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  1. Article ; Online: Identification of Potential Biomarkers in Glioblastoma through Bioinformatic Analysis and Evaluating Their Prognostic Value

    Yangmei Zhou / Li Yang / Xiaoxi Zhang / Rui Chen / Xiuqiong Chen / Wenhua Tang / Mengxian Zhang

    BioMed Research International, Vol

    2019  Volume 2019

    Abstract: Glioblastoma is a common malignant tumor in the central nervous system with an extremely poor outcome; understanding the mechanisms of glioblastoma at the molecular level is essential for clinical treatment. In the present study, we used bioinformatics ... ...

    Abstract Glioblastoma is a common malignant tumor in the central nervous system with an extremely poor outcome; understanding the mechanisms of glioblastoma at the molecular level is essential for clinical treatment. In the present study, we used bioinformatics analysis to identify potential biomarkers associated with prognosis in glioblastoma and elucidate the underlying mechanisms. The result revealed that 552 common genes were differentially expressed between glioblastoma and normal tissues based on TCGA, GSE4290, and GSE 50161 datasets. Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and protein-protein interaction (PPI) network were carried out to gain insight into the actions of differentially expressed genes (DEGs). As a result, 20 genes (CALB1, CDC20, CDCA8, CDK1, CEP55, DLGAP5, KIF20A, KIF4A, NDC80, PBK, RRM2, SYN1, SYP, SYT1, TPX2, TTK, VEGFA, BDNF, GNG3, and TOP2A) were found as hub genes via CytoHubba in Cytoscape and functioned mainly by participating in cell cycle and p53 signaling pathway; among them, RRM2 and CEP55 were considered to have relationship with the prognosis of glioblastoma, especially RRM2. High expression of RRM2 was consistent with shorter overall survival time. In conclusion, our study displayed the bioinformatic analysis methods in screening potential oncogenes in glioblastoma and underlying mechanisms. What is more is that we successfully identified RRM2 as a novel biomarker linked with prognosis, which might be expected to be a promising target for the therapy of glioblastoma.
    Keywords Medicine ; R
    Subject code 570
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Investigation of actual exposure to facial sheet mask preceding its risk assessment

    Lihong Zhou / Jian Chen / Tian Chen / Huailong Chang / Wenguang Cui / Yuanyuan She / Zhu Li / Wenhua Tang / Dengfeng Yuan / Zhitao Chen / Jin Su

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 8

    Abstract: Abstract The present study aimed to reveal the amount per application of facial sheet masks and its influencing factors in Chinese population to form the base for an accurate exposure assessment. A total of 175 healthy subjects aged 18 years or older ... ...

    Abstract Abstract The present study aimed to reveal the amount per application of facial sheet masks and its influencing factors in Chinese population to form the base for an accurate exposure assessment. A total of 175 healthy subjects aged 18 years or older were recruited and divided into two subgroups: one group of 35 subjects were asked to apply same mask for 5, 10, 15, 20, 25, and 30 min respectively, and the other 140 subjects were instructed to apply one of four types of facial sheet masks presented in the market for 15 min. Furthermore, phenoxyethanol and methylparaben were measured to reflect actual exposure to chemicals. The sharp increase in the relative exposure to phenoxyethanol (CAS NO.122-99-6) and methylparaben at 25 min and longer suggests applying facial sheet masks for longer than 20 min may drive the exposure to hazardous chemicals to increase significantly. The 90th percentile of amount per application for plant-cellulose, bamboo charcoal fiber, bio-cellulose, and binchotan charcoal fiber-based masks was 5.753, 5.371, 5.017, and 4.821 g respectively. In addition, men and subjects with sebaceous skin demonstrated lower amount per application compared to women and subjects with dry skin, respectively. Finally, our data showed that the larger the contacting area between face and mask, the more amount per application. We concluded that the appropriate time of application should be less than 20 min. And mask fabrics, gender, sebum content, and contacting area could significantly impact the risk assessment of facial sheet masks. Our data for the first time provides insights into a realistic risk assessment of facial sheet masks in Chinese population.
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Core–shell like glass containing lanthanide doped nanocrystals for efficient luminescence

    Liu, Qunhuo / Jiawei Zhang / Junjie Zhang / Shiqing Xu / Wenhua Tang / Xufeng Jing / Ying Tian / Zhen Xiao

    Chemical communications. 2018 Nov. 20, v. 54, no. 93

    2018  

    Abstract: We constructed a core–shell like nanoarchitecture in Yb/Er ion and Yb/Ho SrTiO3 nanocrystal-codoped tellurite–borate glass. We demonstrated that the adverse energy transfer between Er3+ ions in the glass region and Ho3+ ions in the crystal region was ... ...

    Abstract We constructed a core–shell like nanoarchitecture in Yb/Er ion and Yb/Ho SrTiO3 nanocrystal-codoped tellurite–borate glass. We demonstrated that the adverse energy transfer between Er3+ ions in the glass region and Ho3+ ions in the crystal region was effectively prohibited, which permits independent and highly efficient emission from Er3+ and Ho3+ ions.
    Keywords chemical compounds ; chemical reactions ; energy transfer ; glass ; ions ; luminescence ; nanocrystals
    Language English
    Dates of publication 2018-1120
    Size p. 13092-13095.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c8cc07911k
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Structural Characteristics and Genetic Mechanism of Fracture in Shiwu Oilfield

    Hu Li / Qirong Qin / Wenhua Tang / Mingyuan Tang

    Modern Applied Science, Vol 5, Iss

    2011  Volume 1

    Abstract: Based on the core, chip,drilling, Seismic data,etc,Combining the tectonic evolution of shiwu fault, comprehensive study the Charcteristics of Structural, fracture and the genetic mechanism of fracture.after study:on the basis of the reaearch on the ... ...

