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  1. AU="Weiying, Lu"
  2. AU="Hiroki Ishikawa"
  3. AU=Fischer Lorenz
  4. AU="Hooberman, B H"
  5. AU="Vaid, Nidhi"
  6. AU="Xiao Han"
  7. AU="Stuart G. Tangye"
  8. AU="Yao-Zhong Zhao"
  9. AU="Chern, Chang-Ming"
  10. AU="Floeter, Jens"
  11. AU="Wijnen, Petal"
  12. AU="Saravanamuthu, Pira"
  13. AU="Kalpana Deepa Priya Dorayappan"
  14. AU="Xiao, Hongkui"
  15. AU="Lali, Arvind M"
  16. AU="Kim, Hyojeong"
  17. AU="Nasseri, Saeed"
  18. AU="Kluge"
  19. AU="Bierbaumer, Lisa"
  20. AU="Rashid, Muhammad"
  21. AU="Huang, Chiun-Sheng"
  22. AU="Shevchuk, O O"
  23. AU="Mulvihill, Emily"
  24. AU="Gandhi, Adarsh"
  25. AU="Zhao, Chuanrui"
  26. AU="Shelley Wiart"
  27. AU="Lydia E. Wroblewski" AU="Lydia E. Wroblewski"
  28. AU="Paterson, Ross"
  29. AU="Alexander Marx"
  30. AU="Robinson, Jill"
  31. AU="Mitchell, Adam W M"
  32. AU="Ingham, Jesse R"

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  1. Artikel ; Online: Characterizing Variances of Adulterated Extra Virgin Olive Oils by UV-Vis Spectroscopy Combined with Analysis of Variance-Projected Difference Resolution (ANOVA-PDR) and Multivariate Classification

    Boyan Gao / Jingyao Zhang / Weiying Lu

    Applied Sciences, Vol 13, Iss 4360, p

    2023  Band 4360

    Abstract: The analysis of variance-projected difference resolution (ANOVA-PDR) was proposed and compared with multivariate classification for its potential in detecting possible food adulteration in extra virgin olive oils (EVOOs) by UV-Vis spectra. Three factors ... ...

    Abstract The analysis of variance-projected difference resolution (ANOVA-PDR) was proposed and compared with multivariate classification for its potential in detecting possible food adulteration in extra virgin olive oils (EVOOs) by UV-Vis spectra. Three factors including origin, adulteration level, and adulteration type were systematically examined by the ANOVA-derived methods. The ANOVA-PDR quantitatively presented the separation of the internal classes according to the three main factors. Specifically, the average ANOVA-derived PDRs of the EVOO origination and adulteration level, respectively, is 4.01 and 1.78, while the conventional PDRs of the three factors are all less than 1.5. Furthermore, the partial least-squares-discriminant analysis (PLS-DA) and the PLS regression (PLSR) modeling with the selected sub-datasets from different origins were used to verify the results. The resulting models suggested that the three main factors and their interactions were all important sources of spectral variations.
    Schlagwörter ANOVA-PDR ; extra virgin olive oil adulteration ; UV-Vis spectroscopy ; partial least-squares ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 519
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Pressure injury prevalence and characteristics in patients with COVID-19 admitted to acute inpatient rehabilitation unit

    Weiying Lu / Ona Bloom / Melissa Rathgeber / Susan Maltser

    Frontiers in Rehabilitation Sciences, Vol

    2023  Band 4

    Abstract: ObjectiveTo investigate the incidence and severity of pressure injuries among COVID-19 patients who required acute hospitalization and subsequent acute inpatient rehabilitation (AIR).DesignData was collected retrospectively from medical charts of COVID- ... ...

    Abstract ObjectiveTo investigate the incidence and severity of pressure injuries among COVID-19 patients who required acute hospitalization and subsequent acute inpatient rehabilitation (AIR).DesignData was collected retrospectively from medical charts of COVID-19 patients who were admitted to AIR during April 2020–April 2021.SettingAcute Inpatient Rehabilitation at a single hospital in the greater New York metropolitan area.ParticipantsSubjects included COVID-19 patients (N = 120) who required acute hospitalization and subsequent acute inpatient rehabilitation, of whom 39 (32.5%) had pressure injuries.InterventionsNot applicable.Main outcome measure(s)The incidence, location, and severity of pressure injuries in COVID-19 patients, as well as demographic and clinical characteristics of the acute hospitalization.ResultsAmong patients who developed pressure injuries, more patients received mechanical ventilation (59% vs. 33%, P < 0.05) and tracheostomy (67% vs. 17%, P < 0.00001). The lengths of stay were longer in both the intensive care unit (ICU) (34 vs. 15 days, P < 0.005), and in acute inpatient rehabilitation (22 vs. 17 days P < 0.05).ConclusionPressure injuries were more common in COVID-19 patients who had longer lengths of stay, received mechanical ventilation or tracheostomy, during acute hospitalization. This supports the use of protocols to prioritize pressure offloading in this patient population.
    Schlagwörter COVID-19 ; pressure injury ; rehabilitation coronavirus 2 (SARS-CoV-2) ; acute rehabilitation humans ; quality improvement-outcomes ; Other systems of medicine ; RZ201-999 ; Medical technology ; R855-855.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Mendelian randomization investigation identified the causal relationship between body fat indexes and the risk of bladder cancer

