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Article ; Online: GRACE time-variable gravity and its application to geoscience

Cao Liu / WenKe Sun

Earth and Planetary Physics, Vol 7, Iss 2, Pp 295-

Quantitative analysis of relevant literature

2023 Volume 309

Abstract: The Gravity Recovery and Climate Experiment (GRACE) is the most important gravity satellite to date in human history. Since its launch in 2002, GRACE time-varying gravity has had an unprecedented impact on earth science and has generated revolutionary ... ...

Abstract	The Gravity Recovery and Climate Experiment (GRACE) is the most important gravity satellite to date in human history. Since its launch in 2002, GRACE time-varying gravity has had an unprecedented impact on earth science and has generated revolutionary changes. Because of natural phenomena such as climate warming, glacial melting, sea level rise, and earthquakes, earth science research has become an increasingly popular discipline in recent years. This article summarizes the importance of GRACE time-varying gravity, its application to geoscience, and its development. We analyzed the historical development and current status of GRACE time-varying gravity as well as research hotspots by searching the literature in the core collection databases of the China National Knowledge Infrastructure and the Web of Science over the past 20 years. The CiteSpace and VOSviewer software packages were applied with reference to the principle of literature metrology. Our investigation and analysis of characteristic indexes, such as the numbers of publications, co-occurrence of keywords, and co-citation of documents, uncovered the wide application and promotion of gravity satellites, especially GRACE time-varying gravity, in earth science. The results showed that the number of publications addressing GRACE data and time-varying gravity theory is increasing annually and that the USA, China, and Germany are the main producers. The Chinese Academy of Sciences, the National Aeronautics and Space Administration of the United States, and the Helmholtz Association of German Research Centres rank among the top three institutions in the world in terms of producing the most publications on this topic. We found that GRACE time-varying gravity plays unique roles in measuring changes in terrestrial water storage changes, ice and snow melting and sea level changes, and (co)seismic gravity changes, as well as in promoting other disciplines.
Keywords	gravity recovery and climate experiment (grace) ; gravity recovery and climate experiment follow-on (grace-fo) ; time-varying gravity ; bibliometry ; mass change ; citespace ; vosviewer ; Science ; Q ; Geophysics. Cosmic physics ; QC801-809 ; Environmental sciences ; GE1-350
Subject code	001
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Science Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dietary steroids promote body weight growth and induce gametogenesis by increasing the expressions of genes related to cell proliferation of sea cucumber (Apostichopus japonicus).

Liang, Wen-Ke / Zhang, Li-Bin / Xu, Jia-Lei

Comparative biochemistry and physiology. Part D, Genomics & proteomics

2024 Volume 49, Page(s) 101191

Abstract: Steroids play a vital role in animal survival, promoting growth and development when administered appropriate concentration exogenously. However, it remains unclear whether steroids can induce gonadal development and the underlying mechanism. This study ... ...

Abstract	Steroids play a vital role in animal survival, promoting growth and development when administered appropriate concentration exogenously. However, it remains unclear whether steroids can induce gonadal development and the underlying mechanism. This study assessed sea cucumber weights post-culturing, employing paraffin sections and RNA sequencing (RNA-seq) to explore gonadal changes and gene expression in response to exogenous steroid addition. Testosterone and cholesterol, dissolved in absolute ethanol, were incorporated into sea cucumber diets. After 30 days, testosterone and cholesterol significantly increased sea cucumber weights, with the total weight of experimental groups surpassing the control. The testosterone-fed group exhibited significantly higher eviscerated weight than the control group. In addition, dietary steroids influenced gonad morphology and upregulated genes related to cell proliferation，such as RPL35, PC, eLF-1, MPC2, ADCY10 and CYP2C18. Thees upregulated differentially expressed genes were significantly enriched in the organic system, metabolism, genetic information and environmental information categories. These findings imply that steroids may contribute to the growth and the process of genetic information translation and protein synthesis essential for gonadal development and gametogenesis.
MeSH term(s)	Animals ; Stichopus/genetics ; Sea Cucumbers/genetics ; Weight Gain ; Cell Proliferation ; Gametogenesis ; Testosterone ; Cholesterol
Chemical Substances	Testosterone (3XMK78S47O) ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2024-01-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2212119-5
ISSN	1878-0407 ; 1744-117X
ISSN (online)	1878-0407
ISSN	1744-117X
DOI	10.1016/j.cbd.2024.101191
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Article ; Online: Managing Emotion In The Workplace

Shih-Wen Ke / Chih-Fong Tsai / Yi-Jun Chen

Applied Artificial Intelligence, Vol 38, Iss

An Empirical Study With Enterprise Instant Messaging

2024 Volume 1

Abstract: ABSTRACTEnterprise Instant Messaging (EIM) has become an increasingly important tool for enterprises to operate efficiently and for the employees to communicate smoothly, especially with the recent outbreak of the pandemic. This means that employers and ... ...

Abstract	ABSTRACTEnterprise Instant Messaging (EIM) has become an increasingly important tool for enterprises to operate efficiently and for the employees to communicate smoothly, especially with the recent outbreak of the pandemic. This means that employers and employees are having to adapt to new ways of working, e.g. teleworking or home-based working, and they could experience emotional stress, irritability and anxiety. However, few studies have used sentiment analysis to help employees manage their emotions and past studies mostly applied retrospective sentiment analysis on user-generated content as such as Twitter or the internal enterprise data. In this study we present an Employee Sentiment Analysis and Management System (ESAMS) that continuously monitors the emotions of the employees in real time by analyzing the conversations so the managerial members and the team members can actively manage their emotions or adjust their actions on the spot. As a proof-of-concept, we use Naïve Bayes as our sentiment classifier and achieve an average classification accuracy of 74%. The ESAMS was pilot-tested for one month by 10 participants, who were later interviewed as part of the evaluation. The results show that the ESAMS was helpful in improving team performance and team management.
Keywords	Enterprise instant messaging ; emotion management ; machine learning ; sentiment analysis ; Electronic computers. Computer science ; QA75.5-76.95 ; Cybernetics ; Q300-390
Subject code	650
Language	English
Publishing date	2024-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
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Article ; Online: Small money, big change: The distributional impact of differentiated doctor's visit fee on healthcare utilization.

Wang, Tianyu / Wen, Ke / Gao, Qiuming / Sun, Ruochen

Social science & medicine (1982)

2023 Volume 339, Page(s) 116355

Abstract: A prominent issue in China's healthcare sector is the overcrowding of high-tier hospitals, whereas low-tier hospitals and community health centers are severely underutilized. This study aims to examine whether doctor's visit fee and copay differentiated ... ...

Abstract	A prominent issue in China's healthcare sector is the overcrowding of high-tier hospitals, whereas low-tier hospitals and community health centers are severely underutilized. This study aims to examine whether doctor's visit fee and copay differentiated by the level of healthcare providers can change the distribution of outpatient visits across different levels of healthcare providers. By leveraging the exogeneity of the policy change implemented in a megacity in China in 2017, we apply a parametric discontinuity regression model to study the causal impact of differentiated pricing on patients' health-seeking behavior, using a large-scale insurance claim database. We find that the reform of differentiated doctor's visit fee schedule effectively increases the proportion of visits to primary care facilities among all outpatient visits. This effect is driven by a decline in visits to the highest-tier hospitals and an increase in visits to community healthcare centers. Furthermore, the policy effects are more pronounced among the elderly and people with chronic diseases. Our results suggest that shifting the focus of pricing policies from coinsurance to copays while continuing to improve the capacity of primary care facilities is an effective way to facilitate triaging patients into different levels of care without triggering moral hazard.
MeSH term(s)	Humans ; Aged ; Patient Acceptance of Health Care ; Costs and Cost Analysis ; Hospitals ; China
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2023.116355
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Article ; Online: The Neural Processes in Food Decision-making and their Effect on Daily Diet Management in Successful and Unsuccessful Restrained Eaters.

Zhang, Xuemeng / Wen, Ke / Han, Jinfeng / Chen, Hong

Neuroscience

2023 Volume 517, Page(s) 1–17

Abstract: This study aimed to explore the neural mechanisms underlying food decision making in unsuccessful restrained eaters (US-REs) and successful restrained eaters (S-REs). During a functional magnetic resonance imaging scan, participants were required to ... ...

Abstract	This study aimed to explore the neural mechanisms underlying food decision making in unsuccessful restrained eaters (US-REs) and successful restrained eaters (S-REs). During a functional magnetic resonance imaging scan, participants were required to choose between pairs of high- and low-calorie foods under the following conditions: the congruent condition (choose between high- and low-calorie foods with the same level of tastiness) and incongruent condition (choose between high-calorie foods tastier than the corresponding low-calorie foods). Subsequently, the participants' diets were monitored for one week. The behavioral results showed that US-REs (n = 28) chose more high-calorie foods than S-REs (n = 26); in contrast, S-REs spent more time in choosing for the incongruent than the congruent condition. The fMRI results found that US-REs exhibited more activity in reward regions (caudate and thalamus) than S-REs in the congruent condition. In the incongruent condition, S-REs showed stronger functional connectivity between the conflict-monitoring region (anterior cingulate cortex) and inhibitory-control regions (inferior frontal gyrus [IFG] and medial frontal gyrus) than US-REs. In both the conditions, increased activation of the insula, putamen, middle frontal gyrus, and IFG could predict increased food intake among US-REs in the following week. Furthermore, in both the conditions, increased IFG activation could predict decreased food cravings among S-REs during the following week. Our results suggest that US-REs have a strong reward response to food. Compared to US-REs, S-REs are more guided more by the goal of weight control, and exhibit strong functional connections between the conflict-monitoring and inhibitory-control regions. Therefore, eating enjoyment and weight-control goals influence restrained eating in daily life.
MeSH term(s)	Humans ; Feeding Behavior/physiology ; Food ; Motivation ; Craving ; Diet ; Magnetic Resonance Imaging ; Eating
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2023.01.023
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Article ; Online: Safety and efficacy of non-reduced use of caspofungin in patients with Child-Pugh B or C cirrhosis: a real-world study.

Yuan, Shi-Dan / Wen, Ke-Li / Cao, Yun-Xing / Huang, Wen-Qi / Zhang, An

Infection

2024

Abstract: Background and purpose: The need for dose adjustment of caspofungin in patients with hepatic impairment is controversial, especially for those with Child-Pugh B or C cirrhosis. The purpose of this study was to investigate the safety and efficacy of ... ...

Abstract	Background and purpose: The need for dose adjustment of caspofungin in patients with hepatic impairment is controversial, especially for those with Child-Pugh B or C cirrhosis. The purpose of this study was to investigate the safety and efficacy of standard-dose caspofungin administration in Child-Pugh B and C cirrhotic patients in a real-world clinical setting. Patients and methods: The electronic medical records of 258 cirrhotic patients, including 67 Child-Pugh B patients and 191 Child-Pugh C patients, who were treated with standard-dose of caspofungin at the Second Affiliated Hospital of Chongqing Medical University, China, from March 2018 to June 2023 were reviewed retrospectively. The white blood cells (WBC), hepatic, renal and coagulation function results before administration and post administration on days 7, 14 and 21 were collected, and the efficacy was assessed in all patients at the end of caspofungin therapy. Results: Favorable responses were achieved in 137 (53.1%) patients while 34 (13.2%) patients died. We observed that some patients experienced an increase of prothrombin time (PT) or international normalized ratio (INR), or a decrease of WBC, but no exacerbation of hepatic or renal dysfunction were identified and no patient required dose interruption or adjustment because of an adverse drug reaction during treatment with caspofungin. Conclusions: Standard-dose of caspofungin can be safely and effectively used in patients with Child-Pugh B or C cirrhosis, and we appealed to re-assess the most suitable dosing regimen in this population to avoid a potential subtherapeutic exposure.
Language	English
Publishing date	2024-01-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-023-02162-0
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Exploring the molecular mechanism of Xuebifang in the treatment of diabetic peripheral neuropathy based on bioinformatics and network pharmacology.

Hu, Faquan / Lin, Jiaran / Xiong, Liyuan / Li, Zhengpin / Liu, Wen-Ke / Zheng, Yu-Jiao

Frontiers in endocrinology

2024 Volume 15, Page(s) 1275816

Abstract: Background: Xuebifang (XBF), a potent Chinese herbal formula, has been employed in managing diabetic peripheral neuropathy (DPN). Nevertheless, the precise mechanism of its action remains enigmatic.: Purpose: The primary objective of this ... ...

