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Article ; Online: Discrepancies in Sagittal Alignment of the Lower Extremity Among Different Brands of Robotic Total Knee Arthroplasty Systems.

An, Hao-Ming / Wen, Jia-Xin / Gu, Wang / Chen, Ji-Ying / Chai, Wei / Li, Rui

2024

Abstract: Background: There is an increasing number of different brands of robotic total knee arthroplasty (TKA) systems. Most robotic TKA systems share the same coronal alignment, while the definitions of sagittal alignment vary. The purpose of this study was to ...

Abstract	Background: There is an increasing number of different brands of robotic total knee arthroplasty (TKA) systems. Most robotic TKA systems share the same coronal alignment, while the definitions of sagittal alignment vary. The purpose of this study was to investigate whether these discrepancies impact the sagittal alignment of the lower extremity. Methods: A total of 72 lower extremity computed tomography scans were included in our study, and 3-dimensional models were obtained using software. A total of 7 brands of robotic TKA systems were included in the study. The lower extremity axes were defined based on the surgical guide for each implant. We also set the intramedullary axis as a reference to evaluate the discrepancies in sagittal alignment of each brand of robotic system. Results: On the femoral side, the axis definition was the same for all 7 robotic TKA systems. The robotic TKA axes showed a 2.41° (1.58°, 3.38°) deviation from the intramedullary axis. On the tibial side, the 7 robots had different axis definitions. The tibial mechanical axis of 6 of the TKA systems was more flexed than that of the intramedullary axis, which means the posterior tibial slope was decreased while the tibial mechanical axis of the remaining system was more extended. Conclusions: The sagittal alignment of the lower extremity for 7 different brands of robotic TKA systems differed from each other and all deviated from the intramedullary axis. Surgeons should be aware of this discrepancy when using different brands of robotic TKA systems to avoid unexpected sagittal alignment and corresponding adverse clinical outcomes. Level of evidence: Level IV, Therapeutic Study.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2024.03.029
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Zs.A 2134: Show issues

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Article ; Online: Human cadaver model as a training tool for enzymatic burn debridement (Nexobrid®): A feasibility study.

Wen, Jiaxin / Johnson, Kirsty / O'Boyle, Ciaran P

Burns : journal of the International Society for Burn Injuries

2022 Volume 48, Issue 7, Page(s) 1706–1709

Abstract: Objectives: To determine the feasibility of using human cadavers to demonstrate enzymatic burn debridement, as a training aid for clinical staff.: Material and methods: A single, fresh-frozen human cadaver was used. Prior consent had been given. ... ...

Abstract	Objectives: To determine the feasibility of using human cadavers to demonstrate enzymatic burn debridement, as a training aid for clinical staff. Material and methods: A single, fresh-frozen human cadaver was used. Prior consent had been given. Burns were created by flame and scalding. Unburned control sites were also assessed. Nexobrid® enzymatic burn debridement paste was applied to all sites, in adherence to the local clinical protocol for treating burned patients. After removal of Nexobrid®, wounds were assessed to determine if the cadaveric tissue appeared similar to what would be expected in living burned patients and whether the technique could be viable for training of burn care staff. Results: Nexobrid® had a very similar effect upon burned cadaveric skin to what would have been expected in living burned skin. Burns of partial thickness burn depth and full thickness burn depth were debrided and could be clearly identified. Conclusions: Fresh-frozen human cadaveric tissue is a valid means of provision of training in the technique of enzymatic burn debridement. This finding was unexpected and shows that our understanding of the mechanism of action of Nexobrid® is incomplete.
MeSH term(s)	Humans ; Bromelains/therapeutic use ; Burns/surgery ; Burns/drug therapy ; Debridement/methods ; Feasibility Studies ; Cadaver
Chemical Substances	Bromelains (9001-00-7)
Language	English
Publishing date	2022-02-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2022.02.008
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Zs.A 1250: Show issues

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Article ; Online: Developmental dysplasia of the hip: A systematic review of susceptibility genes and epigenetics.

Wen, Jiaxin / Ping, Hangyu / Kong, Xiangpeng / Chai, Wei

Gene

2022 Volume 853, Page(s) 147067

Abstract: Background: Developmental dysplasia of the hip (DDH) is a complex developmental deformity whose pathogenesis and susceptibility-related genes have yet to be elucidated. This systematic review summarizes the current literature on DDH-related gene ... ...

