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Article ; Online: MiR-144-5p/CCL12 Signaling Axis Modulates Ischemic Preconditioning-Mediated Cardio-protection by Reducing Cell Viability, Enhancing Cell Apoptosis, Fibrosis, and Pyroptosis

Chen, Jun-yu / Ruan, Huan-jun / Chen, Shi-yu / Wang, Xiao-qing / Wen, Jun-min / Wang, Zan-xin

Appl Biochem Biotechnol. 2023 Mar., v. 195, no. 3 p.1999-2014

2023

Abstract: Ischemic postconditioning (IPost) represents short periods of nonlethal ischemia–reperfusion performed at the onset of reperfusion. Studies have shown that IPost involves various biological processes such as cell proliferation, apoptosis, and pyroptosis ... ...

Abstract	Ischemic postconditioning (IPost) represents short periods of nonlethal ischemia–reperfusion performed at the onset of reperfusion. Studies have shown that IPost involves various biological processes such as cell proliferation, apoptosis, and pyroptosis and can activate complex signaling pathways. CCL12 is a critical mediator in the inflammatory process after tissue injury. In the present study, we examined the potential actions of CCL12-mediated signaling pathways in cardioprotection after IPost using a cardiomyocyte model. By applying the bioinformatics analysis, we found that CCL12 was upregulated in the rat heart tissues after I/R injury, and the expression level of CCL12 was restored in rats with IPost. The in vitro studies showed that CCL12 and CCR2 expression levels were upregulated in the hypoxia/reoxygenation (H/R)-induced H9C2 cells, which was attenuated in the H/R + hypoxia post-conditioning (PostC) group. The functional assays showed that H/R treatment reduced cell viability, increased cell apoptosis, and promoted fibrosis and pyroptosis of H9C2 cells, which was attenuated in the H/R + PostC group. Overexpression of CCL12 impaired the protective action of hypoxia post-conditioning in the H9C2 cells. Further mechanistic studies showed that miR-144-5p could directly target the 3′ untranslated region of CCL12. Overexpression of miR-144-5p markedly repressed the expression levels of CCL12 and CCR2 in H9C2 cells, while miR-144-5p inhibition had the opposite effects. Furthermore, the inhibition of miR-144-5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R + PostC treatment. In conclusion, CCL12 was downregulated in cardiomyocytes following ischemic postconditioning, and CCL12 overexpression impaired the cardioprotective actions of ischemic postconditioning by reducing cell viability, enhancing cell apoptosis, fibrosis, and pyroptosis. Further mechanistic evidence revealed that CCL12 was a direct target of miR-144-5p, and miR-144-5p/CCL12/CCR2 signaling may represent a critical pathway in mediating the cardioprotective effects of ischemic postconditioning.
Keywords	bioinformatics ; cardiomyocytes ; cardioprotective effect ; cell proliferation ; cell viability ; fibrosis ; hypoxia ; models ; pyroptosis ; rats
Language	English
Dates of publication	2023-03
Size	p. 1999-2014.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	392344-7
ISSN	0273-2289
ISSN	0273-2289
DOI	10.1007/s12010-022-04208-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Hybrid two-stage repair of Stanford A dissection with visceral or peripheral malperfusion.

Wang, Zanxin / Zhuang, Xianmian / Chen, Bailang / Wen, Junmin / Wei, Minxin

Journal of cardiothoracic surgery

2020 Volume 15, Issue 1, Page(s) 265

Abstract: Background: The present study aimed to evaluate the effect of two-stage hybrid aortic repair at the distal aorta of Stanford A dissection with malperfusion.: Methods: This retrospective case series included 20 patients with Stanford A dissection ... ...

Abstract	Background: The present study aimed to evaluate the effect of two-stage hybrid aortic repair at the distal aorta of Stanford A dissection with malperfusion. Methods: This retrospective case series included 20 patients with Stanford A dissection administered two-stage thoracic endovascular aortic repair (TEVAR) about 1 month after central repair because of visceral or limb malperfusion. The patients were examined by computed tomography (CT) angiography at 3, 6, 12 and 24 months after operation. Recovery of malperfusion and true lumen index were evaluated during follow-up. Results: Twenty patients underwent two-stage hybrid aortic repair, including 11 males and 9 females. The follow-up time was 24 ± 7 months. No intervention-related complications were observed, including stent graft-induced new re-entry tears, death, stroke and spinal cord injury. Malperfusion in all cases was corrected. The true lumen was not enlarged enough 1 month after the first surgery. Thrombosis of the false lumen was observed around the elephant trunk at the carina level and the celiac artery. Three months after second stage TEVAR, the false lumen thrombosis was resorbed; in addition, the trunk was fully expanded at the carina level, and the true lumen was enlarged at the celiac artery. Conclusions: Two-stage hybrid aortic repair for residual true lumen in the distal aorta 1 month after initial surgery is helpful for descending aorta remodeling and effective in treating malperfusion. This procedure may be a good option for patients suffering from Stanford A dissection with small true lumen in the distal aorta and malperfusion.
MeSH term(s)	Aged ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-09-24
Publishing country	England
Document type	Journal Article
ISSN	1749-8090
ISSN (online)	1749-8090
DOI	10.1186/s13019-020-01307-8
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Article ; Online: Changes in Coagulation and Fibrinolysis Systems During the Perioperative Period of Acute Type A Aortic Dissection.

Zhou, Chuzhi / Li, Yanzhen / Yan, Yalan / Feng, Dongjie / Wei, Minxin / Wen, Junmin

The heart surgery forum

2021 Volume 24, Issue 2, Page(s) E223–E230

Abstract: Background: Acute type A aortic dissection (ATAAD) has a high risk of perioperative bleeding and often requires extensive blood product infusions. Analysis of the changes in coagulation and fibrinolysis is both helpful for proper treatment and an ... ...

Abstract	Background: Acute type A aortic dissection (ATAAD) has a high risk of perioperative bleeding and often requires extensive blood product infusions. Analysis of the changes in coagulation and fibrinolysis is both helpful for proper treatment and an improved prognosis. The present study investigated the changes in the coagulation and fibrinolysis systems during the perioperative period of ATAAD. Methods: Twenty-two patients with ATAAD were included in this study. After diagnosis, all patients underwent ascending aorta replacement, aortic arch replacement, and implantation of a special stented endovascular graft. The control group included 25 patients undergoing elective aortic surgery. Baseline preoperative, intraoperative, and postoperative data were collected in both groups. Venous blood samples of all subjects were collected at five time points, after admission (T1), before surgery (T2), after protamine reversal (T3), postoperative 6 h (T4), and postoperative 24 h (T5), measuring the concentrations of platelet factor 4 (PF4), prothrombin fragment 1 + 2 (F1+2), tissue factor (TF), tissue factor pathway inhibitor (TFPI), plasminogen activator (PA), plasminogen activator inhibitor-1 (PAI-1) and thrombin antithrombin complex (TAT) by enzyme-linked immunosorbent assays (ELISAs). Results: The average age of the ATAAD group was 49.9±12.5 years old, while that of the control group was 57.0±12.1 years old. There were more patients with a smoking history, and the cardiopulmonary bypass time, aortic cross-clamp time, and preoperative left ventricular ejection fraction were higher in the ATAAD group than in the control group (P < 0.05). Additionally, preoperative fibrin degradation products (FDP) and preoperative D-dimer were higher in the ATAAD group than in the control group (P < 0.05). However, time from onset to operation, intraoperative core temperature, preoperative B-type natriuretic peptide (BNP), and left ventricular end-diastolic diameter in the ATAAD group were lower than those in the control group (P < 0.05). In contrast, however, the proportion of abnormal bicuspid aortic valves in the control group was higher (P < 0.05). TF in the ATAAD group was significantly higher at T1 (7.9±3.7 ng/mL versus 0.9±0.7 ng/mL, P < 0.05). The TFPI in the ATAAD group was higher than that in the control group at T1 and T2 (P < 0.05). Additionally, PA in the ATAAD group was higher than that in the control group at T1, T2, T3, and T5 (P < 0.05), while PA in the control group was significantly higher at T3 than at T1 (P < 0.05). There was no significant difference in PAI-1 between the two groups before surgery (P > 0.05). Nevertheless, both groups reached their peak value at T3. The platelet count and fibrinogen (FBG) in the ATAAD group decreased significantly from T1 to T2 and continued to decrease after cardiopulmonary bypass. F1+2 and TAT in the ATAAD group were higher than in the control group (P < 0.05); however, they peaked at T3. The PF4 in the ATAAD group slightly increased at T1, while PF4 at T3 was significantly higher than at T1 (P < 0.05). Conclusion: The changes in coagulation and fibrinolysis in the ATAAD group before surgery were very significant, which caused a large amount of fibrinogen and platelet consumption. Cardiopulmonary bypass (CPB) and a lower intraoperative core temperature exacerbated the coagulation and fibrinolysis disorder, and the pro-coagulant function of the platelets was activated after surgery. Maintaining the normal concentration of fibrinogen was helpful to correct the coagulation function disorder.
MeSH term(s)	Acute Disease ; Aneurysm, Dissecting/blood ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm, Thoracic/blood ; Aortic Aneurysm, Thoracic/surgery ; Biomarkers/blood ; Blood Coagulation/physiology ; Female ; Fibrinolysis/physiology ; Humans ; Male ; Middle Aged ; Perioperative Period ; Prospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2069188-9
ISSN	1522-6662 ; 1098-3511
ISSN (online)	1522-6662
ISSN	1098-3511
DOI	10.1532/hsf.3503
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Article ; Online: MiR-144-5p/CCL12 Signaling Axis Modulates Ischemic Preconditioning-Mediated Cardio-protection by Reducing Cell Viability, Enhancing Cell Apoptosis, Fibrosis, and Pyroptosis.

