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Article ; Online: Exogenous Brassinosteroid Enhances Zinc tolerance by activating the Phenylpropanoid Biosynthesis pathway in Citrullus lanatus L

Xuefang Liu / Quanwen Zhu / Wentao Liu / Jun Zhang

Plant Signaling & Behavior, Vol 18, Iss

2023 Volume 1

Abstract: Zinc (Zn) is an important element in plants, but over-accumulation of Zn is harmful. The phytohormone brassinosteroids (BRs) play a key role in regulating plant growth, development, and response to stress. However, the role of BRs in watermelon ( ... ...

Abstract	Zinc (Zn) is an important element in plants, but over-accumulation of Zn is harmful. The phytohormone brassinosteroids (BRs) play a key role in regulating plant growth, development, and response to stress. However, the role of BRs in watermelon (Citrullus lanatus L.) under Zn stress, one of the most important horticultural crops, remains largely unknown. In this study, we revealed that 24-epibrassinolide (EBR), a bioactive BR enhanced Zn tolerance in watermelon plants, which was related to the EBR-induced increase in the fresh weight, chlorophyll content, and net photosynthetic rate (Pn) and decrease in the content of hydrogen peroxide (H2O2), malondialdehyde (MDA), and Zn in watermelon leaves. Through RNA deep sequencing (RNA-seq), 350 different expressed genes (DEG) were found to be involved in the response to Zn stress after EBR treatment, including 175 up-regulated DEGs and 175 down-regulated DEGs. The up-regulated DEGs were significantly enriched in ‘phenylpropanoid biosynthesis’ pathway (map00940) using KEGG enrichment analysis. The gene expression levels of PAL, 4CL, CCR, and CCoAOMT, key genes involved in phenylpropanoid pathway, were significantly induced after EBR treatment. In addition, compared with Zn stress alone, EBR treatment significantly promoted the activities of PAL, 4CL, and POD by 30.90%, 20.69%, and 47.28%, respectively, and increased the content of total phenolic compounds, total flavonoids, and lignin by 23.02%, 40.37%, and 29.26%, respectively. The present research indicates that EBR plays an active role in strengthening Zn tolerance, thus providing new insights into the mechanism of BRs enhancing heavy metal tolerance.
Keywords	24-epibrassinolide ; heavy metal ; oxidative damage ; phenylpropanoid biosynthesis ; rna-seq ; watermelon ; zinc stress ; Plant ecology ; QK900-989 ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 24-Epibrassinolide confers zinc stress tolerance in watermelon seedlings through modulating antioxidative capacities and lignin accumulation

Xuefang Liu / Quanwen Zhu / Wentao Liu / Jun Zhang

PeerJ, Vol 11, p e

2023 Volume 15330

Abstract: Zinc (Zn) is an important element in plants, but over-accumulation of Zn is harmful. It is well-known that brassinolide (BR) plays a key role in the regulation of abiotic stress responses in plants. However, the effects of brassinolide on alleviating Zn ... ...

Abstract	Zinc (Zn) is an important element in plants, but over-accumulation of Zn is harmful. It is well-known that brassinolide (BR) plays a key role in the regulation of abiotic stress responses in plants. However, the effects of brassinolide on alleviating Zn phytotoxicity in watermelon (Citrullus lanatus L.) seedlings are not clear. The purpose of this study was to study the effect of 24-epibrassinolide (EBR, one of the bioactive BRs) on Zn tolerance of watermelon seedlings and its potential resistance mechanism. Exposure to excessive Zn significantly inhibited shoot and root fresh weight of watermelon, but this could be significantly alleviated by the optimum 0.05 μM EBR. Exogenous spraying EBR increased the pigments and alleviated oxidative damage caused by Zn through reducing Zn accumulation and the levels of reactive oxygen species (ROS) and malonaldehyde (MDA) and increasing the activities of antioxidant enzymes and contents of ascorbic acid (AsA) and glutathione (GSH). Importantly, the relative mRNA levels of antioxidant genesincluding Cu/Zn-superoxidedismutase (Cu-Zn SOD), catalase (CAT), ascorbic acid peroxidase (APX), and glutathione reductase (GR) were significantly induced after EBR treatment. In addition, EBR pre-treatment induced lignin accumulation under Zn stress, and the activity of phenylalanine ammonia-lyase (PAL) and 4-coumaric ligase (4CL), two key enzymes regulating lignin synthesis, also tended to be consistent. Collectively, the present research proves the beneficial effects of EBR in response to Zn stress through enhancing antioxidant defense and lignin accumulation and provides a new insight into the mechanism of BR-enhancing heavy metal tolerance.
Keywords	Antioxidant defense ; 24-epibrassinolide ; Lignin ; Oxidative damage ; Watermelon ; Zinc stress ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantification of ferroptosis pattern in bladder carcinoma and its significance on immunotherapy

Xu Cheng / Yinhuai Wang / Yijian Li / Wentao Liu

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 12

Abstract: Abstract The role of ferroptosis in tumor development and therapy has been previously proved. Nonetheless, its potential role in tumor microenvironment (TME) and immunotherapy for bladder carcinoma remains unclear. Based on 38 ferroptosis-related genes, ... ...

Abstract	Abstract The role of ferroptosis in tumor development and therapy has been previously proved. Nonetheless, its potential role in tumor microenvironment (TME) and immunotherapy for bladder carcinoma remains unclear. Based on 38 ferroptosis-related genes, the characteristic of ferroptosis patterns and interactions with immune cell-infiltrating features in 2043 bladder cancer samples were systematically investigated. We further proposed the FerrScore to quantify the ferroptosis patterns for each patient. As results, three diverse ferroptosis patterns with distinct tumor-infiltrating immune cell features were established. By determination of ferroptosis patterns of each patient, we found that high FerrScore was related to lower proportion of luminal-papillary molecular subtype, more frequent TP53 mutations, activation of immunity and stroma, and lower 5-year survival. High FerrScore also seemed to be associated with decreased neoantigen load, tumor mutational burden and poorer response to anti-PD-L1/1 therapy. External verification in two immunotherapy cohorts showed FerrScore was an independent and effective prognostic factor for therapeutic effect and survival outcome. Overall, the present study indicated the ferroptosis strongly is closely correlated with TME diversity. Evaluation of the ferroptosis patterns may strengthen the cognition of TME immune cell infiltrations and guide more individualized immunotherapeutic strategies in bladder carcinoma.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Urban rail transit FAO system

Tao Tang / Wentao Liu / Shukui Ding / Chunhai Gao / Shuai Su

Autonomous Intelligent Systems, Vol 2, Iss 1, Pp 1-

technological development and trends

2022 Volume 13

Abstract: Abstract This paper introduces the worldwide history of fully automatic operation (FAO) system in urban rail transit, followed by the development status in China. Then, the architecture and characteristics of the FAO system are described, and the ... ...

Abstract	Abstract This paper introduces the worldwide history of fully automatic operation (FAO) system in urban rail transit, followed by the development status in China. Then, the architecture and characteristics of the FAO system are described, and the analysis method of system design requirements is proposed based on the human factors engineering. The key technologies are introduced from the aspects of signaling system, vehicle system, communication system, traffic integrated automation system and reliability, availability, maintainability, and safety (RAMS) assurance. Furthermore, based on the independent practical experience of the FAO system, this paper summarizes the management methods for the construction and operation of FAO lines and prospects its future development trends toward a more intelligent urban rail transit system.
Keywords	Urban rail transit ; Fully automatic operation ; Independent innovation ; Intelligent rail transit system ; Electronic computers. Computer science ; QA75.5-76.95 ; Computer engineering. Computer hardware ; TK7885-7895
Subject code	380
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of brimonidine tartrate 0.2 and 0.15% ophthalmic solution on the static and dynamic pupil characteristics

Jing Yang / Xiaodi Zhang / Mei Zhong / Yanhui Bai / Wentao Liu / Jinge Hu / Weiqun Wang

Frontiers in Medicine, Vol

2023 Volume 10

Abstract: AimsTo investigate the differences between 0.2 and 0.15% brimonidine tartrate eye drops for anti-mydriatic effects and the optical quality under different light conditions.MethodsThis prospective study involved 80 consecutive high myopia patients ... ...

Abstract	AimsTo investigate the differences between 0.2 and 0.15% brimonidine tartrate eye drops for anti-mydriatic effects and the optical quality under different light conditions.MethodsThis prospective study involved 80 consecutive high myopia patients undergoing implantation of a V4c ICL. The patients were randomly instilled with brimonidine 0.2 and 0.15% 2 weeks postoperatively. Visual quality, pupil center, pupil size, and refraction under different light conditions were measured before and 0.5 h after brimonidine administration. A symptom questionnaire was also evaluated.ResultsThere was no statistical difference in the static and dynamic pupil diameters and velocity after LS between the two groups (p > 0.05). The 0.2% group had significant changes in pupil center before and after treatment, while there was no obvious movement of the 0.15% group under all illumination condition (p > 0.05). The OSI after treatment of the 0.15% group was lower than that of 0.2% group (p = 0.012). The PVA9% and PVA100% of the 0.15% group was higher than that of 0.2% group in the dark (p = 0.009, p = 0.012). The HOA RMS of the 0.15% group was lower than that of 0.2% group (p = 0.016). The QIRC score in the 0.15% group was significantly higher than that in the 0.2% group (p = 0.043).Conclusion0.15 and 0.2% brimonidine tartrate eye drops had similar anti-mydriatic ability, while 0.15% group had better visual quality than 0.2% concentration, and hardly introduced pupil shift. 0.15% brimonidine tartrate eye drops may be more suitable for patients with nocturnal glare symptoms in the early postoperative period after ICL implantation.
Keywords	ICL V4c ; high myopia ; brimonidine tartrate ; visual quality ; scotopic pupil ; Medicine (General) ; R5-920
Subject code	796
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnosis of multiple tuberculous muscle abscesses in a patient with systemic lupus erythematosus by metagenomic next-generation sequencing- a case report and literature review.

