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  1. Book: Textbook of SARS-CoV-2 and COVID-19

    Mani, Subramani / Weitkamp, Jorn-Hendrik

    epidemiology, etiopathogenesis, immunology, clinical manifestations, treatment, complications and preventive measures

    2024  

    Author's details Subramani Mani, Jorn-Hendrik Weitkamp
    Keywords COVID-19 (Disease)
    Subject code 614.5924144
    Language English
    Size xiii, 380 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT021729344
    ISBN 978-0-323-87539-4 ; 0-323-87539-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 453 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Gut-derived T cells might cause brain injury in NEC.

    Weitkamp, Jörn-Hendrik

    Nature reviews. Gastroenterology & hepatology

    2021  Volume 18, Issue 5, Page(s) 291–292

    MeSH term(s) Animals ; Brain ; Brain Injuries/etiology ; Enterocolitis, Necrotizing ; Humans ; Infant, Newborn ; Infant, Premature ; T-Lymphocytes
    Language English
    Publishing date 2021-02-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-021-00432-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6020: Show issues Location:
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    Zs.MG 97: Show issues

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  3. Article ; Online: The Role of Biomarkers in Suspected Neonatal Sepsis.

    Weitkamp, Jörn-Hendrik

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 2, Page(s) e391–e393

    MeSH term(s) Biomarkers ; C-Reactive Protein/analysis ; Humans ; Infant, Newborn ; Neonatal Sepsis/diagnosis ; Procalcitonin ; Sepsis/diagnosis
    Chemical Substances Biomarkers ; Procalcitonin ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 480: Show issues

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  4. Article ; Online: Procalcitonin versus C-reactive protein: review of kinetics and performance for diagnosis of neonatal sepsis.

    Eschborn, Samantha / Weitkamp, Joern-Hendrik

    Journal of perinatology : official journal of the California Perinatal Association

    2019  Volume 39, Issue 7, Page(s) 893–903

    Abstract: Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers, but their diagnostic advantage for neonatal early-onset (EOS) or late-onset (LOS) sepsis is controversial. In a comprehensive literature review we found significant ... ...

    Abstract Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers, but their diagnostic advantage for neonatal early-onset (EOS) or late-onset (LOS) sepsis is controversial. In a comprehensive literature review we found significant heterogeneity between studies in sample timing, cut-off values, consideration of blood culture results for sepsis classification, and definition of EOS versus LOS. We identified 39 studies directly comparing PCT with CRP, but only four in very low birth weight (VLBW) neonates. The mean sensitivity for EOS, LOS, and EOS + LOS was 73.6%, 88.9%, and 76.5% for PCT, compared to 65.6%, 77.4%, and 66.4% for CRP, respectively. Mean specificity of PCT and CRP was 82.8% versus 82.7% for EOS, 75.6% versus 81.7% for LOS, and 80.4% versus 91.3% for EOS + LOS. More studies directly comparing both biomarkers for EOS and LOS, especially in extremely and very-low-birth-weight infants, are needed to determine their clinical value for guidance of antibiotic therapy in neonatal sepsis.
    MeSH term(s) Bacteria/pathogenicity ; Biomarkers/blood ; C-Reactive Protein/analysis ; C-Reactive Protein/pharmacokinetics ; Humans ; Infant, Low Birth Weight/blood ; Infant, Newborn/blood ; Neonatal Sepsis/blood ; Neonatal Sepsis/diagnosis ; Procalcitonin/blood ; Procalcitonin/pharmacokinetics ; Severity of Illness Index ; Virulence
    Chemical Substances Biomarkers ; Procalcitonin ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2019-03-29
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-019-0363-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2412: Show issues Location:
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  5. Article ; Online: Effects of pasteurization on osteopontin concentrations in human breastmilk.

    McClanahan, Kathleen G / Reese, Jeff / Weitkamp, Jörn-Hendrik / Olivares-Villagómez, Danyvid

    Pediatric research

    2023  Volume 95, Issue 3, Page(s) 641–646

    Abstract: Background: Osteopontin (OPN) is an important breastmilk protein involved in infant intestinal, immunological, and brain development. However, little is known about how common milk pasteurization and storage techniques affect this important bioactive ... ...