    Bangbei Wan / Ning Ma / Weiying Lu

    PeerJ, Vol 11, p e

    2023  Band 14739

    Abstract: Background Observational studies have suggested that obesity is associated with the risk of bladder cancer (BCa). However, their causal relationship remains unclear. This study aimed to prove the causal relationship between obesity and the risk of BCa by ...

    Abstract Background Observational studies have suggested that obesity is associated with the risk of bladder cancer (BCa). However, their causal relationship remains unclear. This study aimed to prove the causal relationship between obesity and the risk of BCa by using Mendelian randomization. Methods Single-nucleotide polymorphisms (SNPs) correlated with body fat indexes were screened from several genome-wide association studies (GWAS) with more than 300,000 individuals. Summary-level genetic data of BCa-related GWAS were obtained from a European cohort with a sample size of 218,792. An inverse-variance-weighted (IVW) method was used as the major MR analysis. The MR-Egger regression, IVW regression, leave-one-out test, and MR-Pleiotropy Residual Sum and Outlier methods were used to test the reliability and stability of MR results. Results Genetically predicted per 1-SD increase in body fat indexes (whole body fat mass, and the right leg, left leg, right arm, left arm, and trunk fat mass) were associated with increased BCa risk with values of 51.8%, 77.9%, 75.1%, 67.2%, 59.7%, and 36.6%, respectively. Sensitivity analyses suggested that the genetically determined risk effect of obesity on BCa was stable and reliable. Conclusions Our study provided powerful evidence to support the causal hypothesis that the genetically predicted high body fat mass was associated with a risk increase for BCa. The finding is a new idea for drawing up prevention strategies for BCa.
    Schlagwörter Bladder cancer ; Body fat mass ; Mendelian randomization ; Genome-wide association study ; Single-nucleotide polymorphisms ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Evaluating the causal relationship between five modifiable factors and the risk of spinal stenosis

    Bangbei Wan / Ning Ma / Weiying Lu

    PeerJ, Vol 11, p e

    a multivariable Mendelian randomization analysis

    2023  Band 15087

    Abstract: Background Spinal stenosis is a neurological disorder related to the compression of the spinal cord or nerve roots, and its incidence increases yearly. We aimed to use Mendelian randomization (MR) to investigate the causal relationship between several ... ...

    Abstract Background Spinal stenosis is a neurological disorder related to the compression of the spinal cord or nerve roots, and its incidence increases yearly. We aimed to use Mendelian randomization (MR) to investigate the causal relationship between several modifiable risk factors and the risk of spinal stenosis. Methods We obtained genome-wide association study summary data of large-sample projects (more than 100,000 individuals) from public databases. The data were associated with traits, including years of schooling (educational attainment) from the IEU OpenGWAS Project, smoking behavior (never vs. initiation) from the IEU OpenGWAS Project, body mass index (BMI) from the UK Biobank, length of mobile phone use from the UK Biobank, time spent watching television (TV) from the UK Biobank, and spinal stenosis from FinnGen biobank. Spinal stenosis was used as the outcome, whereas the other four traits were used as exposures. Inverse variance weighted (IVW) regressions were used as a primary to estimate the causal-effect size. Several sensitive analyses (including consistency, heterogenicity, and pleiotropy analyses) were conducted to test the stability and reliability of causal estimates. Results Univariable MR analyses showed that genetically predicted higher educational attainment (IVW; odds ratio (OR) = 0.606; 95% confidence interval (CI): 0.507–0.724; P = 3.37 × 10−8) and never smoking (IVW; OR = 1.388; 95% CI [1.135–1.697]; P = 0.001) were negatively correlated with the risk of spinal stenosis. Meanwhile, a higher BMI (IVW; OR = 1.569; 95% CI [1.403–1.754]; P = 2.35 × 10−8), longer time spent using a mobile phone (IVW; OR = 1.895; 95% CI [1.306–2.750]; P = 0.001), and watching TV (IVW; OR = 1.776; 95% CI [1.245–2.532]; P = 0.002) were positively associated with the risk of spinal stenosis. Multivariable MR analysis indicated that educational attainment (IVW; OR = 0.670; 95% CI [0.465–0.967]; P = 0.032) and BMI (IVW; OR = 1.365; 95% CI [1.179–1.580]; P = 3.12 × 10−5) were independently causally related to the risk ...
    Schlagwörter Spinal stenosis ; Educational attainment ; Mendelian randomization ; Genome-wide association study ; Causal investigation ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Gut fungi differentially response to the antipyretic (heat-clearing) and diaphoretic (exterior-releasing) traditional Chinese medicines in Coptis chinensis-conditioned gut microbiota

    Yanan Yang / Weiying Lu / Xiaopo Zhang / Chongming Wu

    Frontiers in Pharmacology, Vol

    2022  Band 13

    Abstract: Antipyretic (heat-clearing) and diaphoretic (exterior-releasing) drugs are two main groups of traditional Chinese medicines (TCMs) possessing anti-microbes and anti-inflammation effects, with the former mainly through clearing pyrogens while the latter ... ...

    Abstract Antipyretic (heat-clearing) and diaphoretic (exterior-releasing) drugs are two main groups of traditional Chinese medicines (TCMs) possessing anti-microbes and anti-inflammation effects, with the former mainly through clearing pyrogens while the latter through promoting diaphoresis. Although anti-microorganism is a common action of these two kinds of TCMs, their difference in antimicrobial spectrums and their interactions when combinedly used remain unclear. Herein, we prepared aqueous extracts from Coptis chinensis (HL) and other antipyretic or diaphoretic TCMs, orally administrated them to C57BL/6 mice at a clinical dose for fourteen days, and analyzed their impaction on both gut bacteria and fungi using full-length 16 S rRNA gene sequencing and internal transcribed spacer 1/2 (ITS1/2) gene sequencing, respectively. Oral administration of HL significantly changed the structure of gut bacteria but showed little influence on gut fungi. Co-treatment with antipyretic or diaphoretic TCMs alleviated the impact of HL on gut bacteria to a similar degree. However, combined with either heat-clearing or exterior-releasing TCMs significantly strengthened the influence of HL on gut fungi, with the latter superior to the former. The antipyretic TCMs enriched Penicillium spp. while diaphoretic TCMs promoted Fusarium spp. Further analysis revealed that the diaphoretic TCMs-enriched fungi Fusarium spp. were positively related to Akkermansia spp., a beneficial bacterium that interacts with Toll-like receptor 4 (TLR4) and regulates thermogenesis, thus providing a potential linkage with their pro-diaphoresis effect. Together, our results reveal that gut fungi differentially respond to the impact of heat-clearing and exterior-releasing TCMs on Coptis chinensis-conditioned gut microbiota, which provides insights into their functional characteristics.
    Schlagwörter gut fungi ; gut bacteria ; traditional Chinese medicine (TCM) ; antipyretic (heat-clearing) drugs ; diaphoretic (exterior-releasing) drugs ; gut microbiome ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: The long non-coding RNA BBOX1 antisense RNA 1 is upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian granulose cells

    Zhi Zhou / Yong Zhang / Can Tan / Juan Zhang / Guohui Yi / Bangbei Wang / Yejuan Li / Hui Lu / Weiying Lu / Xiaopo Zhang

    BMC Women's Health, Vol 23, Iss 1, Pp 1-

    2023  Band 8

    Abstract: Abstract Background MicroRNA-19b (miR-19b) has been reported to be downregulated in polycystic ovary syndrome (PCOS), while its upstream regulators are unclear. We speculated that miR-19b could potentially form a binding relationship with BBOX1 antisense ...

