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  1. Book ; Online ; E-Book: Mitral Valve Disease

    Anderson, Robert H. / Wells, F. C.

    Basic Sciences and Current Approaches to Management

    2021  

    Abstract: This book provides a comprehensive review of the basic science of the mitral valve needed to begin to comprehend both normal and the failing valve. This knowledge is infrequently discussed in the clinical arena, with a rush towards definition of lesions ... ...

    Author's details edited by Francis C. Wells, Robert H. Anderson
    Abstract This book provides a comprehensive review of the basic science of the mitral valve needed to begin to comprehend both normal and the failing valve. This knowledge is infrequently discussed in the clinical arena, with a rush towards definition of lesions based on limited analysis. It provides a ready single source of the most important basic science subjects pertaining to the valve, and the pathologies found therein, and thus a more complete understanding of the factors that result in dysfunction may be appreciated. Mitral Valve Disease: Basic Sciences and Current Approaches to Management includes chapters on embryology and anatomy, including details of structural, comparative and functional features. Since the valve is completely influenced by genetics and molecular biology, subjects rarely if ever addressed in the clinical arena, these topics receive in-depth attention. Coverage concludes with lengthy discussions of the importance of multi-disciplinary work, along with the importance of the electrophysiological disturbances encountered in some groups of these patients. It therefore is an essential and up-to-date resource for the practicing and trainee cardiac surgeon and any researcher working within this topic.
    Keywords Heart/Surgery ; Cardiology ; Cardiac Surgery ; Vàlvules cardíaques ; Malalties del cor ; Cirurgia cardíaca
    Subject code 616.125
    Language English
    Size 1 online resource (x, 211 pages) :, illustrations
    Edition 1st ed. 2021.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-67947-0 ; 3-030-67946-2 ; 978-3-030-67947-7 ; 978-3-030-67946-0
    DOI 10.1007/978-3-030-67947-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Reoperation after failure of mitral valve repair for degenerative disease: A single surgeon experience.

    Divya, Aabha / Akintoye, Oluwanifemi O / Wells, Francis

    JTCVS open

    2023  Volume 16, Page(s) 221–233

    Abstract: Background: With an increasing number of patients undergoing mitral valve repair, more patients are presenting for reoperation. This study aimed to evaluate factors influencing mortality and survival of patients undergoing reoperation for mitral valve ... ...

    Abstract Background: With an increasing number of patients undergoing mitral valve repair, more patients are presenting for reoperation. This study aimed to evaluate factors influencing mortality and survival of patients undergoing reoperation for mitral valve surgery after previous mitral valve repair under a single surgeon.
    Methods: We retrospectively collected data from 117 patients who underwent reoperation after previous mitral valve repair between 2010 and 2022. We aimed to identify preoperative, operative, and postoperative factors affecting outcomes. The primary outcome was overall survival, and the secondary outcomes included prolonged hospital stay and in-hospital mortality. The mean follow-up was 9.13 ± 10.36 years (median, 6.50 years).
    Results: Out of 117 patients, 85 underwent mitral valve replacement (MVR) and 32 underwent mitral valve repair (MVr). The mean age was 64.7 ± 12.7 years (65.5 ± 12.2 years in the MVR group and 62.7 ± 14.0 years in the MVr group), and 66 (56.4%) were men. On a standard multivariate analysis of the overall factors influencing mortality, advanced age was associated with a higher risk of overall mortality (hazard ratio [HR], 1.07; 95% confidence interval [CI], f1.03-1.12;
    Conclusions: Our single surgeon experience demonstrates that mitral valve reoperation after a previous repair is associated with good outcomes and survival.
    Language English
    Publishing date 2023-10-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2023.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Healthcare staff perceptions towards influenza and potential COVID-19 vaccination in the 2020 pandemic context.

    Robbins, T / Berry, L / Wells, F / Randeva, H / Laird, S

    The Journal of hospital infection

    2021  Volume 112, Page(s) 45–48

    Abstract: The COVID-19 pandemic generated renewed focus on infectious disease transmission in healthcare settings. This study aimed to evaluate staff perceptions towards influenza vaccination in the COVID-19 context. All healthcare workers within a major UK ... ...

    Abstract The COVID-19 pandemic generated renewed focus on infectious disease transmission in healthcare settings. This study aimed to evaluate staff perceptions towards influenza vaccination in the COVID-19 context. All healthcare workers within a major UK tertiary referral hospital were invited to answer a survey conducted from September 2
    MeSH term(s) COVID-19/prevention & control ; COVID-19/psychology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/standards ; Cross-Sectional Studies ; Health Personnel/psychology ; Humans ; Influenza Vaccines/administration & dosage ; Influenza, Human/prevention & control ; Influenza, Human/psychology ; Surveys and Questionnaires ; United Kingdom ; Vaccination/psychology
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2021-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2021.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1586: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Mitral valve disease

    Wells, F. C.

    1996  

    Author's details ed. by F. C. Wells
    Keywords Mitral Valve / physiopathology ; Mitral Valve / ultrasonography ; Mitral Valve / surgery ; Heart Valve Diseases / ultrasonography ; Heart Valve Diseases / surgery ; Mitralinsuffizienz
    Subject Mitralklappeninsuffizienz
    Language English
    Size VIII, 204 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Butterworth-Heinemann
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007287966
    ISBN 0-7506-1212-6 ; 978-0-7506-1212-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 4783 order for loan Magazin

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  5. Article ; Online: Creation of Markerless Genome Modifications in a Nonmodel Bacterium by Fluorescence-Aided Recombineering.

