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  1. Article ; Online: Transcriptomic signatures have a place in short-term prediction of incident tuberculosis.

    Wejse, Christian

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 3, Page(s) 299–300

    MeSH term(s) Biomarkers ; Computational Biology ; Humans ; Mycobacterium tuberculosis/genetics ; Transcriptome ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30980-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  2. Article ; Online: Stool testing for pulmonary TB diagnosis in adults.

    Laursen, L L / Dahl, V N / Wejse, C

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2022  Volume 26, Issue 6, Page(s) 516–523

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Adult ; Feces/microbiology ; Humans ; Mycobacterium tuberculosis/genetics ; Nucleic Acid Amplification Techniques/methods ; Sputum/microbiology ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/microbiology
    Language English
    Publishing date 2022-06-01
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.21.0305
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    Zs.A 4776: Show issues Location:
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    Zs.MO 261: Show issues

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  3. Article ; Online: Xpert MTB/RIF is cost-effective, but less so than expected.

    Wejse, Christian

    The Lancet. Global health

    2019  Volume 7, Issue 6, Page(s) e692–e693

    MeSH term(s) Cost-Benefit Analysis ; Humans ; Microscopy ; Mycobacterium tuberculosis ; Point-of-Care Systems ; Primary Health Care ; Tuberculosis
    Language English
    Publishing date 2019-05-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(19)30159-7
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  4. Article ; Online: Infectious purpura fulminans associated with pneumococcal septicaemia in a patient with unacknowledged functional asplenia.

    Duus, Savannah / Jespersen, Sanne / Wejse, Christian

    BMJ case reports

    2024  Volume 17, Issue 3

    Abstract: Purpura fulminans (PF) is a life-threatening complication of septic shock that can occur due to disseminated infections ... ...

    Abstract Purpura fulminans (PF) is a life-threatening complication of septic shock that can occur due to disseminated infections with
    MeSH term(s) Female ; Humans ; Purpura Fulminans/diagnosis ; Shock, Septic/complications ; Pneumococcal Infections/microbiology ; Streptococcus pneumoniae ; Sepsis/complications ; Bacteremia/complications ; Splenic Diseases/complications
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-251397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Historical review of studies on the effect of treating latent tuberculosis.

    Mølhave, M / Wejse, C

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 92S, Page(s) S31–S36

    Abstract: Tuberculosis Preventive Therapy (TPT) is widely used in particular among high-risk populations such as close contacts and immunosuppressed people mostly in high-income settings. TPT is widely recommended for high-risk populations including HIV-infected ... ...

    Abstract Tuberculosis Preventive Therapy (TPT) is widely used in particular among high-risk populations such as close contacts and immunosuppressed people mostly in high-income settings. TPT is widely recommended for high-risk populations including HIV-infected and household contacts globally, but is not widely used. Historical trials on risk groups as well as the general population have documented a marked effect on reductions in incidence of active disease among those treated, as well as on prevalence of latent TB infection (LTBI) in populations where massive roll-out of TPT has previously taken place. This review summarizes the results of large historical trials conducted more than 50 years ago among Inuit and African populations as well as risk groups in the USA and Europe exhibiting similarities with current high-burden populations with current limited use of TPT. The trials demonstrated a 27-95% reduction in incidence of active TB among those receiving preventive treatment compared with placebo, with efficacy depending somewhat on length of treatment but mostly on adherence rates. It was possible to achieve satisfactory adherence rates in most of the trial populations and liver toxicity rates were generally low. The historical trials on preventive treatment for LTBI have documented that large-scale TPT is possible and effective even in high-burden populations in high-incidence areas and is therefore a relevant tool to consider in striving to eliminate the TB epidemic.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Coinfection/history ; Europe ; Female ; HIV Infections/complications ; HIV Infections/history ; History, 20th Century ; Humans ; Incidence ; Latent Tuberculosis/epidemiology ; Latent Tuberculosis/history ; Latent Tuberculosis/prevention & control ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Young Adult
    Language English
    Publishing date 2020-03-18
    Publishing country Canada
    Document type Historical Article ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.03.011
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    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Medical treatment for urogenital tuberculosis (UGTB).

    Wejse, Christian

    GMS infectious diseases

    2018  Volume 6, Page(s) Doc04

    Abstract: Urogenital tuberculosis (UGTB) should in general be treated as pulmonary TB with a four-drug regimen of Isoniazid, Rifampicin, Ethambutol and Pyrazinamide for a total of 6 months, Ethambutol and Pyrazinamide only the first two months. Some patients may ... ...

