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  1. Article ; Online: Roles and interactions of tumor microenvironment components in medulloblastoma with implications for novel therapeutics.

    Yang, Hanjie / Li, Min / Deng, Yuhao / Wen, Huantao / Luo, Minjie / Zhang, Wangming

    Genes, chromosomes & cancer

    2024  Volume 63, Issue 4, Page(s) e23233

    Abstract: Medulloblastomas, the most common malignant pediatric brain tumors, can be classified into the wingless, sonic hedgehog (SHH), group 3, and group 4 subgroups. Among them, the SHH subgroup with the TP53 mutation and group 3 generally present with the ... ...

    Abstract Medulloblastomas, the most common malignant pediatric brain tumors, can be classified into the wingless, sonic hedgehog (SHH), group 3, and group 4 subgroups. Among them, the SHH subgroup with the TP53 mutation and group 3 generally present with the worst patient outcomes due to their high rates of recurrence and metastasis. A novel and effective treatment for refractory medulloblastomas is urgently needed. To date, the tumor microenvironment (TME) has been shown to influence tumor growth, recurrence, and metastasis through immunosuppression, angiogenesis, and chronic inflammation. Treatments targeting TME components have emerged as promising approaches to the treatment of solid tumors. In this review, we summarize progress in research on medulloblastoma microenvironment components and their interactions. We also discuss challenges and future research directions for TME-targeting medulloblastoma therapy.
    MeSH term(s) Humans ; Child ; Hedgehog Proteins/genetics ; Medulloblastoma/genetics ; Tumor Microenvironment/genetics ; Brain Neoplasms ; Cerebellar Neoplasms/genetics
    Chemical Substances Hedgehog Proteins
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1018988-9
    ISSN 1098-2264 ; 1045-2257
    ISSN (online) 1098-2264
    ISSN 1045-2257
    DOI 10.1002/gcc.23233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2966: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Predictive factors for persistent postoperative hydrocephalus in children undergoing surgical resection of periventricular tumors.

    Chen, Zitao / Zhou, Ming / Wen, Huantao / Wang, Qiang / Guan, Jianwei / Zhang, Yuan / Zhang, Wangming

    Frontiers in neurology

    2023  Volume 14, Page(s) 1136840

    Abstract: Objective: The aim of this study is to identify the factors predicting persistent hydrocephalus after periventricular tumor resection in children and assess the need and efficacy of perioperative cerebrospinal fluid (CSF) intervention.: Methods: We ... ...

    Abstract Objective: The aim of this study is to identify the factors predicting persistent hydrocephalus after periventricular tumor resection in children and assess the need and efficacy of perioperative cerebrospinal fluid (CSF) intervention.
    Methods: We performed a retrospective analysis of pediatric patients who underwent resection surgery of a periventricular tumor between March 2012 and July 2021 at the Department of Neurosurgery in Zhujiang Hospital of South Medical University. Demographic, radiographic, perioperative, and dispositional data were analyzed using univariate and multivariate models.
    Results: A total of 117 patients were enrolled in our study. Incidence of postoperative persistent hydrocephalus varied with tumor pathology (
    Conclusion: Tumor pathology, location, surgical approach, the extension of resection, tumor volume, preoperative Evan's index, and preoperative CSF diversion were considered to be predictive factors for postoperative persistent hydrocephalus. Notably, posterior median approach, partial resection, and tumor volume > 90cm
    Language English
    Publishing date 2023-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1136840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An Integrative Pan-Cancer Analysis of PBK in Human Tumors.

    Wen, Huantao / Chen, Zitao / Li, Min / Huang, Qiongzhen / Deng, Yuhao / Zheng, Jiawei / Xiong, Moliang / Wang, Pengfei / Zhang, Wangming

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 755911

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.755911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma.

    Deng, Yuhao / Wen, Huantao / Yang, Hanjie / Zhu, Zhengqiang / Huang, Qiongzhen / Bi, Yuewei / Wang, Pengfei / Zhou, Ming / Guan, Jianwei / Zhang, Wangming / Li, Min

    Oncology reports

    2022  Volume 48, Issue 1

    Abstract: Medulloblastoma (MB) is the most frequent malignant brain tumor in pediatrics. Since the current standard of care for MB consisting of surgery, cranio‑spinal irradiation and chemotherapy often leads to a high morbidity rate, a number of patients suffer ... ...

    Abstract Medulloblastoma (MB) is the most frequent malignant brain tumor in pediatrics. Since the current standard of care for MB consisting of surgery, cranio‑spinal irradiation and chemotherapy often leads to a high morbidity rate, a number of patients suffer from long‑term sequelae following treatment. Targeted therapies hold the promise of being more effective and less toxic. Therefore, the present study aimed to identify hub genes with an upregulated expression in MB and to search for potential therapeutic targets from these genes. For this purpose, gene expression profile datasets were obtained from the Gene Expression Omnibus database and processed using R 3.6.0 software to screen differentially expressed genes (DEGs) between MB samples and normal brain tissues. A total of 282 upregulated and 436 downregulated DEGs were identified. Functional enrichment analysis revealed that the upregulated DEGs were predominantly enriched in the cell cycle, DNA replication and cell division. The top 10 hub genes were identified from the protein‑protein interaction network of upregulated genes, and one identified hub gene [PDZ binding kinase (PBK)] was selected for further investigation due to its possible role in the pathogenesis of MB. The aberrant expression of PBK in MB was verified in additional independent gene expression datasets. Survival analysis demonstrated that a higher expression level of PBK was significantly associated with poorer clinical outcomes in non‑Wingless MBs. Furthermore, targeting PBK with its inhibitor, HI‑TOPK‑032, impaired the proliferation and induced the apoptosis of two MB cell lines, with the diminished phosphorylation of downstream effectors of PBK, including ERK1/2 and Akt, and the activation of caspase‑3. Hence, these results suggest that PBK may be a potential prognostic biomarker and a novel candidate of targeted therapy for MB.
    MeSH term(s) Cerebellar Neoplasms/genetics ; Child ; Computational Biology/methods ; Extracellular Signal-Regulated MAP Kinases ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Humans ; Medulloblastoma/genetics ; Protein Interaction Maps
    Chemical Substances Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2022-05-20
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2022.8336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4213: Show issues Location:
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  5. Article ; Online: Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats.

    Chen, Jiazhi / Wang, Qiang / Li, Nanxiang / Huang, Shujie / Li, Min / Cai, Junbin / Wang, Yuzheng / Wen, Huantao / Lv, Siyuan / Wang, Ning / Wang, Jinyan / Luo, Fei / Zhang, Wangming

    Neuroscience bulletin

    2020  Volume 37, Issue 3, Page(s) 323–338

    Abstract: Excessive theta (θ) frequency oscillation and synchronization in the basal ganglia (BG) has been reported in elderly parkinsonian patients and animal models of levodopa (L-dopa)-induced dyskinesia (LID), particularly the θ oscillation recorded during ... ...

    Abstract Excessive theta (θ) frequency oscillation and synchronization in the basal ganglia (BG) has been reported in elderly parkinsonian patients and animal models of levodopa (L-dopa)-induced dyskinesia (LID), particularly the θ oscillation recorded during periods when L-dopa is withdrawn (the off L-dopa state). To gain insight into processes underlying this activity, we explored the relationship between primary motor cortex (M1) oscillatory activity and BG output in LID. We recorded local field potentials in the substantia nigra pars reticulata (SNr) and M1 of awake, inattentive resting rats before and after L-dopa priming in Sham control, Parkinson disease model, and LID model groups. We found that chronic L-dopa increased θ synchronization and information flow between the SNr and M1 in off L-dopa state LID rats, with a SNr-to-M1 flow directionality. Compared with the on state, θ oscillational activity (θ synchronization and information flow) during the off state were more closely associated with abnormal involuntary movements. Our findings indicate that θ oscillation in M1 may be consequent to abnormal synchronous discharges in the BG and support the notion that M1 θ oscillation may participate in the induction of dyskinesia.
    MeSH term(s) Aged ; Animals ; Antiparkinson Agents ; Dyskinesias ; Humans ; Levodopa ; Motor Cortex ; Oxidopamine ; Pars Reticulata ; Rats ; Substantia Nigra
    Chemical Substances Antiparkinson Agents ; Levodopa (46627O600J) ; Oxidopamine (8HW4YBZ748)
    Language English
    Publishing date 2020-11-19
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-020-00606-3
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    In stock of ZB MED Cologne/Königswinter

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