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  1. Book ; Thesis: Perioperative Ergebnisse der minimal invasiven Ösophagektomie im Vergleich zur konventionellen Ösophagektomie

    Hasanovic, Jasmin / Welsch, Thilo / Hampe, Jochen

    2021  

    Institution Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie
    Author's details von Hasanovic, Jasmin aus Tuzla ; Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie [Dresden]
    Language German
    Size 85 Seiten, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT021385578
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Thesis: Stellenwert der intraoperativen Bakterobilie als prädiktiver Marker postoperativer Komplikationen nach Pankreaskopfresektionen

    Marx, Carolin / Welsch, Thilo / Hampe, Jochen

    2020  

    Institution Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie
    Author's details von Carolin Marx aus Waddeweitz ; Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie [Dresden]
    Language German
    Size 79 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2021
    HBZ-ID HT021003407
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Outcome der chirurgischen Therapie der chronischen Pankreatitis

    Willner, Antonie / Welsch, Thilo / Hampe, Jochen

    2020  

    Institution Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie
    Author's details von Antonie Willner aus Ingolstadt ; Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie [Dresden]
    Language German
    Size X, 123 Blätter, Illustrationen
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2020.
    HBZ-ID HT020632354
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Effects of early postoperative mobilization following gastrointestinal surgery: systematic review and meta-analysis.

    Willner, Antonie / Teske, Christian / Hackert, Thilo / Welsch, Thilo

    BJS open

    2023  Volume 7, Issue 5

    Abstract: Background: Early postoperative mobilization is considered a key element of enhanced recovery after surgery protocols. The aim of this study was to summarize the effect of early postoperative mobilization following gastrointestinal operations on patient ...

    Abstract Background: Early postoperative mobilization is considered a key element of enhanced recovery after surgery protocols. The aim of this study was to summarize the effect of early postoperative mobilization following gastrointestinal operations on patient recovery, mobility, the morbidity rate and duration of hospital stay.
    Methods: A systematic literature search was conducted in December, 2022, using PubMed, Web of Science and the Cochrane Central Register of Controlled Trials. Controlled trials reporting the effects of early postoperative mobilization after gastrointestinal surgery were included. The risk of bias was assessed using a modified Downs and Black tool and the Cochrane Collaboration tool for randomized trials. The outcomes of interest were gastrointestinal recovery (defined passage of first flatus or bowel movements), mobility (step count on postoperative day 3), the morbidity rate and duration of hospital stay.
    Results: After elimination of duplicates, 3678 records were identified, and 71 full-text articles were screened. Finally, 15 studies (eight RCTs) reporting on 3538 patients were included. Most trials evaluated early postoperative mobilization after different gastrointestinal operations, including upper gastrointestinal (n = 8 studies), hepatopancreatobiliary (n = 10 studies) and colorectal resections (n = 10 studies). The investigated early postoperative mobilization protocols, operative techniques (minimally invasive or open) and outcome parameters were heterogeneous between the studies. Early postoperative mobilization seemed to significantly accelerate clinical gastrointestinal recovery (mean difference, hours: -11.53 (-22.08, -0.97), P = 0.03). However, early postoperative mobilization did not significantly improve the morbidity rate (risk ratio: 0.93 (0.70, 1.23), P = 0.59), postoperative mobility of patients (step count mean difference: 1009 (-803, 2821), P = 0.28) or shorten the duration of hospital stay (mean difference, days: -0.25 (-0.99,0.43), P = 0.47) in randomized trials.
    Conclusion: There is a large heterogeneity among the study cohorts, operations and interventions. The available evidence currently does not support specific early postoperative mobilization protocols as an isolated element to further reduce the morbidity rate and duration of hospital stay. Further well-designed trials are required to identify effective early postoperative mobilization protocols.
    MeSH term(s) Humans ; Digestive System Surgical Procedures ; Early Ambulation
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Zur Rolle des CD2-assoziierten Proteins in Podozyten

    Welsch, Thilo

    2003  

    Author's details vorgelegt von Thilo Welsch
    Language German
    Size 105 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2003
    HBZ-ID HT014164364
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Intraoperative minimally invasive left bronchial reconstruction using a pericardial flap during robot-assisted esophagectomy.