    Abstract Urogenital tuberculosis (UGTB) should in general be treated as pulmonary TB with a four-drug regimen of Isoniazid, Rifampicin, Ethambutol and Pyrazinamide for a total of 6 months, Ethambutol and Pyrazinamide only the first two months. Some patients may need longer treatment (cavitary disease, kidney abscess/malfunction, HIV co-infection). Treatment of multi-drug resistant tuberculosis (MDR-TB) requires use of long-term intravenous treatment with aminoglycosides and other drugs with considerable toxicity for 18-24 months. Complications such as urinary tract obstruction may occur and should be treated with corticosteroids or surgery.
    Language English
    Publishing date 2018-08-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2725110-X
    ISSN 2195-8831 ; 2195-8831
    ISSN (online) 2195-8831
    ISSN 2195-8831
    DOI 10.3205/id000039
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  7. Article ; Online: Does vitamin D and phenylbutyrate have impact on the course of tuberculosis?

    Wejse, Christian

    Journal of internal medicine

    2018  Volume 284, Issue 3, Page(s) 318–320

    MeSH term(s) Cholecalciferol ; Ethiopia ; Humans ; Phenylbutyrates ; Tuberculosis ; Tuberculosis, Pulmonary ; Vitamin D
    Chemical Substances Phenylbutyrates ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2018-07-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.12784
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    Ua VI Zs.44: Show issues Location:
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  8. Article ; Online: Population attributable fraction for undernutrition due to TB does not take account of bidirectional causality.

    Patsche, C B / Sifna, A / Wejse, C

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2021  Volume 25, Issue 9, Page(s) 763–765

    MeSH term(s) Humans ; Causality ; Malnutrition/epidemiology ; Tuberculosis/epidemiology
    Language English
    Publishing date 2021-11-20
    Publishing country France
    Document type Letter
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.21.0073
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4776: Show issues Location:
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    Zs.MO 261: Show issues

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  9. Article ; Online: High coverage of polio immunization program in refugees resettling in Denmark. A cross-sectional study of polio serology in newly arrived refugees.

    Hvass, A M F / Wejse, C

    Expert review of vaccines

    2019  Volume 18, Issue 12, Page(s) 1317–1322

    Abstract: ... ...

    Abstract Objectives
    MeSH term(s) Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Child ; Child, Preschool ; Cross-Sectional Studies ; Denmark ; Emigrants and Immigrants ; Female ; Humans ; Infant ; Male ; Middle Aged ; Poliomyelitis/prevention & control ; Poliovirus/immunology ; Poliovirus Vaccines/administration & dosage ; Poliovirus Vaccines/immunology ; Refugees ; Seroepidemiologic Studies ; Young Adult
    Chemical Substances Antibodies, Viral ; Poliovirus Vaccines
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2019.1698953
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    Zs.A 6077: Show issues Location:
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  10. Article ; Online: Clinical presentations and outcomes of HIV-1 and HIV-2 among infected children in Guinea-Bissau: a nationwide study.

    Dutschke, A / Jensen, M M / Nanque, J P / Medina, C / Sanha, F C / Holm, M / Wejse, C / Jespersen, S / Hønge, B L

    Public health

    2024  Volume 230, Page(s) 38–44

    Abstract: Objectives: Disease progression, loss to follow-up, and mortality of HIV-2 compared with HIV-1 in children is not well understood. This is the first nationwide study reporting outcomes in children with the two HIV types in Guinea-Bissau.: Study design! ...

    Abstract Objectives: Disease progression, loss to follow-up, and mortality of HIV-2 compared with HIV-1 in children is not well understood. This is the first nationwide study reporting outcomes in children with the two HIV types in Guinea-Bissau.
    Study design: Nationwide retrospective follow-up study.
    Methods: This is a retrospective follow-up study among HIV-infected children <15 years at nine ART centers from 2006 to 2021. Baseline parameters and disease outcomes for children with HIV-2 and HIV-1 were compared.
    Results: The annual number of children diagnosed with HIV peaked in 2017. HIV-2 (n = 64) and HIV-1 (n = 1945) infected children were different concerning baseline median age (6.5 vs 3.1 years, P < 0.01), but had similar levels of severe immunodeficiency (P = 0.58) and severe anemia (P = 0.26). Within the first year of follow-up, 36.3% were lost, 5.9% died, 2.7% had transferred clinic, and 55.2% remained for follow-up. Mortality (HR = 1.05 95% CI: 0.53-2.08 for HIV-2) and attrition (HR = 0.86 95% CI: 0.62-1.19 for HIV-2) rates were similar for HIV types.
    Conclusions: The decline in children diagnosed per year since 2017 is possibly due to lower HIV prevalence, lack of HIV tests, and the SARS-CoV-2 epidemic. Children with HIV-2 were twice as old as HIV-1 infected when diagnosed, which suggests a slower disease progression. However, once they develop immunosuppression mortality is similar.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Follow-Up Studies ; HIV-1 ; Retrospective Studies ; HIV Infections/epidemiology ; HIV-2 ; Guinea-Bissau/epidemiology ; HIV Seropositivity ; Disease Progression
    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2024.02.008
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