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  1. AU="Wenzel, Ross"
  2. AU="Wang, Ruihan"
  3. AU=Qing Enya AU=Qing Enya
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  1. Artikel ; Online: Serum and tissue metallome of pancreatic ductal adenocarcinoma.

    Byeon, Sooin / du Toit-Thompson, Taymin / Hipperson, Luke / Maloney, Sarah / Wenzel, Ross / Gill, Anthony J / Samra, Jaswinder S / Mittal, Anubhav / Sahni, Sumit

    Cancer science

    2024  Band 115, Heft 5, Seite(n) 1446–1458

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) patients have late presentation at the time of diagnosis and a poor prognosis. Metal dyshomeostasis is known to play a role in cancer progression. However, the blood and tissue metallome of PDAC patients has not ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) patients have late presentation at the time of diagnosis and a poor prognosis. Metal dyshomeostasis is known to play a role in cancer progression. However, the blood and tissue metallome of PDAC patients has not been assessed. This study aimed to determine the levels of essential and toxic metals in the serum and pancreatic tissue from PDAC patients. Serum samples were obtained from PDAC patients before surgical resection. Tissue (tumor and adjacent normal pancreas) were obtained from the surgically resected specimen. Inductively coupled plasma-mass spectrometry (ICP-MS) analysis was performed to quantify the levels of 10 essential and 3 toxic metals in these samples. Statistical analysis was performed to identify dysregulated metals in PDAC and their role as potential diagnostic and prognostic biomarkers. Significantly decreased serum levels of magnesium, potassium, calcium, iron, zinc, selenium, arsenic, and mercury and increased levels of molybdenum were shown to be associated with PDAC. There were significantly decreased levels of zinc, manganese and molybdenum, and increased levels of calcium and selenium in the pancreatic tumor tissue compared with the adjacent normal pancreas. Notably, lower serum levels of calcium, iron, and selenium, and higher levels of manganese, were significantly associated with a poor prognosis (i.e., overall survival) in PDAC patients. In conclusion, this is the first study to comprehensively assess the serum and tissue metallome of PDAC patients. It identified the association of metals with PDAC diagnosis and prognosis.
    Mesh-Begriff(e) Humans ; Carcinoma, Pancreatic Ductal/blood ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/metabolism ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/metabolism ; Female ; Male ; Middle Aged ; Aged ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/metabolism ; Prognosis ; Metals/blood ; Metals/metabolism ; Metals/analysis ; Pancreas/metabolism ; Pancreas/pathology ; Magnesium/blood ; Magnesium/metabolism ; Magnesium/analysis ; Adult ; Calcium/blood ; Calcium/metabolism ; Calcium/analysis ; Selenium/blood ; Selenium/analysis ; Selenium/metabolism ; Iron/metabolism ; Iron/blood ; Zinc/blood ; Zinc/metabolism ; Zinc/analysis ; Molybdenum/blood
    Sprache Englisch
    Erscheinungsdatum 2024-03-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.16124
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Commentary on Paper: "Controlling the misuse of cobalt in horses".

    Major, Derek / Wenzel, Ross

    Drug testing and analysis

    2016  Band 8, Heft 8, Seite(n) 880–881

    Mesh-Begriff(e) Animals ; Cobalt ; Horses
    Chemische Substanzen Cobalt (3G0H8C9362)
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.1901
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Determination of vitamin B

    Wenzel, Ross / Major, Derek / Hesp, Karly / Doble, Philip

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2018  Band 50, Seite(n) 634–639

    Abstract: Regulating authorities in the racing industry have restricted the administration of potentially performance enhancing cobalt salts to horses. There are severe penalties for trainers presenting horses with elevated urine cobalt concentrations, and ... ...

