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Article ; Online: Case Report: Gene expression profiling of COVID-19 vaccination-related lymphadenopathies reveals evidence of a dominantly extrafollicular immune response.

Menter, Thomas / Zinner, Carl P / Berger, Christoph T / Went, Philip / Tzankov, Alexandar

2023 Volume 14, Page(s) 1285168

Abstract: mRNA-based vaccines against SARS-CoV-2 have been proven to be very efficient in preventing severe COVID-19. Temporary lymphadenopathy (LA) has been observed as a common adverse event following immunization. Here we describe a case series of three female ... ...

Abstract	mRNA-based vaccines against SARS-CoV-2 have been proven to be very efficient in preventing severe COVID-19. Temporary lymphadenopathy (LA) has been observed as a common adverse event following immunization. Here we describe a case series of three female patients with prominent local to generalized LA after SARS-CoV-2 mRNA-1273 vaccination, which led to lymph node biopsy due to the suspicion of lymphoma or metastasis. All three patients morphologically showed similar patterns of follicular hyperplasia and especially extrafollicular blast activation. Two of the three patients only had short-lasting humoral immune responses to the vaccination. Gene expression profiling (GEP) using the HTG
MeSH term(s)	Female ; Humans ; 2019-nCoV Vaccine mRNA-1273 ; COVID-19 ; COVID-19 Vaccines/adverse effects ; Gene Expression Profiling ; Hyperplasia ; Immunologic Memory ; Lymphadenopathy/etiology ; SARS-CoV-2 ; Vaccination/adverse effects
Chemical Substances	2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; COVID-19 Vaccines
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't ; Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1285168
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Article: A Rare Case of Breast Malignancy in an Adolescent Woman: Lessons Learned from Diagnosis and Management.

Fehr, Célina Alexandra / Went, Philip / Maranta, Martina / Cathomas, Richard

Breast care (Basel, Switzerland)

2020 Volume 16, Issue 5, Page(s) 539–543

Abstract: Introduction: Primary breast malignancy in adolescent women is very rare and differs in several aspects from findings in adult women.: Case presentation: A young woman aged 16 years presented with a locally aggressive breast tumor. The patient ... ...

Abstract	Introduction: Primary breast malignancy in adolescent women is very rare and differs in several aspects from findings in adult women. Case presentation: A young woman aged 16 years presented with a locally aggressive breast tumor. The patient received cisplatin-based chemotherapy followed by tumor resection assuming a diagnosis of germ cell tumor. Four months later, she developed locally recurrent disease and underwent a mastectomy. No definite diagnosis was agreed upon despite intensive pathological workup. Subsequent management consisted of follow-up only and the patient remains in complete remission 9 years later. Conclusion: This case demonstrates the difficulty of diagnosis and management of rare malignancies in adolescents, and highlights the importance of international and interdisciplinary collaboration in diagnosis and clinical decision-making.
Language	English
Publishing date	2020-12-16
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2202236-3
ISSN	1661-3805 ; 1661-3791
ISSN (online)	1661-3805
ISSN	1661-3791
DOI	10.1159/000512975
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Article: Die Klinische Autopsie in der Schweiz – ein Statusbericht.

Rotman, Samuel / Varga, Zsuzsanna / Went, Philip / Cathomas, Gieri / Langer, Rupert

Therapeutische Umschau. Revue therapeutique

2020 Volume 76, Issue 7, Page(s) 397–403

Abstract: Clinical autopsy in Switzerland - a status ... ...

Title translation	Clinical autopsy in Switzerland - a status report.
Abstract	Clinical autopsy in Switzerland - a status report
MeSH term(s)	Autopsy/statistics & numerical data ; Communication ; Diagnosis, Differential ; Humans ; Prevalence ; Switzerland
Language	German
Publishing date	2020-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
DOI	10.1024/0040-5930/a001112
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Article: Die Klinische Autopsie in der Schweiz - ein Statusbericht

Rotman, Samuel / Varga, Zsuzsanna / Went, Philip / Cathomas, Gieri / Langer, Rupert

Therapeutische Umschau

2019 Volume 76, Issue 7, Page(s) 397–403

Abstract: Die klinische Autopsie ist ein wichtiges diagnostisches Instrument zur Qualitätssicherung, zur Aus- und Weiterbildung und letztlich zur generellen Weiterentwicklung der Medizin. ...

Abstract	Die klinische Autopsie ist ein wichtiges diagnostisches Instrument zur Qualitätssicherung, zur Aus- und Weiterbildung und letztlich zur generellen Weiterentwicklung der Medizin.
Keywords	diagnsotisches Instrument ; Qualitätssicherung ; unterschiedliche Aspekte
Language	German
Document type	Article
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
Database	bibnet.org

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Article ; Online: Immunohistochemical and Transcriptional Analysis of SARS-CoV-2 Entry Factors and Renin-Angiotensin-Aldosterone System Components in Lethal COVID-19.

Haslbauer, Jasmin Dionne / Stalder, Anna / Zinner, Carl / Bassetti, Stefano / Mertz, Kirsten Diana / Went, Philip / Matter, Matthias / Tzankov, Alexandar

Pathobiology : journal of immunopathology, molecular and cellular biology

2021 Volume 89, Issue 3, Page(s) 166–177

Abstract: Introduction: Since angiotensin converting enzyme-2 (ACE2) was discovered as an essential entry factor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), there has been conflicting evidence regarding the role of renin-angiotensin- ... ...

Abstract	Introduction: Since angiotensin converting enzyme-2 (ACE2) was discovered as an essential entry factor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), there has been conflicting evidence regarding the role of renin-angiotensin-aldosterone system (RAAS) in COVID-19. This study elucidates pulmonary expression patterns SARS-CoV-2 entry factors (ACE2 and transmembrane protease serine subtype 2, TMPRSS2) and RAAS components in lethal COVID-19. Methods: Lung tissue from COVID-19 autopsies (n = 27) and controls (n = 23) underwent immunohistochemical staining for RAAS components (angiotensin receptors 1 and 2, ACE2 and Mas-receptor) and bradykinin receptors 1 and 2. Staining of individual cellular populations (alveolar pneumocytes [ALV], desquamated cells [DES] and endothelium [END]) was measured by a binary scale (positive/negative). SARS-CoV-2 was detected using immunohistochemistry against nucleocapsid protein, in-situ hybridization and quantitative reverse transcriptase polymerase chain reaction. Gene expression profiling for ACE2, ACE and TMPRSS2 was performed. Results: Subtle differences were observed when comparing COVID-19 patients and controls not reaching statistical significance, such as a higher incidence of ACE2-positivity in END (52% vs. 39%) but lower positivity in ALVs (63% vs. 70%) and an overall downregulation of ACE2 gene expression (0.25 vs. 0.55). However, COVID-19 patients with RAAS inhibitor (RAASi) intake had significantly shorter hospitalization times (5 vs. 12 days), higher viral loads (57,517 vs. 15,980/106 RNase P-gene copies) and decreased ACE/ACE2-expression ratios (4.58 vs. 11.07) than patients without. TMPRSS2 expression was significantly (1.76-fold) higher in COVID-19 patients than controls. Conclusion: Our study delineates the heterogeneous expression patterns of RAAS components in the lungs, which vary amongst cellular populations, and implies that COVID-19 patients with RAASi-intake present with a more rapid disease progression, although this requires further investigation.
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme Inhibitors ; COVID-19 ; Humans ; Renin-Angiotensin System/physiology ; SARS-CoV-2
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-12-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1022703-9
ISSN	1423-0291 ; 1015-2008
ISSN (online)	1423-0291
ISSN	1015-2008
DOI	10.1159/000520221
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Article: Tall cell carcinoma of the breast with reversed polarity (TCCRP) with mutations in the IDH2 and PIK3CA genes: a case report

Haefliger, Simon / Muenst, Simone / Went, Philip / Bihl, Michel / Dellas, Sophie / Weber, Walter Paul / Vlajnic, Tatjana

Molecular biology reports. 2020 June, v. 47, no. 6

2020

Abstract: Tall cell carcinoma with reversed polarity (TCCRP) is a rare breast carcinoma with low malignant potential, initially named “breast tumor resembling the tall cell variant of papillary thyroid carcinoma”, which has recently been recognized as a separate ... ...

Abstract	Tall cell carcinoma with reversed polarity (TCCRP) is a rare breast carcinoma with low malignant potential, initially named “breast tumor resembling the tall cell variant of papillary thyroid carcinoma”, which has recently been recognized as a separate entity in the 5th edition of the WHO (World Health Organization) classification of breast tumors. Since the first report of this entity in 2003, more than 40 cases have been reported in the literature. Here, we report another case of this rare tumor in a 60-year-old woman. We performed immunohistochemical analyses and next-generation-sequencing (NGS) using the Oncomine™ Comprehensive DNA Panel (Thermo Fisher Scientific). The tumor showed the typical morphological features of TCCRP and a “triple-negative” phenotype. Moreover, we identified pathogenic mutations in the IDH2 (p.R172G) and PIK3CA (p.H1047R) genes. We report a case of TCCRP of the breast showing the characteristic morphologic, immunohistochemical and molecular features of this entity. There is still a limited number of cases with comprehensive molecular analyses reported in the literature. Therefore, we herewith contribute to a better understanding of the morphological and molecular characteristics as well as the clinical behavior of this rare entity.
Keywords	DNA ; World Health Organization ; breast neoplasms ; breasts ; carcinoma ; case studies ; high-throughput nucleotide sequencing ; immunohistochemistry ; molecular biology ; phenotype ; women
Language	English
Dates of publication	2020-06
Size	p. 4917-4921.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-05553-w
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Article ; Online: Tall cell carcinoma of the breast with reversed polarity (TCCRP) with mutations in the IDH2 and PIK3CA genes: a case report.

Haefliger, Simon / Muenst, Simone / Went, Philip / Bihl, Michel / Dellas, Sophie / Weber, Walter Paul / Vlajnic, Tatjana

Molecular biology reports

2020 Volume 47, Issue 6, Page(s) 4917–4921

Abstract: Tall cell carcinoma with reversed polarity (TCCRP) is a rare breast carcinoma with low malignant potential, initially named "breast tumor resembling the tall cell variant of papillary thyroid carcinoma", which has recently been recognized as a separate ... ...

Abstract	Tall cell carcinoma with reversed polarity (TCCRP) is a rare breast carcinoma with low malignant potential, initially named "breast tumor resembling the tall cell variant of papillary thyroid carcinoma", which has recently been recognized as a separate entity in the 5th edition of the WHO (World Health Organization) classification of breast tumors. Since the first report of this entity in 2003, more than 40 cases have been reported in the literature. Here, we report another case of this rare tumor in a 60-year-old woman. We performed immunohistochemical analyses and next-generation-sequencing (NGS) using the Oncomine™ Comprehensive DNA Panel (Thermo Fisher Scientific). The tumor showed the typical morphological features of TCCRP and a "triple-negative" phenotype. Moreover, we identified pathogenic mutations in the IDH2 (p.R172G) and PIK3CA (p.H1047R) genes. We report a case of TCCRP of the breast showing the characteristic morphologic, immunohistochemical and molecular features of this entity. There is still a limited number of cases with comprehensive molecular analyses reported in the literature. Therefore, we herewith contribute to a better understanding of the morphological and molecular characteristics as well as the clinical behavior of this rare entity.
MeSH term(s)	Biomarkers, Tumor/genetics ; Breast/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma/pathology ; Cell Shape ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Middle Aged ; Mutation/genetics
Chemical Substances	Biomarkers, Tumor ; IDH2 protein, human (EC 1.1.1.41) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CA protein, human (EC 2.7.1.137)
Language	English
Publishing date	2020-05-30
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-05553-w
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Article ; Online: Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19.

Haslbauer, Jasmin D / Zinner, Carl / Stalder, Anna K / Schneeberger, Jan / Menter, Thomas / Bassetti, Stefano / Mertz, Kirsten D / Went, Philip / Matter, Matthias S / Tzankov, Alexandar

Frontiers in immunology

2021 Volume 12, Page(s) 763098

Abstract: Although initial immunophenotypical studies on peripheral blood and bronchoalveolar lavage samples have provided a glimpse into the immunopathology of COVID-19, analyses of pulmonary draining lymph nodes are currently scarce. 22 lethal COVID-19 cases and ...

