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  1. Article: Gastrointestinal and liver adverse effects of anti-tumoral immune therapy: from recognition to treatment.

    Weissman, Simcha / Saleem, Saad / Aldulaimi, David

    Gastroenterology and hepatology from bed to bench

    2021  Volume 14, Issue 3, Page(s) 195–199

    Abstract: Anti-tumoral immune therapy consists of monoclonal antibodies that target intra-cellular immune checkpoints-which under normal circumstances, act as regulators of T-cell immunity. By serving as inhibitors of cellular checkpoints, monoclonal antibodies ... ...

    Abstract Anti-tumoral immune therapy consists of monoclonal antibodies that target intra-cellular immune checkpoints-which under normal circumstances, act as regulators of T-cell immunity. By serving as inhibitors of cellular checkpoints, monoclonal antibodies stimulate the immune system thus augmenting the body's response against cancer. These immune-enhancers or stimulators have revolutionized the treatment of malignancy as they continue to show improvement in the overall survival of cancer patients. Currently, in the United States, six immune checkpoint inhibitors are approved for the treatment of a variety of solid tumors (1). As these checkpoint inhibitors are relatively new, only a scant amount of literature is available regarding both their adverse effects and management thereof. In addition, as newer antibodies are being developed, and expected to be enlisted among the armamentarium of cancer chemotherapeutic agents-the need to understand their toxicity and adverse effects is of paramount importance. Herein, we review some of the gastrointestinal and liver sequelea secondary to the usage of immunotherapeutic checkpoint inhibitor agents in cancer chemotherapy, as well as present the diagnosis and recommended treatment strategies for their adverse effects.
    Language English
    Publishing date 2021-06-24
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Leptospirosis as an unusual culprit of acute pancreatitis and portal vein thrombosis in a New Yorker.

    Afzal, Iman / Thaker, Rishi / Weissman, Simcha / Kothari, Megha

    Clinical case reports

    2020  Volume 8, Issue 4, Page(s) 690–695

    Abstract: Leptospirosis often takes clinicians by surprise when presenting in urban locations with unusual manifestations. This delays diagnosis and treatment which increases mortality rate. Our case illustrates the importance of taking into account the ... ...

    Abstract Leptospirosis often takes clinicians by surprise when presenting in urban locations with unusual manifestations. This delays diagnosis and treatment which increases mortality rate. Our case illustrates the importance of taking into account the socioeconomic backgrounds, environmental exposures, and clinical presentations of patients to create a good differential diagnosis.
    Language English
    Publishing date 2020-02-19
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The black esophagus and duodenum: a rare case report.

    Saleem, Saad / Weissman, Simcha / Ahmad, Sumair

    Gastroenterology and hepatology from bed to bench

    2020  Volume 13, Issue 3, Page(s) 264–267

    Abstract: Acute esophageal necrosis is a rare esophageal disease, typically characterized by the circumferential black appearance of the esophagus mucosa that usually affects the distal esophagus. It commonly affects elderly men with multiple comorbidities. In the ...

    Abstract Acute esophageal necrosis is a rare esophageal disease, typically characterized by the circumferential black appearance of the esophagus mucosa that usually affects the distal esophagus. It commonly affects elderly men with multiple comorbidities. In the medical literature, some cases have been reported regarding acute necrotizing esophagus, but according to our knowledge, only one case has been reported concerning a patient with ischemic duodenum and esophagus. The case of a 71-year-old man with upper gastrointestinal bleeding and subsequent acute necrotizing esophagus and duodenum has been described below.
    Language English
    Publishing date 2020-08-06
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dietary Fiber and the Risk of Acute Diverticulitis.

    Fung, Brian M / Weissman, Simcha / Tabibian, James H

    The American journal of gastroenterology

    2020  Volume 115, Issue 6, Page(s) 953–954

    MeSH term(s) Dietary Fiber ; Diverticulitis ; Fruit ; Humans ; Vegetables
    Chemical Substances Dietary Fiber
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: A Rare Case of Severe Hypokalemia and Hypomagnesemia due to Venetoclax and Polypharmacy Leading to Life-Threatening Cardiac Arrhythmias.

    Torres Cruz, Laura / Pulipaka, Sai Priyanka / Anthony, Neenu / Liu, James / Barkhodarian, Maryam / Al Awwa, Ahmad / Weissman, Simcha

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 1390–1394

    Abstract: Venetoclax is a novel agent used in hematologic malignancies. Although no long-term studies have directly implicated venetoclax, few studies show possible association with electrolyte abnormalities. Severe derangements in serum electrolyte levels can ... ...

    Abstract Venetoclax is a novel agent used in hematologic malignancies. Although no long-term studies have directly implicated venetoclax, few studies show possible association with electrolyte abnormalities. Severe derangements in serum electrolyte levels can cause cardiac dysrhythmias, which can be potentially fatal. We present a case of venetoclax in association with the other medications causing life-threatening arrhythmias. Hypothesized mechanisms include damage to the distal tubules causing loss of potassium and magnesium. Our patient required modification of his medications and aggressive repletion of electrolytes with good outcomes. For patients on venetoclax, especially those with polypharmacy, caution should be exercised to prevent severe electrolyte derangements, which can lead to life-threatening arrhythmias.
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000534135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Recent advances in endoscopy.

    Weissman, Simcha / Sciarra, Michael A / Al-Dulaimi, David

    Gastroenterology and hepatology from bed to bench

    2019  Volume 12, Issue 4, Page(s) 374–375

    Language English
    Publishing date 2019-10-22
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biliary Fibrosis and Portal Hypertension as a Rare Cause of Cholangiocarcinoma.

    Hassan, Ammar / Weissman, Simcha / Pinkhasov, Mark / Sciarra, Michael

    Journal of gastrointestinal cancer

    2019  Volume 51, Issue 2, Page(s) 647–648

    MeSH term(s) Aged ; Bile Duct Neoplasms/etiology ; Bile Duct Neoplasms/pathology ; Bile Ducts/pathology ; Cholangiocarcinoma/etiology ; Cholangiocarcinoma/pathology ; Female ; Fibrosis/complications ; Fibrosis/pathology ; Humans ; Hypertension, Portal/complications ; Hypertension, Portal/pathology ; Prognosis
    Language English
    Publishing date 2019-11-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-019-00346-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Landmark studies and emerging strategies for the management of acute severe ulcerative colitis.

    Weissman, Simcha / Saleem, Saad / Aldulaimi, David

    Gastroenterology and hepatology from bed to bench

    2019  Volume 12, Issue 3, Page(s) 179–182

    Language English
    Publishing date 2019-08-21
    Publishing country Iran
    Document type Editorial
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Morbidity and mortality of infections in the cirrhotic patients: a US population-based study.

    Saleem, Saad / Katragadda, Rathnavali / Weissman, Simcha / Bleibel, Wissam

    Gastroenterology and hepatology from bed to bench

    2019  Volume 12, Issue 3, Page(s) 233–238

    Abstract: Aim: This study aims to investigate the morbidity, mortality, and health care utilization of infection in patients with cirrhosis, with the hope of making clinical recommendations.: Background: The pathophysiology of liver cirrhosis makes patients ... ...