    Abstract Abstract Background MicroRNA-19b (miR-19b) has been reported to be downregulated in polycystic ovary syndrome (PCOS), while its upstream regulators are unclear. We speculated that miR-19b could potentially form a binding relationship with BBOX1 antisense RNA 1 (BBOX1-AS1), a long non-coding RNA recognized for its critical role in ovarian cancer. Subsequently, we investigated into their interaction in PCOS. Methods The expression of miR-19b and BBOX1-AS1 in follicular fluid from both control women (n = 80) and women with PCOS (n = 80) was detected by RT-qPCR. Correlations were analyzed with Pearson’ correlation coefficient. The binding of miR-19b to the wild-type (-wt) ad mutant (-mut) BBOX1-AS1 was determined by RNA-RNA pulldown assay. Their interactions were detected by overexpression assay. Bromodeoxyuridine (BrdU) assay was applied for proliferation analysis. Results BBOX1-AS1 was highly upregulated, while miR-19b was downregulated in PCOS. There was no close correlation across PCOS and the control samples. Consistently, they did not regulate the expression of each other in granulosa cells. However, BBOX1-AS1-wt, but not BBOX1-AS1-mut, could directly interact with miR-19b. BBOX1-AS1 suppressed the role of miR-19b in inhibiting granulosa cell proliferation. Conclusion BBOX1-AS1 is highly upregulated in PCOS, and it may serve as an endogenous competing RNA for miR-19b to suppress its role in inhibiting granulosa cell proliferation. Our study suggested the role of BBOX1-AS1 as a potential target to treat PCOS.
    Schlagwörter Polycystic ovary syndrome ; miR-19b ; BBOX1-AS1 ; Granulosa cell proliferation ; Gynecology and obstetrics ; RG1-991 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Differential Response of Mycosis Fungoides Cells to Vorinostat

    Zachary A. Bordeaux / Sriya V. Reddy / Kevin Lee / Weiying Lu / Justin Choi / Meghan Miller / Callie Roberts / Anthony Pollizzi / Shawn G. Kwatra / Madan M. Kwatra

    International Journal of Molecular Sciences, Vol 24, Iss 8075, p

    2023  Band 8075

    Abstract: Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL) and is characterized by epidermotrophism of malignant CD4+ T-lymphocytes. When MF advances to a recurrent stage, patients require treatment with systemic therapies such as ...

    Abstract Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL) and is characterized by epidermotrophism of malignant CD4+ T-lymphocytes. When MF advances to a recurrent stage, patients require treatment with systemic therapies such as vorinostat, a histone deacetylase inhibitor. While vorinostat has been shown to exhibit anti-tumor activity in MF, its exact molecular mechanism has yet to be fully discerned. In the present study, we examined the transcriptomic and proteomic profiles of vorinostat treatment in two MF cell lines, Myla 2059 and HH. We find that vorinostat downregulates CTLA-4, CXCR4, and CCR7 in both cell lines, but its effect on several key pathways differs between the two MF cell lines. For example, vorinostat upregulates CCL5, CCR5, and CXCL10 expression in Myla cells but downregulates CCL5 and CXCL10 expression in HH cells. Furthermore, vorinostat upregulates IFN-γ and IL-23 signaling and downregulates IL-6, IL-7, and IL-15 signaling in Myla cells but does not affect these pathways in HH cells. Although Myla and HH represent established MF cell lines, their distinct tumor origin from separate patients demonstrates that inherent phenotypic variations within the disease persist, underscoring the importance of using a variety of MF cells in the preclinical development of MF therapeutics.
    Schlagwörter mycosis fungoides (MF) ; cutaneous T-cell lymphoma (CTCL) ; histone deacetylase inhibitor ; vorinostat ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Laurolitsine ameliorates type 2 diabetes by regulating the hepatic LKB1-AMPK pathway and gut microbiota

    Yong, Zhang / ruiqi, Wang / Yanan, Yang / ning, Ma / Zhi, Zhou / Yinfeng, Tan / Lin, Dong / Yiying, Li / Weiying, Lu / Chongming, Wu / Xiaopo, Zhang

    Phytomedicine. 2022 Nov., v. 106

    2022  

    Abstract: Type 2 diabetes mellitus (DM) is a highly prevalent chronic metabolic disease. Effective antidiabetic drugs are needed to improve and expand the available treatments. Using the ob/ob diabetic mouse model, we previously demonstrated that the alkaloid-rich ...

