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  1. AU="Wenhong, Chen"
  2. AU="Alaverdyan, Zaruhi"
  3. AU="Steenland, Mathieu"
  4. AU="Ferreira, Regiane"
  5. AU="Coskun, Ozlem"
  6. AU="Pustz, Jennifer"
  7. AU="McEntagart, Meriel M"
  8. AU=Zou X AU=Zou X
  9. AU="Benyus, Janine"
  10. AU=Siddiqui Ruqaiyyah AU=Siddiqui Ruqaiyyah
  11. AU="Ruf, Hans-Georg"
  12. AU="Laginestra, Maria Antonella"
  13. AU="Novak, Jeff M"
  14. AU="Singh, Suvir"
  15. AU="Cannon, Carolyn L"
  16. AU="Hamidi, Mohammad"
  17. AU="Alam, Md Noor A"
  18. AU="Yang, Panting"
  19. AU="Jeff Lewis"
  20. AU=Carbone Antonino
  21. AU="Walker, Naomi"
  22. AU="Alaskar, Turki M"
  23. AU=Hofstra Julia M
  24. AU="Françoise Baldi"
  25. AU="Chen, Zipeng"
  26. AU=Bilinski Alyssa
  27. AU="Honboh, Takuya"
  28. AU=Dobie David Robertson
  29. AU=Gagnon R F
  30. AU="Suthaharan, Praveen"
  31. AU=Freeman Alexandra F
  32. AU="Szabo, Gergo"

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  1. Artikel: Assessing resting-state brain functional connectivity in adolescents and young adults with narcolepsy using functional near-infrared spectroscopy.

    Wenhong, Chen / Xiaoying, Mo / Lingli, Shi / Binyun, Tang / Yining, Wen / Mingming, Zhao / Yian, Lu / Lixia, Qin / Wenyu, Hu / Fengjin, Pan

    Frontiers in human neuroscience

    2024  Band 18, Seite(n) 1373043

    Abstract: This study aimed to elucidate the alterations in the prefrontal cortex's functional connectivity and network topology in narcolepsy patients using functional near-infrared spectroscopy (fNIRS). Twelve narcolepsy-diagnosed patients from Guangxi Zhuang ... ...

    Abstract This study aimed to elucidate the alterations in the prefrontal cortex's functional connectivity and network topology in narcolepsy patients using functional near-infrared spectroscopy (fNIRS). Twelve narcolepsy-diagnosed patients from Guangxi Zhuang Autonomous Region's People's Hospital Sleep Medicine Department and 11 matched healthy controls underwent resting fNIRS scans. Functional connectivity and graph theory analyses were employed to assess the prefrontal cortex network's properties and their correlation with clinical features. Results indicated increased functional connectivity in these adolescent and young adult patients with narcolepsy, with significant variations in metrics like average degree centrality and node efficiency, particularly in the left middle frontal gyrus. These alterations showed correlations with clinical symptoms, including depression and sleep efficiency. However, the significance of these findings was reduced post False Discovery Rate adjustment, suggesting a larger sample size is needed for validation. In conclusion, the study offers initial observations that alterations in the prefrontal cortex's functional connectivity may potentially act as a neurobiological indicator of narcolepsy, warranting further investigation with a larger cohort to substantiate these findings and understand the underlying mechanisms.
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2024.1373043
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Abnormal prefrontal functional network in adult obstructive sleep apnea: A resting-state fNIRS study.

    Mingming, Zhao / Wenhong, Chen / Xiaoying, Mo / Yang, Jianrong / Liu, Howe Hao / Lingli, Shi / Hongwu, Ma / Zhirong, Jiang

    Journal of sleep research

    2023  Band 33, Heft 2, Seite(n) e14033

    Abstract: To assess prefrontal brain network abnormality in adults with obstructive sleep apnea (OSA), resting-state functional near infrared spectroscopy (rs-fNIRS) was used to evaluate 52 subjects, including 27 with OSA and 25 healthy controls (HC). The study ... ...

    Abstract To assess prefrontal brain network abnormality in adults with obstructive sleep apnea (OSA), resting-state functional near infrared spectroscopy (rs-fNIRS) was used to evaluate 52 subjects, including 27 with OSA and 25 healthy controls (HC). The study found that patients with OSA had a decreased connection edge number, particularly in the connection between the right medial frontal cortex (MFG-R) and other right-hemisphere regions. Graph-based analysis also revealed that patients with OSA had a lower global efficiency, local efficiency, and clustering coefficient than the HC group. Additionally, the study found a significant positive correlation between the Montreal Cognitive Assessment (MoCA) score and both the connection edge number and the graph-based indicators in patients with OSA. These preliminary results suggest that prefrontal rs-fNIRS could be a useful tool for objectively and quantitatively assessing cognitive function impairment in patients with OSA.
    Mesh-Begriff(e) Adult ; Humans ; Brain Mapping/methods ; Magnetic Resonance Imaging/methods ; Sleep Apnea, Obstructive ; Cognition ; Cognitive Dysfunction/etiology
    Sprache Englisch
    Erscheinungsdatum 2023-09-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.14033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: A simple electrochemical biosensor for highly sensitive and specific detection of microRNA based on mismatched catalytic hairpin assembly

    Zhang, Ye / Dandan Li / Hong Wang / Huangxian Ju / Shengqiang Li / Shijia Ding / Wei Cheng / Wenhong Chen / Xiaojuan Ding / Yurong Yan

    Biosensors & bioelectronics. 2015 June 15, v. 68

    2015  

    Abstract: MicroRNAs (miRNAs) play vital regulatory roles in cancer development and a variety of diseases, which make them become promising biomarkers. Here, a simple electrochemical biosensor was developed for highly sensitive and specific detection of target ... ...

    Abstract MicroRNAs (miRNAs) play vital regulatory roles in cancer development and a variety of diseases, which make them become promising biomarkers. Here, a simple electrochemical biosensor was developed for highly sensitive and specific detection of target miRNA using mismatched catalytic hairpin assembly (CHA). The target miRNA triggered the toehold strand displacement assembly of two hairpin substrates, which led to the cyclic reuse of the target miRNA and the CHA products. Compared with the traditional CHA, mismatched CHA could decrease the nonspecific CHA products, which reduced the background signal significantly. Under the optimal experimental conditions and using differential pulse voltammetry, the established biosensor could detect target miRNA down to 0.6pM (S/N=3) with a linear range from 1pM to 25nM, and discriminate target miRNA from mismatched miRNA with a high selectivity. It was also applied to the determination of miRNA spiked into human total RNA samples. Thus, this biosensing strategy might become a potential alternative tool for detection of miRNA in biomedical research and early clinical diagnosis.
    Schlagwörter biomarkers ; biomedical research ; biosensors ; carcinogenesis ; electrochemistry ; humans ; microRNA ; neoplasms
    Sprache Englisch
    Erscheinungsverlauf 2015-0615
    Umfang p. 343-349.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2015.01.026
    Datenquelle NAL Katalog (AGRICOLA)

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