    Lal, Piyush Behari / Wells, Fritz / Kiley, Patricia J

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2479, Page(s) 53–70

    Abstract: Metabolic engineering of nonmodel bacteria is often challenging because of the paucity of genetic tools for iterative genome modification necessary to equip bacteria with pathways to produce high-value products. Here, we outline a homologous ... ...

    Abstract Metabolic engineering of nonmodel bacteria is often challenging because of the paucity of genetic tools for iterative genome modification necessary to equip bacteria with pathways to produce high-value products. Here, we outline a homologous recombination-based method developed to delete or add genes to the genome of a nonmodel bacterium, Zymomonas mobilis, at the desired locus using a suicide plasmid that contains gfp as a fluorescence marker to track its presence in cells. The suicide plasmid is engineered to contain two 500 bp regions homologous to the DNA sequence immediately flanking the target locus. A single crossover event at one of the two homologous regions facilitates insertion of the plasmid into the genome and subsequent homologous recombination events excise the plasmid from the genome, leaving either the original genotype or the desired modified genotype. A key feature of this plasmid is that Green Fluorescent Protein (GFP) expressed from the suicide plasmid allows easy identification and sorting of cells that have lost the plasmid by use of a fluorescence activated cell sorter. Subsequent PCR amplification of genomic DNA from strains lacking GFP allows rapid identification of the desired genotype, which is confirmed by DNA sequencing. This method provides an efficient and flexible platform for improved genetic engineering of Z. mobilis, which can be easily adapted to other nonmodel bacteria.
    MeSH term(s) Base Sequence ; DNA/metabolism ; Humans ; Metabolic Engineering ; Plasmids/genetics ; Zymomonas/genetics ; Zymomonas/metabolism
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2233-9_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Report of Committee on Hygiene of Dress.

    Wells, F

    Public health papers and reports

    2009  Volume 30, Page(s) 153–159

    Language English
    Publishing date 2009-07-14
    Publishing country United States
    Document type Journal Article
    ISSN 0737-8769
    ISSN 0737-8769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of Biogenic and Chemogenic Selenium Nanoparticles on Model Eukaryotic Lipid Membranes.

    Piacenza, Elena / Sule, Kevin / Presentato, Alessandro / Wells, Frieda / Turner, Raymond J / Prenner, Elmar J

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 30, Page(s) 10406–10419

    Abstract: Microbial nanotechnology is an expanding research area devoted to producing biogenic metal and metalloid nanomaterials (NMs) using microorganisms. Often, biogenic NMs are explored as antimicrobial, anticancer, or antioxidant agents. Yet, most studies ... ...

    Abstract Microbial nanotechnology is an expanding research area devoted to producing biogenic metal and metalloid nanomaterials (NMs) using microorganisms. Often, biogenic NMs are explored as antimicrobial, anticancer, or antioxidant agents. Yet, most studies focus on their applications rather than the underlying mechanism of action or toxicity. Here, we evaluate the toxicity of our well-characterized biogenic selenium nanoparticles (bSeNPs) produced by the
    MeSH term(s) Selenium/toxicity ; Selenium/chemistry ; Eukaryotic Cells/metabolism ; Saccharomyces cerevisiae ; Nanoparticles/chemistry ; Lipids ; Metal Nanoparticles
    Chemical Substances Selenium (H6241UJ22B) ; Lipids
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c00718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Psychometric patterns in adjustment problems at upper extremes of test "intelligence": cases XXIX-LVI, Department of Hygiene referrals.

    WELLS, F L

    The Pedagogical seminary and journal of genetic psychology

    2013  Volume 76, Issue 1, Page(s) 3–37

    MeSH term(s) Adaptation, Psychological ; Humans ; Hygiene ; Intelligence ; Intelligence Tests ; Psychometrics ; Referral and Consultation
    Language English
    Publishing date 2013-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4797-1
    ISSN 0885-6559
    ISSN 0885-6559
    DOI 10.1080/08856559.1950.10533525
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 331: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Size of the shadow.

    Garbi, Madalina / Wells, Francis / Weirmccall, Jonathan / Anderson, Robert H

    Heart (British Cardiac Society)

    2021  

    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Letter
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-318810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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  10. Article ; Online: Nosocomial outbreak of measles amongst a highly vaccinated population in an English hospital setting.

    Berry, L / Palmer, T / Wells, F / Williams, E / Sibal, B / Timms, J

    Infection prevention in practice

    2019  Volume 1, Issue 2, Page(s) 100018

    Abstract: In May 2017 a patient attended the emergency department at a hospital in England, with a presumed allergic reaction. He was subsequently diagnosed with measles. There were seven further confirmed cases, five of whom had received two doses of MMR vaccine. ...

    Abstract In May 2017 a patient attended the emergency department at a hospital in England, with a presumed allergic reaction. He was subsequently diagnosed with measles. There were seven further confirmed cases, five of whom had received two doses of MMR vaccine. This outbreak highlights the importance of not relying on vaccination status to rule out the diagnosis of measles. Epidemiological investigations of this outbreak were particularly challenging due to the highly infectious nature of the measles virus, and prevented full elucidation of either the source of this outbreak or the transmission pathways.
    Language English
    Publishing date 2019-08-17
    Publishing country England
    Document type Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2019.100018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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