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  1. Article ; Online: A life in death

    Tedros Adhanom Ghebreyesus / Wendy J. Graham

    Global Health Action, Vol 14, Iss S

    reflections of Peter

    2021  Volume 1

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Correction

    Susannah L Woodd / Abdunoor M Kabanywanyi / Andrea M Rehman / Oona M R Campbell / Asila Kagambo / Warda Martiasi / Louise T Day / Alexander M Aiken / Wendy J Graham

    PLoS ONE, Vol 18, Iss 6, p e

    Postnatal infection surveillance by telephone in Dar es Salaam, Tanzania: An observational cohort study.

    2023  Volume 0287801

    Abstract: This corrects the article DOI:10.1371/journal.pone.0254131.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0254131.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Maternal mortality in the covid-19 pandemic

    Clara Calvert / Jeeva John / Farirai P Nzvere / Jenny A. Cresswell / Sue Fawcus / Edward Fottrell / Lale Say / Wendy J. Graham

    Global Health Action, Vol 14, Iss S

    findings from a rapid systematic review

    2021  Volume 1

    Abstract: Background The COVID-19 pandemic is having significant direct and associated effects on many health outcomes, including maternal mortality. As a useful marker of healthcare system functionality, trends in maternal mortality provide a lens to gauge impact ...

    Abstract Background The COVID-19 pandemic is having significant direct and associated effects on many health outcomes, including maternal mortality. As a useful marker of healthcare system functionality, trends in maternal mortality provide a lens to gauge impact and inform mitigation strategies. Objective To report the findings of a rapid systematic review of studies on levels of maternal mortality before and during the COVID-19 pandemic. Methods We systematically searched for studies on the 1st March 2021 in MEDLINE and Embase, with additional studies identified through MedRxiv and searches of key websites. We included studies that reported levels of mortality in pregnant and postpartum women in time-periods pre- and during the COVID-19 pandemic. The maternal mortality ratio was calculated for each study as well as the excess mortality. Results The search yielded 3411 references, of which five studies were included in the review alongside two studies identified from grey literature searches. Five studies used data from national health information systems or death registries (Mexico, Peru, Uganda, South Africa, and Kenya), and two studies from India were record reviews from health facilities. There were increased levels of maternal mortality documented in all studies; however, there was only statistical evidence for a difference in maternal mortality in the COVID-19 era for four of these. Excess maternal mortality ranged from 8.5% in Kenya to 61.5% in Uganda. Conclusions Measuring maternal mortality in pandemics presents many challenges, but also essential opportunities to understand and ameliorate adverse impact both for women and their newborns. Our systematic review shows a dearth of studies giving reliable information on levels of maternal mortality, and we call for increased and more systematic reporting of this largely preventable outcome. The findings help to highlight four measurement-related issues which are priorities for continuing research and development.
    Keywords maternal deaths ; maternal mortality ratio ; rapid systematic review ; sars-cov-2 ; Public aspects of medicine ; RA1-1270
    Subject code 310
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A Better Disinfectant for Low-Resourced Hospitals? A Multi-Period Cluster Randomised Trial Comparing Hypochlorous Acid with Sodium Hypochlorite in Nigerian Hospitals

    Giorgia Gon / Lucia Dansero / Alexander M. Aiken / Christian Bottomley / Stephanie J. Dancer / Wendy J. Graham / Olivia C. Ike / Michelle Lewis / Nick Meakin / Obiora Okafor / Nkolika S. Uwaezuoke / Tochi Joy Okwor

    Microorganisms, Vol 10, Iss 910, p

    The EWASH Trial

    2022  Volume 910

    Abstract: Environmental hygiene in hospitals is a major challenge worldwide. Low-resourced hospitals in African countries continue to rely on sodium hypochlorite (NaOCl) as major disinfectant. However, NaOCl has several limitations such as the need for daily ... ...

    Abstract Environmental hygiene in hospitals is a major challenge worldwide. Low-resourced hospitals in African countries continue to rely on sodium hypochlorite (NaOCl) as major disinfectant. However, NaOCl has several limitations such as the need for daily dilution, irritation, and corrosion. Hypochlorous acid (HOCl) is an innovative surface disinfectant produced by saline electrolysis with a much higher safety profile. We assessed non-inferiority of HOCl against standard NaOCl for surface disinfection in two hospitals in Abuja, Nigeria using a double-blind multi-period randomised cross-over study. Microbiological cleanliness [Aerobic Colony Counts (ACC)] was measured using dipslides. We aggregated data at the cluster-period level and fitted a linear regression. Microbiological cleanliness was high for both disinfectant (84.8% HOCl; 87.3% NaOCl). No evidence of a significant difference between the two products was found (RD = 2%, 90%CI: −5.1%–+0.4%; p -value = 0.163). We cannot rule out the possibility of HOCl being inferior by up to 5.1 percentage points and hence we did not strictly meet the non-inferiority margin we set ourselves. However, even a maximum difference of 5.1% in favour of sodium hypochlorite would not suggest there is a clinically relevant difference between the two products. We demonstrated that HOCl and NaOCl have a similar efficacy in achieving microbiological cleanliness, with HOCl acting at a lower concentration. With a better safety profile, and potential applicability across many healthcare uses, HOCl provides an attractive and potentially cost-efficient alternative to sodium hypochlorite in low resource settings.
    Keywords hypochlorous acid ; disinfectant ; hospital ; environmental hygiene ; Nigeria ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A call for responsible estimation of global health.