    Welsch, Thilo / Straub, Andreas / Corvinus, Florian / Ohlemacher, Florian / Lessing, Peter / Melling, Nathaniel / Hackert, Thilo

    JTCVS techniques

    2023  Volume 21, Page(s) 221–223

    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2023.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Case-Based Serious Gaming for Complication Management in Colorectal and Pancreatic Surgery: Prospective Observational Study.

    Schwarzkopf, Sophie-Caroline / Distler, Marius / Welsch, Thilo / Krause-Jüttler, Grit / Weitz, Jürgen / Kolbinger, Fiona R

    JMIR serious games

    2023  Volume 11, Page(s) e44708

    Abstract: Background: The potential risk and subsequent impact of serious complications after pancreatic and colorectal surgery can be significantly reduced through early recognition, correct assessment, and timely initiation of appropriate therapy. Serious ... ...

    Abstract Background: The potential risk and subsequent impact of serious complications after pancreatic and colorectal surgery can be significantly reduced through early recognition, correct assessment, and timely initiation of appropriate therapy. Serious gaming (SG) is an innovative teaching method that combines play with knowledge acquisition, increased concentration, and quick decision-making and could therefore be used for clinically oriented education.
    Objective: This study aims to develop a case-based SG platform for complication management in pancreatic and colorectal surgery, validate the application by comparing game courses of various professional groups in the health care sector, and test the acceptance of the developed platform in the context of clinical education by measuring levels of usability and applicability within the framework of a validity and usefulness analysis.
    Methods: In this observational trial, a novel SG for management of postoperative complications was developed and prospectively validated in a cohort of 131 human caregivers with varying experience in abdominal surgery. A total of 6 realistic patient cases were implemented, representing common complications after pancreatic and colorectal surgery. Cases were developed and illustrated using anonymized images, data, and histories of postoperative patients. In the prospective section of this study, following a brief case presentation, participants were asked to triage the virtual patient, make an initial suspected diagnosis, and design a 3-step management plan, throughout which the results of selected diagnostic and therapeutic actions were presented. Participants' proposed case management was compared to ideal case management according to clinical guidelines. Usability, applicability, validity, and acceptance of the application were assessed using the Trier Teaching Evaluation Inventory as part of a noncomparative analysis. In addition, a comparative analysis of conventional teaching and learning formats was carried out.
    Results: A total of 131 cases were answered. Physicians selected more appropriate therapeutic measures than nonphysicians. In the Trier Teaching Evaluation Inventory, design, structure, relevance, timeliness, and interest promotion were predominantly rated positively. Most participants perceived the application to be superior to conventional lecture-based formats (training courses, lectures, and seminars) in terms of problem-solving skills (102/131, 77.9%), self-reflection (102/131, 77.9%), and usability and applicability (104/131, 79.4%).
    Conclusions: Case-based SG has educational potential for complication management in surgery and could thereby contribute to improvements in postoperative patient care.
    Language English
    Publishing date 2023-11-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2798265-8
    ISSN 2291-9279
    ISSN 2291-9279
    DOI 10.2196/44708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Label-free differentiation of human pancreatic cancer, pancreatitis, and normal pancreatic tissue by molecular spectroscopy.

    Teske, Christian / Kahlert, Christoph / Welsch, Thilo / Liedel, Katja / Weitz, Jürgen / Uckermann, Ortrud / Steiner, Gerald

    Journal of biomedical optics

    2022  Volume 27, Issue 7, Page(s) 75001

    Abstract: Significance: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths with a best median survival of only 40 to 50 months for localized disease despite multimodal treatment. The standard tissue differentiation method ... ...

