LIVIVO - Search results -

Search results

Result 1 - 10 of total 41

Search options

Article ; Online: The coronavirus recombination pathway.

Wells, Heather L / Bonavita, Cassandra M / Navarrete-Macias, Isamara / Vilchez, Blake / Rasmussen, Angela L / Anthony, Simon J

Cell host & microbe

2023 Volume 31, Issue 6, Page(s) 874–889

Abstract: Recombination is thought to be a mechanism that facilitates cross-species transmission in coronaviruses, thus acting as a driver of coronavirus spillover and emergence. Despite its significance, the mechanism of recombination is poorly understood, ... ...

Abstract	Recombination is thought to be a mechanism that facilitates cross-species transmission in coronaviruses, thus acting as a driver of coronavirus spillover and emergence. Despite its significance, the mechanism of recombination is poorly understood, limiting our potential to estimate the risk of novel recombinant coronaviruses emerging in the future. As a tool for understanding recombination, here, we outline a framework of the recombination pathway for coronaviruses. We review existing literature on coronavirus recombination, including comparisons of naturally observed recombinant genomes as well as in vitro experiments, and place the findings into the recombination pathway framework. We highlight gaps in our understanding of coronavirus recombination illustrated by the framework and outline how further experimental research is critical for disentangling the molecular mechanism of recombination from external environmental pressures. Finally, we describe how an increased understanding of the mechanism of recombination can inform pandemic predictive intelligence, with a retrospective emphasis on SARS-CoV-2.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; Retrospective Studies ; COVID-19 ; Phylogeny ; Recombination, Genetic
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2023.05.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6578: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Sex-dependent acrolein sensitivity in mice is associated with differential lung cell, protein, and transcript changes.

Bein, Kiflai / Birru, Rahel L / Wells, Heather / Larkin, Theodore P / Ge, Tengziyi / Leikauf, George D

Physiological reports

2021 Volume 9, Issue 19, Page(s) e14997

Abstract: Acrolein is a reactive inhalation hazard. Acrolein's initial interaction, which in itself can be function-altering, is followed by time-dependent cascade of complex cellular and pulmonary responses that dictate the severity of the injury. To investigate ... ...

Abstract	Acrolein is a reactive inhalation hazard. Acrolein's initial interaction, which in itself can be function-altering, is followed by time-dependent cascade of complex cellular and pulmonary responses that dictate the severity of the injury. To investigate the pathophysiological progression of sex-dependent acrolein-induced acute lung injury, C57BL/6J mice were exposed for 30 min to sublethal, but toxic, and lethal acrolein. Male mice were more sensitive than female mice. Acrolein of 50 ppm was sublethal to female but lethal to male mice, and 75 ppm was lethal to female mice. Lethal and sublethal acrolein exposure decreased bronchoalveolar lavage (BAL) total cell number at 3 h after exposure. The cell number decrease was followed by progressive total cell and neutrophil number and protein increases. The BAL total cell number in female mice exposed to a sublethal, but not lethal dose, returned to control levels at 16 h. In contrast, BAL protein content and neutrophil number were higher in mice exposed to lethal compared to sublethal acrolein. RNASeq pathway analysis identified greater increased lung neutrophil, glutathione metabolism, oxidative stress responses, and CCL7 (aka MCP-3), CXCL10 (aka IP-10), and IL6 transcripts in males than females, whereas IL10 increased more in female than male mice. Thus, the IL6:IL10 ratio, an indicator of disease severity, was greater in males than females. Further, H3.3 histone B (H3F3B) and pro-platelet basic protein (PPBP aka CXCL7), transcripts increased in acrolein exposed mouse BAL and plasma at 3 h, while H3F3B protein that is associated with neutrophil extracellular traps formation increased at 12 h. These results suggest that H3F3B and PPBP transcripts increase may contribute to extracellular H3F3B and PPBP proteins increase.
MeSH term(s)	Acrolein/toxicity ; Acute Lung Injury/chemically induced ; Acute Lung Injury/genetics ; Acute Lung Injury/metabolism ; Animals ; Chemokine CCL7/genetics ; Chemokine CCL7/metabolism ; Chemokine CXCL10/genetics ; Chemokine CXCL10/metabolism ; Female ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lung/drug effects ; Lung/metabolism ; Male ; Mice ; Oxidative Stress/drug effects ; Sex Factors
Chemical Substances	Chemokine CCL7 ; Chemokine CXCL10 ; Interleukin-6 ; Acrolein (7864XYD3JJ)
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.14997
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Plasma sterols and vitamin D are correlates and predictors of ozone-induced inflammation in the lung: A pilot study.