    Wendy J Graham / Sam Adjei

    PLoS Medicine, Vol 7, Iss 11, p e

    2010  Volume 1001003

    Keywords Medicine ; R
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Postnatal infection surveillance by telephone in Dar es Salaam, Tanzania

    Susannah L Woodd / Abdunoor M Kabanywanyi / Andrea M Rehman / Oona M R Campbell / Asila Kagambo / Warda Martiasi / Louise M TinaDay / Alexander M Aiken / Wendy J Graham

    PLoS ONE, Vol 16, Iss 7, p e

    An observational cohort study.

    2021  Volume 0254131

    Abstract: Introduction Maternal and newborn infections are important causes of mortality but morbidity data from low- and middle-income countries is limited. We used telephone surveillance to estimate infection incidence and risk factors in women and newborns ... ...

    Abstract Introduction Maternal and newborn infections are important causes of mortality but morbidity data from low- and middle-income countries is limited. We used telephone surveillance to estimate infection incidence and risk factors in women and newborns following hospital childbirth in Dar es Salaam. Methods We recruited postnatal women from two tertiary hospitals and conducted telephone interviews 7 and 28 days after delivery. Maternal infection (endometritis, caesarean or perineal wound, or urinary tract infection) and newborn infection (umbilical cord or possible severe bacterial infection) were identified using hospital case-notes at the time of birth and self-reported symptoms. Adjusted Cox regression models were used to assess the association between potential risk-factors and infection. Results We recruited 879 women and interviewed 791 (90%). From day 0-7, 6.7% (49/791) women and 6.2% (51/762) newborns developed infection. Using full follow-up data, the infection rate was higher in women with caesarean childbirth versus women with a vaginal delivery (aHR 1.93, 95%CI 1.11-3.36). Only 24% of women received pre-operative antibiotic prophylaxis before caesarean section. Infection was higher in newborns resuscitated at birth versus newborns who were not resuscitated (aHR 4.45, 95%CI 2.10-9.44). At interview, 66% (37/56) of women and 88% (72/82) of newborns with possible infection had sought health-facility care. Conclusions Telephone surveillance identified a substantial risk of postnatal infection, including cases likely to have been missed by hospital-based data-collection alone. Risk of maternal endometritis and newborn possible severe bacterial infection were consistent with other studies. Caesarean section was the most important risk-factor for maternal infection. Improved implementation of pre-operative antibiotic prophylaxis is urgently required to mitigate this risk.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Maternal death surveillance and response

    Isabella Danel / Wendy J Graham / Ties Boerma

    Bulletin of the World Health Organization, Vol 89, Iss 11, Pp 779-

    2011  Volume 780

    Keywords Public aspects of medicine ; RA1-1270 ; Medicine ; R
    Language English
    Publishing date 2011-11-01T00:00:00Z
    Publisher World Health Organization
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Maternal death surveillance and response

    Isabella Danel / Wendy J Graham / Ties Boerma

    Bulletin of the World Health Organization, Vol 89, Iss 11, Pp 779-

    2011  Volume 780

    Keywords Public aspects of medicine ; RA1-1270 ; Medicine ; R
    Language English
    Publishing date 2011-11-01T00:00:00Z
    Publisher World Health Organization
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article ; Online: Maternal death surveillance and response

    Isabella Danel / Wendy J Graham / Ties Boerma

    Bulletin of the World Health Organization, Vol 89, Iss 11, Pp 779-

    2011  Volume 780

    Keywords Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-11-01T00:00:00Z
    Publisher World Health Organization
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  10. Article ; Online: Maternal death surveillance and response

    Isabella Danel / Wendy J Graham / Ties Boerma

    Bulletin of the World Health Organization, Vol 89, Iss 11, Pp 779-

    2011  Volume 780

    Keywords Public aspects of medicine ; RA1-1270 ; Medicine ; R
    Language English
    Publishing date 2011-11-01T00:00:00Z
    Publisher World Health Organization
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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