    Abstract Significance: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths with a best median survival of only 40 to 50 months for localized disease despite multimodal treatment. The standard tissue differentiation method continues to be pathology with histological staining analysis. Microscopic discrimination between inflammatory pancreatitis and malignancies is demanding.
    Aim: We aim to accurately distinguish native pancreatic tissue using infrared (IR) spectroscopy in a fast and label-free manner.
    Approach: Twenty cryopreserved human pancreatic tissue samples were collected from surgical resections. In total, more than 980,000 IR spectra were collected and analyzed using aMATLAB package. For differentiation of PDAC, pancreatitis, and normal tissue, a three-class training set for supervised classification was created with 25,000 spectra and the principal component analysis (PCA) score values for each cohort. Cross-validation was performed using the leaveone- out method. Validation of the algorithm was accomplished with 13 independent test samples.
    Results: Reclassification of the training set and the independent test samples revealed an overall accuracy of more than 90% using a discrimination algorithm.
    Conclusion: IR spectroscopy in combination with PCA and supervised classification is an efficient analytical method to reliably distinguish between benign and malignant pancreatic tissues. It opens up a wide research field for oncological and surgical applications.
    MeSH term(s) Humans ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Pancreas/pathology ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/pathology ; Pancreatitis/diagnosis ; Pancreatitis/pathology ; Spectrum Analysis/methods ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.27.7.075001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Conference proceedings: Der Einfluss von präoperativem Diabetes mellitus auf das Langzeitüberleben nach kurativer Pankreaskarzinom-Resektion – Eine systematische Übersichtsarbeit und Meta-Analyse

    Welsch, Thilo

    2014  , Page(s) 14dgch457

    Event/congress 131. Kongress der Deutschen Gesellschaft für Chirurgie; Berlin; Deutsche Gesellschaft für Chirurgie; 2014
    Keywords Medizin, Gesundheit
    Publishing date 2014-03-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/14dgch457
    Database German Medical Science

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  10. Article ; Online: Predicting postoperative pancreatic fistula in pancreatic head resections: which score fits all?

    Adamu, Mariam / Plodeck, Verena / Adam, Claudia / Roehnert, Anne / Welsch, Thilo / Weitz, Juergen / Distler, Marius

    Langenbeck's archives of surgery

    2021  Volume 407, Issue 1, Page(s) 175–188

    Abstract: Purpose: Postoperative pancreatic fistula (POPF) is a major complication of pancreatic surgery and can be fatal. Better stratification of patients into risk groups may help to select those who might benefit from strategies to prevent complications. The ... ...

    Abstract Purpose: Postoperative pancreatic fistula (POPF) is a major complication of pancreatic surgery and can be fatal. Better stratification of patients into risk groups may help to select those who might benefit from strategies to prevent complications. The aim of this study was to validate ten prognostic scores in patients who underwent pancreatic head surgery.
    Methods: A total of 364 patients were included in this study between September 2012 and August 2017. Ten risk scores were applied to this cohort. Univariate and multivariate analyses were performed considering all risk factors in the scores. Furthermore, the stratification of patients into risk categories was statistically tested.
    Results: Nine of the scores (Ansorge et al., Braga et al., Callery et al., Graham et al., Kantor et al., Mungroop et al., Roberts et al., Yamamoto et al. and Wellner et al.) showed strong prognostic stratification for developing POPF (p < 0.001). There was no significant prognostic value for the Fujiwara et al. risk score. Histology, pancreatic duct diameter, intraabdominal fat thickness in computed tomography findings, body mass index, and C-reactive protein were independent prognostic factors on multivariate analysis.
    Conclusion: Most risk scores tend to stratify patients correctly according to risk for POPF. Nevertheless, except for the fistula risk score (Callery et al.) and its alternative version (Mungroop et al.), many of the published risk scores are obscure even for the dedicated pancreatic surgeon in terms of their clinical practicability. There is a need for future studies to provide strategies for preventing POPF and managing patients with high-risk stigmata.
    MeSH term(s) Humans ; Pancreas/surgery ; Pancreatectomy/adverse effects ; Pancreatic Ducts ; Pancreatic Fistula/etiology ; Pancreatic Fistula/surgery ; Pancreaticoduodenectomy/adverse effects ; Postoperative Complications ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-08-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-021-02290-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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