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  1. Article: Stacking-interaction-induced host–guest chemistry and Borromean rings based on a polypyridyl ligand

    Zhang, Hai-Ning / Guo-Xin Jin / Wen-Xi Gao / Yue-Jian Lin / Yu-Xin Deng

    Chemical communications. 2018 Feb. 8, v. 54, no. 13

    2018  

    Abstract: Template-free molecular Borromean rings (BRs) and open-ended molecular capsules were realized by strategic selection of the polypyridyl ligand tetrapyrido[3,2-a:2′,3′-c:3′′,2′′-h:2′′′,3′′′-j] phenazine (TPPHZ) with a large surface area and specific ... ...

    Abstract Template-free molecular Borromean rings (BRs) and open-ended molecular capsules were realized by strategic selection of the polypyridyl ligand tetrapyrido[3,2-a:2′,3′-c:3′′,2′′-h:2′′′,3′′′-j] phenazine (TPPHZ) with a large surface area and specific geometry. The topology of these intricate architectures was constructed via precisely controlled stacking interactions, as evidenced from single-crystal X-ray analysis.
    Keywords chemical reactions ; geometry ; ligands ; surface area ; topology ; X-radiation
    Language English
    Dates of publication 2018-0208
    Size p. 1559-1562.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c7cc09448e
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Sanjin tablets for acute uncomplicated lower urinary tract infection (syndrome of dampness-heat in the lower jiao)

    Jian Lyu / Yan-ming Xie / Zhan Gao / Jian-wu Shen / Yue-yi Deng / Song-tao Xiang / Wen-xi Gao / Wen-tong Zeng / Chun-he Zhang / Dan-hui Yi / Lian-xin Wang / Zhi-fei Wang

    Trials, Vol 20, Iss 1, Pp 1-

    protocol for randomized, double-blind, double-dummy, parallel control of positive drug, multicenter clinical trial

    2019  Volume 9

    Abstract: Abstract Background Acute uncomplicated lower urinary tract infection (UTI) is one of the most common bacterial infections. Patients usually present with dysuria, urinary urgency, urinary frequency, and suprapubic pain or tenderness. Approximately 150 ... ...

    Abstract Abstract Background Acute uncomplicated lower urinary tract infection (UTI) is one of the most common bacterial infections. Patients usually present with dysuria, urinary urgency, urinary frequency, and suprapubic pain or tenderness. Approximately 150 million people are diagnosed with UTI each year worldwide. The high recurrence rate of lower UTI is a common problem of clinical treatment. The misuse of antibiotics has led to the emergence of a number of resistant bacterial strains. Thus, traditional Chinese medicine is considered as an alternative option for treating acute uncomplicated lower UTI. Thus, this study aims to evaluate the efficacy and safety of Sanjin tablets (SJT) for the treatment of acute uncomplicated lower UTI, explore whether SJT can reduce or substitute the use of antibiotics, and reduce the recurrence rate in the treatment of acute uncomplicated lower UTI. Methods/design In this study, a randomized, double-blind, double-dummy, parallel control of positive drug, multicenter clinical study will be established. A total of 252 patients with acute uncomplicated lower UTI (syndrome of dampness-heat in the lower jiao) will be randomly allocated in the ratio of 1:1:1 to three groups: experimental group; control group 1; and control group 2. The experimental group receives Sanjin tablets plus levofloxacin tablets (LT) placebo; the control group 1 receives LT plus SJT placebo; and the control group 2 receives SJT plus LT on the first five days, SJT plus LT placebo on the last two days. Each group will be treated for seven days and followed-up 1–2 times. The primary outcome measures of effective rate and recurrence rate are symptoms. Secondary outcome measures of effective rate and recurrence rate are the urine leukocytes, bacteriology examination, and safety assessment. Outcomes will be assessed at baseline and after treatment. Discussion This study protocol will provide the research data of efficacy and safety of SJT for the treatment of acute uncomplicated lower UTI. The first aim is to determine whether Sanjin tablets can reduce the use of antibiotics; the second aim is to determine whether Sanjin tablets can substitute the use of antibiotics. The recurrence rate will be assessed after cured to determine whether SJT can reduce the recurrence rate. The results of this study will improve the rational use of drugs, especially the rational application of antibiotics. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment. Trial registration ClinicalTrials.gov, NCT03658291. Registered on 4 September 2018.
    Keywords Acute uncomplicated UTI ; Syndrome of dampness-heat in the lower jiao ; Randomized controlled trial ; Clinical trials ; Sanjin tablets ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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