Chen, Jun-Yu / Ruan, Huan-Jun / Chen, Shi-Yu / Wang, Xiao-Qing / Wen, Jun-Min / Wang, Zan-Xin

Applied biochemistry and biotechnology

2022 Volume 195, Issue 3, Page(s) 1999–2014

Abstract: Ischemic postconditioning (IPost) represents short periods of nonlethal ischemia-reperfusion performed at the onset of reperfusion. Studies have shown that IPost involves various biological processes such as cell proliferation, apoptosis, and pyroptosis ... ...

Abstract	Ischemic postconditioning (IPost) represents short periods of nonlethal ischemia-reperfusion performed at the onset of reperfusion. Studies have shown that IPost involves various biological processes such as cell proliferation, apoptosis, and pyroptosis and can activate complex signaling pathways. CCL12 is a critical mediator in the inflammatory process after tissue injury. In the present study, we examined the potential actions of CCL12-mediated signaling pathways in cardioprotection after IPost using a cardiomyocyte model. By applying the bioinformatics analysis, we found that CCL12 was upregulated in the rat heart tissues after I/R injury, and the expression level of CCL12 was restored in rats with IPost. The in vitro studies showed that CCL12 and CCR2 expression levels were upregulated in the hypoxia/reoxygenation (H/R)-induced H9C2 cells, which was attenuated in the H/R + hypoxia post-conditioning (PostC) group. The functional assays showed that H/R treatment reduced cell viability, increased cell apoptosis, and promoted fibrosis and pyroptosis of H9C2 cells, which was attenuated in the H/R + PostC group. Overexpression of CCL12 impaired the protective action of hypoxia post-conditioning in the H9C2 cells. Further mechanistic studies showed that miR-144-5p could directly target the 3' untranslated region of CCL12. Overexpression of miR-144-5p markedly repressed the expression levels of CCL12 and CCR2 in H9C2 cells, while miR-144-5p inhibition had the opposite effects. Furthermore, the inhibition of miR-144-5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R + PostC treatment. In conclusion, CCL12 was downregulated in cardiomyocytes following ischemic postconditioning, and CCL12 overexpression impaired the cardioprotective actions of ischemic postconditioning by reducing cell viability, enhancing cell apoptosis, fibrosis, and pyroptosis. Further mechanistic evidence revealed that CCL12 was a direct target of miR-144-5p, and miR-144-5p/CCL12/CCR2 signaling may represent a critical pathway in mediating the cardioprotective effects of ischemic postconditioning.
MeSH term(s)	Rats ; Animals ; Pyroptosis/genetics ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/prevention & control ; Cell Survival ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Apoptosis/genetics ; Ischemic Preconditioning ; Myocytes, Cardiac/metabolism ; Hypoxia/metabolism
Chemical Substances	MicroRNAs ; MIRN144 microRNA, rat
Language	English
Publishing date	2022-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-022-04208-9
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Article ; Online: Gene expression profiling analysis to investigate the role of remote ischemic postconditioning in ischemia-reperfusion injury in rats.

