LIVIVO - Search results -

Search results

Result 1 - 10 of total 11

Search options

Article ; Online: Research on an Evaluation Model of Urban Seismic Resilience Based on System Dynamics

Xunchang Li / Yifan Liu / Wenyong Zhang / Yaqian Wang

Sustainability, Vol 15, Iss 10112, p

A Case Study of Chengdu, China

2023 Volume 10112

Abstract: In response to the frequent occurrence of earthquakes in Chengdu, which poses a great threat to the economy, social development, production, and people’s lives, in this study, we construct an index evaluation system and a system dynamics model for urban ... ...

Abstract	In response to the frequent occurrence of earthquakes in Chengdu, which poses a great threat to the economy, social development, production, and people’s lives, in this study, we construct an index evaluation system and a system dynamics model for urban seismic resilience based on an analysis of the interaction between earthquake disasters and the urban system. Four types of schemes, namely, the current continuity type, economic development type, government intervention type, and resilience construction type, were designed, and the dynamic evaluation and simulation prediction of Chengdu’s seismic resilience capacity under each scheme were conducted. The research results show that, compared with the other three schemes, the resilience construction type has better universality and expansibility in terms of improving Chengdu’s seismic resilience. Therefore, it is necessary to maintain a certain level of economic development, to attach importance to the construction of monitoring and warning systems, and to strive to improve emergency rescue capabilities and disaster awareness education. The model and evaluation indicators have strong applicability, and the research results can provide a theoretical reference for the evaluation of seismic resilience in Chengdu.
Keywords	public safety ; resilience ; urban system ; system dynamics ; earthquake disaster ; simulation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690 ; 710
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers

Yujie Zhou / Songyan Yu / Wenyong Zhang

International Journal of Molecular Sciences, Vol 24, Iss 14511, p

2023 Volume 14511

Abstract: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated ... ...

Abstract	Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways and lead to the secretion of various cytokines. In recent years, cumulative studies have revealed the significant impacts of NLRs in gastrointestinal (GI) inflammatory diseases and cancers. Deciphering the role and molecular mechanism of the NLR signaling pathways may provide new opportunities for the development of therapeutic strategies related to GI inflammatory diseases and GI cancers. This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway.
Keywords	NOD-like receptor ; gastrointestinal inflammatory diseases ; esophageal cancer ; gastric cancer ; colorectal cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Percutaneous coronary intervention for chronic total occlusion of the left circumflex branch in mirror dextrocardia: a case report.

Hailin, Du / Hongtu, Qiao / Wenyong, Zhang

Journal of medical case reports

2023 Volume 17, Issue 1, Page(s) 486

Abstract: Background: Mirror dextrocardia (MDC) is a condition in which the heart is located in a mirror-image position on the right side of the chest compared to the normal position in individuals with physiological variations. Patients with MDC and chronic ... ...

Abstract	Background: Mirror dextrocardia (MDC) is a condition in which the heart is located in a mirror-image position on the right side of the chest compared to the normal position in individuals with physiological variations. Patients with MDC and chronic total occlusion (CTO) of the left circumflex branch (LCX) are extremely rare in clinical practice. The treatment of MDC-CTO-LCX differs significantly from patients without mirror dextrocardia and the same condition in terms of instrument selection and procedural techniques. In this article, we report a successful case of interventional treatment in a patient with MDC-CTO-LCX. We summarize the anatomical and electrocardiographic variations in patients with MDC-CTO-LCX, and discuss the selection of interventional instruments and techniques that can be useful for interventionists as well as the diagnostic and therapeutic considerations that can be helpful for clinical physicians. Case presentation: A male Han Chinese patient, 51, was admitted, presenting recurrent chest pain for a year and recent onset of exertional fatigue over the past week.He reported episodes of chest pain following physical activities over the past year, lasting between 5 and 20 min.Despite these symptoms, the patient did not seek immediate medical attention, and the occurrence of his chest pain has progressively lessened within the year.A week prior, the patient developed exertional dyspnea after brief walks, though without any episodes of nocturnal paroxysmal dyspnea.Upon arrival at our hospital for evaluation, he was initially diagnosed with chronic coronary syndrome, previous inferior myocardial infarction, atrial arrhythmia, and classified under the New York Heart Association functional class III.Following his admission, a chest X-ray and coronary angiography were conducted.The results indicated mirror dextrocardia and total occlusion of the left circumflex branch. Percutaneous coronary intervention (PCI) was performed on the left circumflex branch. Subsequent angiography demonstrated optimal stent positioning without evidence of hematoma or dissection.Following the procedure, the patient's symptoms of chest pain and exertional dyspnea were resolved, which led to his subsequent discharge.A follow-up electrocardiogram, 10 months post-procedure, displayed a slow and regular atrial rhythm. Conclusions: The incidence of dextrocardia is very low, and it may appear normal on an electrocardiogram; however, careful diagnosis is required when there is an abnormal direction of the P wave in limb leads. During the operation for chronic occlusive lesions of the right-sided coronary artery, the anomalous anatomical structure necessitates specific requirements for instrument selection and operative techniques. After revascularization of chronic occlusive vessels in dextrocardia, routine electrocardiographic examination may show false normalization, requiring caution in interpretation.
MeSH term(s)	Humans ; Male ; Atrial Fibrillation ; Chest Pain/etiology ; Chronic Disease ; Coronary Angiography ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/surgery ; Dextrocardia/complications ; Dextrocardia/diagnostic imaging ; Dextrocardia/surgery ; Dyspnea ; Percutaneous Coronary Intervention/methods ; Treatment Outcome ; Middle Aged
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04196-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Fine Characterization of the Macromolecular Structure of Huainan Coal Using XRD, FTIR, 13C-CP/MAS NMR, SEM, and AFM Techniques

Dun Wu / Hui Zhang / Guangqing Hu / Wenyong Zhang

Molecules, Vol 25, Iss 2661, p

2020 Volume 2661

Abstract: Research on the composition and structure of coal is the most important and complex basic research in the coal chemistry field. Various methods have been used to study the structure of coal from different perspectives. However, due to the complexity of ... ...

Abstract	Research on the composition and structure of coal is the most important and complex basic research in the coal chemistry field. Various methods have been used to study the structure of coal from different perspectives. However, due to the complexity of coal and the limitations of research methods, research on the macromolecular structure of coal still lacks systematicness. Huainan coalfield is located in eastern China and is the largest coal production and processing base in the region. In this study, conventional proximate analysis and ultimate analysis, as well as advanced instrumental analysis methods, such as Fourier transform infrared spectroscopy (FITR), X-ray diffraction (XRD), 13C-CP/MAS NMR, and other methods (SEM and AFM), were used to analyze the molecular structure of Huainan coal (HNC) and the distribution characteristics of oxygen in different oxygen-containing functional groups (OCFGs) in an in-depth manner. On the basis of SEM observation, it could be concluded that the high-resolution morphology of HNC’s surface contains pores and fractures of different sizes. The loose arrangement pattern of HNC’s molecular structure could be seen from 3D AFM images. The XRD patterns show that the condensation degree of HNC’s aromatic ring is low, and the orientation degree of carbon network lamellae is poor. The calculated ratio of the diameter of aromatic ring lamellae to their stacking height (La/Lc = 1.05) and the effective stacking number of aromatic nuclei (Nave = 7.3) show that the molecular space structure of HNC is a cube formed of seven stacked aromatic lamellae. The FTIR spectra fitting results reveal that the aliphatic chains in HNC’s molecular structure are mainly methyne and methylene. Oxygen is mainly –O–, followed by –C=O, and contains a small amount of –OH, the ratio of which is about 8:1:2. The molar fraction of binding elements has the approximate molecular structure C100H76O9N of organic matter in HNC. The results of the 13C NMR experiments show that the form of aromatic carbon atoms in HNC’s structure (the average structural size X_b of aromatic nucleus = 0.16) is mainly naphthalene with a condensation degree of 2, and the rest are aromatic rings composed of benzene rings and heteroatoms. In addition, HNC is relatively rich in ≡CH and –CH2– structures.
Keywords	fine characterization ; macromolecular structure ; XRD ; FTIR ; 13C NMR ; Huainan coal ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Spatiotemporal changes of ecosystem health and their driving mechanisms in alpine regions on the northeastern Tibetan Plateau