Abstract	Background: Xuebifang (XBF), a potent Chinese herbal formula, has been employed in managing diabetic peripheral neuropathy (DPN). Nevertheless, the precise mechanism of its action remains enigmatic. Purpose: The primary objective of this investigation is to employ a bioinformatics-driven approach combined with network pharmacology to comprehensively explore the therapeutic mechanism of XBF in the context of DPN. Study design and methods: The active chemicals and their respective targets of XBF were sourced from the TCMSP and BATMAN databases. Differentially expressed genes (DEGs) related to DPN were obtained from the GEO database. The targets associated with DPN were compiled from the OMIM, GeneCards, and DrugBank databases. The analysis of GO, KEGG pathway enrichment, as well as immuno-infiltration analysis, was conducted using the R language. The investigation focused on the distribution of therapeutic targets of XBF within human organs or cells. Subsequently, molecular docking was employed to evaluate the interactions between potential targets and active compounds of XBF concerning the treatment of DPN. Results: The study successfully identified a total of 122 active compounds and 272 targets associated with XBF. 5 core targets of XBF for DPN were discovered by building PPI network. According to GO and KEGG pathway enrichment analysis, the mechanisms of XBF for DPN could be related to inflammation, immune regulation, and pivotal signalling pathways such as the TNF, TLR, CLR, and NOD-like receptor signalling pathways. These findings were further supported by immune infiltration analysis and localization of immune organs and cells. Moreover, the molecular docking simulations demonstrated a strong binding affinity between the active chemicals and the carefully selected targets. Conclusion: In summary, this study proposes a novel treatment model for XBF in DPN, and it also offers a new perspective for exploring the principles of traditional Chinese medicine (TCM) in the clinical management of DPN.
MeSH term(s)	Humans ; Computational Biology ; Diabetes Mellitus ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/genetics ; Molecular Docking Simulation ; Network Pharmacology ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-02-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1275816
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Article ; Online: The Long-Term Survival Outcome in Older Patients with Different Pathological Types of Chronic Kidney Disease.

Yu, Feng / He, Ganyuan / Hao, Wen-Ke / Hu, Wenxue

Kidney & blood pressure research

2023 Volume 48, Issue 1, Page(s) 338–346

Abstract: Introduction: Chronic kidney diseases (CKDs) are prevalent in older people, and renal pathological manifestations are important for diagnosis, treatment, and prognosis. However, the long-term survival outcome and risk factors for older CKD patients with ...

Abstract	Introduction: Chronic kidney diseases (CKDs) are prevalent in older people, and renal pathological manifestations are important for diagnosis, treatment, and prognosis. However, the long-term survival outcome and risk factors for older CKD patients with different pathological types are not fully understood and need to be further investigated. Methods: Medical data were recorded and all-cause mortality was followed up in patients who underwent renal biopsy diagnosed in Guangdong Provincial People's Hospital from 2005 to 2015. Kaplan-Meier analysis was used to identify the incidence of survival outcomes. Multivariate Cox regression models and nomograms were applied to analyze pathological types and other factors for overall survival outcomes. Results: 368 cases were included and the median follow-up was 85 (46.5, 111) months. Overall mortality was 35.6%. The highest mortality was in the mesangioproliferative glomerulonephritis (MPGN) group (88.9%), followed by amyloidosis (AMY) group (84.6%), and the lowest mortality was in the minimal change disease (MCD) group (21.9%). Moreover, multivariate Cox regression model showed that survival times of MPGN {hazard ratio (HR) = 8.215 (95% confidence interval [CI]: 2.735-24.674), p < 0.001} and AMY (HR = 6.130 [95% CI: 2.219-16.94], p < 0.001) were significantly shorter than MCD. In addition, age, lower baseline estimated glomerular filtration rate (eGFR), history of chronic obstructive pulmonary disease (COPD) and cerebrovascular accidents (CVA)/transient ischemic attack (TIA), MPGN, and AMY were independent risk factors for the mortality of older patients with CKD. Conclusion: The long-term survival outcome of older CKD patients showed differences among different pathological types, and MPGN, AMY, age, baseline eGFR, CVA/TIA, and COPD were independent predictors for mortality.
MeSH term(s)	Humans ; Aged ; Ischemic Attack, Transient/epidemiology ; Renal Insufficiency, Chronic ; Kidney ; Prognosis ; Glomerulonephritis ; Stroke/complications ; Risk Factors ; Pulmonary Disease, Chronic Obstructive/complications ; Glomerular Filtration Rate ; Retrospective Studies
Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1326018-2
ISSN	1423-0143 ; 1420-4096
ISSN (online)	1423-0143
ISSN	1420-4096
DOI	10.1159/000530507
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Article ; Online: Application of exogenous glutathione decreases chromium translocation and alleviates its toxicity in soybean (Glycine max L.).

