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  1. Article ; Online: Corrigendum to "Tick-borne encephalitis: Acute clinical manifestations and severity in 581 cases from Germany, 2018-2020" [J Infect 86 (2023) 369-375].

    Nygren, Teresa M / Pilic, Antonia / Böhmer, Merle M / Wagner-Wiening, Christiane / Went, Simone-Beatrice / Wichmann, Ole / Hellenbrand, Wiebke

    The Journal of infection

    2024  Volume 88, Issue 2, Page(s) 218

    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2024.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Tick-borne encephalitis: Acute clinical manifestations and severity in 581 cases from Germany, 2018-2020.

    Nygren, Teresa M / Pilic, Antonia / Böhmer, Merle M / Wagner-Wiening, Christiane / Went, Simone-Beatrice / Wichmann, Ole / Hellenbrand, Wiebke

    The Journal of infection

    2023  Volume 86, Issue 4, Page(s) 369–375

    Abstract: Objectives: Tick-borne encephalitis (TBE) is a growing public health problem with an average of 361 cases notified annually to Germany's passive surveillance system since 2001. We aimed to assess clinical manifestations and identify covariates ... ...

    Abstract Objectives: Tick-borne encephalitis (TBE) is a growing public health problem with an average of 361 cases notified annually to Germany's passive surveillance system since 2001. We aimed to assess clinical manifestations and identify covariates associated with severity.
    Methods: We included cases notified 2018-2020 in a prospective cohort study and collected data with telephone interviews, questionnaires to general practitioners, and hospital discharge summaries. Covariates' causal associations with severity were evaluated with multivariable logistic regression, adjusted for variables identified via directed acyclic graphs.
    Results: Of 1220 eligible cases, 581 (48%) participated. Of these, 97.1% were not (fully) vaccinated. TBE was severe in 20.3% of cases (children: 9.1%, ≥70-year-olds: 48.6%). Routine surveillance data underreported the proportion of cases with central nervous system involvement (56% vs. 84%). Ninety percent required hospitalization, 13.8% intensive care, and 33.4% rehabilitation. Severity was most notably associated with age (odds ratio (OR): 1.04, 95% confidence interval (CI): 1.02-1.05), hypertension (OR: 2.27, 95%CI: 1.37-3.75), and monophasic disease course (OR: 1.67, 95%CI: 1.08-2.58).
    Conclusions: We observed substantial TBE burden and health service utilization, suggesting that awareness of TBE severity and vaccine preventability should be increased. Knowledge of severity-associated factors may help inform patients' decision to get vaccinated.
    MeSH term(s) Child ; Humans ; Encephalitis Viruses, Tick-Borne ; Encephalitis, Tick-Borne/complications ; Encephalitis, Tick-Borne/epidemiology ; Encephalitis, Tick-Borne/pathology ; Encephalitis, Tick-Borne/prevention & control ; Germany/epidemiology ; Prospective Studies ; Viral Vaccines ; Cohort Studies ; Child, Preschool ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Female ; Patient Acuity ; Vaccination/statistics & numerical data ; Patient Acceptance of Health Care/statistics & numerical data ; Surveys and Questionnaires
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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