Perryman, Alexia N / Kim, Hye-Young H / Payton, Alexis / Rager, Julia E / McNell, Erin E / Rebuli, Meghan E / Wells, Heather / Almond, Martha / Antinori, Jamie / Alexis, Neil E / Porter, Ned A / Jaspers, Ilona

PloS one

2023 Volume 18, Issue 5, Page(s) e0285721

Abstract: Background: Ozone (O3) exposure causes respiratory effects including lung function decrements, increased lung permeability, and airway inflammation. Additionally, baseline metabolic state can predispose individuals to adverse health effects from O3. For ...

Abstract	Background: Ozone (O3) exposure causes respiratory effects including lung function decrements, increased lung permeability, and airway inflammation. Additionally, baseline metabolic state can predispose individuals to adverse health effects from O3. For this reason, we conducted an exploratory study to examine the effect of O3 exposure on derivatives of cholesterol biosynthesis: sterols, oxysterols, and secosteroid (25-hydroxyvitamin D) not only in the lung, but also in circulation. Methods: We obtained plasma and induced sputum samples from non-asthmatic (n = 12) and asthmatic (n = 12) adult volunteers 6 hours following exposure to 0.4ppm O3 for 2 hours. We quantified the concentrations of 24 cholesterol precursors and derivatives by UPLC-MS and 30 cytokines by ELISA. We use computational analyses including machine learning to determine whether baseline plasma sterols are predictive of O3 responsiveness. Results: We observed an overall decrease in the concentration of cholesterol precursors and derivatives (e.g. 27-hydroxycholesterol) and an increase in concentration of autooxidation products (e.g. secosterol-B) in sputum samples. In plasma, we saw a significant increase in the concentration of secosterol-B after O3 exposure. Machine learning algorithms showed that plasma cholesterol was a top predictor of O3 responder status based on decrease in FEV1 (>5%). Further, 25-hydroxyvitamin D was positively associated with lung function in non-asthmatic subjects and with sputum uteroglobin, whereas it was inversely associated with sputum myeloperoxidase and neutrophil counts. Conclusion: This study highlights alterations in sterol metabolites in the airway and circulation as potential contributors to systemic health outcomes and predictors of pulmonary and inflammatory responsiveness following O3 exposure.
MeSH term(s)	Adult ; Humans ; Ozone/adverse effects ; Pilot Projects ; Sterols/pharmacology ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Lung ; Inflammation/chemically induced ; Vitamins/pharmacology ; Vitamin D/pharmacology
Chemical Substances	Ozone (66H7ZZK23N) ; Sterols ; Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285721
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke-induced neutrophilic and eosinophilic airway inflammation.

Peden, David B / Almond, Martha / Brooks, Christian / Robinette, Carole / Wells, Heather / Burbank, Allison / Hernandez, Michelle / Hinderliter, Alan / Caughey, Melissa / Jiang, Qing / Wang, Qianyue / Li, Haolin / Zhou, Haibo / Alexis, Neil

The journal of allergy and clinical immunology. Global

2023 Volume 2, Issue 4, Page(s) 100177

Abstract: Background: Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced ...

Abstract	Background: Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced inflammation. Objective: The objective of this study was to determine whether γ-tocopherol would prevent experimental wood smoke-induced airway inflammation in humans. Methods: This was a randomized, placebo-controlled clinical trial testing the effect of a short course of γ-tocopherol-enriched supplementation on airway inflammation following a controlled exposure to wood smoke particulates. Results: Short-course γ-tocopherol intervention did not reduce wood smoke-induced neutrophilic airway inflammation, but it did prevent wood smoke-induced eosinophilic airway inflammation. Conclusion: γ-Tocopherol is a potential intervention for exacerbation of allergic airway inflammation, but further study examining longer dosing periods is required.
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ISSN	2772-8293
ISSN (online)	2772-8293
DOI	10.1016/j.jacig.2023.100177
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Antimicrobial and Anti-Inflammatory Activity of Apple Polyphenol Phloretin on Respiratory Pathogens Associated With Chronic Obstructive Pulmonary Disease.