Abstract	Although initial immunophenotypical studies on peripheral blood and bronchoalveolar lavage samples have provided a glimpse into the immunopathology of COVID-19, analyses of pulmonary draining lymph nodes are currently scarce. 22 lethal COVID-19 cases and 28 controls were enrolled in this study. Pulmonary draining lymph nodes (mediastinal, tracheal, peribronchial) were collected at autopsy. Control lymph nodes were selected from a range of histomorphological sequelae [unremarkable histology, infectious mononucleosis, follicular hyperplasia, non-SARS related HLH, extrafollicular plasmablast activation, non-SARS related diffuse alveolar damage (DAD), pneumonia]. Samples were mounted on a tissue microarray and underwent immunohistochemical staining for a selection of immunological markers and
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/immunology ; COVID-19/pathology ; Cohort Studies ; Female ; Humans ; Lung ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Macrophage Activation/immunology ; Male ; Middle Aged ; SARS-CoV-2 ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Thromboinflammation/immunology ; Thromboinflammation/pathology ; Thromboinflammation/virology
Language	English
Publishing date	2021-12-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.763098
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Article ; Online: Identification of a Remodeled Neo-tendon After Arthroscopic Latarjet Procedure.

Smolen, Daniel / Went, Philip / Tomala, Dirk / Sternberg, Christoph / Lafosse, Laurent / Leuzinger, Jan

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2017 Volume 33, Issue 3, Page(s) 534–542

Abstract: Purpose: To macroscopically, histologically, and radiologically describe a time-dependent remodeling process of a neo-tendon or -ligament in the shoulder after the arthroscopic Latarjet procedure.: Methods: During follow-up surgery after the ... ...

Abstract	Purpose: To macroscopically, histologically, and radiologically describe a time-dependent remodeling process of a neo-tendon or -ligament in the shoulder after the arthroscopic Latarjet procedure. Methods: During follow-up surgery after the arthroscopic Latarjet procedure, 17 shoulders in 16 patients were evaluated for a remodeled tendon-like structure. The mean overall follow-up period was 27.4 months. The mean time between the arthroscopic Latarjet procedure and revision was 11.6 months. All shoulders were evaluated with magnetic resonance imaging, and seven histologic specimens were obtained during revision surgery. Results: A distinct, oriented strand of tissue was found in 16 of 17 shoulders on revision surgery. Postoperative magnetic resonance imaging analyses showed a signal-free, longitudinal tendon-like structure originating at the tip of the acromion, traversing the space of the former subcoracoid bursa to attach in the course of the transposed conjoint tendon or the proximal short head of the biceps. Histologic analysis of seven specimens showed a characteristic timeline of remodeling. Conclusions: A tendon- or ligament-like structure is remodeled between the anterior bottom tip of the acromion and the transposed coracoid process in a time-dependent manner after the arthroscopic Latarjet procedure. Level of evidence: Level IV, therapeutic case series.
MeSH term(s)	Adolescent ; Adult ; Arthroscopy/methods ; Coracoid Process/transplantation ; Female ; Follow-Up Studies ; Humans ; Joint Instability/surgery ; Male ; Regeneration ; Reoperation ; Shoulder Dislocation/surgery ; Shoulder Joint/diagnostic imaging ; Shoulder Joint/surgery ; Tendons/diagnostic imaging ; Tendons/physiology ; Young Adult
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2016.08.020
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Article ; Online: An immunocompetent patient with a recurrence-free Epstein-Barr virus positive plasmacytoma possesses robust Epstein-Barr virus specific T-cell responses.

Chatterjee, Bithi / Sahli, Laura / Chijioke, Obinna / Went, Philip / Münz, Christian / Trojan, Andreas

Haematologica

2017 Volume 102, Issue 10, Page(s) e419–e422

MeSH term(s)	Herpesvirus 4, Human/immunology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Plasmacytoma/radiotherapy ; Plasmacytoma/surgery ; Plasmacytoma/virology ; T-Lymphocytes/virology
Language	English
Publishing date	2017-07-13
Publishing country	Italy
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2017.172791
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