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Article ; Online: The energetic and allosteric landscape for KRAS inhibition.

Weng, Chenchun / Faure, Andre J / Escobedo, Albert / Lehner, Ben

2023 Volume 626, Issue 7999, Page(s) 643–652

Abstract: Thousands of proteins have been validated genetically as therapeutic targets for human ... ...

Abstract	Thousands of proteins have been validated genetically as therapeutic targets for human diseases
MeSH term(s)	Humans ; Allosteric Regulation/drug effects ; Allosteric Regulation/genetics ; Allosteric Site/drug effects ; Allosteric Site/genetics ; Mutation ; Protein Binding ; Protein Folding ; Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors ; Proto-Oncogene Proteins p21(ras)/chemistry ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Reproducibility of Results ; Substrate Specificity/drug effects ; Substrate Specificity/genetics ; Thermodynamics
Chemical Substances	KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06954-0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA.

Wang, Yun / Weng, Chenchun / Chen, Xiangyang / Zhou, Xufei / Huang, Xinya / Yan, Yonghong / Zhu, Chengming

BMC biology

2020 Volume 18, Issue 1, Page(s) 115

Abstract: Background: Modification of RNAs, particularly at the terminals, is critical for various essential cell processes; for example, uridylation is implicated in tumorigenesis, proliferation, stem cell maintenance, and immune defense against viruses and ... ...

Abstract	Background: Modification of RNAs, particularly at the terminals, is critical for various essential cell processes; for example, uridylation is implicated in tumorigenesis, proliferation, stem cell maintenance, and immune defense against viruses and retrotransposons. Ribosomal RNAs can be regulated by antisense ribosomal siRNAs (risiRNAs), which downregulate pre-rRNAs through the nuclear RNAi pathway in Caenorhabditis elegans. However, the biogenesis and regulation of risiRNAs remain obscure. Previously, we showed that 26S rRNAs are uridylated at the 3'-ends by an unknown terminal polyuridylation polymerase before the rRNAs are degraded by a 3' to 5' exoribonuclease SUSI-1(ceDIS3L2). Results: Here, we found that CDE-1, one of the three C.elegans polyuridylation polymerases (PUPs), is specifically involved in suppressing risiRNA production. CDE-1 localizes to perinuclear granules in the germline and uridylates Argonaute-associated 22G-RNAs, 26S, and 5.8S rRNAs at the 3'-ends. Immunoprecipitation followed by mass spectrometry (IP-MS) revealed that CDE-1 interacts with SUSI-1(ceDIS3L2). Consistent with these results, both CDE-1 and SUSI-1(ceDIS3L2) are required for the inheritance of RNAi. Conclusions: This work identified a rRNA surveillance machinery of rRNAs that couples terminal polyuridylation and degradation.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Gene Silencing ; Germ Cells/metabolism ; RNA Interference ; RNA, Helminth/metabolism ; RNA, Ribosomal/metabolism ; RNA, Small Interfering/metabolism ; Uridine/metabolism
Chemical Substances	CID-1 proterin, C elegans ; Caenorhabditis elegans Proteins ; Cell Cycle Proteins ; RNA, Helminth ; RNA, Ribosomal ; RNA, Small Interfering ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2020-09-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2133020-7
ISSN	1741-7007 ; 1741-7007
ISSN (online)	1741-7007
ISSN	1741-7007
DOI	10.1186/s12915-020-00850-z
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Article ; Online: A chromodomain protein mediates heterochromatin-directed piRNA expression.

Huang, Xinya / Cheng, Peng / Weng, Chenchun / Xu, Zongxiu / Zeng, Chenming / Xu, Zheng / Chen, Xiangyang / Zhu, Chengming / Guang, Shouhong / Feng, Xuezhu

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 27

Abstract: PIWI-interacting RNAs (piRNAs) play significant roles in suppressing transposons, maintaining genome integrity, and defending against viral infections. How piRNA source loci are efficiently transcribed is poorly understood. Here, we show that ... ...

Abstract	PIWI-interacting RNAs (piRNAs) play significant roles in suppressing transposons, maintaining genome integrity, and defending against viral infections. How piRNA source loci are efficiently transcribed is poorly understood. Here, we show that in
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Chromatin Assembly and Disassembly ; Genetic Testing ; Germ Cells/cytology ; Germ Cells/metabolism ; Heterochromatin/metabolism ; Histones/metabolism ; Lysine/metabolism ; Methylation ; Peptides/metabolism ; Polycomb Repressive Complex 2/metabolism ; Protein Binding ; RNA, Small Interfering/metabolism ; Temperature
Chemical Substances	Caenorhabditis elegans Proteins ; Heterochromatin ; Histones ; Peptides ; RNA, Small Interfering ; Polycomb Repressive Complex 2 (EC 2.1.1.43) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2021-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2103723118
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Article ; Online: A Cytoplasmic Argonaute Protein Promotes the Inheritance of RNAi.

Xu, Fei / Feng, Xuezhu / Chen, Xiangyang / Weng, Chenchun / Yan, Qi / Xu, Ting / Hong, Minjie / Guang, Shouhong

Cell reports

2018 Volume 23, Issue 8, Page(s) 2482–2494

Abstract: RNAi-elicited gene silencing is heritable and can persist for multiple generations after its initial induction in C. elegans. However, the mechanism by which parental-acquired trait-specific information from RNAi is inherited by the progenies is not ... ...

Abstract	RNAi-elicited gene silencing is heritable and can persist for multiple generations after its initial induction in C. elegans. However, the mechanism by which parental-acquired trait-specific information from RNAi is inherited by the progenies is not fully understood. Here, we identified a cytoplasmic Argonaute protein, WAGO-4, necessary for the inheritance of RNAi. WAGO-4 exhibits asymmetrical translocation to the germline during early embryogenesis, accumulates at the perinuclear foci in the germline, and is required for the inheritance of exogenous RNAi targeting both germline- and soma-expressed genes. WAGO-4 binds to 22G-RNAs and their mRNA targets. Interestingly, WAGO-4-associated endogenous 22G-RNAs target the same cohort of germline genes as CSR-1 and contain untemplated addition of uracil at the 3' ends. The poly(U) polymerase CDE-1 is required for the untemplated uridylation of 22G-RNAs and inheritance of RNAi. Therefore, we conclude that, in addition to the nuclear RNAi pathway, the cytoplasmic RNAi machinery also promotes RNAi inheritance.
MeSH term(s)	Animals ; Argonaute Proteins/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cytoplasm/metabolism ; Gene Silencing ; Genes, Helminth ; Germ Cells/metabolism ; Inheritance Patterns/genetics ; Open Reading Frames/genetics ; Protein Binding ; RNA Interference ; RNA, Small Interfering/metabolism ; Uridine/metabolism
Chemical Substances	Argonaute Proteins ; Caenorhabditis elegans Proteins ; RNA, Small Interfering ; WAGO-4 protein, C elegans ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2018-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2018.04.072
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Article ; Online: Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA.

Zhu, Chengming / Yan, Qi / Weng, Chenchun / Hou, Xinhao / Mao, Hui / Liu, Dun / Feng, Xuezhu / Guang, Shouhong

Proceedings of the National Academy of Sciences of the United States of America

2018 Volume 115, Issue 40, Page(s) 10082–10087

Abstract: Ribosome biogenesis is a multistep process, during which mistakes can occur at any step of pre-rRNA processing, modification, and ribosome assembly. Misprocessed rRNAs are usually detected and degraded by surveillance machineries. Recently, we identified ...

Abstract	Ribosome biogenesis is a multistep process, during which mistakes can occur at any step of pre-rRNA processing, modification, and ribosome assembly. Misprocessed rRNAs are usually detected and degraded by surveillance machineries. Recently, we identified a class of antisense ribosomal siRNAs (risiRNAs) that down-regulate pre-rRNAs through the nuclear RNAi pathway. To further understand the biological roles of risiRNAs, we conducted both forward and reverse genetic screens to search for more suppressor of siRNA (
MeSH term(s)	Gene Silencing ; Humans ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein O-Methyltransferase ; RNA, Ribosomal/genetics ; RNA, Ribosomal/metabolism ; RNA, Ribosomal, 18S/genetics ; RNA, Ribosomal, 18S/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; RNA-Binding Proteins ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	Nuclear Proteins ; RNA, Ribosomal ; RNA, Ribosomal, 18S ; RNA, Small Interfering ; RNA, ribosomal, 26S ; RNA-Binding Proteins ; Saccharomyces cerevisiae Proteins ; Methyltransferases (EC 2.1.1.-) ; Protein O-Methyltransferase (EC 2.1.1.-) ; RRP8 protein, S cerevisiae (EC 2.1.1.-) ; RRP8 protein, human (EC 2.1.1.-)
Language	English
Publishing date	2018-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1800974115
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Article ; Online: Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma.

Sun, Haoyu / Song, Jiaxi / Weng, Chenchun / Xu, Jing / Huang, Mei / Huang, Qiang / Sun, Rui / Xiao, Weihua / Sun, Cheng

Journal of gastroenterology and hepatology

2017 Volume 32, Issue 5, Page(s) 1107–1114

Abstract: Background and aim: The macrophage receptor with collagenous structure (MARCO) belongs to the scavenger receptor family; however, few studies have assessed their potentials in modulating inflammatory signaling other than the typical function of pattern ... ...

Abstract	Background and aim: The macrophage receptor with collagenous structure (MARCO) belongs to the scavenger receptor family; however, few studies have assessed their potentials in modulating inflammatory signaling other than the typical function of pattern recognition and phagocytic clearance. Interestingly, RNA-Seq analyses of hepatocellular carcinoma (HCC) have identified MARCO as one of the top 30 differentially expressed genes between cancerous and adjacent noncancerous tissues. However, no research has been performed to study MARCO in liver cancer. Methods: MARCO protein expression was evaluated by immunostaining liver tissue specimens collected from 88 HCC patients, 10 liver cirrhosis patients, 6 metastatic patients, and 5 healthy controls. All sections were reviewed by blinded observers followed by the interpretation of integral optical density per area as a measure of protein intensity. Results: We observed significantly decreased expression of MARCO in intratumoral tissues of HCC compared with expression in peritumoral tissues. The expression of MARCO declined progressively as the disease condition was aggravated, with the highest expression found in healthy controls and the lowest found in patients with HCC metastasis. Furthermore, MARCO expression decreased along with tumor progression. MARCO Conclusions: Our study is the first to demonstrate an association between MARCO expression and the progression and prognosis of HCC.
MeSH term(s)	Adult ; Aged ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/mortality ; Disease Progression ; Female ; Gene Expression ; Genetic Association Studies ; Humans ; Liver/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/mortality ; Male ; Middle Aged ; Prognosis ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Receptors, Immunologic/physiology ; Survival Rate
Chemical Substances	MARCO protein, human ; Receptors, Immunologic
Language	English
Publishing date	2017-05
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.13633
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 299: Show issues

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Article ; Online: Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation.

Zeng, Chenming / Weng, Chenchun / Wang, Xiaoyang / Yan, Yong-Hong / Li, Wen-Jun / Xu, Demin / Hong, Minjie / Liao, Shanhui / Dong, Meng-Qiu / Feng, Xuezhu / Xu, Chao / Guang, Shouhong

Cell reports

2019 Volume 27, Issue 12, Page(s) 3561–3572.e3

Abstract: piRNAs play significant roles in suppressing transposons and nonself nucleic acids, maintaining genome integrity, and defending against viral infections. In C. elegans, piRNA precursors are transcribed in the nucleus and are subjected to a number of ... ...

Abstract	piRNAs play significant roles in suppressing transposons and nonself nucleic acids, maintaining genome integrity, and defending against viral infections. In C. elegans, piRNA precursors are transcribed in the nucleus and are subjected to a number of processing and maturation steps. The biogenesis of piRNAs is not fully understood. We use functional proteomics in C. elegans and identify a piRNA biogenesis and chromosome segregation (PICS) complex. The PICS complex contains TOFU-6, PID-1, PICS-1, TOST-1, and ERH-2, which exhibit dynamic localization among different subcellular compartments. In the germlines, the PICS complex contains TOFU-6/PICS-1/ERH-2/PID-1, is largely concentrated at the perinuclear granule zone, and engages in piRNA processing. During embryogenesis, the TOFU-6/PICS-1/ERH-2/TOST-1 complex accumulates in the nucleus and plays essential roles in chromosome segregation. The functions of these factors in mediating chromosome segregation are independent of piRNA production. We speculate that differential compositions of PICS factors may help cells coordinate distinct cellular processes.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Chromosome Segregation ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/metabolism ; Gene Expression Regulation ; Germ Cells/cytology ; Germ Cells/metabolism ; Proteome/analysis ; RNA, Small Interfering/biosynthesis ; RNA, Small Interfering/genetics
Chemical Substances	Caenorhabditis elegans Proteins ; Proteome ; RNA, Small Interfering
Language	English
Publishing date	2019-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2019.05.076
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Article ; Online: The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans.

Mao, Hui / Zhu, Chengming / Zong, Dandan / Weng, Chenchun / Yang, Xiangwei / Huang, Hui / Liu, Dun / Feng, Xuezhu / Guang, Shouhong

Current biology : CB

2015 Volume 25, Issue 18, Page(s) 2398–2403

Abstract: Small-RNA-mediated chromatin modifications have been widely studied in plants and S. pombe. However, direct evidence of small-RNA-guided sequence-specific chromatin alterations is scarce in animals. In C. elegans, the nuclear RNAi defective (Nrde) ... ...

Abstract	Small-RNA-mediated chromatin modifications have been widely studied in plants and S. pombe. However, direct evidence of small-RNA-guided sequence-specific chromatin alterations is scarce in animals. In C. elegans, the nuclear RNAi defective (Nrde) pathway functions to transport siRNA from the cytoplasm to the nucleus, modulate transcription elongation, induce histone H3 lysine 9 (H3K9) trimethylation, and mediate transgenerational inheritance of RNAi. Here, we show that both exogenous RNAi and NRDE-bound endogenous 22G RNAs can direct sequence-specific histone H3 lysine 27 (H3K27) trimethylation at targeted loci through the Nrde pathway. The resulting H3K27me3 status can be inherited by progeny for multiple generations. piRNAs and WAGO-1-associated siRNAs induce H3K27 methylation as well. Interestingly, CSR-1-associated endogenous siRNAs fail to trigger H3K27 methylation, whereas exogenous provision of dsRNAs can induce H3K27 methylation at the CSR-1-targeted loci via the Nrde pathway. We further observed distinct genetic requirements of H3K9 and H3K27 trimethylation. Whereas set-25 and met-2 are required for K9 methylation, mes-2 is required for K27 methylation. The depletion of mes-2 leads to a nuclear RNAi defective phenotype. These results indicate that dsRNA-triggered chromatin modification is a sequence-specific response that engages the Nrde pathway in C. elegans.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Histones/metabolism ; Lysine/metabolism ; Methylation ; RNA Interference ; RNA, Double-Stranded/genetics ; RNA, Double-Stranded/metabolism ; RNA, Helminth/genetics ; RNA, Helminth/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Chemical Substances	Caenorhabditis elegans Proteins ; Histones ; RNA, Double-Stranded ; RNA, Helminth ; RNA, Small Interfering ; RNA-Binding Proteins ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2015-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2015.07.051
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Article ; Online: The USTC co-opts an ancient machinery to drive piRNA transcription in

Weng, Chenchun / Kosalka, Joanna / Berkyurek, Ahmet C / Stempor, Przemyslaw / Feng, Xuezhu / Mao, Hui / Zeng, Chenming / Li, Wen-Jun / Yan, Yong-Hong / Dong, Meng-Qiu / Morero, Natalia Rosalía / Zuliani, Cecilia / Barabas, Orsolya / Ahringer, Julie / Guang, Shouhong / Miska, Eric A

Genes & development

2018 Volume 33, Issue 1-2, Page(s) 90–102

Abstract: Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and are essential for fertility in a variety of organisms. ... ...

Abstract	Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and are essential for fertility in a variety of organisms. In
MeSH term(s)	Amino Acid Motifs ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Gene Expression Regulation/genetics ; Genome, Helminth/genetics ; Protein Binding ; Proteomics ; RNA, Small Interfering/biosynthesis ; RNA, Small Interfering/genetics
Chemical Substances	Caenorhabditis elegans Proteins ; RNA, Small Interfering
Language	English
Publishing date	2018-12-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.319293.118
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Zs.A 2292: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 54: Show issues

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Article ; Online: The predictive value of centre tumour CD8⁺ T cells in patients with hepatocellular carcinoma: comparison with Immunoscore.

Sun, Cheng / Xu, Jing / Song, Jiaxi / Liu, ChaoQun / Wang, Jinyu / Weng, Chenchun / Sun, Haoyu / Wei, Haiming / Xiao, Weihua / Sun, Rui / Tian, Zhigang

Oncotarget

2015 Volume 6, Issue 34, Page(s) 35602–35615

Abstract: The increasing evidences suggest that Immunoscore(IS), a combinatorial density analysis of CD8+ and CD3+ cells in the centre and invasive margin of tumour (CT and IM), has an advantage over the currently used tumour staging methods in a variety of ... ...

Abstract	The increasing evidences suggest that Immunoscore(IS), a combinatorial density analysis of CD8+ and CD3+ cells in the centre and invasive margin of tumour (CT and IM), has an advantage over the currently used tumour staging methods in a variety of tumours; however, IS in hepatocellular carcinoma remains unreported. In this study, IS was performed on serial sections from two HCC cohorts (total 449) and compared with current tumour staging systems. Kaplan-Meier curves illustrate a positive association between a higher IS (IS≥2) and longer survival of HCC patients. Although the IS was highly related to the outcome of patients, however, IS seems not to be the optimal prognostic factor when compared with the CD8CT. As noted, among CD8CT, CD8IM, CD3CT, CD3IM and IS, CD8CT, as an independent indicator, demonstrated the highest prognostic impact on both DFS and OS in our Cox multivariate regression analysis (P< 0.0001). In our study, the minimum cut-off value was 93 CD8CT cells per mm2, to be used to divide the patients into CD8CTHi group and CD8CTLo group in clinical settings. Our results suggest that CD8CT densities analysis notably improved the accuracy of survival prediction with convenience of clinical manipulation in HCC.
MeSH term(s)	Aged ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Female ; Humans ; Immunologic Tests/methods ; Liver Neoplasms/diagnosis ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; Survival Analysis ; T-Lymphocyte Subsets/immunology
Language	English
Publishing date	2015-11-03
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.5801
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