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Article ; Online: Current developments of hypercrosslinked polymers as green carbon resources

Wenliang Song / Yunxin Tang / Minxin Zhang / Deng-Guang Yu

Current Research in Green and Sustainable Chemistry, Vol 5, Iss , Pp 100335- (2022)

2022

Abstract: Carbons and their composites are the most valuable materials in the modern field of catalysis, energy storage/conversion, and environments. In past decades, breakthroughs have been made in preparing carbon materials, such as fullerenes, carbon nanotubes, ...

Abstract	Carbons and their composites are the most valuable materials in the modern field of catalysis, energy storage/conversion, and environments. In past decades, breakthroughs have been made in preparing carbon materials, such as fullerenes, carbon nanotubes, and graphene. Meanwhile, the carbon materials with high surface areas, tunable pore size, heteroatom doping, and controlled morphologies also can promote their application performances in heterogeneous catalysis, drug encapsulation, electrode, and photonic devices. Hypercrosslinked polymers (HCPs) generally have high surface areas versatile synthetic routes, well-defined chemical-physical stability, and have emerged as excellent candidates for carbon precursors. More and more green and sustainable chemical synthetic methodologies have become possible to directly control particle size, surface area, chemical composition, and morphologies of carbons from the carbonization of HCPs. This graphical review demonstrates current approaches toward the synthesis of HCPs as carbon precursors following green and sustainable principles. And we also discussed the challenges and future directions of green HCPs production as carbon resources.
Keywords	Carbon ; Hypercrosslinked polymers ; Green synthesis ; Sustainable ; Self-assembly ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electrospinning spinneret

Wenliang Song / Yunxin Tang / Cheng Qian / Bumjoon J. Kim / Yaozu Liao / Deng-Guang Yu

The Innovation, Vol 4, Iss 2, Pp 100381- (2023)

A bridge between the visible world and the invisible nanostructures

2023

Keywords	Science (General) ; Q1-390
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein

Jiansheng Huang / Wenliang Song / Hui Huang / Quancai Sun

Journal of Clinical Medicine ; Volume 9 ; Issue 4

From Mechanistic Studies to Clinical Trials for COVID-19

2020

Abstract: An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in December 2019, has expanded rapidly, with cases now confirmed in more than 211 countries or areas. This constant transmission of a novel coronavirus and its ability to ... ...

Abstract	An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in December 2019, has expanded rapidly, with cases now confirmed in more than 211 countries or areas. This constant transmission of a novel coronavirus and its ability to spread from human to human have prompted scientists to develop new approaches for treatment of COVID-19. A recent study has shown that remdesivir and chloroquine effectively inhibit the replication and infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, 2019-nCov) in vitro. In the United States, one case of COVID-19 was successfully treated with compassionate use of remdesivir in January of 2020. In addition, a clinically proven protease inhibitor, camostat mesylate, has been demonstrated to inhibit Calu-3 infection with SARS-CoV-2 and prevent SARS-2-spike protein (S protein)-mediated entry into primary human lung cells. Here, we systemically discuss the pharmacological therapeutics targeting RNA-dependent RNA polymerase (RdRp), proteinase and S protein for treatment of SARS-CoV-2 infection. This review should shed light on the fundamental rationale behind inhibition of SARS-CoV-2 enzymes RdRp as new therapeutic approaches for management of patients with COVID-19. In addition, we will discuss the viability and challenges in targeting RdRp and proteinase, and application of natural product quinoline and its analog chloroquine for treatment of coronavirus infection. Finally, determining the structural-functional relationships of the S protein of SARS-CoV-2 will provide new insights into inhibition of interactions between S protein and angiotensin-converting enzyme 2 (ACE2) and enable us to develop novel therapeutic approaches for novel coronavirus SARS-CoV-2.
Keywords	RNA-dependent RNA polymerase ; remdesivir ; chloroquine ; SARS-CoV-2 ; COVID-19 ; spike glycoproteins ; covid19
Subject code	572
Language	English
Publishing date	2020-04-15
Publisher	Multidisciplinary Digital Publishing Institute
Publishing country	ch
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein

Jiansheng Huang / Wenliang Song / Hui Huang / Quancai Sun

Journal of Clinical Medicine, Vol 9, Iss 1131, p

From Mechanistic Studies to Clinical Trials for COVID-19

2020 Volume 1131

Abstract	An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in December 2019, has expanded rapidly, with cases now confirmed in more than 211 countries or areas. This constant transmission of a novel coronavirus and its ability to spread from human to human have prompted scientists to develop new approaches for treatment of COVID-19. A recent study has shown that remdesivir and chloroquine effectively inhibit the replication and infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, 2019-nCov) in vitro. In the United States, one case of COVID-19 was successfully treated with compassionate use of remdesivir in January of 2020. In addition, a clinically proven protease inhibitor, camostat mesylate, has been demonstrated to inhibit Calu-3 infection with SARS-CoV-2 and prevent SARS-2-spike protein (S protein)-mediated entry into primary human lung cells. Here, we systemically discuss the pharmacological therapeutics targeting RNA-dependent RNA polymerase (RdRp), proteinase and S protein for treatment of SARS-CoV-2 infection. This review should shed light on the fundamental rationale behind inhibition of SARS-CoV-2 enzymes RdRp as new therapeutic approaches for management of patients with COVID-19. In addition, we will discuss the viability and challenges in targeting RdRp and proteinase, and application of natural product quinoline and its analog chloroquine for treatment of coronavirus infection. Finally, determining the structural-functional relationships of the S protein of SARS-CoV-2 will provide new insights into inhibition of interactions between S protein and angiotensin-converting enzyme 2 (ACE2) and enable us to develop novel therapeutic approaches for novel coronavirus SARS-CoV-2.
Keywords	RNA-dependent RNA polymerase ; remdesivir ; chloroquine ; SARS-CoV-2 ; COVID-19 ; spike glycoproteins ; Medicine ; R ; covid19
Subject code	572
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications

Mingxin Zhang / Wenliang Song / Yunxin Tang / Xizi Xu / Yingning Huang / Dengguang Yu

Polymers, Vol 14, Iss 351, p

2022 Volume 351

Abstract: The search for higher-quality nanomaterials for medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled electrospun fibers to make significant progress in medical applications. ... ...

Abstract	The search for higher-quality nanomaterials for medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled electrospun fibers to make significant progress in medical applications. However, electrospun fibers are limited to tissue scaffolding applications. When nanoparticles and nanofibers are combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery and biosensing. To prepare nanofiber and nanoparticle hybrids (NNHs), there are two primary ways. The electrospinning technology was used to produce NNHs in a single step. An alternate way is to use a self-assembly technique to create nanoparticles in fibers. This paper describes the creation of NNHs from routinely used biocompatible polymer composites. Single-step procedures and self-assembly methodologies are used to discuss the preparation of NNHs. It combines recent research discoveries to focus on the application of NNHs in drug release, antibacterial, and tissue engineering in the last two years.
Keywords	polymer composites ; nanoparticle ; polymer blends ; medical applications ; electrospinning ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Xinkuan Liu / Mingxin Zhang / Wenliang Song / Yu Zhang / Deng-Guang Yu / Yanbo Liu

Gels, Vol 8, Iss 357, p

2022 Volume 357

Abstract: The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new ... ...

Abstract	The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.
Keywords	HPMC ; coaxial electrospinning ; core–shell nanohybrids ; orodispersible drug delivery ; fast dissolution ; poorly water-soluble drug ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dynamic increase in myoglobin level is associated with poor prognosis in critically ill patients

Yishan Liu / Jinlong Jiang / Hao Yuan / Luhao Wang / Wenliang Song / Fei Pei / Xiang Si / Shumin Miao / Minying Chen / Bin Gu / Xiangdong Guan / Jianfeng Wu

Frontiers in Medicine, Vol

a retrospective cohort study

2024 Volume 10

Abstract: BackgroundMyoglobin is an important biomarker for monitoring critically ill patients. However, the relationship between its dynamic changes and prognosis remains unclear.MethodsWe retrospectively enrolled 11,218 critically ill patients from a general and ...

Abstract	BackgroundMyoglobin is an important biomarker for monitoring critically ill patients. However, the relationship between its dynamic changes and prognosis remains unclear.MethodsWe retrospectively enrolled 11,218 critically ill patients from a general and surgical intensive care unit (ICU) of a tertiary hospital between June 2016 and May 2020. Patients with acute cardiovascular events, cardiac and major vascular surgeries, and rhabdomyolysis were excluded. To investigate the early myoglobin distribution, the critically ill patients were stratified according to the highest myoglobin level within 48 h after ICU admission. Based on this, the critically ill patients with more than three measurements within 1 week after ICU admission were included, and latent class trajectory modeling was used to classify the patients. The characteristics and outcomes were compared among groups. Sensitivity analysis was performed to exclude patients who had died within 72 h after ICU admission. Restricted mean survival time regression model based on pseudo values was used to determine the 28-day relative changes in survival time among latent classes. The primary outcome was evaluated with comparison of in-hospital mortality among each Trajectory group, and the secondary outcome was 28-day mortality.ResultsOf 6,872 critically ill patients, 3,886 (56.5%) had an elevated myoglobin level (≥150 ng/mL) at admission to ICU, and the in-hospital mortality significantly increased when myoglobin level exceeded 1,000 μg/mL. In LCTM, 2,448 patients were unsupervisedly divided into four groups, including the steady group (n = 1,606, 65.6%), the gradually decreasing group (n = 523, 21.4%), the slowly rising group (n = 272, 11.1%), and the rapidly rising group (n = 47, 1.9%). The rapidly rising group had the largest proportion of sepsis (59.6%), the highest median Sequential Organ Failure Assessment (SOFA) score (10), and the highest in-hospital mortality (74.5%). Sensitivity analysis confirmed that 98.2% of the patients were classified into the same ...
Keywords	myoglobin ; critically ill patients ; post-surgery ; Sepsis ; in-hospital motality ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lymphocyte trajectories are associated with prognosis in critically ill patients

Fei Pei / Wenliang Song / Luhao Wang / Liqun Liang / Bin Gu / Minying Chen / Yao Nie / Yishan Liu / Yu Zhou / Xiangdong Guan / Jianfeng Wu

Frontiers in Medicine, Vol

A convenient way to monitor immune status

2022 Volume 9

Abstract: BackgroundImmunosuppression is a risk factor for poor prognosis of critically ill patients, but current monitoring of the immune status in clinical practice is still inadequate. Absolute lymphocyte count (ALC) is not only a convenient biomarker for ... ...

