton J / Fausto, Alejandra / Tan, Li Hui / Weiss, Susan R / Cohen, Noam A

    Journal of visualized experiments : JoVE

    2023  , Issue 199

    Abstract: Three highly pathogenic human coronaviruses (HCoVs) - SARS-CoV (2002), MERS-CoV (2012), and SARS-CoV-2 (2019) - have emerged and caused significant public health crises in the past 20 years. Four additional HCoVs cause a significant portion of common ... ...

    Abstract Three highly pathogenic human coronaviruses (HCoVs) - SARS-CoV (2002), MERS-CoV (2012), and SARS-CoV-2 (2019) - have emerged and caused significant public health crises in the past 20 years. Four additional HCoVs cause a significant portion of common cold cases each year (HCoV-NL63, -229E, -OC43, and -HKU1), highlighting the importance of studying these viruses in physiologically relevant systems. HCoVs enter the respiratory tract and establish infection in the nasal epithelium, the primary site encountered by all respiratory pathogens. We use a primary nasal epithelial culture system in which patient-derived nasal samples are grown at an air-liquid interface (ALI) to study host-pathogen interactions at this important sentinel site. These cultures recapitulate many features of the in vivo airway, including the cell types present, ciliary function, and mucus production. We describe methods to characterize viral replication, host cell tropism, virus-induced cytotoxicity, and innate immune induction in nasal ALI cultures following HCoV infection, using recent work comparing lethal and seasonal HCoVs as an example
    MeSH term(s) Humans ; Middle East Respiratory Syndrome Coronavirus ; Epithelial Cells ; SARS-CoV-2 ; Virus Replication ; Nasal Mucosa
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/64868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Importance of a standard unit dose for cannabis research.

    Volkow, Nora D / Weiss, Susan R B

    Addiction (Abingdon, England)

    2020  Volume 115, Issue 7, Page(s) 1219–1221

    MeSH term(s) Cannabidiol ; Cannabis ; Dronabinol ; Hallucinogens
    Chemical Substances Hallucinogens ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.14984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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