Wen, Ke / Li, Xingang / Huang, Rong / Nian, Hai

Ecotoxicology and environmental safety

2022 Volume 234, Page(s) 113405

Abstract: Chromium is considered one of the most severe toxic elements affecting agriculture. Soybean seedlings under chromium stress were treated with glutathione and buthionine sulfoximine. The effects of exogenous glutathione on the physiological effects of two ...

Abstract	Chromium is considered one of the most severe toxic elements affecting agriculture. Soybean seedlings under chromium stress were treated with glutathione and buthionine sulfoximine. The effects of exogenous glutathione on the physiological effects of two different chromium-resistant soybean seedlings and the expression levels of expression levels related genes were studied. This study tested the seedling weight and SPAD values, detected enzymatic antioxidants (i.e., superoxide dismutase, peroxidase, catalase, catalase, ascorbate peroxidase), and non-enzymatic antioxidants (i.e., glutathione, proline, soluble sugars, and soluble phenols) that attenuate chromium-induced reactive oxygen species, and quantified several genes associated with glutathione-mediated chromium stress. The results showed that exogenous glutathione could improve the physiological adaptability of soybean seedlings by regulating photosynthesis, antioxidant, and related enzyme activities, osmotic system, the compartmentalization of ion chelation, and regulating the transcription level of related genes, thereby increasing the chromium accumulation of soybean seedlings, enhancing the tolerance of chromium stress, and reducing the toxicity of chromium. Overall, the application of glutathione alleviates chromium toxicity in soybeans, and this strategy may be a potential farming option for soybean bioremediation in chromium-contaminated soils.
Language	English
Publishing date	2022-03-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113405
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Article ; Online: Seismic performance analysis of a concrete filled steel tubes arch bridge

Xuhui Zhang / Qinghui Zhang / Hao Sun / Wen Ke / Lin Ma / Lijuan Men

Engineering Reports, Vol 5, Iss 4, Pp n/a-n/a (2023)

A parametric study

2023

Abstract: Abstract Numerical method is widely used in bridge seismic performance analysis, but the diversity and complexity structures increase trouble in the modeling process. This article presents a systematic, universal, and flexible bridge numerical modeling ... ...

Abstract	Abstract Numerical method is widely used in bridge seismic performance analysis, but the diversity and complexity structures increase trouble in the modeling process. This article presents a systematic, universal, and flexible bridge numerical modeling method, and the seismic performance of a concrete filled steel tubes arch bridge is studied. The geometric/attribute model involves structural/stiffness equivalence, and the bridge parametric modeling strategy combined commercial computer‐aided design language of software MATLAB and ANSYS. Data exchange in different fields and rapid reconstruction of numerical model are realizing. Finally, the vibration mode, deformation and internal force of the bridge under seismic load are studied. The results indicating that the proposed parametric model formed a complete data transfer process, and the bridge model can be rapidly modifying and reconstructing. The numerical calculation efficiency is greatly improved because of the structure element is employed instead of solid element. The displacement and internal force of arch rib are mainly controlling by lateral load under horizontal uni‐input, and the combined horizontal and vertical load should be considering in seismic design. The leaning angle and width‐span ratio of transverse braces are considered to improve the seismic performance of bridges.
Keywords	CFST arch bridge ; dynamic response ; modal analysis ; parametric design ; seismic performance ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	690
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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