Wentao, Liu / Shuxia, Xie / Guoxing, Zhu / Qiaoping, Chen / Peiran, Chen / Angela, Wu / Meirong, Li / Songchao, Yin / Peiying, Feng

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 284

Abstract: Background: Early diagnosis of muscular tuberculosis (TB) without coexistent active skeletal involvement is often challenging because the disease is very rare and its clinical manifestation is nonspecific and misleading. To raise the awareness and ... ...

Abstract	Background: Early diagnosis of muscular tuberculosis (TB) without coexistent active skeletal involvement is often challenging because the disease is very rare and its clinical manifestation is nonspecific and misleading. To raise the awareness and emphasize early diagnosis of muscular TB, we present a case of multiple tuberculous muscle abscesses in a systemic lupus erythematosus (SLE) female, but without pulmonary tuberculosis (PTB), in order to increase awareness of and stress the need of early detection of muscular TB. Case presentation: A 44-year-old woman with a 6-year history of SLE who had been treated with methylprednisolone for a long time complained of erythema on her trunk and extremities for five months, along with edema and myalgia for two months, and fever for one month. The patient was first misdiagnosed as SLE overlap dermatomyositis. However, an ultrasound-guided drainage of muscle abscesses revealed positive acid-fast staining combined with positive deoxyribonucleic acid fragment of Mycobacterium tuberculosis using metagenomic next-generation sequencing (mNGS). The patient was cured and released following standard anti-tuberculosis medication, local puncture drainage, and an intravitreal injection of streptomycin. Literature search found only 19 cases of tuberculous muscle abscesses occurring in the extremities reported from 1999 to 2023. Conclusions: Extrapulmonary TB with predominantly muscle involvement is rare and with no specific clinical presentation. Muscular tuberculosis may be disdiagnosed for dermatomyositis due to the high muscle enzyme levels, delaying diagnosis and treatment. mNGS technology is helpful in the early and rapid diagnosis of muscular TB. On the basis of traditional anti-tuberculosis treatment, an ultrasound-guided percutaneous puncture drainage and intracavitary injection of streptomycin for the treatment of tuberculous muscle abscess is easy to operate, safe and effective, which is worthy of clinical popularization and application.
MeSH term(s)	Female ; Humans ; Adult ; Abscess/diagnosis ; Dermatomyositis/complications ; Dermatomyositis/diagnosis ; Muscles ; Tuberculosis/complications ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; High-Throughput Nucleotide Sequencing ; Streptomycin
Chemical Substances	Streptomycin (Y45QSO73OB)
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09179-2
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Article ; Online: Chemically Roughened, Sputtered Au Films with Trace-Loaded Manganese Oxide for both On-Chip and Off-Chip High Frequency Supercapacitors

Pai Lu / Haitao Xue / Wentao Liu / Zhongbao Feng / Qiang Sun

Nanomaterials, Vol 11, Iss 2, p

2021 Volume 257

Abstract: High frequency supercapacitors (HFSCs) are promising in alternating current line filtering and adaptable storage of high-frequency pulse electrical energy. Herein, we report a facile yet integrated-circuit-compatible fabrication of HFSC electrodes by ... ...

Abstract	High frequency supercapacitors (HFSCs) are promising in alternating current line filtering and adaptable storage of high-frequency pulse electrical energy. Herein, we report a facile yet integrated-circuit-compatible fabrication of HFSC electrodes by combining chemical roughening of the sputtered metal (Au) films and in situ trace loading of a pseudocapacitive material (MnO x ). The developed electrode fabrication route is versatile for different substrates, and is described with the application paradigms of both on-chip (with Si/SiO 2 substrate) and off-chip (without Si/SiO 2 substrate, with Ti substrate as an example in this study) HFSCs. With Au/MnO x films on Si/SiO 2 substrates as the working electrodes, the derived on-chip HFSC displayed satisfactory performance in high frequency applications (i.e., an areal capacitance of 131.7 µF cm −2 , a phase angle of −78°, and a RC time constant of 0.27 ms, at 120 Hz).
Keywords	high frequency supercapacitor ; thin film electrode ; sputtering ; oxidative etching ; chemical roughening ; trace loading ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Stimuli‐Responsive Antibacterial Materials

Xianghong Wang / Mengyao Shan / Shike Zhang / Xin Chen / Wentao Liu / Jinzhou Chen / Xuying Liu

Advanced Science, Vol 9, Iss 13, Pp n/a-n/a (2022)

Molecular Structures, Design Principles, and Biomedical Applications

2022

Abstract: Abstract Infections are regarded as the most severe complication associated with human health, which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic platforms for antibacterial treatments, which provide great potential for ...

Abstract	Abstract Infections are regarded as the most severe complication associated with human health, which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic platforms for antibacterial treatments, which provide great potential for accurate theranostics. In this review, the advantages, the response mechanisms, and the key design principles of stimuli‐responsive antibacterial materials are highlighted. The biomedical applications, the current challenges, and future directions of stimuli‐responsive antibacterial materials are also discussed. First, the categories of stimuli‐responsive antibacterial materials are comprehensively itemized based on different sources of stimuli, including external physical environmental stimuli (e.g., temperature, light, electricity, salt, etc.) and bacterial metabolites stimuli (e.g., acid, enzyme, redox, etc.). Second, structural characteristics, design principles, and biomedical applications of the responsive materials are discussed, and the underlying interrelationships are revealed. The molecular structures and design principles are closely related to the sources of stimuli. Finally, the challenging issues of stimuli‐responsive materials are proposed. This review will provide scientific guidance to promote the clinical applications of stimuli‐responsive antibacterial materials.
Keywords	antibacterial theranostics ; bacterial metabolites stimuli ; molecular structures ; physical stimuli ; stimuli‐responsive materials ; Science ; Q
Subject code	670
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Correction

Dejiang Pang / Chengcheng Yang / Chao Li / Yuanfeng Zou / Bin Feng / Lixia Li / Wentao Liu / Qihui Luo / Zhengli Chen / Chao Huang

Biology Open, Vol 12, Iss

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway

2023 Volume 1

Keywords	Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	The Company of Biologists
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Article ; Online: Melting Behaviors of Bio-Based Poly(propylene 2,5-furan dicarboxylate)-b-poly(ethylene glycol) Co Polymers Related to Their Crystal Morphology

Ouyang Shi / Peng Li / Chao Yang / Haitian Jiang / Liyue Qin / Wentao Liu / Xiaolin Li / Zhenming Chen

Polymers, Vol 16, Iss 1, p

2023 Volume 97

Abstract: In this experiment, a series of poly(propylene 2,5-furan dicarboxylate)-b-poly(ethylene glycol) (PPFEG) copolymers with different ratios were synthesized using melt polycondensation of dimethylfuran-2,5-dicarboxylate (DMFD), 1,3-propanediol (PDO) and ... ...

Abstract	In this experiment, a series of poly(propylene 2,5-furan dicarboxylate)-b-poly(ethylene glycol) (PPFEG) copolymers with different ratios were synthesized using melt polycondensation of dimethylfuran-2,5-dicarboxylate (DMFD), 1,3-propanediol (PDO) and poly(ethylene glycol) (PEG). The effect of PEG content on the crystallization behavior of the poly(propylene 2,5-furan dicarboxylate) (PPF) copolymers was investigated. For PPF, the nucleation density of the β -crystals was higher than that of α -crystals. As T c increases, the β crystals are suppressed more, but at T c = 140 °C, the bulk of PPF has already been converted to α crystals, which crystallize faster at higher nucleation densities, resulting in a difference in polymer properties. For this case, we chose to add a soft segment material, PEG, which led to an early multi–melt crystallization behavior of the PPF. The addition of PEG led to a decrease in the crystallization temperature of PPF, as well as a decrease in the cold crystallization peak of PPF. From the crystalline morphology, it can be seen that the addition of PEG caused the transformation of the PPF crystalline form to occur earlier. From the crystalline morphology of PPF at 155 °C, it can be observed that the ring-banded spherical crystals of the PPF appear slowly with increasing time. With the addition of PEG, spherical crystals of the ring band appeared earlier, and even appeared first, and then disappeared slowly.
Keywords	crystallization and melt ; random block copolymer ; poly(dimethyl 2,5-furandicarboxylate) ; crystalline morphology ; cyclic ring-banded spherical crystal ; biodegradable polymer ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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