    Abstract Aim: This study aims to investigate the morbidity, mortality, and health care utilization of infection in patients with cirrhosis, with the hope of making clinical recommendations.
    Background: The pathophysiology of liver cirrhosis makes patients susceptible to a variety of complications including infection. It contributes to a staggering rate of death and places a tremendous financial burden on the health care system.
    Methods: The pathophysiology of liver cirrhosis makes patients susceptible to a variety of complications including infection. It contributes to a staggering rate of death and places a tremendous financial burden on the health care system.
    Results: In this cross-sectional study, we queried the National Inpatient Sample (NIS) database for patients discharged from United States (US) hospitals with International classification of diseases (ICD) diagnostic codes consistent with liver cirrhosis, between January 2011 and December 2014. The patients were classified based upon the presence or absence of an infection, as well as their demographics and comorbidities. The data was then analyzed using the IBM SPSS version 25 statistical software.
    Conclusion: From 2011 to 2014, 660,727 cirrhotic patients were identified. Of these, 20.6% were found to have an infection. The mortality rate during hospitalization was 4.7% of all cirrhotic patients. The hospital length of stay was significantly longer for the study group than the control group (8.22 days versus 5.11 days) (P <0.0001). Similarly, the mean hospital cost was higher in the study group compared to the control group ($74,729.53 ± $125,963.75 vs. $46,413.32 ± $71,936.50 P< 0.0001).
    Language English
    Publishing date 2019-08-21
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparison of Artificial Intelligence With Other Interventions to Improve Adenoma Detection Rate for Colonoscopy: A Network Meta-analysis.

    Aziz, Muhammad / Haghbin, Hossein / Sayeh, Wasef / Alfatlawi, Halah / Gangwani, Manesh K / Sohail, Amir H / Zahdeh, Tamer / Weissman, Simcha / Kamal, Faisal / Lee-Smith, Wade / Nawras, Ali / Sharma, Prateek / Shaukat, Aasma

    Journal of clinical gastroenterology

    2024  Volume 58, Issue 2, Page(s) 143–155

    Abstract: Introduction: Recent randomized controlled trials (RCTs) and meta-analysis have demonstrated improved adenoma detection rate (ADR) for colonoscopy with artificial intelligence (AI) compared with high-definition (HD) colonoscopy without AI. We aimed to ... ...

    Abstract Introduction: Recent randomized controlled trials (RCTs) and meta-analysis have demonstrated improved adenoma detection rate (ADR) for colonoscopy with artificial intelligence (AI) compared with high-definition (HD) colonoscopy without AI. We aimed to perform a systematic review and network meta-analysis of all RCTs to assess the impact of AI compared with other endoscopic interventions aimed at increasing ADR such as distal attachment devices, dye-based/virtual chromoendoscopy, water-based techniques, and balloon-assisted devices.
    Methods: A comprehensive literature search of PubMed/Medline, Embase, and Cochrane was performed through May 6, 2022, to include RCTs comparing ADR for any endoscopic intervention mentioned above. Network meta-analysis was conducted using a frequentist approach and random effects model. Relative risk (RR) and 95% CI were calculated for proportional outcome.
    Results: A total of 94 RCTs with 61,172 patients (mean age 59.1±5.2 y, females 45.8%) and 20 discrete study interventions were included. Network meta-analysis demonstrated significantly improved ADR for AI compared with autofluorescence imaging (RR: 1.33, CI: 1.06 to 1.66), dye-based chromoendoscopy (RR: 1.22, CI: 1.06 to 1.40), endocap (RR: 1.32, CI: 1.17 to 1.50), endocuff (RR: 1.19, CI: 1.04 to 1.35), endocuff vision (RR: 1.26, CI: 1.13 to 1.41), endoring (RR: 1.30, CI: 1.10 to 1.52), flexible spectral imaging color enhancement (RR: 1.26, CI: 1.09 to 1.46), full-spectrum endoscopy (RR: 1.40, CI: 1.19 to 1.65), HD (RR: 1.41, CI: 1.28 to 1.54), linked color imaging (RR: 1.21, CI: 1.08 to 1.36), narrow band imaging (RR: 1.33, CI: 1.18 to 1.48), water exchange (RR: 1.22, CI: 1.06 to 1.42), and water immersion (RR: 1.47, CI: 1.19 to 1.82).
    Conclusions: AI demonstrated significantly improved ADR when compared with most endoscopic interventions. Future RCTs directly assessing these associations are encouraged.
    MeSH term(s) Female ; Humans ; Middle Aged ; Network Meta-Analysis ; Colonoscopy/methods ; Adenoma/diagnostic imaging ; Artificial Intelligence ; Water ; Colorectal Neoplasms/diagnosis
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1523: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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