Songbing Zou / Jikun Qian / Baorong Xu / Zhenyu Tu / Wenyong Zhang / Xuanlong Ma / Yu Liang

Ecological Indicators, Vol 143, Iss , Pp 109396- (2022)

2022

Abstract: Ecosystem health plays a vital role in the development of regional ecological environment. Gannan Plateau, an important water conservation area in the upper reaches of the Yellow River, is located at the northeastern margin of the Qinghai-Tibet Plateau. ... ...

Abstract	Ecosystem health plays a vital role in the development of regional ecological environment. Gannan Plateau, an important water conservation area in the upper reaches of the Yellow River, is located at the northeastern margin of the Qinghai-Tibet Plateau. Due to the importance of the region, understanding the spatiotemporal patterns of the ecosystem health within this region is particularly critical. Previous studies on regional ecosystem health assessment mainly focused on single ecosystem type such as wetland, forest, and grassland, while there are relatively few studies that comprehensively assessed ecosystem health at high-spatial resolution in Gannan alpine areas. In this study, 11 counties and cities in Gannan Tibetan and Linxia Hui Autonomous Prefecture of the Gansu Province, China were used as the study area. We evaluated the ecosystem health of 154 township units from 2000 to 2020 with methods of Pressure-State-Response model (PSR) and Analytic Hierarchy Process (AHP), using a combination of satellite remote sensing data, social statistics data, meteorological data, and other geospatial data sources. The results showed that overall ecosystems in the southwestern part of the study area exhibited healthier condition than those located in the northeastern part, which is mainly due to the combination of the natural environment and the intensity of human activities in different regions. Over the past 20 years, due to the active implementation of relevant ecological protection and restoration policies by various regional governments and the improvement of the natural environment, the average ecosystem health status of Gannan Plateau has increased by 15.04 %, showing an improving trend in varying degrees or being stable, no declining trend was observed except for a small town. Our results implied that management should take different measures according to the differences of regional ecosystem health level, also pay more attention to areas where the ecosystem health status has not improved.
Keywords	Ecosystem health ; Pressure-state-response model ; Alpine region ; Yellow river Basin ; Ecology ; QH540-549.5
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Bi-Directional Pollution Characteristics and Ecological Health Risk Assessment of Heavy Metals in Soil and Crops in Wanjiang Economic Zone, Anhui Province, China

Dun Wu / Hai Liu / Jian Wu / Xia Gao / Ndhlovu kataza Nyasha / Guojun Cai / Wenyong Zhang

International Journal of Environmental Research and Public Health, Vol 19, Iss 9669, p

2022 Volume 9669

Abstract: Understanding the extent of contamination, sources and various carcinogenic and non-carcinogenic risks associated with different heavy metals in soil-crop systems is crucial for the prevention of heavy metal pollution. A survey was undertaken to ... ...

Abstract	Understanding the extent of contamination, sources and various carcinogenic and non-carcinogenic risks associated with different heavy metals in soil-crop systems is crucial for the prevention of heavy metal pollution. A survey was undertaken to determine heavy metal concentrations and degree of pollution in soil-crop systems (rice, wheat, and corn) using various indices such as pollution factor ( CF ), geo-accumulation index ( I geo ), enrichment coefficients and transfer coefficient, and to determine the source of heavy metals pollution in the Wanjiang Economic Zone, Anhui Province, China. A total of 308 pairs of soil-crop samples were collected in this study, comprising 245 pairs of soil-rice samples, 53 pairs of soil-wheat samples, and 10 pairs of soil-corn samples. The concentrations of cadmium (Cd) and nickel (Ni) in the soil of the study area exceeded the national limitation of heavy metals in the soil of China (GB 15618-2018, Soil Environmental Quality: Risk Control Standard for Soil Contamination of Agricultural Land. Ministry of Environmental Protection of China. Beijing. China ). The concentrations of copper (Cu), zinc (Zn) and lead (Pb) were also above the national limits to a lesser extent. All eight heavy metals (Cd, Cu, Ni, Pb Zn, arsenic (As), chromium (Cr), and mercury (Hg)) exceeded the background values in the study area. The enrichment coefficients of rice, wheat and maize to Cd, Cu and Zn were higher than those to other elements. On the basis of I geo , it can be indicated that the rhizosphere soil of rice was slightly polluted by Cd and Hg, while the concentrations of the other heavy metals were below the safety limits. The CF and pollution load index ( PLI ) indicated that the soil in the study area was heavily contaminated with heavy metals. A principal component analysis identified different sources of soil heavy metal pollution, that is, Cu, Pb, Zn and Cd from industrial sources, Cr and Ni from natural sources, and As and Hg from agricultural sources. The carcinogenic risk of heavy ...
Keywords	bi-directional pollution ; risk assessment ; heavy metals ; soil and crops ; wanjiang economic zone ; Medicine ; R
Subject code	910
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits

Hemi, Luan / Xuan, Li / Liang-Feng, Liu / Min, Li / Wenyong, Zhang / Tiangang, Luan

2023

Abstract: Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their ... ...

Abstract	Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented. However, the protein targets associated with microbiota-derived bile acids in AD have received limited attention. To address this gap, we conducted comprehensive thermal proteomic analyses to unravel and comprehend the protein targets affected by microbiota-derived bile acids in AD. Our investigation identified sixty-five unique proteins as potential targets of deoxycholic acid (DCA), a primary component of the bile acid pool originating from the gut microbiota. Particularly noteworthy among these proteins were Nicastrin and Casein kinase 1 epsilon. We found that DCA, through its interaction with the Nicastrin subunit of {\gamma}-secretase, significantly contributed to the formation of amyloid beta, a key hallmark of AD pathology. Additionally, We observed substantial elevations in the urine levels of four bile acids (DCA, GHCA, GHDCA, and GUDCA) in AD patients compared to healthy controls. Moreover, the ratios of DCA to cholic acid (CA) and glycodeoxycholic acid (GDCA) to DCA were significantly increased in AD patients, indicating aberrations in the biosynthetic pathway responsible for bile acid dehydroxylation. The augmented levels of microbiota-derived bile acids and their altered ratios to primary bile acids exhibited notable associations with AD. Collectively, our findings provide crucial insights into the intricate interplay between microbiota-derived bile acids and the pathogenesis of AD, thereby shedding light on potential therapeutic targets for this debilitating disease.
Keywords	Physics - Biological Physics
Subject code	571
Publishing date	2023-10-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Copy number variants landscape of multiple cancers and clinical applications based on NGS gene panel

Kangpeng Yan / Li Niu / Boyu Wu / Chongwu He / Lei Deng / Chuan Chen / Zhangzhang Lan / Chao Lin / Weihua Kuang / Huihong Lin / Jun Zou / Wenyong Zhang / Zhiqiang Luo

Annals of Medicine, Vol 55, Iss

2023 Volume 2

Abstract: AbstractBackground The rapid adoption of next-generation sequencing in clinical oncology has enabled detection of molecular biomarkers which are shared between multiple tumour types. Intra-tumour heterogeneity is a mechanism of therapeutic resistance and ...

Abstract	AbstractBackground The rapid adoption of next-generation sequencing in clinical oncology has enabled detection of molecular biomarkers which are shared between multiple tumour types. Intra-tumour heterogeneity is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, the tumour-related copy number variants (CNVs), as key regulators of cancer origination, development, and progression, across various types of cancers are poorly understood.Methods We performed pan-cancer CNV analysis of cancer-related genes in 15 types of cancers including 1438 cancerous patients by next-generation sequencing using a commercially available pan-cancer panel (Onco PanScan™). Downstream bioinformatics analysis was performed in order to detect CNVs, cluster analysis of the found CNVs, and comparison of the frequency of gained CNVs between different types of cancers. LASSO analysis was used for identification of the most important CNVs.Results We also identified 523 CNVs among which 16 CNVs were common while 22 CNVs were caner-specific CNVs. Meanwhile, FAM58A was most commonly found in all studied cancers in this study and significant differences were found in FAM58A between female and male patients (p = .001). Common CNVs, such as FOXA1, NFKBIA, HEY1, MECOM, CHD7, AGO2, were mutated in 6.79%, 8.45%, 7.51%, 6.43%, 7.59%, 8.16% of tumours, while most of these mutations have proven roles in positive regulation of transcription from RNA polymerase II promoter. 11 features including sex, DIS3, EPHB1, ERBB2, FLT1, HCK, KEAP1, MYD88, PARP3, TBX3, and TOP2A were found as the key features for classification of cancers using CNVs.Conclusion The 16 common CNVs between cancers can be used to identify the target of pan-cancer drug design and targeted therapies. Additionally, 22 caner-specific CNVs can be used as unique diagnostic markers for each cancer type.
Keywords	Pan-cancer ; copy number variants ; GO and KEGG analysis ; cluster analysis ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients

Hemi Luan / Wanjian Gu / Hua Li / Zi Wang / Lu Lu / Mengying Ke / Jiawei Lu / Wenjun Chen / Zhangzhang Lan / Yanlin Xiao / Jinyue Xu / Yi Zhang / Zongwei Cai / Shijia Liu / Wenyong Zhang

Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract Background Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative RA cases by studying metabolomic and lipidomic changes in RA patient ...

Abstract	Abstract Background Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative RA cases by studying metabolomic and lipidomic changes in RA patient serum. Methods We performed comprehensive metabolomic and lipidomic profiling in serum of 225 RA patients and 100 normal controls. These samples were divided into a discovery set (n = 243) and a validation set (n = 82). A machine-learning-based multivariate classification model was constructed using distinctive metabolites and lipids signals. Results Twenty-six metabolites and lipids were identified from the discovery cohort to construct a RA diagnosis model. The model was subsequently tested on a validation set and achieved accuracy of 90.2%, with sensitivity of 89.7% and specificity of 90.6%. Both seropositive and seronegative patients were identified using this model. A co-occurrence network using serum omics profiles was built and parsed into six modules, showing significant association between the inflammation and immune activity markers and aberrant metabolism of energy metabolism, lipids metabolism and amino acid metabolism. Acyl carnitines (20:3), aspartyl-phenylalanine, pipecolic acid, phosphatidylethanolamine PE (18:1) and lysophosphatidylethanolamine LPE (20:3) were positively correlated with the RA disease activity, while histidine and phosphatidic acid PA (28:0) were negatively correlated with the RA disease activity. Conclusions A panel of 26 serum markers were selected from omics profiles to build a machine-learning-based prediction model that could aid in diagnosing seronegative RA patients. Potential markers were also identified in stratifying RA cases based on disease activity.
Keywords	Rheumatoid arthritis ; Seronegative ; Metabolomic ; Lipidomic ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome

Lili Jiang / Feng Chen / Xiaofan Hu / Yingying Hu / Yange Wang / Wenyong Zhang / Yudong Peng / Longxian Cheng

Disease Markers, Vol

2017 Volume 2017

Abstract: Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural ... ...

Abstract	Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is known about its role in ACS. We therefore examined Helios+ Tregs in patients with ACS, patients with stable angina, and control subjects. 73 patients with ACS, 30 patients with stable angina, and 48 control subjects were enrolled. The frequencies and estimated absolute numbers of different Treg subsets in peripheral blood were measured by flow cytometry. Plasma cytokine level was measured by ELISA. The mRNA expression of Foxp3 and Helios in purified CD4+ T cells was determined by RT-PCR. Helios+ Tregs was decreased significantly in patients with ACS. The frequency and estimated absolute numbers of CD4+Foxp3+Helios+ Tregs were negatively correlated with IL-6 and positively correlated with circulating level of TGF-beta1 and HDL-C. The mRNA expression of Foxp3 and Helios was decreased in CD4+ T cells from patients with ACS. In summary, Helios+ Tregs was downregulated in patients with ACS and may play a role in ACS.
Keywords	Medicine (General) ; R5-920
Subject code	616 ; 610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED