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Article ; Online: An Extended Functional Design Approach Based on Working Principle and Property and Its Application

Song Li / Wenqiang Li / Yan Li

Applied Sciences, Vol 12, Iss 6284, p

2022 Volume 6284

Abstract: 1) Background: Functional design is an activity that is part of conceptual design; it aims to clarify customer needs and develop the functional architecture and solution concepts for a product or system under development. The existing functional design ... ...

Abstract	(1) Background: Functional design is an activity that is part of conceptual design; it aims to clarify customer needs and develop the functional architecture and solution concepts for a product or system under development. The existing functional design approaches mainly focus on assisting designers in searching for design solutions to desired functions, which rely too much on established design knowledge. This type of approach is usually characterized by the relevant design analogy, especially case analogy, or structure analogy. However, this cannot help to generate new design solutions if there is little established design knowledge. (2) Methods: To overcome this limitation, working principle and property are designated as intermediate transformation variables. The corresponding mapping relationships, from function to working principle, and from working principle to property, are comprehensively discussed. Then, an extended functional design approach is proposed, which is characterized by the function (F)–working principle (WP)–property (P)–structure (S) mapping process. The conceptual design of a self-adaptive luggage transfer device is taken as an example to illustrate the proposed approach. (3) Conclusions: Based on the working principle and the desired property, how to generate a possible structure solution according to an expected function is clarified explicitly. The proposed approach could be regarded as a complement to the existing functional design approach.
Keywords	conceptual design ; functional design ; working principle ; property ; concept generation ; self-adaptive luggage transfer device ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vascular Reactivity Index as an Effective Predictor of Mortality in Patients With Septic Shock: A Retrospective Study.

Jingyi, Sun / Cunliang, Gao / Biao, Chen / Yingguang, Xie / Jinluan, Ma / Xiaohua, Cao / Wenqiang, Li

Journal of intensive care medicine

2024 , Page(s) 8850666241233183

Abstract: Background: Sepsis is a serious complication that occurs after trauma, burns, and infections, and it is an important cause of death in intensive care unit (ICU) patients. Despite many new measures being proposed for sepsis treatment, its mortality rate ... ...

Abstract	Background: Sepsis is a serious complication that occurs after trauma, burns, and infections, and it is an important cause of death in intensive care unit (ICU) patients. Despite many new measures being proposed for sepsis treatment, its mortality rate remains high; sepsis has become a serious threat to human health, and there is an urgent need to carry out in-depth clinical research related to sepsis. In recent years, it has been found that septic shock-induced vasoplegia is a result of vascular hyporesponsiveness to vasopressors. Therefore, this study intended to establish an objective formula related to vasoplegia that can be used to assess the prognosis of patients and guide clinical treatment. Materials and methods: A retrospective cohort study was conducted using data from 106 septic shock patients admitted to the ICU of Jining No. 1 People's Hospital from January 2020 to December 2022. The patients were divided into mortality and survival groups based on 28-day survival, and hemodynamics were monitored by the pulse index continuous cardiac output system. The dose and duration of vasopressors, major hemodynamic parameters, lactic acid (Lac) levels, and Sequential Organ Failure Assessment scores were recorded within 48 h of hospital admission. Multifactorial logistic regression was used to analyze the independent risk factors affecting the prognosis of patients, and the predictive value of the vascular response index (VRI) was analyzed by the receiver operating characteristic (ROC) curve. Results: The differences between the survival and mortality groups in terms of age, sex ratio, body weight, ICU length of stay, distribution of infection sites, underlying disease conditions, baseline Lac levels, and some hemodynamic parameters were not statistically significant ( Conclusions: The VRI is a good predictor of mortality in patients with septic shock, and a lower VRI indicates more severe vasoplegia, poorer prognosis, and higher mortality in patients with septic shock.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	632828-3
ISSN	1525-1489 ; 0885-0666
ISSN (online)	1525-1489
ISSN	0885-0666
DOI	10.1177/08850666241233183
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Article ; Online: The Profiles of Long Non-coding RNA and mRNA Transcriptome Reveals the Genes and Pathway Potentially Involved in Pasteurella multocida Infection of New Zealand Rabbits

