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Article ; Online: Selenium Enrichment of the Edible Medicinal Mushroom

Li, Jin / Wen, Sai / Zhang, Baoyuan / Wang, Fenghuan

2023 Volume 28, Issue 7

Abstract: Selenium (Se) is an essential nutrient element in human physiological metabolism and immune function. Supplementation of bioavailable Se will confer benefit on human life, especially when intake of this nutrient is inadequate. The edible and medicinal ... ...

Abstract	Selenium (Se) is an essential nutrient element in human physiological metabolism and immune function. Supplementation of bioavailable Se will confer benefit on human life, especially when intake of this nutrient is inadequate. The edible and medicinal mushroom
MeSH term(s)	Humans ; Selenium/metabolism ; Fermentation ; Agaricales ; Polysaccharides/chemistry ; Antrodia/chemistry
Chemical Substances	Selenium (H6241UJ22B) ; Polysaccharides
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28073036
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Zs.MO 81: Show issues

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Article ; Online: Ruxolitinib for severe fever with thrombocytopenia syndrome (SFTS)

Wen, Sai / Xu, Nannan / Wang, Gang

Heliyon. 2022 Dec., v. 8, no. 12 p.e12462-

2022

Abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality. A 73-year-old woman presented to the hospital with fever after being bitten by ticks and was diagnosed with SFTS. Three days after treatment with ... ...

Abstract	Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality. A 73-year-old woman presented to the hospital with fever after being bitten by ticks and was diagnosed with SFTS. Three days after treatment with high-flow oxygen and supportive therapy, her condition deteriorated to septic shock and multiple organ failure. Ruxolitinib, a JAK1/2 inhibitor, was used for the treatment of cytokine release syndrome, and the patient finally recovered. Ruxolitinib and other host-based immunomodulatory drugs may be potential treatments for fatal SFTS.
Keywords	cytokines ; fever ; hospitals ; mortality ; oxygen ; patients ; septic shock ; severe fever with thrombocytopenia syndrome ; therapeutics ; women ; Ruxolitinib ; Hyperinflammation ; Cytokine release syndrome
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12462
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of metagenomic next-generation sequencing and conventional culture for the diagnostic performance in febrile patients with suspected infections.

Yang, Hui / Xu, Nannan / Yan, Meichen / Yang, Lulu / Wen, Sai / Wang, Shanshan / Qu, Chunmei / Xu, Ke / Yang, Xuying / Wang, Gang

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 350

Abstract: Background: Timely and accurate identification of pathogens is crucial for appropriate treatment and prognosis of infectious diseases. As an increasingly popular pathogen detection method, the performance of metagenomic next-generation sequencing (mNGS) ...

Abstract	Background: Timely and accurate identification of pathogens is crucial for appropriate treatment and prognosis of infectious diseases. As an increasingly popular pathogen detection method, the performance of metagenomic next-generation sequencing (mNGS) in detecting pathogens in febrile patients with suspected infection requires further exploration. Methods: This study included 368 febrile patients with suspected infections who were admitted to the Infectious Disease Department of Qilu Hospital, Shandong University between January 5, 2021 and April 14, 2023. Both mNGS testing and conventional culture were performed in all patients. Clinical data of enrolled patients were collected, and the diagnostic performances of mNGS and culture were compared. Results: Of the 368 enrolled patients, 231 were finally diagnosed with infection and 137 were with diseases other than infection. The sensitivity (58.01% vs. 21.65%, p < 0.001) and negative predictive value (54.67% vs. 42.9%) of mNGS were superior to those of culture. In contrast, the culture exhibited higher specificity (99.27% vs. 85.40%, p < 0.001) and positive predictive value (98.84% vs. 87.01%) than mNGS. Among infected patients with positive mNGS results, 64 received adjusted antibiotic therapy including treatment transitions, antibiotic downgrading, and combination therapy. Among them, 9 had additional antifungal drugs and 21 patients had a treatment turning point based on the mNGS results and these patients recovered and discharged due to timely antibiotic adjustment. Both positive rates of puncture fluid mNGS and tissue mNGS were higher than those of culture in the patients who had prior antibiotic use, and this difference was statistically significant (p = 0.000). Conclusion: mNGS is more sensitive and accurate than traditional culture, making it ideal for identifying pathogens and screening infectious diseases, especially for those with uncultivated or difficult-to-cultivate species. Early diagnosis allows for prompt treatment with targeted antibiotics, and mNGS is recommended when samples are limited.
MeSH term(s)	Humans ; High-Throughput Nucleotide Sequencing ; Anti-Bacterial Agents ; Antifungal Agents ; Combined Modality Therapy ; Fever ; Communicable Diseases ; Sensitivity and Specificity
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09236-w
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Article ; Online: The presence of foci of