    Abstract Background: Osteopontin (OPN) is an important breastmilk protein involved in infant intestinal, immunological, and brain development. However, little is known about how common milk pasteurization and storage techniques affect this important bioactive protein.
    Methods: Human milk osteopontin concentration was measured in single-donor fresh (n = 1) or frozen (n = 20) breastmilk, pooled Holder-pasteurized donor breastmilk (n = 11), and a shelf-stable (retort pasteurized) breastmilk product (n = 2) by ELISA. Single-donor breastmilk samples were subjected to pasteurization and/or freezing before measuring osteopontin concentrations.
    Results: Holder pasteurization of breastmilk resulted in an ∼50% decrease in osteopontin concentration within single-donor samples. Breastmilk from mothers of preterm infants trended toward higher osteopontin concentration than mothers of term infants; however, samples from preterm mothers experienced greater osteopontin degradation upon pasteurization. A commercial breastmilk product that underwent retort pasteurization had lower osteopontin concentration than a Holder-pasteurized pooled breastmilk product. Finally, freezing breastmilk prior to Holder pasteurization resulted in less osteopontin degradation than Holder pasteurization prior to freezing.
    Conclusions: Commonly used breastmilk pasteurization and storage techniques, including freezing and Holder pasteurization, decrease the concentration of the bioactive protein osteopontin in human breastmilk. Holder pasteurization reduced osteopontin concentration by an average of 63%, while freezing resulted in an 8-12% decrease.
    Impact: Pasteurization of human breastmilk significantly decreases the concentration of the bioactive protein osteopontin. Use of both pasteurization and freezing techniques for breastmilk preservation results in greater loss of osteopontin. This study presents for the first time an analysis of osteopontin concentrations in single-donor pasteurized milk samples.
    MeSH term(s) Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Milk, Human ; Osteopontin ; Pasteurization/methods
    Chemical Substances Osteopontin (106441-73-0)
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02838-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  6. Article ; Online: Case 3: Abdominal Distention in a Preterm Infant.

    Sanlorenzo, Lauren A / Grossarth, Sarah / Weitkamp, Joern-Hendrik

    NeoReviews

    2020  Volume 21, Issue 6, Page(s) e411–e413

    MeSH term(s) Abdomen/pathology ; Digestive System Abnormalities/diagnosis ; Diseases in Twins/diagnosis ; Female ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/diagnosis ; Infant, Premature ; Infant, Premature, Diseases/diagnosis
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Case Reports ; Journal Article ; Twin Study
    ISSN 1526-9906
    ISSN (online) 1526-9906
    DOI 10.1542/neo.21-6-e411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: More than a gut feeling: predicting surgical necrotising enterocolitis.

    Weitkamp, Jörn-Hendrik

    Gut

    2013  Volume 63, Issue 8, Page(s) 1205–1206

    MeSH term(s) Algorithms ; Biomarkers/urine ; Enterocolitis, Necrotizing/urine ; Female ; Fibrinogen/urine ; Humans ; Male ; Peptides/urine
    Chemical Substances Biomarkers ; Peptides ; Fibrinogen (9001-32-5)
    Language English
    Publishing date 2013-09-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2013-305928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 160: Show issues Location:
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  8. Article: Multidrug-Resistant Bacterial Infections Among Very Low Birthweight Infants With Late-Onset Sepsis in Johannesburg, South Africa.

    Licona, Genesis / Ballot, Daynia / Moon, Troy D / Banerjee, Ritu / Amorim, Gustavo / Agthe, Alexander G / Weitkamp, Jörn-Hendrik

    Open forum infectious diseases

    2023  Volume 10, Issue 8, Page(s) ofad362

    Abstract: Background: An estimated 2.4 million babies died within the first 28 days of life in 2020. The third leading cause of neonatal death continues to be neonatal sepsis. Sepsis-causing bacterial pathogens vary temporally and geographically and, with a rise ... ...