    Abstract Regulating authorities in the racing industry have restricted the administration of potentially performance enhancing cobalt salts to horses. There are severe penalties for trainers presenting horses with elevated urine cobalt concentrations, and compliance is ensured via analysis of total urinary cobalt at thresholds of 100 μg/L. When cobalt is present as part of the cobalamin molecule it is not considered performance enhancing. This paper demonstrates that a horse can excrete a significant proportion of a commercially available vitamin B12 injection in urine without metabolic modification. A liquid chromatography - inductively coupled plasma - mass spectrometry (LC-ICP-MS) method is presented for urinary cobalt speciation. Given the serious nature surrounding performance enhancing drug offences, we conclude that presumptive positives identified by urine total cobalt measurements require further analysis to differentiate inorganic cobalt from vitamin B12.
    Mesh-Begriff(e) Animals ; Chromatography, Liquid/methods ; Cobalt/urine ; Horses ; Mass Spectrometry/methods ; Vitamin B 12/urine
    Chemische Substanzen Cobalt (3G0H8C9362) ; Vitamin B 12 (P6YC3EG204)
    Sprache Englisch
    Erscheinungsdatum 2018-05-09
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2018.05.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Life-threatening barium carbonate poisoning managed with intravenous potassium, continuous veno-venous haemodialysis and endoscopic removal of retained ceramic glazes.

    Jamshidi, Nazila / Dhaliwal, Nina / Hearn, Dean / McCalman, Craig / Wenzel, Ross / Koutsogiannis, Zeff / Roberts, Darren M

    Clinical toxicology (Philadelphia, Pa.)

    2022  Band 60, Heft 8, Seite(n) 974–978

    Abstract: Introduction: Barium poisoning is rare but potentially severe. We describe a case of acute barium carbonate poisoning with cardiac arrest, managed with intravenous potassium, dialysis and endoscopic removal of retained ceramic glazes.: Case report: A ...

    Abstract Introduction: Barium poisoning is rare but potentially severe. We describe a case of acute barium carbonate poisoning with cardiac arrest, managed with intravenous potassium, dialysis and endoscopic removal of retained ceramic glazes.
    Case report: A 38-year-old woman presented with vomiting 90 min after ingesting 3 cups of barium and strontium carbonate. Initial bloods noted potassium 2.8 mmol/L and creatinine 53 μmol/L. Electrocardiogram demonstrated prolonged corrected QT interval 585msec. Initial management included intravenous potassium. Four hours post-ingestion she developed proximal muscle weakness in upper limbs with a potassium of 2.2 mmol/L. At 15 h post-ingestion she developed profound muscle weakness, polymorphic ventricular tachycardia and cardiac arrest. Treatment included defibrillation, endotracheal intubation and continuous veno-venous haemodialysis (CVVHD) for metabolic derangement and enhanced elimination of barium. Chest X-ray 17 h post-ingestion demonstrated a large radio-opaque mass in the stomach, thought to be the ceramic glaze. Endoscopy removed the retained material 41 h post-ingestion. She was extubated 58 h post-ingestion and CVVHD was ceased on day 3. Serum creatinine peaked at 348 μmol/L on day 7, but normalised by discharge. Biphasic barium concentrations were noted, notably 94 μmol/L on admission, 195 μmol/L at 16 h, 95 μmol/L at 20 h, and 193 μmol/L at 30 h post-ingestion.
    Conclusion: In barium poisoning with hypokalaemia, prompt potassium supplementation is required but rebound hyperkalaemia can occur. Endoscopic removal of ceramic glazes may be useful more than 12 h post-ingestion. Consider extracorporeal methods to enhance barium elimination in severe cases.
    Mesh-Begriff(e) Adult ; Barium ; Carbonates ; Ceramics ; Continuous Renal Replacement Therapy ; Creatinine ; Endoscopy ; Female ; Heart Arrest/chemically induced ; Heart Arrest/therapy ; Humans ; Muscle Weakness ; Poisoning/therapy ; Potassium
    Chemische Substanzen Carbonates ; Barium (24GP945V5T) ; barium carbonate (6P669D8HQ8) ; Creatinine (AYI8EX34EU) ; Potassium (RWP5GA015D)
    Sprache Englisch
    Erscheinungsdatum 2022-05-04
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2022.2068424
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 419: Hefte anzeigen Standort:
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  5. Artikel ; Online: Microfluidic high performance liquid chromatography-chip hyphenation to inductively coupled plasma-mass spectrometry.

