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Article ; Online: Biomechanical response of lower limb joints to lateral wedge insoles

Weijin Du / Yuan Guo / Chenyan Wang / Weiling Cui / Weiyi Chen / Xiaona Li

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 12

Abstract: Abstract Lateral wedge insole (LWI) is a frequently recommended treatment option for early and midterm stages of medial knee osteoarthritis. However, studies of its effects on the lower limb joints are incomplete and imperfect. The main purpose of this ... ...

Abstract	Abstract Lateral wedge insole (LWI) is a frequently recommended treatment option for early and midterm stages of medial knee osteoarthritis. However, studies of its effects on the lower limb joints are incomplete and imperfect. The main purpose of this study was to quantitatively analyze the response of intervention of LWI on lower-limb joint kinematics, ground reaction forces (GRFs), and centre of pressure (COP). Gait analysis of 16 healthy subjects was conducted. Three-dimensional motion data and force plate measurements were collected in the control (barefoot) and experimental conditions (wearing a pair of assigned shoes with 0, 7, and 10 mm LWIs). Results showed that the peak knee flexion angle was increased by 3.43°, 3.09°, and 3.27° with 0, 7, and 10 mm LWIs, respectively (p < 0.01). The ankle peak dorsiflexion angle was significantly decreased by 3.79°, 2.19°, and 1.66° with 0, 7, and 10 mm LWIs, respectively (p = 0.02). The internal rotation angle was increased by 2.78°, 3.76°, and 4.58° with 0, 7, and 10 mm LWIs, respectively (p < 0.01). The forefoot with LWIs showed highly significantly smaller inversion, eversion, and adduction angles (all p < 0.01). The 1st peak of the vertical GRF (p = 0.016) also increased significantly by a maximum of 0.06 body weight (BW) with LWIs. These results indicated that biomechanical changes and limitations of lateral wedges insole should be analyzed in more detail, possibly leading to new guidelines for the design and application.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The "Hand as Foot" teaching method in clinical education and doctor-patient communication for the tuberculum sellae.

Ruiyu, Xu / Wei, Zhou / Weiyi, Chen / Zhenzhu, Li

Asian journal of surgery

2022 Volume 46, Issue 6, Page(s) 2352–2353

MeSH term(s)	Humans ; Sella Turcica ; Neurosurgical Procedures ; Hand ; Upper Extremity ; Meningeal Neoplasms/surgery
Language	English
Publishing date	2022-12-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.12.010
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Article ; Online: Modelling Cell Origami via a Tensegrity Model of the Cytoskeleton in Adherent Cells

Lili Wang / Weiyi Chen

Applied Bionics and Biomechanics, Vol

2019 Volume 2019

Abstract: Cell origami has been widely used in the field of three-dimensional (3D) cell-populated microstructures due to their multiple advantages, including high biocompatibility, the lack of special requirements for substrate materials, and the lack of damage to ...

Abstract	Cell origami has been widely used in the field of three-dimensional (3D) cell-populated microstructures due to their multiple advantages, including high biocompatibility, the lack of special requirements for substrate materials, and the lack of damage to cells. A 3D finite element method (FEM) model of an adherent cell based on the tensegrity structure is constructed to describe cell origami by using the principle of the origami folding technique and cell traction forces. Adherent cell models contain a cytoskeleton (CSK), which is primarily composed of microtubules (MTs), microfilaments (MFs), intermediate filaments (IFs), and a nucleoskeleton (NSK), which is mainly made up of the nuclear lamina and chromatin. The microplate is assumed to be an isotropic linear-elastic solid material with a flexible joint that is connected to the cell tensegrity structure model by spring elements representing focal adhesion complexes (FACs). To investigate the effects of the degree of complexity of the tensegrity structure and NSK on the folding angle of the microplate, four models are established in the study. The results demonstrate that the inclusion of the NSK can increase the folding angle of the microplate, indicating that the cell is closer to its physiological environment, while increased complexity can reduce the folding angle of the microplate since the folding angle is depended on the cell types. The proposed adherent cell FEM models are validated by comparisons with reported results. These findings can provide theoretical guidance for the application of biotechnology and the analysis of 3D structures of cells and have profound implications for the self-assembly of cell-based microscale medical devices.
Keywords	Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Kinematic and Kinetic Responses of the Trunk and Lower Extremity Joints during Walking with and without the Spinal Orthosis

Chenyan Wang / Xiaona Li / Yuan Guo / Weijin Du / Hongmei Guo / Weiyi Chen

International Journal of Environmental Research and Public Health, Vol 19, Iss 6952, p

2022 Volume 6952

Abstract: Spinal orthoses are an effective option for restoring the spine to its original position and controlling poor posture. However, the effects of poor posture and spinal orthoses on the kinematics and kinetics of trunk and lower extremity joints remain ... ...

Abstract	Spinal orthoses are an effective option for restoring the spine to its original position and controlling poor posture. However, the effects of poor posture and spinal orthoses on the kinematics and kinetics of trunk and lower extremity joints remain unclear. A six-camera Vicon motion capture system and two AMTI force plates were employed to collect gait parameters, including joint angle (spine, thorax, hip, knee, and ankle), range of motion (ROM), and ground reaction forces (GRFs). Furthermore, joint moments and joint reaction forces (JRFs) were calculated using a full-body musculoskeletal model in OpenSim. One-way repeated-measures ANOVA ( p < 0.05) was used to compare significant differences among three trial conditions. These three conditions were walking in a normal posture, poor posture, and spinal orthosis. The results showed that spine ROM in the coronal and transverse plane was significantly lower when walking with a spinal orthosis compared to walking in normal and poor posture ( p < 0.05). Compared to normal posture, the lumbar moments and back compressive forces were significantly increased when walking in poor posture ( p < 0.05). However, when walking with a spinal orthosis, there was a significant decrease in trunk moments and reaction forces compared to walking in poor posture ( p < 0.05). Individuals with poor posture could potentially induce instability and disorders, as evidenced by an increase in trunk moments and JRF compared to the normal posture. Spinal orthosis not only restricts spine ROM but also reduces the load on the spine and thus increases balance and stability.
Keywords	gait ; poor posture ; spinal orthosis ; musculoskeletal modeling ; Medicine ; R
Subject code	629
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluating Short-Term and Long-Term Risks Associated with Renal Artery Stenosis Position and Severity

Yawei Zhao / Yike Shi / Yusheng Jin / Yifan Cao / Hui Song / Lingfeng Chen / Fen Li / Xiaona Li / Weiyi Chen

Bioengineering, Vol 10, Iss 1002, p

A Hemodynamic Study

2023 Volume 1002

Abstract: Background: Moderate renal artery stenosis (50–70%) may lead to uncontrolled hypertension and eventually cause irreversible damage to renal function. However, the clinical criteria for interventional treatment are still ambiguous in this condition. This ... ...

Abstract	Background: Moderate renal artery stenosis (50–70%) may lead to uncontrolled hypertension and eventually cause irreversible damage to renal function. However, the clinical criteria for interventional treatment are still ambiguous in this condition. This study investigated the impact of the position and degree of renal artery stenosis on hemodynamics near the renal artery to assess the short-term and long-term risks associated with this disease. Methods: Calculation models with different degrees of stenosis (50%, 60%, and 70%) located at different positions in the right renal artery were established based on the computed tomography angiography (CTA) of a personalized case. And computational fluid dynamics (CFD) was used to analyze hemodynamic surroundings near the renal artery. Results: As the degree of stenosis increases and the stenosis position is far away from the aorta, there is a decrease in renal perfusion. An analysis of the wall shear stress (WSS)-related parameters indicated areas near the renal artery (downstream of the stenosis and the entrance of the right renal artery) with potential long-term risks of thrombosis and inflammation. Conclusion: The position and degree of stenosis play a significant role in judging short-term risks associated with renal perfusion. Moreover, clinicians should consider not only short-term risks but also independent long-term risk factors, such as certain regions of 50% stenosis with adequate renal perfusion may necessitate prompt intervention.
Keywords	renal artery stenosis ; computational fluid dynamics ; hemodynamics ; renal perfusion ; Technology ; T ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response of membrane tension to gravity in an approximate cell model

Lili Wang / Weiyi Chen / Hongmei Guo / Airong Qian

Theoretical Biology and Medical Modelling, Vol 16, Iss 1, Pp 1-

2019 Volume 9

Abstract: Abstract Background Gravity, especially hypergravity, can affect the morphology of membranes, and further influence most biological processes. Since vesicle structures are relatively simple, the vesicle can be treated as a vital model to study the ... ...

Abstract	Abstract Background Gravity, especially hypergravity, can affect the morphology of membranes, and further influence most biological processes. Since vesicle structures are relatively simple, the vesicle can be treated as a vital model to study the mechanical properties of membranes in most cases. Basic research on membrane tension has become a vital research topic in cellular biomechanics. Methods In this study, a new vesicle model is proposed to quantitatively investigate the response of membrane tension to gravity. In the model, the aqueous lumen inside the vesicle is represented by water, and the vesicle membrane is simplified as a closed, thin, linear elastic shell. Then, the corresponding static equilibrium differential equations of membrane tension are established, and the analytical expression is obtained by the semi-inverse method. The model parameters of the equations are accurately obtained by fitting the reported data, and the values calculated by the model agree well with the reported results. Results The results are as follows: First, both the pseudo-ellipsoidal cap and the pseudo-spherical cap can be used to describe the deformed vesicle model; however, the former can better represent the deformation of the vesicle model because the variance of the pseudo-ellipsoidal cap is smaller. Second, the value of membrane tension is no longer a constant for both models. Interestingly, it varies with the vesicle height under the action of gravity. The closer it is to the substrate, the greater the membrane tension. Finally, the inclination between the tangent and the radial lines at a certain point is nearly proportional to the radius of the cross section in both models. Conclusion These findings may be helpful to study the vesicle model spreading more accurately by taking into account the influence of gravity because it could affect the distribution of membrane tension. Furthermore, it may also provide some guidance for cell spreading and may have some implications for membrane tension-related mechanobiology studies, especially in the hypergravity conditions.
Keywords	Gravity ; Equilibrium differential equation ; Membrane tension ; Pseudo-ellipsoidal cap ; Pseudo-spherical cap ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Finite Element Modelling of Single Cell Based on Atomic Force Microscope Indentation Method

Lili Wang / Li Wang / Limeng Xu / Weiyi Chen

Computational and Mathematical Methods in Medicine, Vol

2019 Volume 2019

Abstract: The stiffness of cells, especially cancer cells, is a key mechanical property that is closely associated with their biomechanical functions, such as the mechanotransduction and the metastasis mechanisms of cancer cells. In light of the low survival rate ... ...

Abstract	The stiffness of cells, especially cancer cells, is a key mechanical property that is closely associated with their biomechanical functions, such as the mechanotransduction and the metastasis mechanisms of cancer cells. In light of the low survival rate of single cells and measurement uncertainty, the finite element method (FEM) was used to quantify the deformations and predict the stiffness of single cells. To study the effect of the cell components on overall stiffness, two new FEM models were proposed based on the atomic force microscopy (AFM) indentation method. The geometric sizes of the FEM models were determined by AFM topography images, and the validity of the FEM models was verified by comparison with experimental data. The effect of the intermediate filaments (IFs) and material properties of the cellular continuum components on the overall stiffness were investigated. The experimental results showed that the stiffness of cancer cells has apparent positional differences. The FEM simulation results show that IFs contribute only slightly to the overall stiffness within 10% strain, although they can transfer forces directly from the membrane to the nucleus. The cytoskeleton (CSK) is the major mechanical component of a cell. Furthermore, parameter studies revealed that the material properties (thickness and elasticity) of the continuum have a significant influence on the overall cellular stiffness while Poisson’s ratio has less of an influence on the overall cellular stiffness. The proposed FEM models can determine the contribution of the major components of the cells to the overall cellular stiffness and provide insights for understanding the response of cells to the external mechanical stimuli and studying the corresponding mechanical mechanisms and cell biomechanics.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	621
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The relationship between phosphine, methane, and ozone over paddy field in Guangzhou, China

Jinling Ma / Weiyi Chen / Xiaojun Niu / Yimin Fan

Global Ecology and Conservation, Vol 17, Iss , Pp - (2019)

2019

Abstract: Greenhouse effect has been attracting more and more attention in the world. Carbon dioxide (CO2) and methane (CH4) are the most important greenhouse gases. Phosphine (PH3) may have a potential greenhouse effect because it can react with hydroxyl radicals ...

Abstract	Greenhouse effect has been attracting more and more attention in the world. Carbon dioxide (CO2) and methane (CH4) are the most important greenhouse gases. Phosphine (PH3) may have a potential greenhouse effect because it can react with hydroxyl radicals (·OH) in competition with other reducing gases. The aim of this study is to discover the relationship among PH3, ozone (O3) and CH4 in paddy fields and estimate the potential greenhouse effect of PH3 by field experiment. The results reveal that there was a significant negative correlation between O3 and PH3 (r = −0.494, p = 0.001, n = 42) during the whole period of rice growth. Similarly, CH4 was also negatively correlated with PH3, but not significant (r = −0.283, p = 0.069, n = 42). However, it was found that PH3 and CH4 corresponded to the reciprocal model. These results show that there was a certain competition relationship between PH3 and CH4. It was widely speculated that PH3 and CH4 were similar in the photochemical elimination process. ·OH could react with PH3, resulting in PH bond break. Then PH3 was oxidized to phosphate and other oxidation substances. Through Pearson correlation analysis and multiple stepwise linear regression analysis, light intensity was the principal factor affecting PH3 levels over the paddy field. The regression equation was [PH3] = -0.0003*[L] +20.025 (R2 = 0.243; F = 5.177; P < 0.01). These discoveries in this study have great reference values for the future investigation of greenhouse effect. Keywords: Phosphine, Methane, Ozone, Greenhouse effect, Paddy fields, Meteorological factor
Keywords	Ecology ; QH540-549.5
Subject code	571
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant

Xiangyu Zhang / Guannan Zhang / Maozhou Chai / Xiaohong Yao / Weiyi Chen / Paul K. Chu

Bioactive Materials, Vol 6, Iss 1, Pp 12-

2021 Volume 25

Abstract: Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of the implants. Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic ... ...

Abstract	Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of the implants. Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter. In this work, TiO2 nanorod arrays in combination with irradiation with 808 near-infrared (NIR) light are proven to eradicate single specie biofilms by combining photothermal therapy, photodynamic therapy, and physical killing of bacteria. The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species (ROS). Physiologically, the combined actions of hyperthermia, ROS, and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo. More importantly, bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time, the TiO2 nanorod arrays improve the new bone formation around implants. In this protocol, besides the biocompatible TiO2 nanorod arrays, an extra photosensitizer is not needed and no other ions would be released. Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation. The concept and antibacterial system described here have large clinical potential in orthopedic and dental applications.
Keywords	Titanium implants ; TiO2 nanorod ; Anti-biofilm ; Physical insertion ; Light-triggered therapy ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
Subject code	600
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex

Huanhuan Zhang / Yanqiu Li / Xiaoxin Zhang / Weiyi Chen / Qianhong Liang / Changchang Li / Luke D. Knibbs / Cunrui Huang / Qiong Wang

Ecotoxicology and Environmental Safety, Vol 233, Iss , Pp 113314- (2022)

2022

Abstract: Background: Maternal occupational exposure to endocrine disrupting chemicals (EDCs) may have adverse effect on birth outcomes. However, little is known about paternal EDCs exposure and the combined effect of parental exposure on birth outcomes. ... ...

Abstract	Background: Maternal occupational exposure to endocrine disrupting chemicals (EDCs) may have adverse effect on birth outcomes. However, little is known about paternal EDCs exposure and the combined effect of parental exposure on birth outcomes. Objectives: To assess the effects of both maternal and paternal occupational EDCs exposure on adverse birth outcomes, and further explore if multi-vitamins supplement and infant sex modify the association. Methods: We conducted a prospective cohort study of 5421 mother-father-newborn groups in Guangzhou, China. A questionnaire informed by a job exposure matrix (JEM) was applied to collect parental occupational EDCs exposure based on the type of work performed. We used logistic regression to estimate association between parental EDCs exposure and birth outcomes (including preterm birth (PTB), low birth weight (LBW), birth defects and congenital heart defects (CHD)). Stratified analyses and Cochran Q tests were performed to assess the modifying effect of maternal multi-vitamins supplement use and infant sex. Results: Compared with mothers unexposed, we found that mothers those exposed to EDCs were associated with increased odds of birth defects (aOR=1.70, 95% confidence interval (CI): 1.10–2.62), especially for those exposed for > 1.5 years (aOR= 3.00, 95% CIs: 1.78–5.03), or those with directly occupational exposed to EDCs (aOR= 2.94, 95% CIs: 1.72–5.04). Maternal exposure for > 1.5 years and direct exposure increased the risk of CHD, with aORs of 2.47 (1.21–5.02) and 2.79 (1.37–5.69), respectively. Stronger adverse effects were also observed when mothers and fathers were both exposed to EDCs. Paternal occupational EDCs exposure and exposure ≤ 1.5 years was associated with increased odds of LBW, with aORs of 2.14 (1.63–2.79) and 1.54 (1.10–2.15), respectively. When stratified by multi-vitamins supplement and infant sex, we observed slightly stronger effects for maternal exposure on birth defects/CHD as well as paternal EDCs exposure on PTB and LBW, among those ...
Keywords	Birth outcomes ; Endocrine disrupting chemicals ; Multi-vitamins ; Infant sex ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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