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  1. Book ; Online ; E-Book: Radiation therapy for sarcomas and skin cancers

    Kim, Edward / Parvathaneni, Upendra / Welliver, Meng Xu

    a practical guide on treatment techniques

    (Practical guides in radiation oncology)

    2022  

    Abstract: This practical guide to the use of radiotherapy for the treatment of sarcomas and skin cancers covers a wide range of disease scenarios, identifying which treatment techniques are applicable in particular clinical circumstances. Among the conditions ... ...

    Author's details Edward Kim, Upendra Parvathaneni, Meng Xu Welliver editors
    Series title Practical guides in radiation oncology
    Abstract This practical guide to the use of radiotherapy for the treatment of sarcomas and skin cancers covers a wide range of disease scenarios, identifying which treatment techniques are applicable in particular clinical circumstances. Among the conditions considered are extremity soft tissue sarcomas, retroperitoneal soft tissue sarcomas, bone sarcomas, uterine sarcomas, chordomas, pediatric sarcomas, squamous cell carcinomas, basal cell carcinomas, melanomas, Merkel cell carcinomas, and cutaneous lymphomas. Detailed attention is devoted to the issues and considerations of relevance in everyday practice when treating these diseases. The use of multiple radiotherapy techniques and procedures, including IMRT, brachytherapy, radiosurgery, and particle therapy, is fully explained, and the role of radiotherapy in combination with chemotherapy and emerging therapeutics such as immunotherapy and biologic anticancer agents is also addressed. The book will be of high value for practicing radiation oncologists, medical and surgical oncologists, medical physicists, medical dosimetrists, trainees, and other medical professionals.
    Keywords Medical radiology ; Oncology ; Radiology ; Internal medicine ; Dermatology
    Language English
    Size 1 Online-Ressource (vi, 380 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021584972
    ISBN 978-3-031-06706-8 ; 9783031067051 ; 3-031-06706-1 ; 3031067053
    DOI 10.1007/978-3-031-06706-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Improving intra-fractional target position accuracy using a 3D surface surrogate for left breast irradiation using the respiratory-gated deep-inspiration breath-hold technique.

    Rong, Yi / Walston, Steve / Welliver, Meng Xu / Chakravarti, Arnab / Quick, Allison M

    PloS one

    2014  Volume 9, Issue 5, Page(s) e97933

    Abstract: Purpose: To evaluate the use of 3D optical surface imaging as a surrogate for respiratory gated deep-inspiration breath-hold (DIBH) for left breast irradiation.: Material and methods: Patients with left-sided breast cancer treated with lumpectomy or ... ...

    Abstract Purpose: To evaluate the use of 3D optical surface imaging as a surrogate for respiratory gated deep-inspiration breath-hold (DIBH) for left breast irradiation.
    Material and methods: Patients with left-sided breast cancer treated with lumpectomy or mastectomy were selected as candidates for DIBH treatment for their external beam radiation therapy. Treatment plans were created on both free breathing (FB) and DIBH computed tomography (CT) simulation scans to determine dosimetric benefits from DIBH. The Real-time Position Management (RPM) system was used to acquire patient's breathing trace during DIBH CT acquisition and treatment delivery. The reference 3D surface models from FB and DIBH CT scans were generated and transferred to the "AlignRT" system for patient positioning and real-time treatment monitoring. MV Cine images were acquired during treatment for each beam as quality assurance for intra-fractional position verification. The chest wall excursions measured on these images were used to define the actual target position during treatment, and to investigate the accuracy and reproducibility of RPM and AlignRT.
    Results: Reduction in heart dose can be achieved using DIBH for left breast/chest wall radiation. RPM was shown to have inferior correlation with the actual target position, as determined by the MV Cine imaging. Therefore, RPM alone may not be an adequate surrogate in defining the breath-hold level. Alternatively, the AlignRT surface imaging demonstrated a superior correlation with the actual target positioning during DIBH. Both the vertical and magnitude real-time deltas (RTDs) reported by AlignRT can be used as the gating parameter, with a recommended threshold of ±3 mm and 5 mm, respectively.
    Conclusion: The RPM system alone may not be sufficient for the required level of accuracy in left-sided breast/CW DIBH treatments. The 3D surface imaging can be used to ensure patient setup and monitor inter- and intra- fractional motions. Furthermore, the target position accuracy during DIBH treatment can be improved by AlignRT as a superior surrogate, in addition to the RPM system.
    MeSH term(s) Breast Neoplasms/diagnostic imaging ; Breath Holding ; Dose Fractionation, Radiation ; Female ; Humans ; Respiration ; Tomography, X-Ray Computed
    Language English
    Publishing date 2014-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0097933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.

    Reid, Michael A / Wang, Wen-I / Rosales, Kimberly Romero / Welliver, Meng Xu / Pan, Min / Kong, Mei

    Molecular cell

    2013  Volume 50, Issue 2, Page(s) 200–211

    Abstract: Glutamine is an essential nutrient for cancer cell survival and proliferation, yet the signaling pathways that sense glutamine levels remain uncharacterized. Here, we report that the protein phosphatase 2A (PP2A)-associated protein, α4, plays a conserved ...