Abstract	Background: Developmental dysplasia of the hip (DDH) is a complex developmental deformity whose pathogenesis and susceptibility-related genes have yet to be elucidated. This systematic review summarizes the current literature on DDH-related gene mutations, animal model experiments, and epigenetic changes in DDH. Methods: We performed a comprehensive search of relevant documents in the Medline, Scopus, Cochrane, and ScienceDirect databases covering the period from October 1991 to October 2021. We analyzed basic information on the included studies and summarized the DDH-related mutation sites, animal model experiments, and epigenetic changes associated with DDH. Results: A total of 63 studies were included in the analysis, of which 54 dealt with the detection of gene mutations, 7 presented details of animal experiments, and 6 were epigenetic studies. No genetic mutations were clearly related to the pathogenesis of DDH, including the most frequently studied genes on chromosomes 1, 17, and 20. Most gene-related studies were performed in Han Chinese or North American populations, and the quality of these studies was medium or low. GDF5 was examined in the greatest number of studies, and mutation sites with odds ratios > 10 were located on chromosomes 3, 9, and 13. Six mutations were found in animal experiments (i.e., CX3CR1, GDF5, PAPPA2, TENM3, UFSP2, and WISP3). Epigenetics research on DDH has focused on GDF5 promoter methylation, three microRNAs (miRNAs), and long noncoding RNAs. In addition, there was also a genetic test for miRNA and mRNA sequencing. Conclusions: DDH is a complex joint deformity with a considerable genetic component whose early diagnosis is significant for preventing disease. At present, no genes clearly involved in the pathogenesis of DDH have been identified. Research on mutations associated with this condition is progressing in the direction of in vivo experiments in animal models to identify DDH susceptibility genes and epigenetics analyses to provide novel insights into its pathogenesis. In the future, genetic profiling may improve matters.
Language	English
Publishing date	2022-11-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.147067
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Zs.A 1357: Show issues

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Article: Non-Target Detection of Diversity of Volatile Chlorine Compounds in Frying Oil and Study on the Influencing Factors of Their Formation

Liu, Yaxiong / Wen, Jiaxin / Luo, Zhuoya

Food analytical methods. 2022 Apr., v. 15, no. 4

2022

Abstract: Headspace-gas-chromatography ion-mobility spectrometry (HS-GC-IMS) proved the diversity of volatile chlorinated compounds (VCCs) in frying oil in this work. First, the VCCs were obtained by headspace by heating the frying oil at 80 °C for 30 min. Then, ... ...

Abstract	Headspace-gas-chromatography ion-mobility spectrometry (HS-GC-IMS) proved the diversity of volatile chlorinated compounds (VCCs) in frying oil in this work. First, the VCCs were obtained by headspace by heating the frying oil at 80 °C for 30 min. Then, those compounds were separated by GC capillary column in the first dimension and by IMS in the second dimension, respectively. And at last, those compounds were detected in negative ion mode for non-targeting. The study results indicated that VCCs' formation depends on the contents of NaCl and water, heating temperature and time, and the types of oil. The refining process does not affect the detection of VCCs, indicating the durability of such targets as indicators for assessing deep-frying oil. Using HS-GC-IMS, the VCCs were detected to evaluate 16 authentic refined deep-frying oils from the market with an accuracy of 100%.
Keywords	chlorine ; deep fat frying ; durability ; headspace analysis ; markets ; spectroscopy ; temperature
Language	English
Dates of publication	2022-04
Size	p. 940-949.
Publishing place	Springer US
Document type	Article
ZDB-ID	2429656-9
ISSN	1936-976X ; 1936-9751
ISSN (online)	1936-976X
ISSN	1936-9751
DOI	10.1007/s12161-021-02142-w
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Re$^3$Dial

Wen, Jiaxin / Zhou, Hao / Huang, Minlie

Retrieve, Reorganize and Rescale Dialogue Corpus for Long-Turn Open-Domain Dialogue Pre-training

2023

Abstract: Large-scale open-domain dialogue data crawled from public social media has greatly improved the performance of dialogue models. However, long-turn dialogues are still highly scarce. Specifically, most dialogue sessions in existing corpora have less than ... ...

Abstract	Large-scale open-domain dialogue data crawled from public social media has greatly improved the performance of dialogue models. However, long-turn dialogues are still highly scarce. Specifically, most dialogue sessions in existing corpora have less than three turns. To alleviate this issue, we propose the Retrieve, Reorganize and Rescale framework (Re$^3$Dial), which can automatically construct a billion-scale long-turn dialogue corpus from existing short-turn dialogue data. Re$^3$Dial first trains an Unsupervised Dense Session Retriever (UDSR) to capture semantic and discourse relationships within multi-turn dialogues for retrieving relevant and coherent sessions. It then reorganizes the short-turn dialogues into long-turn sessions via recursively retrieving and selecting the consecutive sessions with our proposed diversity sampling strategy. Extensive evaluations on multiple multi-turn dialogue benchmarks demonstrate that Re$^3$Dial consistently and significantly improves the dialogue model's ability to utilize long-term context for modeling multi-turn dialogues across different pre-training settings. Finally, we build a toolkit for efficiently rescaling dialogue corpus with Re$^3$Dial, which enables us to construct a corpus containing 1B Chinese dialogue sessions with 11.3 turns on average (5X longer than the original EVA corpus). We will release our UDSR model, toolkit, and data for public use. Comment: Work in progress
Keywords	Computer Science - Computation and Language
Publishing date	2023-05-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Ethicist