Birru, Rahel L / Bein, Kiflai / Bondarchuk, Natalya / Wells, Heather / Lin, Qiao / Di, Y Peter / Leikauf, George D

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 652944

Abstract: Bacterial infections contribute to accelerated progression and severity of chronic obstructive pulmonary disease (COPD). Apples have been associated with reduced symptoms of COPD and disease development due to their polyphenolic content. We examined if ... ...

Abstract	Bacterial infections contribute to accelerated progression and severity of chronic obstructive pulmonary disease (COPD). Apples have been associated with reduced symptoms of COPD and disease development due to their polyphenolic content. We examined if phloretin, an apple polyphenol, could inhibit bacterial growth and inflammation induced by the main pathogens associated with COPD. Phloretin displayed bacteriostatic and anti-biofilm activity against nontypeable
MeSH term(s)	Animals ; Anti-Infective Agents ; Anti-Inflammatory Agents/pharmacology ; Haemophilus Infections ; Haemophilus influenzae ; Mice ; Phloretin/pharmacology ; Polyphenols/pharmacology ; Pulmonary Disease, Chronic Obstructive/drug therapy
Chemical Substances	Anti-Infective Agents ; Anti-Inflammatory Agents ; Polyphenols ; Phloretin (S5J5OE47MK)
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.652944
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Coronavirus and Paramyxovirus Shedding by Bats in a Cave and Buildings in Ethiopia

Lane, Jennifer K. / Negash, Yohannes / Randhawa, Nistara / Kebede, Nigatu / Wells, Heather / Ayalew, Girma / Anthony, Simon J. / Smith, Brett / Goldstein, Tracey / Kassa, Tesfu / Mazet, Jonna A. K. / Consortium, PREDICT / Smith, Woutrina A.

EcoHealth. 2022 June, v. 19, no. 2

2022

Abstract: Bats are important hosts of zoonotic viruses with pandemic potential, including filoviruses, MERS-Coronavirus (CoV), SARS-CoV -1, and likely SARS-CoV-2. Viral infection and transmission among wildlife are dependent on a combination of factors that ... ...

Abstract	Bats are important hosts of zoonotic viruses with pandemic potential, including filoviruses, MERS-Coronavirus (CoV), SARS-CoV -1, and likely SARS-CoV-2. Viral infection and transmission among wildlife are dependent on a combination of factors that include host ecology and immunology, life history traits, roosting habitats, biogeography, and external stressors. Between 2016 and 2018, four species of insectivorous bats from a readily accessed roadside cave and buildings in Ethiopia were sampled and tested for viruses using consensus PCR assays for five viral families/genera. Previously identified and novel coronaviruses and paramyxoviruses were identified in 99 of the 589 sampled bats. Bats sampled from the cave site were more likely to test positive for a CoV than bats sampled from buildings; viral shedding was more common in the wet season; and rectal swabs were the most common sample type to test positive. A previously undescribed alphacoronavirus was detected in two bat species from different taxonomic families, sampling interfaces, geographic locations, and years. These findings expand knowledge of the range and diversity of coronaviruses and paramyxoviruses in insectivorous bats in Ethiopia and reinforce that an improved understanding of viral diversity and species-specific shedding dynamics is important for designing informed zoonotic disease surveillance and spillover risk reduction efforts.
Keywords	Alphacoronavirus ; Chiroptera ; Filoviridae ; Respirovirus ; Severe acute respiratory syndrome coronavirus 2 ; biogeography ; disease surveillance ; environmental health ; immunology ; insectivores ; life history ; pandemic ; risk reduction ; roadsides ; wet season ; wildlife ; zoonoses ; Ethiopia
Language	English
Dates of publication	2022-06
Size	p. 216-232.
Publishing place	Springer US
Document type	Article
ZDB-ID	2164327-1
ISSN	1612-9210 ; 1612-9202
ISSN (online)	1612-9210
ISSN	1612-9202
DOI	10.1007/s10393-022-01590-y
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 7528: Show issues
Zs Bio Ecohealth: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Development of a screening protocol to identify persons who are responsive to wood smoke particle-induced airway inflammation with pilot assessment of GSTM1 genotype and asthma status as response modifiers.