    Abstract Type 2 diabetes mellitus (DM) is a highly prevalent chronic metabolic disease. Effective antidiabetic drugs are needed to improve and expand the available treatments. Using the ob/ob diabetic mouse model, we previously demonstrated that the alkaloid-rich extract from Litsea glutinosa bark (CG) has potent antidiabetic effects and that laurolitsine (LL) is the richest alkaloid in CG. We conducted a systematic investigation of the antidiabetic effects and potential mechanisms of LL in vitro and in vivo. The antidiabetic effects of LL and its mechanisms of action were explored in HL-7702 hepatocytes in vitro and in db/db mice in vivo by a series of experiments, including cellular toxicity analysis, glucose consumption analysis, serum/liver biochemical analysis, pathological examinations, Western blots, RNA-seq analysis, and gut microbiota analysis. LL stimulated glucose consumption and activated AMP-activated protein kinase (AMPK) without inducing lactic acid production or cytotoxicity in vitro. LL had potent antidiabetic effects with hypoglycemic activity in vivo. It improved insulin resistance, glucose tolerance and lipid metabolism; protected liver, renal and pancreatic functions; and promoted weight loss in db/db mice. Transcriptomic analysis suggested that the antidiabetic effects of LL involved the regulation of mitochondrial oxidative phosphorylation. We further demonstrated that LL effectively activated the hepatic liver kinase B1 (LKB1)/AMPK pathway by regulating the ADP/ATP ratio. Simultaneously, LL significantly modulated the gut microbial community, specifically decreasing the abundances of Mucispirillum schaedleri and Anaerotruncus_sp_G3_2012, which might also contribute to its antidiabetic effects. These results suggest that LL is a promising antidiabetic drug candidate that may improve glucolipid metabolism via modulation of the hepatic LKB1/AMPK pathway and the gut microbiota.
    Schlagwörter AMP-activated protein kinase ; Litsea ; Mucispirillum ; alkaloids ; bark ; blood serum ; cytotoxicity ; glucose ; glucose tolerance ; glycemic effect ; hepatocytes ; hypoglycemic agents ; insulin resistance ; intestinal microorganisms ; lactic acid ; lipid metabolism ; liver ; mice ; microbial communities ; mitochondria ; models ; noninsulin-dependent diabetes mellitus ; oxidative phosphorylation ; sequence analysis ; transcriptomics ; weight loss
    Sprache Englisch
    Erscheinungsverlauf 2022-11
    Erscheinungsort Elsevier GmbH
    Dokumenttyp Artikel
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154423
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel: Authenticating Raw from Reconstituted Milk Using Fourier Transform Infrared Spectroscopy and Chemometrics

    Du, Lijuan / Weiying Lu / Boyan Gao / Jing Wang / Liangli (Lucy) Yu

    Journal of food quality. 2019 Mar. 24, v. 2019

    2019  

    Abstract: Fourier transform infrared (FTIR) spectroscopy combined with chemometrics was used to authenticate raw milk from their reconstituted counterparts. First, the explanatory principal component analysis (PCA) was employed to visualize the relationship ... ...

    Abstract Fourier transform infrared (FTIR) spectroscopy combined with chemometrics was used to authenticate raw milk from their reconstituted counterparts. First, the explanatory principal component analysis (PCA) was employed to visualize the relationship between raw and reconstituted milk samples. However, the degree of separation between two sample classes was not significant according to direct observation of the scores plot, indicating FTIR spectra may contain complicated chemical information. Second, partial least-squares-discriminant analysis (PLS-DA) that incorporate additional class membership information as modelling input was further calculated. The PLS-DA scores yielded clear separation between two classes of samples. Additionally, possible components from the model loading were studied, and the PLS-DA model was validated internally under the model population analysis framework, as well as externally using an independent test set. This study gave insights into the authentication of milk using FTIR spectroscopy with chemometrics techniques.
    Schlagwörter Fourier transform infrared spectroscopy ; chemometrics ; milk ; model validation ; models ; principal component analysis ; raw milk ; reconstituted milk
    Sprache Englisch
    Erscheinungsverlauf 2019-0324
    Umfang p. .
    Erscheinungsort Hindawi
    Dokumenttyp Artikel
    ZDB-ID 2175284-9
    ISSN 1745-4557 ; 0146-9428
    ISSN (online) 1745-4557
    ISSN 0146-9428
    DOI 10.1155/2019/5487890
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel: Nootkatone, a Sesquiterpene Ketone From

    Yong, Zhang / Zibao, Huang / Zhi, Zhou / Ning, Ma / Ruiqi, Wang / Mimi, Chen / Xiaowen, He / Lin, Dong / Zhixuan, Xia / Qiang, Liu / Weiying, Lu / Xiaopo, Zhang

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 909280

    Abstract: Metabolic-associated fatty liver disease (MAFLD) is becoming more common due to lifestyle changes. A long-term high-fat and high-glucose diet induces glycolipid metabolism disorders in the liver, which results in the development of MAFLD. To date, there ... ...

    Abstract Metabolic-associated fatty liver disease (MAFLD) is becoming more common due to lifestyle changes. A long-term high-fat and high-glucose diet induces glycolipid metabolism disorders in the liver, which results in the development of MAFLD. To date, there is no specific clinically useful therapeutics for this disease. Natural products or synthetic compounds were screened and investigated to find effective agents for treating MAFLD. In this study, nootkatone (Nok), a natural sesquiterpene ketone isolated from
    Sprache Englisch
    Erscheinungsdatum 2022-07-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.909280
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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