    Abstract Glutamine is an essential nutrient for cancer cell survival and proliferation, yet the signaling pathways that sense glutamine levels remain uncharacterized. Here, we report that the protein phosphatase 2A (PP2A)-associated protein, α4, plays a conserved role in glutamine sensing. α4 promotes assembly of an adaptive PP2A complex containing the B55α regulatory subunit via providing the catalytic subunit upon glutamine deprivation. Moreover, B55α is specifically induced upon glutamine deprivation in a ROS-dependent manner to activate p53 and promote cell survival. B55α activates p53 through direct interaction and dephosphorylation of EDD, a negative regulator of p53. Importantly, the B55α-EDD-p53 pathway is essential for cancer cell survival and tumor growth under low glutamine conditions in vitro and in vivo. This study delineates a previously unidentified signaling pathway that senses glutamine levels as well as provides important evidence that protein phosphatase complexes are actively involved in signal transduction.
    MeSH term(s) Adaptation, Physiological ; Animals ; Catalytic Domain ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Gene Expression ; Gene Knockdown Techniques ; Glutamine/deficiency ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Nude ; NIH 3T3 Cells ; Neoplasm Transplantation ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Multimerization ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; Protein Phosphatase 2/physiology ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Protein Subunits/physiology ; RNA, Small Interfering/genetics ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Stress, Physiological ; Transcriptional Activation ; Tumor Burden ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Igbp1 protein, mouse ; Phosphoproteins ; Protein Subunits ; RNA, Small Interfering ; Reactive Oxygen Species ; Tumor Suppressor Protein p53 ; Glutamine (0RH81L854J) ; UBR5 protein, mouse (EC 2.3.2.26) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ppp2r2a protein, mouse (EC 3.1.3.16) ; Protein Phosphatase 2 (EC 3.1.3.16)
    Language English
    Publishing date 2013-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2013.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The Role of an Integrated Multidisciplinary Clinic in the Management of Patients with Cutaneous Lymphoma.

    Tyler, Kelly H / Haverkos, Bradley M / Hastings, Justin / Hu, Eileen / Philips, Ramez / Gru, Alejandro A / Welliver, Meng Xu / Mishra, Anjali / Wong, Henry K / Porcu, Pierluigi

    Frontiers in oncology

    2015  Volume 5, Page(s) 136

    Abstract: The clinical benefit of a multidisciplinary clinic practice model has been well described in a variety of medical specialties and cancer types. It proves particularly valuable when an integrated team is needed to optimally manage patients with rare or ... ...

    Abstract The clinical benefit of a multidisciplinary clinic practice model has been well described in a variety of medical specialties and cancer types. It proves particularly valuable when an integrated team is needed to optimally manage patients with rare or complex neoplasms. However, the ideal implementation of an integrated multidisciplinary care program for translational research and education has not been well reported. Herein, we propose how a multimodality cutaneous lymphoma (CL) clinic model can optimally manage CL patients. We offer our perspective on this model as an efficient means for delivering patient care, a continuing education resource for referring physicians, a conduit for translational and clinical research, and an educational tool for medical students, house staff, and fellows.
    Language English
    Publishing date 2015-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2015.00136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation

    Reid, Michael A. / Wang, Wen-I / Rosales, Kimberly Romero / Welliver, Meng Xu / Pan, Min / Kong, Mei

    Molecular cell

    Volume v. 50,, Issue no. 2

    Abstract: Glutamine is an essential nutrient for cancer cell survival and proliferation, yet the signaling pathways that sense glutamine levels remain uncharacterized. Here, we report that the protein phosphatase 2A (PP2A)-associated protein, α4, plays a conserved ...

    Abstract Glutamine is an essential nutrient for cancer cell survival and proliferation, yet the signaling pathways that sense glutamine levels remain uncharacterized. Here, we report that the protein phosphatase 2A (PP2A)-associated protein, α4, plays a conserved role in glutamine sensing. α4 promotes assembly of an adaptive PP2A complex containing the B55α regulatory subunit via providing the catalytic subunit upon glutamine deprivation. Moreover, B55α is specifically induced upon glutamine deprivation in a ROS-dependent manner to activate p53 and promote cell survival. B55α activates p53 through direct interaction and dephosphorylation of EDD, a negative regulator of p53. Importantly, the B55α-EDD-p53 pathway is essential for cancer cell survival and tumor growth under low glutamine conditions in vitro and in vivo. This study delineates a previously unidentified signaling pathway that senses glutamine levels as well as provides important evidence that protein phosphatase complexes are actively involved in signal transduction.
    Keywords cell viability ; dephosphorylation ; glutamine ; signal transduction ; protein subunits
    Language English
    Document type Article
    ISSN 1097-2765
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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