    Abstract Background: An estimated 2.4 million babies died within the first 28 days of life in 2020. The third leading cause of neonatal death continues to be neonatal sepsis. Sepsis-causing bacterial pathogens vary temporally and geographically and, with a rise in multidrug-resistant organisms (MDROs), pose a threat to the neonatal population.
    Methods: This was a single-center, retrospective study of very low birth weight (VLBW) infants with late-onset sepsis (LOS) admitted to a neonatal unit in South Africa. We aimed to calculate the prevalence of multidrug-resistant (MDR) infections in this population. The data collected included demographic and clinical characteristics, length of hospital stay, risk factors for MDRO and mortality, and microbiology results. Logistic regression was used to assess the association between prespecified risk factors with MDR infections and mortality.
    Results: Of 2570 VLBW infants admitted, 34% had LOS, of which 33% was caused by MDROs. Infection with
    Conclusions: More than one-third of LOS cases in VLBW infants were caused by MDROs in this study. MDR infections cause substantial neonatal mortality. Antimicrobial stewardship programs, infection control protocols, and ongoing surveillance are needed to prevent further emergence and spread of MDR infections worldwide.
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Why are preterm newborns at increased risk of infection?

    Collins, Amélie / Weitkamp, Jörn-Hendrik / Wynn, James L

    Archives of disease in childhood. Fetal and neonatal edition

    2018  Volume 103, Issue 4, Page(s) F391–F394

    Abstract: One in 10 newborns will be born before completion of 36 weeks' gestation (premature birth). Infection and sepsis in preterm infants remain a significant clinical problem that represents a substantial financial burden on the healthcare system. Many ... ...

    Abstract One in 10 newborns will be born before completion of 36 weeks' gestation (premature birth). Infection and sepsis in preterm infants remain a significant clinical problem that represents a substantial financial burden on the healthcare system. Many factors predispose premature infants for having the greatest risk of developing and succumbing to infection as compared with all other age groups across the age spectrum. It is clear that the immune system of preterm infants exhibits distinct, rather than simply deficient, function as compared with more mature and older humans and that the immune function in preterm infants contributes to infection risk. While no single review can cover all aspects of immune function in this population, we will discuss key aspects of preterm neonatal innate and adaptive immune function that place them at high risk for developing infections and sepsis, as well as sepsis-associated morbidity and mortality.
    MeSH term(s) Adaptive Immunity/physiology ; B-Lymphocytes/immunology ; Humans ; Immunity, Cellular/physiology ; Immunity, Innate/physiology ; Immunoglobulins/immunology ; Infant, Premature ; Infant, Premature, Diseases/immunology ; Infection/immunology ; Sepsis/immunology
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2018-01-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2017-313595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Innate and adaptive immunity in necrotizing enterocolitis.

    Mara, Madison A / Good, Misty / Weitkamp, Joern-Hendrik

    Seminars in fetal & neonatal medicine

    2018  Volume 23, Issue 6, Page(s) 394–399

    Abstract: Necrotizing enterocolitis (NEC) is the most frequent and devastating gastrointestinal disease of premature infants. Although the precise mechanisms are not fully understood, NEC is thought to develop following a combination of prematurity, formula ... ...

    Abstract Necrotizing enterocolitis (NEC) is the most frequent and devastating gastrointestinal disease of premature infants. Although the precise mechanisms are not fully understood, NEC is thought to develop following a combination of prematurity, formula feeding, and adverse microbial colonization. Within the last decade, studies increasingly support an important role of a heightened mucosal immune response initiating a pro-inflammatory signaling cascade, which can lead to the disruption of the intestinal epithelium and translocation of pathogenic species. In this review, we first describe the cellular composition of the intestinal epithelium and its critical role in maintaining epithelial integrity. We then discuss cell signaling during NEC, specifically, toll-like receptors and nucleotide oligomerization domain-like receptors. We further review cytokines and cellular components that characterize the innate and adaptive immune systems and how they interact to support or modulate NEC development.
    MeSH term(s) Adaptive Immunity/immunology ; Enterocolitis, Necrotizing/immunology ; Humans ; Immunity, Innate/immunology ; Infant, Newborn ; Infant, Premature ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Toll-Like Receptors/metabolism
    Chemical Substances Toll-Like Receptors
    Language English
    Publishing date 2018-08-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2018.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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