Wang, Zanxin / Wen, Junmin / Zhou, Chuzhi / Wang, Zhiwei / Wei, Minxin

BMC genomics

2019 Volume 20, Issue 1, Page(s) 361

Abstract: Background: Blood flow restoration is a definitive therapy for salvaging the myocardium following ischemic injury. Nevertheless, the sudden restoration of blood flow to the ischemic myocardium can induce ischemia-reperfusion injury (IRI).: Results: ... ...

Abstract	Background: Blood flow restoration is a definitive therapy for salvaging the myocardium following ischemic injury. Nevertheless, the sudden restoration of blood flow to the ischemic myocardium can induce ischemia-reperfusion injury (IRI). Results: Herein, we investigated the cardioprotective effect of remote ischemic postconditioning (RPostC) through our in vivo rat model of myocardial IRI. The study included three groups: the control group, the IRI group, and the IRI + RPostC group. Ischemia-reperfusion treatment led to an increase in the myocardial infarction area, which was inhibited by RPostC. In contrast to that in the control group, the myocardial apoptosis level was enhanced in the IRI group, whereas RPostC treatment decreased IRI-induced cellular apoptosis. Affymetrix Rat Gene 2.0 ST chip data identified a total of 265 upregulated genes and 267 downregulated genes between the IRI and IRI + RPostC groups. A group of differentially expressed noncoding RNAs (ncRNAs), such as MTA_TC0600002772.mm, MTA_TC1300002394.mm, U7 small nuclear RNA (Rnu7) and RGD7543256_1, were identified. Gene Ontology (GO) enrichment analysis indicated that the positive regulation of some molecular functions, such as GTPase activity, GTP binding, cyclic-nucleotide phosphodiesterase activity and cytokine activity, may contribute to the cardioprotective role of RPostC. Moreover, pathway enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) suggested the potential implication of the TNF signaling pathway and Toll-like receptor signaling pathway. Global signal transduction network analysis, co-expression network analysis and quantitative real-time polymerase chain reaction analysis further identified several core genes, including Pdgfra, Stat1, Lifr and Stfa3. Conclusion: Remote ischemic postconditioning treatment can decrease IRI-mediated myocardial apoptosis by regulating multiple processes and pathways, such as GTPase activity, cytokine activity, and the TNF and Toll-like receptor signaling pathways. The potential role of the above ncRNAs and core genes in IRI-induced cardiac damage merits further study as well.
MeSH term(s)	Animals ; Apoptosis ; Gene Expression Profiling/methods ; Gene Regulatory Networks ; Ischemic Postconditioning/methods ; Male ; Rats ; Rats, Wistar ; Reperfusion Injury/genetics ; Reperfusion Injury/prevention & control ; Signal Transduction
Language	English
Publishing date	2019-05-09
Publishing country	England
Document type	Journal Article
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/s12864-019-5743-9
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Article ; Online: Implication of inhaled nitric oxide for the treatment of critically ill COVID-19 patients with pulmonary hypertension.

Feng, Wen-Xia / Yang, Yang / Wen, Junmin / Liu, Ying-Xia / Liu, Lei / Feng, Cheng

ESC heart failure

2020 Volume 8, Issue 1, Page(s) 714–718

Abstract: Aims: This study aims to analyse whether inhaled nitric oxide (iNO) was beneficial in the treatment of coronavirus disease 2019 (COVID-19) patients with pulmonary hypertension.: Methods and results: Five critically ill COVID-19 patients with ... ...

