LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Went, Sam C"
  2. AU="Butler, Rachael"
  3. AU="Ortega Arce, Dina Carmenza"
  4. AU="Refson, Keith"
  5. AU="Zawadzki, Pawel"
  6. AU="De Godoi Rezende Costa Molino, Caroline"
  7. AU=Shaw Richard
  8. AU="Vo, Van"
  9. AU="Rosalind F. Shaw"

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Toxin-antitoxin systems as mediators of phage defence and the implications for abortive infection.

    Kelly, Abigail / Arrowsmith, Tom J / Went, Sam C / Blower, Tim R

    Current opinion in microbiology

    2023  Volume 73, Page(s) 102293

    Abstract: Bacteria have evolved a broad range of defence mechanisms to protect against infection by their viral parasites, bacteriophages (phages). Toxin-antitoxin (TA) systems are small loci found throughout bacteria and archaea that in some cases provide phage ... ...

    Abstract Bacteria have evolved a broad range of defence mechanisms to protect against infection by their viral parasites, bacteriophages (phages). Toxin-antitoxin (TA) systems are small loci found throughout bacteria and archaea that in some cases provide phage defence. The recent explosion in phage defence system discovery has identified multiple novel TA systems with antiphage activity. Due to inherent toxicity, TA systems are thought to mediate abortive infection (Abi), wherein the host cell dies in response to phage infection, removing the phage, and protecting clonal siblings. Recent studies, however, have uncovered molecular mechanisms by which TA systems are activated by phages, how they mediate toxicity, and how phages escape the defences. These new models reveal dazzling complexity in phage-host interactions and provide further evidence that TA systems do not in all cases inherently perform classic Abi, suggesting an evolved conceptual definition is required.
    MeSH term(s) Bacteriophages/genetics ; Toxin-Antitoxin Systems/genetics ; Bacteria/genetics
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2023.102293
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 51: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Toxin-antitoxin systems as mediators of phage defence and the implications for abortive infection

    Kelly, Abigail / Arrowsmith, Tom J / Went, Sam C / Blower, Tim R

    Current Opinion in Microbiology. 2023 June, v. 73 p.102293-

    2023  

    Abstract: Bacteria have evolved a broad range of defence mechanisms to protect against infection by their viral parasites, bacteriophages (phages). Toxin-antitoxin (TA) systems are small loci found throughout bacteria and archaea that in some cases provide phage ... ...

    Abstract Bacteria have evolved a broad range of defence mechanisms to protect against infection by their viral parasites, bacteriophages (phages). Toxin-antitoxin (TA) systems are small loci found throughout bacteria and archaea that in some cases provide phage defence. The recent explosion in phage defence system discovery has identified multiple novel TA systems with antiphage activity. Due to inherent toxicity, TA systems are thought to mediate abortive infection (Abi), wherein the host cell dies in response to phage infection, removing the phage, and protecting clonal siblings. Recent studies, however, have uncovered molecular mechanisms by which TA systems are activated by phages, how they mediate toxicity, and how phages escape the defences. These new models reveal dazzling complexity in phage-host interactions and provide further evidence that TA systems do not in all cases inherently perform classic Abi, suggesting an evolved conceptual definition is required.
    Keywords Archaea ; attitudes and opinions ; bacteria ; bacteriophages ; defense mechanisms ; explosions ; hosts ; loci ; models ; parasites ; siblings ; toxicity
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2023.102293
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 51: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands.

    Picton, David M / Harling-Lee, Joshua D / Duffner, Samuel J / Went, Sam C / Morgan, Richard D / Hinton, Jay C D / Blower, Tim R

    Nucleic acids research

    2021  Volume 50, Issue 9, Page(s) 5191–5207

    Abstract: Bacteria are under constant assault by bacteriophages and other mobile genetic elements. As a result, bacteria have evolved a multitude of systems that protect from attack. Genes encoding bacterial defence mechanisms can be clustered into 'defence ... ...

    Abstract Bacteria are under constant assault by bacteriophages and other mobile genetic elements. As a result, bacteria have evolved a multitude of systems that protect from attack. Genes encoding bacterial defence mechanisms can be clustered into 'defence islands', providing a potentially synergistic level of protection against a wider range of assailants. However, there is a comparative paucity of information on how expression of these defence systems is controlled. Here, we functionally characterize a transcriptional regulator, BrxR, encoded within a recently described phage defence island from a multidrug resistant plasmid of the emerging pathogen Escherichia fergusonii. Using a combination of reporters and electrophoretic mobility shift assays, we discovered that BrxR acts as a repressor. We present the structure of BrxR to 2.15 Å, the first structure of this family of transcription factors, and pinpoint a likely binding site for ligands within the WYL-domain. Bioinformatic analyses demonstrated that BrxR-family homologues are widespread amongst bacteria. About half (48%) of identified BrxR homologues were co-localized with a diverse array of known phage defence systems, either alone or clustered into defence islands. BrxR is a novel regulator that reveals a common mechanism for controlling the expression of the bacterial phage defence arsenal.
    MeSH term(s) Bacteria/genetics ; Bacteria/metabolism ; Bacteria/virology ; Bacteriophages/genetics ; Genomic Islands/genetics ; Plasmids ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkac334
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Diverse Durham collection phages demonstrate complex BREX defense responses.

    Kelly, Abigail / Went, Sam C / Mariano, Giuseppina / Shaw, Liam P / Picton, David M / Duffner, Samuel J / Coates, Isabel / Herdman-Grant, Ryan / Gordeeva, Julia / Drobiazko, Alena / Isaev, Artem / Lee, Yan-Jiun / Luyten, Yvette / Morgan, Richard D / Weigele, Peter / Severinov, Konstantin / Wenner, Nicolas / Hinton, Jay C D / Blower, Tim R

    Applied and environmental microbiology

    2023  Volume 89, Issue 9, Page(s) e0062323

    Abstract: Bacteriophages (phages) outnumber bacteria ten-to-one and cause infections at a rate of ... ...

    Abstract Bacteriophages (phages) outnumber bacteria ten-to-one and cause infections at a rate of 10
    MeSH term(s) Bacteriophages/physiology ; Phylogeny ; Biological Evolution ; Bacteria ; England
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00623-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Multi-layered genome defences in bacteria.

    Agapov, Aleksei / Baker, Kate S / Bedekar, Paritosh / Bhatia, Rama P / Blower, Tim R / Brockhurst, Michael A / Brown, Cooper / Chong, Charlotte E / Fothergill, Joanne L / Graham, Shirley / Hall, James Pj / Maestri, Alice / McQuarrie, Stuart / Olina, Anna / Pagliara, Stefano / Recker, Mario / Richmond, Anna / Shaw, Steven J / Szczelkun, Mark D /
    Taylor, Tiffany B / van Houte, Stineke / Went, Sam C / Westra, Edze R / White, Malcolm F / Wright, Rosanna

    Current opinion in microbiology

    2024  Volume 78, Page(s) 102436

    Abstract: Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, ...

    Abstract Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.
    MeSH term(s) CRISPR-Cas Systems ; Bacteria/genetics ; Biological Evolution ; Bacteriophages/genetics
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2024.102436
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 51: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top