    Abstract Based on the core, chip,drilling, Seismic data,etc,Combining the tectonic evolution of shiwu fault, comprehensive study the Charcteristics of Structural, fracture and the genetic mechanism of fracture.after study:on the basis of the reaearch on the Xiaokuan fault and nearby north-south faults,6 secondary structure units are divided.They are: Xiaokuan extrusion and strike-slip zone,Qikeshu syncline belt,Dawujiazi and Xiaowujiazi fault belt,Nanling fault terrace,and Liangjiatun fault terrace.after study on the length and density by Weighting Process, Crack is developed in Shiwu Oilfield;it is affected by five tectonic movements and formed the four periods fracture;extensional directions of these fractures are NE,SN,NW,NNE,NNW,EW, etc.
    Keywords Science (General) ; Q1-390 ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Canadian Center of Science and Education
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.

    Yao Dai / Jeffrey Desano / Wenhua Tang / Xiaojie Meng / Yang Meng / Ezra Burstein / Theodore S Lawrence / Liang Xu

    PLoS ONE, Vol 5, Iss 12, p e

    2010  Volume 14153

    Abstract: Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-κB activation. Celastrol induces apoptosis by means of ... ...

    Abstract Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-κB activation. Celastrol induces apoptosis by means of proteasome inhibition and suppresses prostate tumor growth. However, the detailed mechanism of action remains elusive. In the current study, we aim to test the hypothesis that celastrol suppresses AIPC progression via inhibiting the constitutive NF-κB activity as well as modulating the Bcl-2 family proteins.We examined the efficacy of celastrol both in vitro and in vivo, and evaluated the role of NF-κB in celastrol-mediated AIPC regression. We found that celastrol inhibited cell proliferation in all three AIPC cell lines (PC-3, DU145 and CL1), with IC₅₀ in the range of 1-2 µM. Celastrol also suppressed cell migration and invasion. Celastrol significantly induced apoptosis as evidenced by increased sub-G1 population, caspase activation and PARP cleavage. Moreover, celastrol promoted cleavage of the anti-apoptotic protein Mcl-1 and activated the pro-apoptotic protein Noxa. In addition, celastrol rapidly blocked cytosolic IκBα degradation and nuclear translocation of RelA. Likewise, celastrol inhibited the expression of multiple NF-κB target genes that are involved in proliferation, invasion and anti-apoptosis. Celastrol suppressed AIPC tumor progression by inhibiting proliferation, increasing apoptosis and decreasing angiogenesis, in PC-3 xenograft model in nude mouse. Furthermore, increased cellular IκBα and inhibited expression of various NF-κB target genes were observed in tumor tissues.Our data suggest that, via targeting the proteasome, celastrol suppresses proliferation, invasion and angiogenesis by inducing the apoptotic machinery and attenuating constitutive NF-κB activity in AIPC both in vitro and in vivo. Celastrol as an active ingredient of traditional herbal medicine could thus be developed as a new therapeutic agent for hormone-refractory prostate cancer.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2010-12-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells.

    Qing Ji / Xinbao Hao / Min Zhang / Wenhua Tang / Meng Yang / Ling Li / Debing Xiang / Jeffrey T Desano / Guido T Bommer / Daiming Fan / Eric R Fearon / Theodore S Lawrence / Liang Xu

    PLoS ONE, Vol 4, Iss 8, p e

    2009  Volume 6816

    Abstract: MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. Transcription of the three miRNA miR-34 family members was ... ...

    Abstract MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. Transcription of the three miRNA miR-34 family members was recently found to be directly regulated by p53. Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2, suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells.We examined the roles of miR-34 in p53-mutant human pancreatic cancer cell lines MiaPaCa2 and BxPC3, and the potential link to pancreatic cancer stem cells. Restoration of miR-34 expression in the pancreatic cancer cells by either transfection of miR-34 mimics or infection with lentiviral miR-34-MIF downregulated Bcl-2 and Notch1/2. miR-34 restoration significantly inhibited clonogenic cell growth and invasion, induced apoptosis and G1 and G2/M arrest in cell cycle, and sensitized the cells to chemotherapy and radiation. We identified that CD44+/CD133+ MiaPaCa2 cells are enriched with tumorsphere-forming and tumor-initiating cells or cancer stem/progenitor cells with high levels of Notch/Bcl-2 and loss of miR-34. More significantly, miR-34 restoration led to an 87% reduction of the tumor-initiating cell population, accompanied by significant inhibition of tumorsphere growth in vitro and tumor formation in vivo.Our results demonstrate that miR-34 may restore, at least in part, the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells. Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal, potentially via the direct modulation of downstream targets Bcl-2 and Notch, implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination. Restoration of miR-34 may hold significant promise as a novel molecular therapy for human pancreatic cancer with loss of p53-miR34, potentially via inhibiting pancreatic cancer stem ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 500
    Language English
    Publishing date 2009-08-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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