Abstract	Aims: This study aims to analyse whether inhaled nitric oxide (iNO) was beneficial in the treatment of coronavirus disease 2019 (COVID-19) patients with pulmonary hypertension. Methods and results: Five critically ill COVID-19 patients with pulmonary hypertension designated Cases 1-5 were retrospectively included. Clinical data before and after iNO treatment were serially collected and compared between patients with or without iNO treatment. The five cases experienced pulmonary artery systolic pressure (PASP) elevation (≥50 mmHg) at 30, 24, 33, 23, and 24 days after illness onset (d.a.o), respectively. Cases 1-3 received iNO treatment on the 24th, 13th, and 1st day after the first elevation of PASP, with concentrations varied from 10 to 20 ppm based on the changes of PASP and blood pressure for 10, 9, and 5 days, respectively. Upon iNO treatment, PASP of Cases 1 and 2 returned to normal on the 10th day and 1st day, and maintained between 50 and 58 mmHg in Case 3. Pa0 Conclusions: Inhaled nitric oxide treatment was beneficial in reducing and stabilizing the PASP and might also reduce the risk of right heart failure in COVID-19 with pulmonary hypertension.
MeSH term(s)	Administration, Inhalation ; COVID-19/complications ; COVID-19/drug therapy ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Middle Aged ; Nitric Oxide/administration & dosage ; Nitric Oxide/therapeutic use ; Retrospective Studies
Chemical Substances	Nitric Oxide (31C4KY9ESH)
Keywords	covid19
Language	English
Publishing date	2020-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13023
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Article ; Online: 99-Case Study of Sporadic Aortic Dissection by Whole Exome Sequencing Indicated Novel Disease-Associated Genes and Variants in Chinese Population.

Wang, Zanxin / Zhuang, Xianmian / Chen, Bailang / Wen, Junmin / Peng, Fang / Liu, Xiling / Wei, Minxin

BioMed research international

2020 Volume 2020, Page(s) 7857043

Abstract: Background: In this study, the whole exome sequencing in human aortic dissection, a highly lethal cardiovascular disease, was investigated to explore the aortic dissection-associated genes and variants in Chinese population.: Methods: Whole exome ... ...

Abstract	Background: In this study, the whole exome sequencing in human aortic dissection, a highly lethal cardiovascular disease, was investigated to explore the aortic dissection-associated genes and variants in Chinese population. Methods: Whole exome sequencing was performed in 99 cases of aortic dissection. All single nucleotide polymorphisms (SNPs), insertions/deletions (InDels), and copy number variations (CNVs) were filtered to exclude the benign variants. Enrichment analysis and disease-gene correlation analysis were performed. Results: 3425873 SNPs, 685245 InDels, and 1177 CNVs were identified, and aortic dissection-associated SNPs, InDels, and CNVs were collected. After the disease correlation analysis, 20 candidate genes were identified. Part of these genes such as Conclusion: The pathogenic and likely pathogenic variants in most of AD-associated genes (
MeSH term(s)	Aneurysm, Dissecting/epidemiology ; Aneurysm, Dissecting/genetics ; Aortic Aneurysm, Thoracic/epidemiology ; Aortic Aneurysm, Thoracic/genetics ; Asians/genetics ; China ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Protein Interaction Maps/genetics ; Whole Exome Sequencing/methods
Language	English
Publishing date	2020-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2020/7857043
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Article ; Online: Research on clinical characteristics and prognostic analysis of heparin-induced thrombocytopenia after surgery for acute type a aortic dissection.

Zhou, Chu-Zhi / Feng, Dong-Jie / Fang, Yuan / Zha, Feng-Yan / Wang, Er-Hui / Li, Yan-Zhen / Wei, Min-Xin / Wen, Jun-Min

Journal of cardiothoracic surgery

2021 Volume 16, Issue 1, Page(s) 96

Abstract: Purpose: The present study aimed to explore the clinical characteristics of heparin-induced thrombocytopenia (HIT) after surgery for acute type A aortic dissection and perform a relevant prognostic analysis.: Methods: After continuous observation and ...