Jiaqing Hu / Wenqiang Li / Bing Huang / Qiaoya Zhao / Xinzhong Fan

Frontiers in Veterinary Science, Vol

2021 Volume 8

Abstract: Infection with Pasteurella multocida (P. multocida) causes severe epidemic diseases in rabbits and is responsible for the pronounced economic losses in the livestock industry. Long non-coding RNAs (lncRNAs) have been proven to exert vital functions in ... ...

Abstract	Infection with Pasteurella multocida (P. multocida) causes severe epidemic diseases in rabbits and is responsible for the pronounced economic losses in the livestock industry. Long non-coding RNAs (lncRNAs) have been proven to exert vital functions in regulating the host immune responses to bacterial attacks. However, little is known about how lncRNAs participate in the rabbit's immune response against P. multocida infection in the lungs. LncRNA and mRNA expression profiles were analyzed by transcriptomics and bioinformatics during P. multocida infection. A total of 336 lncRNAs and 7,014 mRNAs were differentially regulated at 1 day and 3 days post infection (dpi). Nearly 80% of the differentially expressed lncRNAs exhibited an increased expression at 3 dpi suggesting that the P. multocida genes are responsible for regulation. Moreover, GO and KEGG enriched analysis indicated that the immune-related pathways including pattern recognition receptors (PRRs), cytokines, and chemokines were significantly enriched at 3 dpi. These results indicate that the dysregulated immune-related genes may play crucial roles in defending against P. multocida attacks. Overall, these results advance our cognition of the role of lncRNAs and mRNAs in modulating the rabbit's innate immune response against P. multocida attacks, which will offer a valuable clue for further studies into exploring P. multocida-related diseases in human.
Keywords	long non-coding RNA ; gene expression ; Pasteurella multocida attacks ; high throughput sequencing ; functional enrichment ; immune response ; Veterinary medicine ; SF600-1100
Subject code	570
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nighttime luminosity transitions are tightly spatiotemporally correlated with land use changes

Junfu Fan / Qingyun Liu / Zhoupeng Ren / Zheng Chen / Wenqiang Li / Yong Yu / Yuke Zhou

Ecological Indicators, Vol 145, Iss , Pp 109649- (2022)

A pixelwise case study in Beijing, China

2022

Abstract: Nighttime light data and land use data derived from remote sensing satellites are commonly used to monitor human activities on the Earth. A thorough understanding of the spatiotemporal interactions between these data enables better characterization and ... ...

Abstract	Nighttime light data and land use data derived from remote sensing satellites are commonly used to monitor human activities on the Earth. A thorough understanding of the spatiotemporal interactions between these data enables better characterization and reconstruction of urbanization processes. In this work, a pixelwise fusion analysis using nighttime light data and land use data was performed to explore the spatiotemporal correlation between urban nighttime light luminosity transitions and land use changes. We found that the nighttime luminosity transitions are tightly related to the corresponding land use change types at the pixel level. A significant spatial correlation was identified between the nighttime light luminosity transitions and urban lands with intensive human activity. Relevant policies enacted in Beijing have greatly influenced the local light luminosity and land use type transitions. Pixels with change values in light luminosity in the same range have the same types of land use changes, the reasons for the changes in light luminosity are similar, and the spatial distribution characteristics are the same. This study provides a theoretical basis for quickly assessing changes in urban land use types through transitions in nighttime light luminosity. Simultaneously, the data in our study after integrating nighttime light luminosity and land use information perform well in urban development research and can provide valuable datasets and decision-making references for adjusting and optimizing urban sustainable development policies.
Keywords	Land use type change ; Nighttime light ; NPP-VIIRS ; Spatial correlation ; Sustainable development ; Ecology ; QH540-549.5
Subject code	710
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Novel Overall Survival Prediction Signature Based on Comprehensive Research in Prostate Cancer Bone Metastases

Konghe Hu / Xinyue Hu / Yang Duan / Wenqiang Li / Jing Qian / Junjie Chen

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: BackgroundProstate adenocarcinoma (PRAD)-related bone metastases are a leading source of morbidity and mortality; however, good diagnostic biomarkers are not known yet. The aim of this study was to identify biomarkers and prognostic indicators for the ... ...