Zhang, Zhexin / Wen, Jiaxin / Huang, Minlie

Targeted Training Data Extraction Through Loss Smoothed Soft Prompting and Calibrated Confidence Estimation

2023

Abstract: Large pre-trained language models achieve impressive results across many tasks. However, recent works point out that pre-trained language models may memorize a considerable fraction of their training data, leading to the privacy risk of information ... ...

Abstract	Large pre-trained language models achieve impressive results across many tasks. However, recent works point out that pre-trained language models may memorize a considerable fraction of their training data, leading to the privacy risk of information leakage. In this paper, we propose a method named Ethicist for targeted training data extraction through loss smoothed soft prompting and calibrated confidence estimation, investigating how to recover the suffix in the training data when given a prefix. To elicit memorization in the attacked model, we tune soft prompt embeddings while keeping the model fixed. We further propose a smoothing loss that smooths the loss distribution of the suffix tokens to make it easier to sample the correct suffix. In order to select the most probable suffix from a collection of sampled suffixes and estimate the prediction confidence, we propose a calibrated confidence estimation method, which normalizes the confidence of the generated suffixes with a local estimation. We show that Ethicist significantly improves the extraction performance on a recently proposed public benchmark. We also investigate several factors influencing the data extraction performance, including decoding strategy, model scale, prefix length, and suffix length. Our code is available at https://github.com/thu-coai/Targeted-Data-Extraction. Comment: ACL 2023 Long Paper (Main Conference)
Keywords	Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
Subject code	006
Publishing date	2023-07-10
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long-Term Performance of Nitrogen Removal and Microbial Analysis in an Anammox MBBR Reactor with Internal Circulation to Provide Low Concentration DO.

Yin, Xuejiao / Wen, Jiaxin / Zhang, Yihang / Zhang, Xin / Zhao, Jujiao

Toxics

2022 Volume 10, Issue 11

Abstract: The anammox process is considered as a revolutionary new denitrification technology. In this study, the anammox process was started in a single-stage moving bed biofilm reactor (MBBR) and the mechanism of excess removal of ammonia nitrogen was studied. ... ...

Abstract	The anammox process is considered as a revolutionary new denitrification technology. In this study, the anammox process was started in a single-stage moving bed biofilm reactor (MBBR) and the mechanism of excess removal of ammonia nitrogen was studied. At stage I (day 0-51), anammox bacteria (AnAOB) was enriched by feeding synthetic sewage without adding organic carbon. The removal rate of ammonia nitrogen was maintained at about 54% and the removal rate of total inorganic nitrogen was maintained at about 62%. At stage II (day 52-91), internal circulation was added into the MBBR. After adding internal circulation, the ammonium removal efficiency reached about 96% (at day 56) and the total nitrogen removal efficiency reached about 86%. At day 90, the biofilm sample was drowned out for high-throughput sequencing. The results showed that the relative abundance of AnAOB was 23.23%. The dominant anammox genus was
Language	English
Publishing date	2022-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics10110640
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Article: Epigenetic Alterations of DNA Methylation and miRNA Contribution to Lung Adenocarcinoma.

Cai, Wenhan / Jing, Miao / Wen, Jiaxin / Guo, Hua / Xue, Zhiqiang

Frontiers in genetics

2022 Volume 13, Page(s) 817552

Abstract: This study focused on the epigenetic alterations of DNA methylation and miRNAs for lung adenocarcinoma (LUAD) diagnosis and treatment using bioinformatics analyses. DNA methylation data and mRNA and miRNA expression microarray data were obtained from The ...

Abstract	This study focused on the epigenetic alterations of DNA methylation and miRNAs for lung adenocarcinoma (LUAD) diagnosis and treatment using bioinformatics analyses. DNA methylation data and mRNA and miRNA expression microarray data were obtained from The Cancer Genome Atlas (TCGA) database. The differentially methylated genes (DMGs), differentially expressed genes (DEGs), and differentially expressed miRNAs were analyzed by using the limma package. The DAVID database performed GO and KEGG pathway enrichment analyses. Using STRING and Cytoscape, we constructed the protein-protein interaction (PPI) network and achieved visualization. The online analysis tool CMap was used to identify potential small-molecule drugs for LUAD. In LUAD, 607 high miRNA-targeting downregulated genes and 925 low miRNA-targeting upregulated genes, as well as 284 hypermethylated low-expression genes and 315 hypomethylated high-expression genes, were obtained. They were mainly enriched in terms of pathways in cancer, neuroactive ligand-receptor interaction, cAMP signaling pathway, and cytosolic DNA-sensing pathway. In addition, 40 upregulated and 84 downregulated genes were regulated by both aberrant alternations of DNA methylation and miRNAs. Five small-molecule drugs were identified as a potential treatment for LUAD, and five hub genes (
Language	English
Publishing date	2022-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.817552
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Article ; Online: Rheb1 is required for limb growth through regulating chondrogenesis in growth plate.