Alexis, Neil E / Zhou, Laura Y / Burbank, Allison J / Almond, Martha / Hernandez, Michelle L / Mills, Katherine H / Noah, Terry L / Wells, Heather / Zhou, Haibo / Peden, David B

Inhalation toxicology

2022 Volume 34, Issue 11-12, Page(s) 329–339

Abstract: Background: We are currently screening human volunteers to determine their sputum polymorphonuclear neutrophil (PMN) response 6- and 24-hours following initiation of exposure to wood smoke particles (WSP). Inflammatory responders (≥10% increase in %PMN) ...

Abstract	Background: We are currently screening human volunteers to determine their sputum polymorphonuclear neutrophil (PMN) response 6- and 24-hours following initiation of exposure to wood smoke particles (WSP). Inflammatory responders (≥10% increase in %PMN) are identified for their subsequent participation in mitigation studies against WSP-induced airways inflammation. In this report we compared responder status (N = 52) at both 6 and 24 hr time points to refine/expand its classification, assessed the impact of the GSTM1 genotype, asthma status and sex on responder status, and explored whether sputum soluble phase markers of inflammation correlate with PMN responsiveness to WSP. Results: Six-hour responders tended to be 24-hour responders and vice versa, but 24-hour responders also had significantly increased IL-1beta, IL-6, IL-8 at 24 hours post WSP exposure. The GSTM1 null genotype significantly (p < 0.05) enhanced the %PMN response by 24% in the 24-hour responders and not at all in the 6 hours responders. Asthma status enhanced the 24 hour %PMN response in the 6- and 24-hour responders. In the entire cohort (not stratified by responder status), we found a significant, but very small decrease in FVC and systolic blood pressure immediately following WSP exposure and sputum %PMNs were significantly increased and associated with sputum inflammatory markers (IL-1beta, IL-6, IL-8, and PMN/mg) at 24 but not 6 hours post exposure. Blood endpoints in the entire cohort showed a significant increase in %PMN and PMN/mg at 6 but not 24 hours. Sex had no effect on %PMN response. Conclusions: The 24-hour time point was more informative than the 6-hour time point in optimally and expansively defining airway inflammatory responsiveness to WSP exposure. GSTM1 and asthma status are significant effect modifiers of this response. These study design and subject parameters should be considered before enrolling volunteers for proof-of-concept WSP mitigation studies.
MeSH term(s)	Humans ; Asthma/genetics ; Biomarkers ; Genotype ; Inflammation ; Interleukin-6 ; Interleukin-8 ; Neutrophils ; Smoke/adverse effects ; Wood ; Glutathione Transferase/genetics
Chemical Substances	Biomarkers ; Interleukin-6 ; Interleukin-8 ; Smoke ; glutathione S-transferase M1 (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18)
Language	English
Publishing date	2022-08-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1038809-6
ISSN	1091-7691 ; 0895-8378
ISSN (online)	1091-7691
ISSN	0895-8378
DOI	10.1080/08958378.2022.2110334
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2618: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Biomarkers of Airway Immune Homeostasis Differ Significantly with Generation of E-Cigarettes.

Hickman, Elise / Payton, Alexis / Duffney, Parker / Wells, Heather / Ceppe, Agathe S / Brocke, Stephanie / Bailey, Aleah / Rebuli, Meghan E / Robinette, Carole / Ring, Brian / Rager, Julia E / Alexis, Neil E / Jaspers, Ilona

American journal of respiratory and critical care medicine

2022 Volume 206, Issue 10, Page(s) 1248–1258

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Electronic Nicotine Delivery Systems ; Vaping/adverse effects ; Matrix Metalloproteinase 2 ; Vascular Endothelial Growth Factor A ; Tobacco Products ; Biomarkers ; Homeostasis
Chemical Substances	Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Vascular Endothelial Growth Factor A ; Biomarkers
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202202-0373OC
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.80: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cytokine signature clusters as a tool to compare changes associated with tobacco product use in upper and lower airway samples.

Payton, Alexis D / Perryman, Alexia N / Hoffman, Jessica R / Avula, Vennela / Wells, Heather / Robinette, Carole / Alexis, Neil E / Jaspers, Ilona / Rager, Julia E / Rebuli, Meghan E

American journal of physiology. Lung cellular and molecular physiology

2022 Volume 322, Issue 5, Page(s) L722–L736

Abstract: Inhalation exposure to cigarette smoke and e-cigarette aerosol is known to alter the respiratory immune system, particularly cytokine signaling. In assessments of health impacts of tobacco product use, cytokines are often measured using a variety of ... ...