Abstract	BackgroundProstate adenocarcinoma (PRAD)-related bone metastases are a leading source of morbidity and mortality; however, good diagnostic biomarkers are not known yet. The aim of this study was to identify biomarkers and prognostic indicators for the diagnosis and treatment of PRAD-associated bone metastases.MethodsBy combining the data from The Cancer Genome Atlas(TCGA) and PRAD SU2C 2019, We performed a comprehensive analysis of the expression differences, biological functions, and interactions of genes associated with PRAD bone metastasis. Annotation, visualization, and integrated discovery were accomplished through the use of gene ontology enrichment and gene set enrichment analysis. The protein-protein interaction network was constructed using the STRING database, and the diagnostic value of prognostic genes was validated using receiver-operating-characteristic and Kaplan-Meier curves.ResultsSix genes (DDX47, PRL17, AS3MT, KLRK1, ISLR, and S100A8) associated with PRAD bone metastases were identified; these had prognostic value as well. Among them, enrichment was observed for the biological processes extracellular matrix tissue, extracellular structural tissue, steroid hormone response, and cell oxidative detoxification. KEGG analysis revealed enrichment in interactions with extracellular matrix receptors, diseases including Parkinson's disease and dilated cardiomyopathy, and estrogen signaling pathways. The area under the curve values of 0.8938, 0.9885, and 0.979, obtained from time-dependent receiver-operating-characteristic curve analysis for 1, 3, and 5-year overall survival confirmed the good performance of the model under consideration. S100A8 expression was not detected in the normal prostate tissue but was detected in PRAD.ConclusionsWe identified ISLR as a potential biomarker for PRAD bone metastasis. Moreover, the genes identified to have prognostic value may act as therapeutic targets for PRAD bone metastasis.
Keywords	differentially expressed genes ; prostate adenocarcinoma ; diagnostic value ; bone metastasis ; gene ontology ; prostate cancer prognosis ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of Ventilation Duct Parameter Optimization on Pollutant Diffusion in Spiral Tunnels

Jiashe Bai / Zhongbin Wu / Tongyong Chen / Wenqiang Li / Ping Zhang / Yu Li

Sustainability, Vol 14, Iss 10540, p

2022 Volume 10540

Abstract: The spiral tunnel could flexibly design the curvature and slope of the tunnel according to the geological structure, avoiding the adverse effect of complex terrain and topography, and had a strong advantage in engineering applications. Different from ... ...

Abstract	The spiral tunnel could flexibly design the curvature and slope of the tunnel according to the geological structure, avoiding the adverse effect of complex terrain and topography, and had a strong advantage in engineering applications. Different from ordinary straight linear tunnels, spiral tunnels have a circular trend with obvious curvature and slope, which ensures certain differences between construction ventilation of the two types of tunnels, especially in terms of ventilation air flow field and pollutant diffusion. Relying on the actual spiral tunnel project, this paper studies the diffusion mechanism of ventilation pollutants in spiral tunnel construction. Optimization of the layout of the air duct based on numerical simulation and proposed pulsating ventilation method was performed to improve the ventilation and drainage effect of the tunnel. The time to reach the carbon monoxide concentration after blasting, and the dust concentration during the spraying process, were determined as indicators to measure the ventilation effect during the construction period. The hanging position of the air duct, the distance from the air duct outlet to the palm face, and the air speed were determined as the main factors affecting the ventilation effect. The main factors, the degree of influence and sensitivity of each influencing factor on the index, are studied, and the optimal air duct layout scheme suitable for the site is determined. The scheme can improve the ventilation effect and ventilation quality and provide effective reference for ventilation problems during the construction of other spiral tunnels. Meanwhile, more factors need to be examined to study the impact of pollutants in spiral tunnel construction, and physical models are needed to study the diffusion mechanism of pollutants in a spiral tunnel.
Keywords	spiral tunnel ; construction ventilation ; pollutants ; orthogonal experimental design ; air duct optimization ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SMALL PLANT AND ORGAN 1 ( SPO1 ) Encoding a Cellulose Synthase-like Protein D4 (OsCSLD4) Is an Important Regulator for Plant Architecture and Organ Size in Rice

Lei Qiao / Qilong Wu / Liuzhen Yuan / Xudong Huang / Yutao Yang / Qinying Li / Nida Shahzad / Haifeng Li / Wenqiang Li

International Journal of Molecular Sciences, Vol 24, Iss 23, p

2023 Volume 16974

Abstract: Plant architecture and organ size are considered as important traits in crop breeding and germplasm improvement. Although several factors affecting plant architecture and organ size have been identified in rice, the genetic and regulatory mechanisms ... ...

Abstract	Plant architecture and organ size are considered as important traits in crop breeding and germplasm improvement. Although several factors affecting plant architecture and organ size have been identified in rice, the genetic and regulatory mechanisms remain to be elucidated. Here, we identified and characterized the small plant and organ 1 ( spo1 ) mutant in rice ( Oryza sativa ), which exhibits narrow and rolled leaf, reductions in plant height, root length, and grain width, and other morphological defects. Map-based cloning revealed that SPO1 is allelic with OsCSLD4 , a gene encoding the cellulose synthase-like protein D4, and is highly expressed in the roots at the seedling and tillering stages. Microscopic observation revealed the spo1 mutant had reduced number and width in leaf veins, smaller size of leaf bulliform cells, reduced cell length and cell area in the culm, and decreased width of epidermal cells in the outer glume of the grain. These results indicate the role of SPO1 in modulating cell division and cell expansion, which modulates plant architecture and organ size. It is showed that the contents of endogenous hormones including auxin, abscisic acid, gibberellin, and zeatin tested in the spo1 mutant were significantly altered, compared to the wild type. Furthermore, the transcriptome analysis revealed that the differentially expressed genes (DEGs) are significantly enriched in the pathways associated with plant hormone signal transduction, cell cycle progression, and cell wall formation. These results indicated that the loss of SPO1 / OsCSLD4 function disrupted cell wall cellulose synthase and hormones homeostasis and signaling, thus leading to smaller plant and organ size in spo1 . Taken together, we suggest the functional role of SPO1 / OsCSLD4 in the control of rice plant and organ size by modulating cell division and expansion, likely through the effects of multiple hormonal pathways on cell wall formation.
Keywords	SPO1 / OsCSLD4 ; narrow and rolled leaf ; plant architecture ; organ size ; plant hormone ; cell division and expansion ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The association of serum choline concentrations with the risk of cancers

Wenqiang Li / Chong Li / Tong Liu / Yun Song / Ping Chen / Lishun Liu / Binyan Wang / Jun Qu

Scientific Reports, Vol 13, Iss 1, Pp 1-

a community-based nested case–control study

2023 Volume 9

Abstract: Abstract Few studies have been designed to investigate the effect of serum choline on the risk of incident cancer. This study aims to explore the association between serum choline and the risk of new-onset cancer. We conducted a case–control study, ... ...

Abstract	Abstract Few studies have been designed to investigate the effect of serum choline on the risk of incident cancer. This study aims to explore the association between serum choline and the risk of new-onset cancer. We conducted a case–control study, including 199 patients with incident cancer and 199 matched controls during a median of 3.9 years of follow-up, nested within the China Stroke Primary Prevention Trial. Cubic spline regression (RCS) and conditional logistic regression analysis was used to assess the association of serum choline and incident cancer risk. We observed a positive dose–response association between serum choline levels and the risk of overall (p for overall = 0.046) and digestive system cancer (p for overall = 0.039). Compared with patients with the lowest choline levels (Q1 group), patients in the highest levels of choline (Q4) had a 3.69-fold and 6.01-fold increased risk of overall (OR = 3.69, 95% CI 1.17–11.63) and digestive system cancer (OR = 6.01, 95% CI 1.14–31.67). Elevated choline levels (per SD, 11.49 μg/mL) were associated with a higher risk of overall cancer among participants who were older, male, and smokers in the subgroup analyses. We found a positive association between elevated levels of serum choline with increased risk of incident cancer. Our findings have critical clinical implications for cancer prevention and diagnosis. Trial registration CSPPT, NCT00794885. Registered: November 20, 2008. https://www.clinicaltrials.gov/ct2/show/study/NCT00794885 https://www.clinicaltrials.gov/ct2/show/study/NCT00794885.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quinoa

Sirpaul Jaikishun / Wenqiang Li / Zhenbiao Yang / Shikui Song

Agronomy, Vol 9, Iss 4, p

In Perspective of Global Challenges

2019 Volume 176

Abstract: The global population is on the path of an increasing trajectory with a simultaneous decline in arable land resources through salinization and desertification that have resulted mainly from climate change and other anthropogenic activities. Rising ... ...

Abstract	The global population is on the path of an increasing trajectory with a simultaneous decline in arable land resources through salinization and desertification that have resulted mainly from climate change and other anthropogenic activities. Rising temperatures will cause changes in the entire ecosystem, resulting in significant alterations in global climate paradigms and a threat to food security. This review focuses on how the highly resilient Chenopodium quinoa Willd. can sustainably mitigate some of the detrimental impacts, such as starvation, and support or provide ecosystem services. In comparison, compared with the traditional staple food crops, quinoa has remarkable tolerance to abiotic stresses and is highly nutritious, with a unique balance and higher amounts of nutrients, and can therefore be an important crop for food security and nutritional adequacy. This crop has the potential to ameliorate global challenges with respect to increase in global population, effects of climate change, desalinization, phytoremediation, satisfying nutrient deficiency, and alleviating poverty.
Keywords	global warming ; nutrient composition ; halophytes ; desertification ; salinization ; phytoremediation ; Agriculture ; S
Subject code	333
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Forecasting Economic Recession through Share Price in the Logistics Industry with Artificial Intelligence (AI)

YM Tang / Ka-Yin Chau / Wenqiang Li / TW Wan

Computation, Vol 8, Iss 70, p

2020 Volume 70

Abstract: Time series forecasting technology and related applications for stock price forecasting are gradually receiving attention. These approaches can be a great help in making decisions based on historical information to predict possible future situations. ... ...

Abstract	Time series forecasting technology and related applications for stock price forecasting are gradually receiving attention. These approaches can be a great help in making decisions based on historical information to predict possible future situations. This research aims at establishing forecasting models with deep learning technology for share price prediction in the logistics industry. The historical share price data of five logistics companies in Hong Kong were collected and trained with various time series forecasting algorithms. Based on the Mean Absolute Percentage Error (MAPE) results, we adopted Long Short-Term Memory (LSTM) as the methodology to further predict share price. The proposed LSTM model was trained with different hyperparameters and validated by the Root Mean Square Error (RMSE). In this study, we found various optimal parameters for the proposed LSTM model for six different logistics stocks in Hong Kong, and the best RMSE result was 0.43%. Finally, we can forecast economic recessions through the prediction of the stocks, using the LSTM model.
Keywords	artificial intelligence ; share price ; stock quote ; long short-term memory ; logistics ; big data ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	330
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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