Abstract	Purpose: The present study aimed to explore the clinical characteristics of heparin-induced thrombocytopenia (HIT) after surgery for acute type A aortic dissection and perform a relevant prognostic analysis. Methods: After continuous observation and analysis of 204 patients who underwent acute type A aortic dissection, we found that blood platelets decreased significantly after surgery and that these patients can be suspected to suffer HIT based on relevant 4Ts scores. For these suspected HIT patients, a latex particle-enhanced immunoturbidimetric assay was conducted to detect heparin-induced antibodies. Perioperative clinical data of patients in HIT and non-HIT groups were recorded as were blood platelet counts, HIT antibody test results, 4Ts scores, thromboembolic complications, clinical prognosis and outcomes. Results: In the present study, 38 suspected HIT patients, 16 HIT patients and 188 non-HIT patients were selected in the clinical setting. Among them, HIT patients were found to have prolonged cardiopulmonary bypass time (223 min on average vs. 164 min) and delayed aortic cross-clamp time (128 min on average vs. 107 min), and these differences between HIT patients and non-HIT patients were significant (P < 0.05). Additionally, the HIT group required longer operation time and higher dose of heparin, but showing no statistical differences (P > 0.05). The transfusions of blood platelets in the HIT group and non-HIT group were 18.7 ± 5.0u and 15.6 ± 7.34 u, respectively. In the HIT group, the mechanic ventilation time and the length of ICU stay were longer comparing the non-HIT group(P < 0.05), though no significant differences in total length of stay or In-hospital mortality were observed (P > 0.05). The incidence of continuous renal replacement therapy in HIT group was higher than the non-HIT group (P < 0.05). Additionally,there were no significant differences in 24-h postoperative drainage or reoperation for bleeding in both group(P > 0.05). However, the HIT antibody titer in the HIT group was significantly higher than that in the Suspected HIT group (2.7 ± 0.8 U/mL vs. 0.3 ± 0.2 U/mL) (P < 0.05). Among patients diagnosed with HIT, the incidence of thromboembolism reached 31.5%.For example, two HIT patients newly developed thromboembolism in both lower extremities,and three patients experienced cerebral infarction. Conclusions: After surgery for acute type A aortic dissection, HIT patients developed postoperative complications, the duration of ventilatory support and length of ICU stay were extended, and the incidence of thromboembolism increased. HIT antibody detection and risk classification should be implemented for high-risk patients showing early clinical characteristics.
MeSH term(s)	Adult ; Aged ; Aneurysm, Dissecting/surgery ; Anticoagulants/adverse effects ; Aortic Aneurysm/surgery ; Female ; Heparin/adverse effects ; Humans ; Male ; Middle Aged ; Postoperative Complications/chemically induced ; Postoperative Complications/diagnosis ; Postoperative Complications/physiopathology ; Postoperative Complications/prevention & control ; Prognosis ; Prospective Studies ; Risk Assessment ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis ; Thrombocytopenia/physiopathology ; Thrombocytopenia/prevention & control
Chemical Substances	Anticoagulants ; Heparin (9005-49-6)
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Journal Article ; Observational Study
ISSN	1749-8090
ISSN (online)	1749-8090
DOI	10.1186/s13019-021-01482-2
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Article: Noninvasive Ventilation in Patients With COVID-19-Related Acute Hypoxemic Respiratory Failure: A Retrospective Cohort Study.

Fu, Yingyun / Guan, Lili / Wu, Weibo / Yuan, Jing / Zha, Shanshan / Wen, Junmin / Lin, Zhenghao / Qiu, Chen / Chen, Rongchang / Liu, Lei

Frontiers in medicine

2021 Volume 8, Page(s) 638201

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.638201
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Article ; Online: Methylation-dependent transcriptional repression of RUNX3 by KCNQ1OT1 regulates mouse cardiac microvascular endothelial cell viability and inflammatory response following myocardial infarction.

Wang, Yanbin / Yang, Xudong / Jiang, An / Wang, Wei / Li, Jian / Wen, Junmin

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2019 Volume 33, Issue 12, Page(s) 13145–13160

Abstract: Myocardial infarction (MI) is a major contributor to death and disability throughout the world. Increasing evidence shows that long noncoding RNAs (lncRNAs) are involved in the progression of MI. Here, we hypothesized that lncRNA potassium voltage-gated ... ...

Abstract	Myocardial infarction (MI) is a major contributor to death and disability throughout the world. Increasing evidence shows that long noncoding RNAs (lncRNAs) are involved in the progression of MI. Here, we hypothesized that lncRNA potassium voltage-gated channel subfamily q member 1 overlapping transcript 1 (KCNQ1OT1) could affect the development of MI
MeSH term(s)	Animals ; Cell Survival/genetics ; Cell Survival/physiology ; Chromatin Immunoprecipitation ; Core Binding Factor Alpha 3 Subunit/genetics ; Core Binding Factor Alpha 3 Subunit/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; Immunoprecipitation ; In Situ Nick-End Labeling ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/genetics ; Myocardial Infarction/immunology ; Myocardial Infarction/metabolism ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism
Chemical Substances	Core Binding Factor Alpha 3 Subunit ; Potassium Channels, Voltage-Gated ; Runx3 protein, mouse ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; Dnmt1 protein, mouse (EC 2.1.1.37)
Language	English
Publishing date	2019-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.201900310R
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In stock of ZB MED Cologne/Königswinter

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