Xu, Nannan / Liu, Hui / Qu, Chunmei / Wen, Sai / Zou, Wenlu / Chang, Caiyun / Wang, Gang

Infectious medicine

2023 Volume 2, Issue 4, Page(s) 334–337

Abstract: China is not considered as an endemic area ... ...

Abstract	China is not considered as an endemic area of
Language	English
Publishing date	2023-09-17
Publishing country	China
Document type	Case Reports
ISSN	2772-431X
ISSN (online)	2772-431X
DOI	10.1016/j.imj.2023.09.002
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Article ; Online: Review and Application of Integrin Alpha v Beta 6 in the Diagnosis and Treatment of Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma.

Lian, Yunyu / Zeng, Silue / Wen, Sai / Zhao, Xingyang / Fang, Chihua / Zeng, Ning

Technology in cancer research & treatment

2023 Volume 22, Page(s) 15330338231189399

Abstract: Integrin Alpha v Beta 6 is expressed primarily in solid epithelial tumors, such as cholangiocarcinoma, pancreatic cancer, and colorectal cancer. It has been considered a potential and promising molecular marker for the early diagnosis and treatment of ... ...

Abstract	Integrin Alpha v Beta 6 is expressed primarily in solid epithelial tumors, such as cholangiocarcinoma, pancreatic cancer, and colorectal cancer. It has been considered a potential and promising molecular marker for the early diagnosis and treatment of cancer. Cholangiocarcinoma and pancreatic ductal adenocarcinoma share genetic, histological, and pathophysiological similarities due to the shared embryonic origin of the bile duct and pancreas. These cancers share numerous clinicopathological characteristics, including growth pattern, poor response to conventional radiotherapy and chemotherapy, and poor prognosis. This review focuses on the role of integrin Alpha v Beta 6 in cancer progression. It addition, it reviews how the marker can be used in molecular imaging and therapeutic targets. We propose further research explorations and questions that need to be addressed. We conclude that integrin Alpha v Beta 6 may serve as a potential biomarker for cancer disease progression and prognosis.
MeSH term(s)	Humans ; Integrin alphaV ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms/genetics ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/therapy ; Cholangiocarcinoma/pathology ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/therapy ; Carcinoma, Pancreatic Ductal/pathology ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/therapy ; Bile Duct Neoplasms/pathology
Chemical Substances	Integrin alphaV
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/15330338231189399
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Article ; Online: Case Report: Suspected Case of

Qu, Chunmei / Xu, Nannan / Niu, Dehong / Wen, Sai / Yang, Hui / Wang, Shanshan / Wang, Gang

Frontiers in immunology

2022 Volume 13, Page(s) 923341

Abstract: Human brucellosis is one of the most prevalent zoonoses. There are many similarities between the pathogenesis ... ...

Abstract	Human brucellosis is one of the most prevalent zoonoses. There are many similarities between the pathogenesis of
MeSH term(s)	Abscess/pathology ; Adult ; Brucella ; Brucellosis/complications ; Brucellosis/diagnosis ; Brucellosis/drug therapy ; Humans ; Immune Reconstitution Inflammatory Syndrome/diagnosis ; Immune Reconstitution Inflammatory Syndrome/drug therapy ; Immune Reconstitution Inflammatory Syndrome/etiology ; Male ; Mycobacterium tuberculosis
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.923341
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Article ; Online: Lysozyme and Its Application as Antibacterial Agent in Food Industry.

Nawaz, Nida / Wen, Sai / Wang, Fenghuan / Nawaz, Shiza / Raza, Junaid / Iftikhar, Maryam / Usman, Muhammad

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 19

Abstract: Lysozymes are hydrolytic enzymes characterized by their ability to cleave the β-(1,4)-glycosidic bonds in peptidoglycan, a major structural component of the bacterial cell wall. This hydrolysis action compromises the integrity of the cell wall, causing ... ...

Abstract	Lysozymes are hydrolytic enzymes characterized by their ability to cleave the β-(1,4)-glycosidic bonds in peptidoglycan, a major structural component of the bacterial cell wall. This hydrolysis action compromises the integrity of the cell wall, causing the lysis of bacteria. For more than 80 years, its role of antibacterial defense in animals has been renowned, and it is also used as a preservative in foods and pharmaceuticals. In order to improve the antimicrobial efficacy of lysozyme, extensive research has been intended for its modifications. This manuscript reviews the natural antibiotic compound lysozyme with reference to its catalytic and non-catalytic mode of antibacterial action, lysozyme types, susceptibility and resistance of bacteria, modification of lysozyme molecules, and its applications in the food industry.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Antiviral Agents ; Bacteria/metabolism ; Food Industry ; Muramidase/chemistry ; Peptidoglycan/metabolism ; Pharmaceutical Preparations
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Antiviral Agents ; Peptidoglycan ; Pharmaceutical Preparations ; Muramidase (EC 3.2.1.17)
Language	English
Publishing date	2022-09-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196305
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Article ; Online: Evaluating the efficacy of serological testing of clinical specimens collected from patients with suspected brucellosis.

Xu, Nannan / Qu, Chunmei / Sai, Lintao / Wen, Sai / Yang, Lulu / Wang, Shanshan / Yang, Hui / Liu, Hui / Wang, Gang

PLoS neglected tropical diseases

2023 Volume 17, Issue 2, Page(s) e0011131

Abstract: Background: This study aims to evaluate the efficacy of the standard agglutination test (SAT), the Brucellacapt test and enzyme-linked immunosorbent assay (ELISA) in clinical specimens collected from patients with suspected brucellosis.: Methods: A ... ...

Abstract	Background: This study aims to evaluate the efficacy of the standard agglutination test (SAT), the Brucellacapt test and enzyme-linked immunosorbent assay (ELISA) in clinical specimens collected from patients with suspected brucellosis. Methods: A prospective study was conducted from December 2020 to December 2021. Brucellosis was diagnosed on the basis of clinical evidence, and confirmed by isolation of Brucella or a four-fold rise in SAT titer. All samples were tested by the SAT, ELISA and the Brucellacapt test. Titers ≥1:100 were considered as SAT positive; ELISA was considered positive when an index greater than 11 was detected, while titers ≥1/160 indicated positivity on the Brucellacapt test. The specificity, sensitivity, and positive (PPVs) and negative predictive values (NPVs) of the three different methods were calculated. Results: A total of 149 samples were collected from patients with suspected brucellosis. The sensitivities for the SAT, IgG, and IgM detection were 74.42%, 88.37% and 74.42%, respectively. The specificities were 95.24%, 93.65%, and 88.89%, respectively. The simultaneous measurement of IgG and IgM improved the sensitivity (98.84%) but reduced the specificity (84.13%) compared to each antibody test separately. The Brucellacapt test had excellent specificity (100%) and a high PPV (100%); however, the sensitivity and NPV were 88.37% and 86.30%, respectively. The combination of IgG detection by ELISA and the Brucellacapt test had excellent diagnostic performance, with 98.84% sensitivity and 93.65% specificity. Conclusion: This study showed that the simultaneous performance of IgG detection by ELISA and the Brucellacapt test has the potential to overcome the current limitations of detection.
MeSH term(s)	Humans ; Prospective Studies ; Antibodies, Bacterial ; Brucellosis/diagnosis ; Agglutination Tests/methods ; Enzyme-Linked Immunosorbent Assay/methods ; Immunoglobulin G ; Immunoglobulin M ; Sensitivity and Specificity
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011131
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Article ; Online: Expression of BSN314 lysozyme genes in Escherichia coli BL21: a study to demonstrate microbicidal and disintegarting potential of the cloned lysozyme.

Naveed, Muhammad / Wen, Sai / Chan, Malik Wajid Hussain / Wang, Fenghuan / Aslam, Sadar / Yin, Xian / Xu, Baocai / Ullah, Asad

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2023 Volume 55, Issue 1, Page(s) 215–233

Abstract: This study is an extension of our previous studies in which the lysozyme was isolated and purified from Bacillus subtilis BSN314 (Naveed et al., 2022; Naveed et al., 2023). In this study, the lysozyme genes were cloned into the E. coli BL21. For the ... ...

Abstract	This study is an extension of our previous studies in which the lysozyme was isolated and purified from Bacillus subtilis BSN314 (Naveed et al., 2022; Naveed et al., 2023). In this study, the lysozyme genes were cloned into the E. coli BL21. For the expression of lysozyme in E. coli BL21, two target genes, Lyz-1 and Lyz-2, were ligated into the modified vector pET28a to generate pET28a-Lyz1 and pET28a-Lyz2, respectively. To increase the production rate of the enzyme, 0.5-mM concentration of IPTG was added to the culture media and incubated at 37 °C and 220 rpm for 24 h. Lyz1 was identified as N-acetylmuramoyl-L-alanine amidase and Lyz2 as D-alanyl-D-alanine carboxypeptidase. They were purified by multi-step methodology (ammonium sulfate, precipitation, dialysis, and ultrafiltration), and antimicrobial activity was determined. For Lyz1, the lowest MIC/MBC (0.25 μg/mL; with highest ZOI = 22 mm) were recorded against Micrococcus luteus, whereas the highest MIC/MBC with lowest ZOI were measured against Salmonella typhimurium (2.50 μg /mL; with ZOI = 10 mm). As compared with Aspergillus oryzae (MIC/MFC; 3.00 μg/mL), a higher concentration of lysozyme was required to control the growth of Saccharomyces cerevisiae (MIC/MFC; 50 μg/mL). Atomic force microscopy (AFM) was used to analyze the disintegrating effect of Lyz1 on the cells of selected Gram-positive bacteria, Gram-negative bacteria, and yeast. The AFM results showed that, as compared to Gram-negative bacteria, a lower concentration of lysozyme (Lyz1) was required to disintegrate the cell of Gram-positive bacteria.
MeSH term(s)	Muramidase/genetics ; Muramidase/pharmacology ; Muramidase/metabolism ; Escherichia coli ; Anti-Infective Agents/pharmacology ; Bacillus subtilis/genetics
Chemical Substances	Muramidase (EC 3.2.1.17) ; Anti-Infective Agents
Language	English
Publishing date	2023-12-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-023-01219-4
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Article ; Online: Disseminated Talaromyces marneffei infection associated with haemophagocytic syndrome in an HIV-negative patient in northern China: a case report.

Yang, Hui / Liu, Ming / Xu, Nannan / Yang, Lulu / Wen, Sai / Wang, Shanshan / Qu, Chunmei / Xu, Ke / Sun, Enhua / Cui, Wen / Liu, Hui / Wang, Gang

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 63

Abstract: Background: Talaromyces marneffei is endemic to eastern India, Southeast Asia, and Guangdong and Guangxi provinces in China. It is common in immunocompromised individuals, especially in HIV-infected patients.: Case presentation: A 66-year-old male ... ...

Abstract	Background: Talaromyces marneffei is endemic to eastern India, Southeast Asia, and Guangdong and Guangxi provinces in China. It is common in immunocompromised individuals, especially in HIV-infected patients. Case presentation: A 66-year-old male who had a history of hypertension and resided in Shandong Province (Northern China) was admitted for recurrent fever for one month. The patient had recurrent fever, multiple lymphadenopathies, hepatosplenomegaly, a back rash, and a progressive decrease in white blood cells and platelets. Talaromyces marneffei was isolated from peripheral blood and bone marrow after admission, and suspected fungal cells were found via lymph node pathology. The patient's infection secondary to haemophagocytic syndrome continued to worsen despite antifungal, anti-inflammatory, and symptomatic treatment, leading to death due to multiple-organ failure. Conclusion: Although rare, infection due to Talaromyces marneffei in HIV-negative patients has been increasing in recent years, and we should be vigilant about "new" infections in nonendemic areas.
MeSH term(s)	Male ; Humans ; Aged ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; China ; HIV Infections
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08953-y
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