Zhang, Yuwei / Wen, Jiaxin / Lai, Ruijun / Zhang, Jiahuan / Li, Kai / Zhang, Yue / Liu, Anling / Bai, Xiaochun

Cell and tissue research

2024 Volume 395, Issue 3, Page(s) 261–269

Abstract: Ras homology enriched in the brain (Rheb) is well established as a critical regulator of cell proliferation and differentiation in response to growth factors and nutrients. However, the role of Rheb1 in limb development remains unknown. Here, we found ... ...

Abstract	Ras homology enriched in the brain (Rheb) is well established as a critical regulator of cell proliferation and differentiation in response to growth factors and nutrients. However, the role of Rheb1 in limb development remains unknown. Here, we found that Rheb1 was dynamically expressed during the proliferation and differentiation of chondrocytes in the growth plate. Given that Prrx1
MeSH term(s)	Animals ; Mice ; Cartilage ; Cell Differentiation ; Chondrocytes/metabolism ; Chondrogenesis ; Growth Plate/metabolism ; Osteogenesis/physiology
Chemical Substances	Rheb protein, mouse
Language	English
Publishing date	2024-01-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-024-03861-2
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Ub I Zs.94: Show issues

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Article ; Online: Metabolic profile and transcriptome reveal the mystery of petal blotch formation in rose

Ji, Naizhe / Wang, Qianyu / Li, Shanshan / Wen, Jiaxin / Wang, Liangsheng / Ding, Xiaohao / Zhao, Shiwei / Feng, Hui

BMC Plant Biol. 2023 Dec., v. 23, no. 1 p.46-46

2023

Abstract: BACKGROUND: Petal blotch is a unique ornamental trait in angiosperm families, and blotch in rose petal is rare and has great esthetic value. However, the cause of the formation of petal blotch in rose is still unclear. The influence of key enzyme genes ... ...

Abstract	BACKGROUND: Petal blotch is a unique ornamental trait in angiosperm families, and blotch in rose petal is rare and has great esthetic value. However, the cause of the formation of petal blotch in rose is still unclear. The influence of key enzyme genes and regulatory genes in the pigment synthesis pathways needs to be explored and clarified. RESULTS: In this study, the rose cultivar ‘Sunset Babylon Eyes’ with rose-red to dark red blotch at the base of petal was selected as the experimental material. The HPLC-DAD and UPLC-TQ-MS analyses indicated that only cyanidin 3,5-O-diglucoside (Cy3G5G) contributed to the blotch pigmentation of ‘Sunset Babylon Eyes’, and the amounts of Cy3G5G varied at different developmental stages. Only flavonols but no flavone were found in blotch and non-blotch parts. As a consequence, kaempferol and its derivatives as well as quercetin and its derivatives may act as background colors during flower developmental stages. Despite of the differences in composition, the total content of carotenoids in blotch and non-blotch parts were similar, and carotenoids may just make the petals show a brighter color. Transcriptomic data, quantitative real-time PCR and promoter sequence analyses indicated that RC7G0058400 (F3’H), RC6G0470600 (DFR) and RC7G0212200 (ANS) may be the key enzyme genes for the early formation and color deepening of blotch at later stages. As for two transcription factor, RC7G0019000 (MYB) and RC1G0363600 (WRKY) may bind to the promoters of critical enzyme genes, or RC1G0363600 (WRKY) may bind to the promoter of RC7G0019000 (MYB) to activate the anthocyanin accumulation in blotch parts of ‘Sunset Babylon Eyes’. CONCLUSIONS: Our findings provide a theoretical basis for the understanding of the chemical and molecular mechanism for the formation of petal blotch in rose.
Keywords	Angiospermae ; aesthetics ; anthocyanins ; carotenoids ; color ; cultivars ; cyanidin ; enzymes ; flowers ; kaempferol ; ornamental value ; pigmentation ; promoter regions ; quantitative polymerase chain reaction ; quercetin ; transcription factors ; transcriptome ; transcriptomics
Language	English
Dates of publication	2023-12
Size	p. 46.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2059868-3
ISSN	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-023-04057-6
Database	NAL-Catalogue (AGRICOLA)

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