    Bishop, David P / Blanes, Lucas / Wilson, Alexander B / Wilbanks, Thor / Killeen, Kevin / Grimm, Rudolf / Wenzel, Ross / Major, Derek / Macka, Mirek / Clarke, David / Schmid, Robin / Cole, Nerida / Doble, Philip A

    Journal of chromatography. A

    2017  Band 1497, Seite(n) 64–69

    Abstract: The Agilent Chip Cube Interface is a microfluidic chip-based technology originally designed for nanospray molecular mass spectrometry in which the sample enrichment, nano-column, tubing, connectors and spray tip were integrated into a single ... ...

    Abstract The Agilent Chip Cube Interface is a microfluidic chip-based technology originally designed for nanospray molecular mass spectrometry in which the sample enrichment, nano-column, tubing, connectors and spray tip were integrated into a single biocompatible chip. Here we describe the hyphenation of the Chip Cube Interface to ICP-MS via modification of the standard HPLC chip design and a new total consumption nebuliser suitable for flow rates as low as 300nLmin
    Mesh-Begriff(e) Animals ; Chromatography, High Pressure Liquid/methods ; Horses/blood ; Limit of Detection ; Mass Spectrometry/methods ; Microfluidics/methods ; Vitamin B 12/blood
    Chemische Substanzen Vitamin B 12 (P6YC3EG204)
    Sprache Englisch
    Erscheinungsdatum 2017-05-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2017.03.025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  6. Artikel: Arsenic speciation in urine by solvent extraction, graphite furnace atomic absorption spectrometry and capillary electrophoresis [and] inductively coupled plasma mass spectrometry

    Wenzel, Ross

    Abstract: A modified version of the solvent extraction method described by Buchet et al (1980) for partially speciating arsenic in human urine specimens was investigated. It was shown to be a valid means of isolating those arsenicals associated with toxicity and ... ...

    Abstract A modified version of the solvent extraction method described by Buchet et al (1980) for partially speciating arsenic in human urine specimens was investigated. It was shown to be a valid means of isolating those arsenicals associated with toxicity and was used to screen subjects with elevated total urinary arsenic levels for toxic arsenicals. This method involves the removal of the toxic arsenicals arsenite (AsIII), arsenate (AsV), methanearsonic acid (MAA) and dimethylarsinic acid (DMAA) from urine by a solvent extraction process. After the addition of concentrated hydrochloric acid and potassium iodide, toxic arsenicals are extracted from the urine into cyclohexane and mixed with a matrix modifier solution of nickel nitrate for analysis by graphite furnace atomic absorption spectrometry (GFAAS). Since, in most subjects, elevated urinary total arsenic levels are due to the presence of non-toxic arsenicals following seafood consumption, partial speciation by solvent extraction / GFAAS is used to confirm or to rule out arsenic poisoning in subjects with elevated total urinary arsenic levels. A capillary electrophoresis (CE) technique was developed, in which CE was interfaced with an inductively coupled plasma mass spectrometer (ICPMS) to permit the isolation and estimation of major arsenic species in urine and other biological specimens. It was possible to separate 5 arsenicals by CE and to detect, by coupled ICPMS, levels of individual arsenicals corresponding to 0.1 ppm (1.3 µmol/L) arsenic in urine. This CE / ICPMS technique was used to evaluate partial speciation by solvent extraction / GFAAS in a range of artificially prepared standard mixtures of arsenicals, and in urine specimens. It was confirmed that the latter technique is a valid means of assessing subjects suspected of arsenic poisoning because of their elevated total urinary arsenic levels. Using the CE / ICPMS technique, it was also confirmed in one leukaemic patient, that, in humans, the main urinary arsenicals excreted after acute exposure to arsenite (AsIII) are DMAA and MAA. In other healthy subjects, it was found that, after seafood consumption, the predominant arsenical present in urine was arsenobetaine. On the basis of these studies, a protocol was defined for the stepwise investigation of urine specimens for inorganic and organic arsenic compounds.Preliminary studies were also carried out on edible seaweeds, which are known to contain arsenosugars and arsenolipids. Partial speciation, of edible seaweed digests, gave incomplete and variable arsenic recoveries. When the same digests were analysed by CE / ICPMS, the only arsenical found was arsenobetaine, suggesting that arsenosugars and arsenolipids may have been broken down to form arsenobetaine during extraction. Although inconclusive, these results demonstrate the usefulness of CE / ICPMS for evaluating arsenic extraction methods in novel sample matrices.
    Sprache Englisch
    Dokumenttyp Artikel
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

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