Abstract	BackgroundImmunosuppression is a risk factor for poor prognosis of critically ill patients, but current monitoring of the immune status in clinical practice is still inadequate. Absolute lymphocyte count (ALC) is not only a convenient biomarker for immune status monitoring but is also suitable for clinical application. In this study, we aimed to explore different trajectories of ALC, and evaluate their relationship with prognosis in critically ill patients.MethodsWe retrospectively enrolled 10,619 critically ill patients admitted to a general intensive care unit (ICU) with 56 beds from February 2016 to May 2020. Dynamic ALC was defined as continuous ALC from before ICU admission to 5 days after ICU admission. Initial ALC was defined as the minimum ALC within 48 h after ICU admission. Group-based trajectory modeling (GBTM) was used to group critically ill patients according to dynamic ALC. Multivariate cox regression model was used to determine the independent association of trajectory endotypes with death and persistent inflammation, immunosuppression, catabolism syndrome (PICS).ResultsA total of 2022 critically ill patients were unsupervisedly divided into four endotypes based on dynamic ALC, including persistent lymphopenia endotype (n = 1,211; 58.5%), slowly rising endotype (n = 443; 22.6%), rapidly decreasing endotype (n = 281; 14.5%) and normal fluctuation endotype (n = 87; 4.4%). Among the four trajectory endotypes, the persistent lymphopenia endotype had the highest incidence of PICS (24.9%), hospital mortality (14.5%) and 28-day mortality (10.8%). In multivariate cox regression model, persistent lymphopenia was associated with increased risk of 28-day mortality (HR: 1.54; 95% CI: 1.06–2.23), hospital mortality (HR: 1.66; 95% CI: 1.20–2.29) and PICS (HR: 1.79; 95% CI: 1.09–2.94), respectively. Sensitivity analysis further confirmed that the ALC trajectory model of non-infected patients and non-elderly patients can accurately distinguished 91 and 90% of critically ill patients into the same endotypes as ...
Keywords	lymphopenia ; immunosuppression ; lymphocyte (LYM) ; critically ill patient ; persistent inflammation immunosuppression and catabolism syndrome ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Straightforward access to linear and cyclic polypeptides

Yu Zhang / Renjie Liu / Hua Jin / Wenliang Song / Rimesh Augustine / Il Kim

Communications Chemistry, Vol 1, Iss 1, Pp 1-

2018 Volume 7

Abstract: Ring-opening polymerisation of amino acid N-carboxyanhydrides is an established route to polypeptides, but controlling the product distribution can require careful optimisation. Here, simple variation of the choice of initiator provides a general route ... ...

Abstract	Ring-opening polymerisation of amino acid N-carboxyanhydrides is an established route to polypeptides, but controlling the product distribution can require careful optimisation. Here, simple variation of the choice of initiator provides a general route to linear or cyclic polypeptides and under mild conditions.
Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Heterogeneous Double Metal Cyanide Catalyzed Synthesis of Poly(ε-caprolactone) Polyols for the Preparation of Thermoplastic Elastomers

Chinh-Hoang Tran / Min-Woong Lee / Sang-Woo Park / Jae-Eon Jeong / Soo-Jeong Lee / Wenliang Song / PilHo Huh / Il Kim

Catalysts, Vol 11, Iss 1033, p

2021 Volume 1033

Abstract: A series of polycaprolactones (PCLs) with molecular weights of 950–10,100 g mol −1 and Ð of 1.10–1.87 have been synthesized via one-pot, solvent-free ring-opening polymerization (ROP) of ε-caprolactone (CL) using a heterogeneous double metal cyanide (DMC) ...

Abstract	A series of polycaprolactones (PCLs) with molecular weights of 950–10,100 g mol −1 and Ð of 1.10–1.87 have been synthesized via one-pot, solvent-free ring-opening polymerization (ROP) of ε-caprolactone (CL) using a heterogeneous double metal cyanide (DMC) catalyst. Various initiators, such as polypropylene glycol, ethylene glycol, propylene glycol, glycerol, and sorbitol, are employed to tune the number of hydroxyl end groups and properties of the resultant PCLs. Kinetic studies indicate that the DMC-catalyzed ROP of CL proceeds via a similar mechanism with the coordination polymerization. Branched PCLs copolymers are also synthesized via the DMC-catalyzed copolymerization of CL with glycidol. The α,ω-hydroxyl functionalized PCLs were successfully used as telechelic polymers to produce thermoplastic poly(ester-ester) and poly(ester-urethane) elastomers with well-balanced stress and strain properties.
Keywords	double metal cyanide ; heterogeneous catalysis ; caprolactone ; ring-opening polymerization ; thermoplastic elastomer ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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