Abstract	Inhalation exposure to cigarette smoke and e-cigarette aerosol is known to alter the respiratory immune system, particularly cytokine signaling. In assessments of health impacts of tobacco product use, cytokines are often measured using a variety of sample types, from serum to airway mucosa. However, it is currently unclear whether and how well cytokine levels from different sample types and the airway locations they represent are correlated, making comparing studies that utilize differing sample types challenging. To address this challenge, we compared baseline cytokine signatures in upper and lower airways and systemic samples and evaluated how groups of coexpressed cytokines change with tobacco product use. Matched nasal lavage fluid (NLF), nasal epithelial lining fluid (NELF), sputum, and circulating serum samples were collected from 14 nonsmokers, 13 cigarette smokers, and 17 e-cigarette users and analyzed for levels of 22 cytokines. Individual cytokine signatures were first compared across each sample type, followed by identification of cytokine clusters within each sample type. Identified clusters were then evaluated for potential alterations following tobacco product use using eigenvector analyses. Individual cytokine signatures in the respiratory tract were significantly correlated (NLF, NELF, and sputum) compared with randomly permutated signatures, whereas serum was not significantly different from random permutations. Cytokine clusters that were similar across airway sample types were modified by tobacco product use, particularly e-cigarettes, indicating a degree of uniformity in terms of how cytokine host defense and immune cell recruitment responses cooperate in the upper and lower airways. Overall, cluster-based analyses were found to be especially useful in small cohort assessments, providing higher sensitivity than individual signatures to detect biologically meaningful differences between tobacco use groups. This novel cluster analysis approach revealed that eigencytokine patterns in noninvasive upper airway samples simulate cytokine patterns in lower airways.
MeSH term(s)	Cytokines ; Electronic Nicotine Delivery Systems ; Humans ; Respiratory System ; Tobacco Products/adverse effects ; Tobacco Use ; Tobacco Use Disorder
Chemical Substances	Cytokines
Language	English
Publishing date	2022-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00299.2021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 2749: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Coronavirus and Paramyxovirus Shedding by Bats in a Cave and Buildings in Ethiopia.

Lane, Jennifer K / Negash, Yohannes / Randhawa, Nistara / Kebede, Nigatu / Wells, Heather / Ayalew, Girma / Anthony, Simon J / Smith, Brett / Goldstein, Tracey / Kassa, Tesfu / Mazet, Jonna A K / Consortium, Predict / Smith, Woutrina A

EcoHealth

2022 Volume 19, Issue 2, Page(s) 216–232

Abstract	Bats are important hosts of zoonotic viruses with pandemic potential, including filoviruses, MERS-Coronavirus (CoV), SARS-CoV -1, and likely SARS-CoV-2. Viral infection and transmission among wildlife are dependent on a combination of factors that include host ecology and immunology, life history traits, roosting habitats, biogeography, and external stressors. Between 2016 and 2018, four species of insectivorous bats from a readily accessed roadside cave and buildings in Ethiopia were sampled and tested for viruses using consensus PCR assays for five viral families/genera. Previously identified and novel coronaviruses and paramyxoviruses were identified in 99 of the 589 sampled bats. Bats sampled from the cave site were more likely to test positive for a CoV than bats sampled from buildings; viral shedding was more common in the wet season; and rectal swabs were the most common sample type to test positive. A previously undescribed alphacoronavirus was detected in two bat species from different taxonomic families, sampling interfaces, geographic locations, and years. These findings expand knowledge of the range and diversity of coronaviruses and paramyxoviruses in insectivorous bats in Ethiopia and reinforce that an improved understanding of viral diversity and species-specific shedding dynamics is important for designing informed zoonotic disease surveillance and spillover risk reduction efforts.
MeSH term(s)	Animals ; COVID-19/epidemiology ; Chiroptera ; Ethiopia/epidemiology ; Genome, Viral ; Humans ; Phylogeny ; SARS-CoV-2 ; Viruses
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2164327-1
ISSN	1612-9210 ; 1612-9202
ISSN (online)	1612-9210
ISSN	1612-9202
DOI	10.1007/s10393-022-01590-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 7528: Show issues
Zs Bio Ecohealth: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED